Springer 2009. Hardcover. Near Fine. Hardcover xiii 360 pages NOT ex-library. Not an economy/Indian edition. Mildly used clean and bright throughout with unmarked text free of inscriptions and stamps firmly bound. Published without a dust jacket. -- Since its first description in 1942 in both serum and cerebrospinal fluid transthyretin TTR has had an eventful history including changes in name from 'prealbumin' to 'thyroxine-binding prealbumin' to 'transthyretin' as knowledge increased about its functions. TTR is synthesised in a wide range of tissues in humans and other eutherian mammals: the liver choroid plexus blood- cerebrospinal fluid barrier retinal pigment epithelium of the eye pancreas intestine and meninges. However its sites of synthesis are more restricted in other vertebrates. This implies that the number of tissues synthesising TTR during vertebrate evolution has increased and raises questions about the selection pressures governing TTR synthesis. TTR is most widely known as a distributor of thyroid hormones. In addition TTR binds retinol-binding protein which binds retinol. In this way TTR is also involved with retinoid distribution. More recently TTR has been demonstrated to bind a wide variety of endocrine disruptors including drugs pollutants industrial compounds heavy metals and some naturally occurring plant flavonoids. These not only interfere with thyroid hormone delivery in the body but also transport such endocrine disruptors into the brain where they have the potential to accumulate. -- Contents: 1 Mechanisms of Molecular Recognition: Structural Characteristics of Transthyretin Ligand Interactions / Vivian Cody & Andrzej Wojtczak; 2 Transthyretin Synthesis During Development and Evolution: What the Marsupials Revealed / Samantha J. Richardson; 3 Evolution of Transthyretin Gene Structure / Porntip Prapunpoj; 4 Evolutionary Insights from Fish Transthyretin / Deborah M. Power; 5 Salmonella sp. TLP: A Periplasmic 5-Hydroxyisourate Hydrolase / Sarah Hennebry; 6 Vertebrate 5-Hydroxyisourate Hydrolase Identification Function Structure and Evolutionary Relationship with Transthyretin / Giuseppe Zanotti; 7 Transthyretin-Related and Transthyretin-like Proteins / A. Elisabeth Sauer-Eriksson; 8 Transthyretin-Retinol-Binding Protein Complex / Hugo L. Monaco; 9 Transthyretin and Retinol-Binding Protein: Implications in Fish Physiology / Sancia Gaetani & Diana Bellovino; 10 Transthyretin and Endocrine Disruptors / Kiyoshi Yamauchi & Akinori Ishihara; 11 Genetics: Clinical Implications of Transthyretin Amyloidosis / Merrill D. Benson; 12 Molecular Pathogenesis Associated with Familial Amyloidotic Polyneuropathy / Maria Jo o Saraiva; 13 Histidine 31: The Achilles' Heel of Human Transthyretin. Microheterogeneity is Not Enough to Understand the Molecular Causes of Amyloidogenicity / Klaus Altland & Samantha J. Richardson; 14 New Therapeutic Approaches for Familial Amyloidotic Polyneuropathy FAP / Yukio Ando; 15 Liver Transplantation for Transthyretin Amyloidosis / Bo-Goran Ericzon; 16 Mouse Models of Transthyretin Amyloidosis / Sadahiro Itoand Shuichiro Maeda; 17 What Have We Learned from Transthyretin-Null Mice: Novel Functions for Transthyretin / Jo o Carlos Sousa & Joana Almeida Palha; 18 Transthyretin Null Mice: Developmental Phenotypes / Julie A. Monk & Samantha J. Richardson; 19 Transthyretin Null Mice as a Model to Study the Involvement of Transthyretin in Neurobiology: From Neuropeptide Processing to Nerve Regeneration / Carolina Estima Fleming; 20 Plasma Transthyretin Reflects the Fluctuations of Lean Body Mass in Health and Disease / Yves Ingenbleek; Index <br/> <br/> Springer hardcover
書籍販売業者の参照番号
: 5312 ISBN : 3642006450 9783642006456
Hardcover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Many of the earliest books particularly those dating back to the 1900s and before are now extremely scarce and increasingly expensive. Pomona Press are republishing these classic works in affordable high quality modern editions usi hardcover
書籍販売業者の参照番号
: ria9781443733397_inp ISBN : 1443733393 9781443733397
Hardcover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Many of the earliest books particularly those dating back to the 1900s and before are now extremely scarce and increasingly expensive. Pomona Press are republishing these classic works in affordable high quality modern editions usi hardcover
書籍販売業者の参照番号
: ria9781443733021_inp ISBN : 1443733024 9781443733021
Hardcover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Reproduktion des Originals: Clarissa Harlowe von Samuel Richardson hardcover
書籍販売業者の参照番号
: ria9783732669202_inp ISBN : 3732669203 9783732669202
Paperback. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Reproduktion des Originals: Clarissa Harlowe von Samuel Richardson paperback
書籍販売業者の参照番号
: ria9783732669387_inp ISBN : 3732669386 9783732669387
Hardcover. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Reproduktion des Originals: Clarissa Harlowe von Samuel Richardson hardcover
書籍販売業者の参照番号
: ria9783732669394_inp ISBN : 3732669394 9783732669394
The Folio Society 1993. Hardcover. Very Good. 1993. Second Printing. Unpaginated. No dust jacket Folio edition with slipcase. 1533 pages over two volumes. Blue & green cloth with gilt lettering. Illustrated by Simon Brett. Top edge dyed blue. B&W illustrations throughout. Clean pages with firm binding. Mild wear to spine board edges and corners with few small marks to boards. Slipcase is very good with minor wear marking and soiling to boards. The Folio Society hardcover
<p>1768. leather. Good. Photo Gallery Clarissa or the History of a Young Lady Vol. 4 -By Samuel Richardson 6th Edition Publisher-Printing Location: London Printed for J. and F. Rivington Date and Numbering: 1768 Size and Page Count: 4.25"" X 7"" Tall approx. 380 pages</p><p>Condition: Good binding good some age yellowing to pages cover has shelf wear first page torn markings on endpages last few pages <strong>missing</strong></p><p>----An excellent opportunity for the collector researcher or historian----</p><p>Contains:</p><p>Clarissa or the History of a Young Lady is an epistolary novel by Samuel Richardson published in 1748. It tells the tragic story of a heroine whose quest for virtue is continually thwarted by her family and is the longest real novel in the English language. -Wikipedia</p> hardcover
P. Byrne J. Moore and A. Grueber. Collectible - Good. Dublin: P. Byrne J. Moore and A. Grueber 1792. New edition corrected. Volume 5. 16mo hardcover in early leather. 360pp. Good. Pencil notation on second rear endpaper. A few stains inside but tightly bound; a beautiful copy. None online and scarce on WorldCat as of 2/18/2020. rare tragedy epistolary novel Inquire if you need further information. P. Byrne, J. Moore, and A. Grueber hardcover
W. Colles. Collectible - Good. Dublin: W. Colles 1780. New edition corrected. Volume 2. 16mo hardcover in early leather. 309pp. Good. Typical shelfwear and joints starting. A few words obscured by a small dark stain on page 3. Otherwise clean and tightly bound; a beautiful copy. None online and scarce on WorldCat as of 2/18/2020. rare tragedy epistolary novel Inquire if you need further information. W. Colles hardcover
P. Byrne J. Moore and A. Grueber. Collectible - Good. Dublin: P. Byrne J. Moore and A. Grueber 1792. New edition corrected. Volume 8. 16mo hardcover in early leather. 372pp. Good. Light shelfwear and front joint just starting. Small dampstains to each pastedown and facing endpaper. Pencil notation on first rear endpaper. Otherwise clean and tightly bound. None online and scarce on WorldCat as of 2/18/2020. rare tragedy epistolary novel Inquire if you need further information. P. Byrne, J. Moore, and A. Grueber hardcover
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