‎Jacob‎

‎Jacob Mira‎

‎The Sleepwalkers Guide to Dancing‎

‎Bloomsbury Publishing. First Edition. Hardcover. Used; Good. Simply Brit Shipped with Premium postal service within 24 hours from the UK with impressive delivery time. We have dispatched from our book depository; items of good condition to over ten million satisfied customers worldwide. We are committed to providing you with reliable and efficient service at all times. 07/03/2014 Bloomsbury Publishing hardcover‎

Bookseller reference : 1670681 ISBN : 1408841142 9781408841143

‎Jacob Mira‎

‎The Sleepwalker's Guide to Dancing: A Novel‎

‎Random House Trade Paperbacks. PAPERBACK. 0812985060 . New. Random House Trade Paperbacks paperback‎

Bookseller reference : Z0812985060ZN ISBN : 0812985060 9780812985061

‎Jacob Mira‎

‎The Sleepwalker's Guide to Dancing : a Novel‎

‎Del Rey. Used; Very Good. Random House Publishing Group 2014 Hardcover stated First Edition. This book has a remainder mark but is otherwise like new. Book Condition: Very Good Jacket Condition: Very Good . 2014. First Edition. HARDCOVER. Del Rey hardcover‎

Bookseller reference : 9780812994780 ISBN : 0812994787 9780812994780

‎Jacob Mira‎

‎The Sleepwalker's Guide to Dancing: A Novel‎

‎Random House. Hardcover. 0812994787 First edition First printing. Not inscribed clipped or otherwise marked. Dust jacket in protective cover. Shipped in a box. Complete # line 10987654321. . Fine. Random House hardcover‎

Bookseller reference : SKU1007511 ISBN : 0812994787 9780812994780

‎Jacob Mira‎

‎The Sleepwalker's Guide to Dancing: A Novel‎

‎Random House Trade Paperbacks. New. Special order direct from the distributor Random House Trade Paperbacks paperback‎

Bookseller reference : ING9780812985061 ISBN : 0812985060 9780812985061

‎JACOB Mira preface notes & catalogue‎

‎Paul Delvaux: Graphic Work‎

‎New York: Rizzoli 1976. First. hardcover. fine/fine. Delvaux Paul. 97 illustrations throughout some in color. The tinted frontispiece and dust wrapper are original lithographs printed in Paris by Mourlot. 166pp. Thick 4to natural cloth d.w. New York: Rizzoli 1976. First American edition. A fine copy in a fine dust wrapper and cardboard slipcase.<br/><br/> Rizzoli unknown books‎

Bookseller reference : 200945 ISBN : 0847800628 9780847800629

‎Jacob MK‎

‎Miljoenenmam‎

‎Archipel Uitgeverij. Used - Good. Ships from the UK. Former Library book. Shows some signs of wear and may have some markings on the inside. 100% Money Back Guarantee. Your purchase also supports literacy charities. Archipel, Uitgeverij unknown‎

Bookseller reference : GRP96520488 ISBN : 9063051786 9789063051785

‎Jacob Monod Lwoff and Brenner‎

‎22 offprints mimeographs etc. on molecular biology and bacterial genetics with two others‎

‎1968. <p>Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints.</p> <p>First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death.</p> <p>The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: </p> <p>1 lysogeny and bacterial conjugation</p> <p> 2 expression of the genetic material via messenger RNA</p> <p> 3 the regulation of the genetic activity of bacterial cells by operons</p> <p>4 the organization of bacterial genetic material.</p> <p> In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology.</p> <p>Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage.</p> <p> "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date.</p> <p>Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. </p> <p>"Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385.</p> <p> In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria.</p> <p>In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103.</p> <p>Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306.</p> <p> Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA.</p> <p>The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. </p> <p>The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below.</p> <p>1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27.</p> <p>2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4.</p> <p>3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles.</p> <p>4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature.</p> <p>5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382.</p> <p>6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7.</p> <p>7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature.</p> <p>8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11.</p> <p>9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400.</p> <p>10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature.</p> <p>11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410.</p> <p>12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature.</p> <p>13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers.</p> <p>14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13.</p> <p>15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning.</p> <p>16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11.</p> <p>17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature.</p> <p>18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature.</p> <p>19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers.</p> <p>20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature.</p> <p>21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers.</p> <p>22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature.</p> <p>23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers.</p> <p>24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp.</p> . unknown books‎

Bookseller reference : 38733

‎Jacob Moses.‎

‎A comparison of cottonseed meal cottonseed meal and tankage peanut oil meal and soybean oil meal fed with corn silage for fattening two-year-old steers / by M. Jacob and H.R. Duncan. Volume v.1671938 1938 Leather Bound‎

‎2020. Leather Bound. New. SPECIAL DISCOUNTED PRICE DURING COVID PANDEMIC. Leather Binding on Spine and Corners with Golden Leaf Printing on round Spine. Reprinted in 2020 with the help of original edition published long back 1938. This book is printed in black & white sewing binding for longer life Printed on high quality Paper re-sized as per Current standards professionally processed without changing its contents. As these are old books we processed each page manually and make them readable but in some cases some pages which are blur or missing or black spots. We expect that you will understand our compulsion in these books. We found this book important for the readers who want to know more about our old treasure so we brought it back to the shelves. Hope you will like it and give your comments and suggestions. Lang: - eng Vol: - Volume v.1671938 Pages 16. EXTRA 10 DAYS APART FROM THE NORMAL SHIPPING PERIOD WILL BE REQUIRED FOR LEATHER BOUND BOOKS.FOLIO EDITION IS ALSO AVAILABLE. Volume v.1671938 hardcover‎

Bookseller reference : LB1111016733248

‎Jacob Moses.‎

‎Winter-finishing two-year-old grass steers / by M. Jacob and H.R. Duncan. Volume v.1561935 1935 Leather Bound‎

‎2020. Leather Bound. New. SPECIAL DISCOUNTED PRICE DURING COVID PANDEMIC. Leather Binding on Spine and Corners with Golden Leaf Printing on round Spine. Reprinted in 2020 with the help of original edition published long back 1935. This book is printed in black & white sewing binding for longer life Printed on high quality Paper re-sized as per Current standards professionally processed without changing its contents. As these are old books we processed each page manually and make them readable but in some cases some pages which are blur or missing or black spots. We expect that you will understand our compulsion in these books. We found this book important for the readers who want to know more about our old treasure so we brought it back to the shelves. Hope you will like it and give your comments and suggestions. Lang: - eng Vol: - Volume v.1561935 Pages 24. EXTRA 10 DAYS APART FROM THE NORMAL SHIPPING PERIOD WILL BE REQUIRED FOR LEATHER BOUND BOOKS.FOLIO EDITION IS ALSO AVAILABLE. Volume v.1561935 hardcover‎

Bookseller reference : LB1111016733245

‎Jacob Mrs. John‎

‎The Art of Vegetable Carving‎

‎Federal Publications 1974. First Edition. Hard Cover. Very Good/Very Good. Creative very well illustrated book on vegetable carving. Jacket has two minor tears and a wrinkle between. Boards are a bit warped. Federal Publications hardcover‎

Bookseller reference : 004108

‎Jacob N‎

‎A Passage Perilous‎

‎Hutchinson 1947-01-01. Hardcover. Good. Binding: Hardback --- Publisher: The Book Club --- Date: 1947 --- Edition: --- Pages: 185 --- Condition: Good --- DJ Condition: None --- Description: All of the internal pages are unmarked uncreased and tightly bound no stamps or inscriptions the only flaws are a couple of minor scuffs to the boards. MOST OF OUR BOOKS ARE SHIPPED WITHIN 1 WORKING DAY OF PURCHASE. . BUY WITH CONFIDENCE - WE UPLOAD A SELECTION OF HIGH QUALITY PHOTOGRAPHS WITH EACH LISTING HOWEVER IF NOT ALREADY PRESENT PHOTOGRAPHS OF ANY OF OUR TITLES CAN BE PROVIDED BY REQUEST VIA E-MAIL B000R0V7G4 Hutchinson hardcover‎

Bookseller reference : SKU1031876

‎Jacob N‎

‎Gollantz.‎

‎Hutchinson 1948 1948. Paperback. Fair. VG/VG 1st. Hutchinson 1948 paperback‎

Bookseller reference : 7853

‎Jacob N‎

‎Me - Over there‎

‎Hutchinson. Used - Good. Ships from the UK. Shows some signs of wear and may have some markings on the inside. 100% Money Back Guarantee. Your purchase also supports literacy charities. Hutchinson unknown‎

Bookseller reference : GRP97842292

‎Jacob N‎

‎Me- And The Stags‎

‎William Kimber 1964. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Dust Jacket in fair condition. William Kimber hardcover‎

Bookseller reference : 5205633

‎Jacob N‎

‎Our Marie: A Biography‎

‎Hutchinson NULL. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item550grams ISBN: Hutchinson hardcover‎

Bookseller reference : 8011813

‎Jacob N‎

‎Search for a Background‎

‎Hutchinson 1960. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. With usual stamps and markings In poor condition suitable as a reading copy. Hutchinson hardcover‎

Bookseller reference : 7419169

‎Jacob N‎

‎The Irish Boy: A Romantic Biography‎

‎The Book Club NULL. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Dust Jacket in fair condition. The Book Club hardcover‎

Bookseller reference : 5850308

‎Jacob N‎

‎White Wool‎

‎The Book Club 1946. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. No dust jacket. The Book Club hardcover‎

Bookseller reference : 7042135

‎Jacob N.‎

‎A Passage Perilous‎

‎Hutchinson 1947. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition suitable as a reading copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item400grams ISBN: Hutchinson hardcover‎

Bookseller reference : 4507132

‎Jacob N.‎

‎Fade Out‎

‎Hutchinson 1953. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition suitable as a study copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item400grams ISBN: Hutchinson hardcover‎

Bookseller reference : 3886619

‎Jacob N.‎

‎Great Black Oxen‎

‎Robert Hale 1962. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition suitable as a study copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item400grams ISBN: Robert Hale hardcover‎

Bookseller reference : 3886620

‎Jacob N.‎

‎Mary of Delight‎

‎Hutchinson 1949. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In poor condition suitable as a reading copy. Please note the Image in this listing is a stock photo and may not match the covers of the actual item500grams ISBN: Hutchinson hardcover‎

Bookseller reference : 4507131

‎Jacob N.‎

‎Me- Likes and Dislikes‎

‎Hutchinson 1954. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In good all round condition. Hutchinson hardcover‎

Bookseller reference : 6772415

‎Jacob N.‎

‎Me- Yesterday and To-day‎

‎Hutchinson 1957. This is an ex-library book and may have the usual library/used-book markings inside.This book has hardback covers. In fair condition suitable as a study copy. No dust jacket. Please note the Image in this listing is a stock photo and may not match the covers of the actual item550grams ISBN: Hutchinson hardcover‎

Bookseller reference : 7788293