‎Journal‎

‎Club, The Journal‎

‎My 14 Day Italian Adventure Journal‎

‎Independently published 2019. Paperback. New. 113 pages. 11.00x8.50x0.27 inches. Independently published paperback‎

Riferimento per il libraio : __1076050344 ISBN : 1076050344 9781076050342

‎Journal, Besties‎

‎Side By Side Or Miles Apart Friends Are Always Close At Heart: Long Distance Friendship Gifts‎

‎like new. unknown‎

Riferimento per il libraio : 38766913 ISBN : 1690978821 9781690978824

‎Journal, Family Love‎

‎Grandpa I wrote a book about you: Gift Idea to celebrate your Grandparent. Perfect present for Birthday Christmas Anniversaries or others occasions.‎

‎new. unknown‎

Riferimento per il libraio : 39705830-n ISBN : 1709146141 9781709146145

‎Dotawo Journal‎

‎Dotawo: A Journal of Nubian Studies: Nubian Women‎

‎Punctum Books 2019. Paperback. New. 268 pages. 9.21x6.14x0.61 inches. Punctum Books paperback‎

Riferimento per il libraio : __1947447998 ISBN : 1947447998 9781947447998

‎Jaguela Diary‎

‎Diary: for a girls teenager‎

‎Hardcover. NEW/NEW. <br/> <br/> hardcover‎

Riferimento per il libraio : Pazz148938

‎Vivid Diary‎

‎Fairy Friends at the Magical Market‎

‎Hardcover. NEW/NEW. <br/> <br/> hardcover‎

Riferimento per il libraio : Pazz124156 ISBN : 9798338805584 9798338805

‎Diary Duchess‎

‎Gratitude Journal: Year Goal Planner with Daily Gratitude Journal for Men & Women Manifestation Journal Daily Wellness Journal for More Mindfulness‎

‎Hardcover. NEW/NEW. <br/> <br/> hardcover‎

Riferimento per il libraio : Pazz125220

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎2/1997‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Warenzeichenkenntnis von Besuchern der Biofach-Messe 4 Berliner Bio-Markt wächst- steigende Nachfrage setzt Bündelung des Angebotes voraus 5 Landwirtschaft und Umwelt Erfahrungen bei der Erprobung mechanischer Baumstreifen-Bearbeitungsgeräte in Apfelanlagen 7 Bekämpfung der Apfel und Pflaumensägewespe mit Quassia- Bitterholzextrakt 11 Förderung von Nützlinen im Obstbau 13 Bericht zur Gemüseexkursion nach Nordrhein-Westfalen und Holland 14 Umfrage zur Bedarfsabschätzung von Gemüse - Jungpflanzen in den neuen Bundesländern 17 Feldtag zum ökologischen Landbau in Roda / Sachsen 18 Gäa Brandenburg - Studienreise nach Oberfranken 20 Drunter und Drüber Einweihung der ökohofbäckerei im Stadtgut Gorlitz 24 Erzeugerzusammenschluß von thüringer Gäa -Betrieben die auf Vielfalt in der Vermarktung setzen 24 27. Evangelischer Kirchentag in Leipzig - Die Bewahrung der Schöpfung in Wort und Tat 25 BOL-Aufgaben erfüllt und Auflösung beschlossen 26 Hinweis für Direktvermarkter von Fleisch u. Fleischerzeugnissen - Fleisch aus Not- und Krankschlachtung 26 Buchempfehlung 27 Veranstaltungskalender 28 Kleinanzeigen 29 gutes Exemplar ordentlich hardcover‎

Riferimento per il libraio : B00053198

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 513 No. 7517 September 2014 In her Genes‎

‎NPG Nature publishing group. Hardcover. Gut. Climate policy: Rethink IPCC reports Voluntary work alone cannot sustain the assessments carried out by the Intergovernmental Panel on Climate Change. Thomas F. Stocker and Gian-Kasper Plattner call for institutional support and a longer report cycle. Economics: Manufacture renewables to build energy security Countries should follow China s lead and boost markets for water wind and solar power technologies to drive down costs say John A. Mathews and Hao Tan. Science fiction: Verne and beyond Danièle Chatelain and George Slusser explore how French science fiction grapples with Cartesian duality. Q&A: The sci-fi optimist Best-selling science-fiction writer Neal Stephenson s works cover everything from cryptography to Sumerian mythology. Ahead of next year s novel Seveneves he talks about his influences the stagnation in material technologies and Hieroglyph the forthcoming science-fiction anthology that he kick-started to stimulate the next generation of engineers. Books in brief Barbara Kiser reviews five of the week s best science picks. Lung cancer Herb Brody Epidemiology: The dominant malignancy Eric Bender Diagnosis: Early warning system Katherine Bourzac Perspective: The screening imperative John K. Field Personalized medicine: Special treatment Michael Eisenstein Immunotherapy: Chemical tricks Bianca Nogrady Aetiology: Crucial clues Sarah Deweerdt Environment: Breathing trouble Traci Watson Public health: A burning issue Nidhi Subbaraman Genomics: Something to swing about Michael J. O Neill & Rachel J. O Neill See also Article by Carbone et al. Microbiology: Bacteria get vaccinated Rodolphe Barrangou & Todd R. Klaenhammer Atmospheric chemistry: No equatorial divide for a cleansing radical Arlene M. Fiore See also Letter by Patra et al. Sustainable development: The promise and perils of roads Stephen G. Perz See also Letter by Laurance et al. Oceanography: What goes down must come up Raffaele Ferrari Sensory systems: Sound processing takes motor control Uri Livneh & Anthony Zador See also Article by Schneider et al. Astrophysics: Quasar complexity simplified Michael S. Brotherton See also Letter by Shen & Ho Articles Top Assembly-line synthesis of organic molecules with tailored shapes Matthew Burns Stéphanie Essafi Jessica R. Bame Stephanie P. Bull Matthew P. Webster et al. The iterative reagent-controlled homologation of a boronic ester is used to create an assembly line capable of synthesizing organic molecules that contain ten contiguous stereochemically defined methyl groups and which have different shapes depending on the stereochemistry of those groups. A synaptic and circuit basis for corollary discharge in the auditory cortex David M. Schneider Anders Nelson & Richard Mooney Here auditory cortex excitatory neurons are shown to decrease their activity during locomotion grooming and vocalization and this decrease was paralleled by increased activity in inhibitory interneurons these findings provide a circuit basis for how self-motion and external sensory signals can be integrated to potentially facilitate hearing. See also News & Views by Livneh & Zador Gibbon genome and the fast karyotype evolution of small apesOpen Lucia Carbone R. Alan Harris Sante Gnerre Krishna R. Veeramah Belen Lorente-Galdos et al. The genome of the gibbon a tree-dwelling ape from Asia positioned between Old World monkeys and the great apes is presented providing insights into the evolutionary history of gibbon species and their accelerated karyotypes as well as evidence for selection of genes such as those for forelimb development and connective tissue that may be important for locomotion through trees. See also News & Views by O Neill & O Neill Comprehensive molecular characterization of gastric adenocarcinomaOpen The Cancer Genome Atlas Research Network The Cancer Genome Atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes which should help with clinical assessment and trials of targeted therapies. Letters Top The diversity of quasars unified by accretion and orientation Yue Shen & Luis C. Ho Analysis of archival quasar data reveals that two quantities the Eddington ratio and orientation explain most of the diverse characteristics of quasars. See also News & Views by Brotherton Probing excitonic dark states in single-layer tungsten disulphide Ziliang Ye Ting Cao Kevin O Brien Hanyu Zhu Xiaobo Yin et al. A series of long-lived excitons in a monolayer of tungsten disulphide are found to have strong binding energy and an energy dependence on orbital momentum that significantly deviates from conventional three-dimensional behaviour. Observational evidence for interhemispheric hydroxyl-radical parity P. K. Patra M. C. Krol S. A. Montzka T. Arnold E. L. Atlas et al. Observations of methyl chloroform combined with an atmospheric transport model predict a Northern to Southern Hemisphere hydroxyl ratio of slightly less than 1 whereas commonly used atmospheric chemistry models predict ratios 15 45% higher. See also News & Views by Fiore A major advance of tropical Andean glaciers during the Antarctic cold reversal V. Jomelli V. Favier M. Vuille R. Braucher L. Martin et al. A moraine chronology determined by surface exposure dating shows that glaciers in the northern tropical Andes expanded to a larger extent during the Antarctic cold reversal 14500 to 12900 years ago than during the Younger Dryas stadial 12800 to 11500 years ago contrary to previous studies as a result previous chronologies and climate interpretations from tropical glaciers may need to be revisited. A global strategy for road building William F. Laurance Gopalasamy Reuben Clements Sean Sloan Christine S. O Connell Nathan D. Mueller et al. A global zoning scheme is proposed to limit the environmental costs of road building while maximizing its benefits for human development by discriminating among areas where road building would have high environmental costs but relatively low agricultural advantage areas where strategic road improvements could promote agricultural production with relatively modest environmental costs and conflict areas where road building may have large agricultural benefits but also high environmental costs. See also News & Views by Perz The evolution of the placenta drives a shift in sexual selection in livebearing fish B. J. A. Pollux R. W. Meredith M. S. Springer T. Garland & D. N. Reznick In poeciliid fish the evolution of the placenta is associated with polyandry in females and correlates with a suite of phenotypic and behavioural traits in males. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome Hao Xu Jieling Yang Wenqing Gao Lin Li Peng Li et al. The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity. Viral tagging reveals discrete populations in Synechococcus viral genome sequence space Li Deng J. Cesar Ignacio-Espinoza Ann C. Gregory Bonnie T. Poulos Joshua S. Weitz et al. The metagenome of uncultured Pacific Ocean viruses linked to a ubiquitous cyanobacteria is characterized using viral-tagging revealing discrete populations in viral sequence space that includes previously cultivated populations and new populations missed in isolate-based studies. Carbonic anhydrases EPF2 and a novel protease mediate CO2 control of stomatal development Cawas B. Engineer Majid Ghassemian Jeffrey C. Anderson Scott C. Peck Honghong Hu et al. The continuing rise in atmospheric carbon dioxide concentrations suppresses the development of stomatal pores and thus gas exchange in plant leaves on a global scale now a framework of mechanisms by which carbon dioxide represses development has been identified. Fructose-16-bisphosphatase opposes renal carcinoma progression Bo Li Bo Qiu David S. M. Lee Zandra E. Walton Joshua D. Ochocki et al. Fructose-16-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma ccRCC and inhibits ccRCC progression by antagonizing glycolytic flux in renal tubular epithelial cells and by restraining cell proliferation glycolysis and the pentose phosphate pathway in von Hippel Lindau-protein-deficient ccRCC cells by blocking hypoxia-inducible factor function. Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins Hani Goodarzi Steven Zhang Colin G. Buss Lisa Fish Saeed Tavazoie et al. Linear sequence elements within messenger RNAs are known to be targeted by regulatory factors such as microRNAs for degradation a process that has been implicated in disease now non-linear regulatory structural elements within mRNAs are shown also to be targeted with the resulting mRNA destabilization mediating breast cancer metastasis. Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser Christopher Kupitz Shibom Basu Ingo Grotjohann Raimund Fromme Nadia A. Zatsepin et al. Femtosecond X-ray pulses were used to obtain diffraction data on photosystem II revealing conformational changes as the complex transitions from the dark S1 state to the double-pumped S3 state the time-resolved serial femtosecond crystallography technique enables structural determination of protein conformations that are highly prone to traditional radiation damage. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042584

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 515 No 7527 November 2014 Head to Tail‎

‎NPG Nature publishing group. Hardcover. Gut. 335 CLIMATE CHANGE Clean up our skies Julia Schmale Drew Shindell Erika von Schneidemesser Ilan Chabay & Mark Lawrence Tackle air quality and mitigate climate change simultaneously EDITORIALS 311 ADVOCACY A global vision The International Council for Science needs a clear direction to thrive 311 SCIENCE &SOCIETY Save the museums Italy s curators can band together to save threatened collections 312 ANNOUNCEMENT Data-access practices strengthened Improved links with Scientific Data will make information more accessible 313 Openness in science is key to keeping public trust Mark Yarborough Researchers must actively seek out problems and fix them RESEARCH HIGHLIChts 314 SELECTIONS FROM THE SCIENTIFIC LITERATURE Mind over genes / Neochromosome an anti-cancer target / Mozartian laser beams / Spot the leopard 316 THE NEWS IN BRIEF US and China announce climate plans / Europe axes science-adviser post / PubPeer contests legal action 453 MENTORING AWARDS Focus on people Commitment is the watchword for the winners of Nature s annual mentoring award who this year are from Ireland and Northern Ireland 455 TURNING POINT Clinical neuroscientist Kate McAllister is keeping in touch in a big way 455 CAREER BRIEFS International supercomputing centres dedicated to climate prediction are needed to reduce uncertainties Pursuing the primordial Ted Nield 341 BOOKS IN BRIEF 343 The evolution debate / Primates in the lab/ Funding ALS research OBITUARY 344 Allison Doupe 1954-2014 Thomas R Insel & Story Landis FUTURES f x3 When the music ends Philip Ball 3i0 ASETTA MISSIOP Philae comet lander s extraordinary 64 hours of science 321 DISASTER RESPONSE Citizen scientists tapped to make crisis maps more reliable 322 ECOLOGY Green List highlights conservation success stories 323 GENOMICS Researchers home in on platinumstandard human genome 324 TECHNOLOGY US labs Pool resources to get supercomputer boost Far-flung physics The International Centre for Theoretical Physics has helped to train more than 100000 researchers around the world NEW ONLINE 345 Papers published this weekat nature.cor NEWS & VIEWS 346 GENOMICS Mice in the ENCODE Spotlight Comparative analyses of mouse and human genomic regulation Piero Carninci SEE ARTICLES R355 P.36! R371 & LETTER R402 347 ORIGINS OF LIFE RNA made in its own mirror image A ribozyme that overcomes enantiomeric cross-inhibition Sandip A Shelke & Joseph A Piccirilli SEE LETTER P.440 348 MATERIALS PHYSICS Reactive walls Domain walls can promote exotic crystallographic phase formation Philippe Ghosez & Jean-Marc Triscone SEE LETTER P.379 35O BIOCHEMISTRY Succinate strikes Succinate accumulation contributes to ischaemic reperfusion injury Luke A J O Neill SEE LETTER R431 351 BIOGEOCHEMISTRY Agriculture and the global carbon cycle Intensive crop production affects seasonal flux of atmospheric CO2 Natasha MacBean & Philippe Peylin SEE LETTERS R394 & R398 352 PLANT SCIENCE Leaf veins share the time of day A circadian clock in the vasculature regulates a clock in the mesophyll Maria C Marti & Alex A R Webb SEE LETTER R419 ARTICLES 355 GENOMICS A comparative encyclopedia of DNA elements in the mouse genome F Yue et al. SEE N&V P.346 365 GENOMICS Conservation of transacting circuitry during mammalian regulatory evolution A B Stergachis et al. SEE N&V P.346 371 GENOMICS Principles of regulatory information conservation between This issue of Nature includes four papers from The Mouse ENCODE Consortium providing comprehensive data on genome regulation in the premier model organism in biomedical research. PAGES 346.355 365371 & 402 mouse and human Y Cheng et al. SEE N&V R346 LETTERS 376 ASTROPHYSICS The power of relativistic Jets is larger than the luminosity of their accretion disks G Ghisellini F Tavecchio L Maraschi A Celotti & T Sbarrato 379 NANOSCALE MATERIALS Artificial chemical and magnetic structure at the domain walls of an epitaxial oxide S Farokhipoor et al. SEE N&V P.348 384 MATERIALS SCIENCE Approaching disorder-free transport in highmobility conjugated polymers D Venkateshvaran et al. 389 ORGANIC CHEMISTRY Overcoming the limitations of directed C H functionalizations of heterocycles Y-J Liu et al. 394 BIOGEOCHEMISTRY Agricultural Green Revolution as a driver of increasing atmospheric CO2 seasonal amplitude N Zeng et al. SEE N&V P.351 39B BIOGEOCHEMISTRY Direct human influence on atmospheric CO2 seasonality from increased cropland productivity J M Gray et al. SEE N&V P.351 402 GENOMICS Topologically associating domains are stable units of replication-timing regulation B D Pope et al. SEE N&V P. 346 406 EVOLUTION The drivers of tropical speciation B T Smith et al. 410 ECOLOGY lndividual improvements and selective mortality shape lifelong migratory performance F Sergio et al. 414 NEUROSCIENCE Synaptic dysregulation in a human iPS cell model of mental disorders Z Wen et al. 419 PLANT SCIENCE Tissue-specific clocks in Arabidopsis Show asymmetric coupling M Endo H Shimizu M A Nohales T Araki &S A Kay SEE N&V P.352 423 MICROBIOLOGY Members of the human gut microbiota involved in recovery from Vibrio cholerae infection A Hsiao et al. 427 IMMUNOLOGY Structure of malaria Invasion protein RH5 with erythrocyte basigin and blocking antibodies K E Wright et al. 431 BIOCHEMISTRY Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS E T Chouchani et al. SEE N&V R350 436 DNA REPAIR Transcript-RNA-templated DNA recombination and repair H Keskin et al. 44O BIOCHEMISTRY A cross-chiral RNA polymerase ribozyme J T Sczepanski 1 & G F Joyce SEE N&V P. 347 443 CANCER Discovery and characterization of small molecules that target the GTPase Ral C Yan et al. 448 STRUCTURAL BIOLOGY Structures of bacterial homologues of SWEET transporters in two distinct conformations Y Xu et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042463

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol. 510 No. 7504 Science Stars of South America Juni 2014‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIAL Open goal International collaborations can help bolster the continent s ambitions FEATURES 201 Stars of South American science Growth in resources and opportunity 202 South America by the numbers A continent quantified Big players The leading lights in Latin American research 7117 Homeward bound Repatriation efforts pay off COMMENT Capacity building: Architects of South American science Eduardo Arzt Gisella Orjeda Carlos Nobre Juan Carlos Castilla Lino Baranao Sidarta Ribeiro Claudia Bifano Jose Eduardo Krieger Pablo C Guerrero & Mary T K Arroyo A continent-wide look at how the region can boost its science base 19 Fellowships: Turning brain drain into brain circulation Torsten Wiesel & Jimena Sierralta Successful scholarships provide sound foundation for Latin American science EDITORIALS A growing problem GM crops are no quick fix for quashing herbicide-resistant weeds 187 REGENERATIVE MEDICINE Good practice A systematic approach to stem cells will reap therapeutic benefits WORLD VIEW 189 Jordan s stem-cell Iaw can guide the Middle East Rana Dajani Framework offers legal and ethical guidance for Islamic nations RESEARCH HIGHLIGHTS 190 SELECTIONS FROM THE SCIENTIFIC LITERATURE Bee-friendly insecticide / Theia s geology / HIV activated / Plankton light / First author first / As the crow thinks SEVEN DAYS 192 THE NEWS IN BRIEF SOFIA telescope saved / Germany pulls out of Square Kilometre Array / NIH sets out BRAIN plan / Illinois bans microbeads 195 REGENERATIVE MEDICINE Cell-replacement therapies back an the agenda for Parkinson s disease 196 SPACE US Russian tensions prompt NASA drive for space-station experiments 198 GENETICS Public database challenges Myriad over genetic test for breast cancer 199 ACOUSTICS Undersea signal offers lead in search for missing Malaysian airliner 303 COLUMN A test that fails Casey Miller & Keivan Stassun Many US graduate-school entry tests are not fit for purpose BOOKS & ARTS 216 /MV The third culture Michael John Gorman 217 The nutrient hunter Journalist Jo Robinson champions purple foods wine included CORRESPONDENCE 218 Darwin Wallace and women / Safe synthetic biology /Joint funding / Otlet first with citation analysis FUTURES 306 Face in the dark Deborah Walker NEW ONLINE 219 Papers published this week at naturecom NEWS & VIEWS 22O MATERIALS SCIENCE Diamond gets harder The synthesis of nanotwinned diamond James Boland SEE LETTER R250 221 PLANT BIOLOGY Pass the ammunition Herbivory-induced emissions are changed into weapons in nearby plants Mark C Mescher & Consuelo M De Moraes 222 IMMUNOLOGY When Iymphocytes run out of steam Familial immunodeficiencies caused by a lack of CTPS1 Andre Seillette & Dominique Davidson SEE LETTER R288 224 PARTICLE PHYSICS The hunt for Majorana neutrinos hots up Searching for the neutrinoless double-ß-decay process David Wark SEE ARTICLE P.229 225 CANCER BIOLOGY Enzyme meets a surprise target A histone modifier acts downstream of oncogenic K-Ras in the cytoplasm Marian M Deuker & Martin McMahon SEE LETTER R283 226 GENE THERAPY Repair and replace An optimized gene-repair protocol for haematopoietic stein cells Alain Fischer SEE ARTICLE P.235 An explanation for the existence of optically Bark y-ray bursters. PAGE 247 Synthetic diamonds go from strength to strength. PAGE 250 ARTICLES 229 PARTICLE PHYSICS Search for Majorana neutrinos with the first two years of EXO-200 data The EX0-200 Collaboration SEE N&V R224 235 IMMUNOLOGY Targeted genome editing in human repopulating haematopoietic stein cells P Genovese et al. SEE N&V P.226 241 MOLECULAR BIOLOGY Homologue engagement controls meiotic DNA break number and distribution D Thacker N Mohibullah X Zhu &S Keeney LETTERS 247 ASTROPHYSICS Two y-ray bursts from dusty regions with little molecular gas B Hatsukade et al. 25O MATERIALS Nanotwinned diamond with unprecedented hardness and stability Q Huang et al. SEE N&V R220 254 CLIMATE SCIENCE Increased frequency of extreme Indian Ocean Dipole events due to greenhouse warming WCaietal. 259 ECOLOGY Elevated CO2 further Iengthens growing season under warming conditions Melissa Reyes-Fox et al. 263 NEUROSCIENCE Emergence of reproducible spatiotemporal activity during motor learning A J Peters SX Chen & T Komiyama 268 STEM CELLS The unfolded protein response governs integrity of the haematopoietic stem-cell Pool during stress P van Galen et al. 273 STEM CELLS Human embryonicstem-cell-derived cardiomyocytes regenerate non-human primate hearts JJ H Chong et al. 278 CANCER Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer I A Asangani et al. 283 CANCER SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer P K Mazur et al. SEE N&V R225 288 IMMUNOLOGY CTP synthase 1 deficiency in humans reveals its central rote in lymphocyte proliferation E Martin et al. SEE N&V P.222 293 STRUCTURAL B10LOGY A Ctf4 trimer couples the CMG helicase to DNA polymerase ct in the eukaryotic replisome A C Simon et al. 298 BIOCHEMISTRY Quantitative flux analysis reveals folate-dependent NADPH production J Fan et al. New projections of future Indian Ocean climate cycles. PAGE 254 NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042458

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 505 No. 7485 Crystallography turns 100‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIAL 5B6 Crystal clear On structures and dipoles FEATURES 6O1 The crystal century The structural Power behind science 6O2 Atomic secrets 100 years of crystallography 6O4 The big guns X-ray lasers get to the heart of matter COMMENT 6O7 Crystallography needs a governing body Paolo G Radaelli Decisions require community input 6O9 Women in crystallography Georgina Ferry A celebration of an egalitarian culture NEWS & VIEWS FORUM 62O Sources of Inspiration Sean McSweeney Petra Fromme Uses of synchrotrons and freeelectron lasers for structural biology CAREERS 711 More than a crystallographer X-ray crystallography remains a good career but it requires diverse skills EDITORIALS 585 OCEANOGRAPHY Support our buoys The Pacific s early-warning system urgently needs to be restored 585 CLIMATE PDLICY Open Invitation Europe s climate plans are a reminder to the rest of the world to pitch in WORLD VIEW 5B7 Quiet green revolution starts to make some noise Owen Gaffney The creation of an advisory board for the UN will aid sustainability efforts RESEARCH HIGHLIGHTS 588 SELECTIONS FROM THE SCIENTIFIC LITERATURE Bacteria go for a ride / Tuberculosis pathogen marches on / Maternal diet / Dogs before farms / Mercury-sensing smartphone SEVEN DAYS 59O THE NEWS IN BRIEF Supernova spotted nearby / Pig virus spreads to Canada / Streams of antihydrogen / ORCHID scheme blossoms 593 MISCONDUCT The man who blew the whistle on Woo Suk Hwang reveals his identity 594 ASTRONOMY US seeks partners to keep telescopes on line 596 REGENERATIVE MEOICINE Stress reprograms body cells into stem cells 597 POLICY Europe s energy goals draw fire for being too conservative 59B SYNTHETIC BIOLOGY Companies switch tack from medicine and biofuels to fine chemicals 599 POLITICS Ukraine s scientists fight for stronger international links 713 TURNING POINT Medically trained Nicholas Wright found experience in the clinic an ideal grounding for a career in nuclear safety policy-making 612 PRECLINICAL RESEARCH NIH plans to enhance reproducibility Francis S Collins & Lawrence A Tabak Revelations that many biomedicalresearch publications are irreproducible mean that urgent action is necessary BOOKS & ARTS 614 PHYSICS Eistein s curveball Graham Farmelo 615 NEUROSCIENCE Joined-up thinking Chris Frith 616 MEDICINE Bad medicine Alison Abbott 617 MATERIALS Vitreous visions Daniel Cressey CORRESPONDENCE 61B Fixing gender bias / Taking a stand / Mantle-plume hypotheses / Opensource hardware cuts costs FUTURES 7I6 Me and my flying saucer lan Watson NEW ONLINE 619 Papers published this week at nature.cor NEWS & VIEWS 62O FORUM: CRYSTALLOGRAPHY Sources of Inspiration Uses of synchrotrons and free-electron lasers for structural biology Sean McSweeney Petra Fromme 62I MOLECULAR BIOLOGY A second layer of information in RNA Transcriptome-wide analysis of secondary structures in eukaryotic RIN/ Silvia 8 V Ramos & Alain Laederach SEE LETTERS R696 P.701 & P.706 622 CELL BIOLOGY Potency unchained Physical stimuli can reprogram cells to an unexpected state of potency Austin Smith SEE ARTICLE R641 & LETTER P.676 625 ASTROPHYSICS Portrait of a dynamic neighbour Spatially resolved maps of the visible surface of a nearby brown dwarf Adam P Showman SEE LETTER R654 626 EVOLUTIONARY MOLOGY Brotherly love benefits females Male relatedness reduces sexual harm to female fruit flies Scott Pitnick & David W Pfennig SEE LETTER P.672 627 ATOMIC PHYSICS Polar exploration Magnetic monopoles created in a Bose Einstein condensate Lindsay J LeBlanc SEE LETTER R657 REVIEW 629 ASTRONOMY Solar System evolution from compositional mapping of the asteroid belt F E DeMeo & B Carry ARTICLES 635 EVDLUTION The evolution of IncRNA repertoires and expression patterns in tetrapods A Necsulea et al. 641 STEM CELLS Stimulus-triggered fate conversion of somatic cells into pluripotency H Obokata et al. SEE N&V P.622 648 CELL BIOLOGY ANP32E is a histone chaperone that removes H2A.Z from chromatin A Obri et al. LETTERS 654 ASTROPHYSICS A global cloud map of the nearest known brown dwarf I J M Crossfield et al. SEE N&V R625 657 ATOMIC PHYSICS Observation of Dirac monopoles in a synthetic magnetic field M W Ray E Ruokokoski S Kandel M Möttönen & D S Hall SEE N&V R627 661 CHEMISTRY Site- and energy-selective slow-electron production through intermolecular Coulombic decay K Gokhberg P Kolorenö A I Kuleff & L S Cederbaum 664 CHEMISTRY Resonant Auger decay driving intermolecular Coulombic decay in molecular dimers F Trinter et al. 667 CLIMATE SCIENCE Australian tropical cyclone activity lower than at any time over the past 550-1500 years J Haig J Nett & G-J Reichart 672 EVOLUTION Within-group male relatedness reduces harm to females in Drosophila P Carazo C K W Tan F Allen S Wigby & T Pizzari SEE N&V P.626 676 STEM CELLS Bidirectional developmental potential in reprogrammed cells with acquired pluripotency H Obokata et al. SEE N&V P.622 681 MICROBIOLOGY Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei B M Mony et al. 686 VIRAL EVOLUTION Mutational and fitness landscapes of an RNA virus revealed through population sequencing A Acevedo L Brodsky & R Andino 691 IMMUNOLOGY Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity J W Schoggins et al. 696 MOLECULAR BIOLOGY In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features Y Ding et al. SEE N&V R621 701 MOLECULAR BIOLOGY Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo S Rouskin M Zubradt S Washietl M Kellis &J S Weissman SEE N&VP.621 706 MOLECULAR BIOLOGY Landscape and variation of RNA secondary structure across the human transcriptome Y Wan et al. SEE N&V P.621 7I0 CORRIGENDUM Primary forests are irreplaceable for sustaining tropical biodiversity L Gibson et al. 710 ERRAT UM Exciting Andreev pairs in a superconducting atomic contact L Bretheau et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042472

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎1/1995 Öko Rindfleisch‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Baldiges Ende der günstigen Einführungsphase des Sächsischen Ökoprüfsiegels 4 Bio-Lebensmittel kann sich jeder leisten 6 Sächsische Marktgemeinschaft erzielt bessere Getreidepreise 7 Marktgemeinschaft mit neuer Weißer und Gelber Linie 7 Neues Öko-Getreidelager in Sachsen 7 Biofach 1995 in Frankfurt/Main 7 Erstmalig Öko-Rindfleisch aus Sachsen auf dem Ladentisch 8 Landwirtschaft und Umwelt Wollen wir be- oder enthornte Rinder 9 Entwicklung des ökologischen Landbaus in Sachsen 10 Fütterung von Legehennen 17 Neues von der Ackerkratzdistel 18 Mensch und Ernährung Nahrungsmittel der Zukunft 19 Drüber und Drunter Wichtige Veranstaltungen und Seminare 20 Gäa-Werbemittel und Verpackungsmaterial 24 Richtlinien und Kennzeichnung Zu Kennzeichnungsfragen für Öko-Produkte aus der Tierhaltung 25 Zeitschriften und Bücher Buchbesprechung 28 Genuß oder erhobener Zeigefinger 29 Stiftungen und Vereine Neue BTQ-Geschäftsstelle eröffnet 30 Die IFOAM stellt sich vor 30 gutes Exemplar ordentlich hardcover‎

Riferimento per il libraio : B00053193

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 515 No. 7526 November 2014 The Great Depression‎

‎NPG Nature publishing group. Hardcover. Gut. Mental health: Depression needs large human-genetics studies To understand the molecular mechanisms of depression collect genetic data from more than 100000 people says Steven Hyman. Infectious disease: Tough choices to reduce Ebola transmission Christopher J. M. Whitty and colleagues explain why the United Kingdom is funding many small community centres to isolate suspected cases in Sierra Leone. Film: Enigma variations Robert P. Crease ponders a brace of biopics on Alan Turing and Stephen Hawking. Review of The Imitation Game and The Theory of Everything Morten Tyldum & James Marsh Q&A: Space-time visionary Thanks to theoretical physicist Kip Thorne real science is embedded in Christopher Nolan s film Interstellar in which explorers seek a new home for humankind. Thorne talks about what he learned from the film s unprecedented visualizations of black holes and wormholes what it and his accompanying book can teach and the likelihood of humans escaping the Solar System. Review of Interstellar and The Science of Interstellar Christopher Nolan & Kip Thorne Books in brief Barbara Kiser reviews five of the week s best science picks. Sickle-cell disease Lauren Gravitz & Stephen Pincock Epidemiology: A moving target Simon Pleasants Drug development: A complicated path Courtney Humphries Q&A: Healthy progress Smriti Mallapaty Neurobiology: Life beyond the pain Bianca Nogrady Perspective: We need a global solution Isaac Odame Gene therapy: Editorial control Katharine Gammon Stem cells: Creating a cure-all Andrew R. Scott Perspective: Thinking beyond survival Michael R. DeBaun Forum Depression: The best way forward Lisa M. Monteggia Robert C. Malenka & Karl Deisseroth Condensed-matter physics: Magnetic fields without magnetic fields Jonathan Simon See also Letter by Jotzu et al. See also Letter by Roushan et al. Palaeontology: Mystery of the horrible hands solved Thomas R. Holtz Jr See also Letter by Lee et al. High-temperature superconductivity: Electron mirages in an iron salt Jan Zaanen See also Letter by Lee et al. Neurobiology: Building a bigger brain Forrest O. Gulden & Nenad estan See also Letter by Lui et al. Neuroscience: Towards unified vesicle endocytosis Vladan Lu i See also Article by Watanabe et al. Articles Top Synaptic transcriptional and chromatin genes disrupted in autism Silvia De Rubeis Xin He Arthur P. Goldberg Christopher S. Poultney Kaitlin Samocha et al. Whole-exome sequencing in a large autism study identifies over 100 autosomal genes that are likely to affect risk for the disorder these genes which show unusual evolutionary constraint against mutations carry de novo loss-of-function mutations in over 5% of autistic subjects and many function in synaptic transcriptional and chromatin-remodelling pathways. The contribution of de novo coding mutations to autism spectrum disorder Ivan Iossifov Brian J. O Roak Stephan J. Sanders Michael Ronemus Niklas Krumm et al. Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism with target genes in affected females overlapping those in males of lower but not higher IQ targets also overlap known targets for intellectual disability and schizophrenia and are enriched for chromatin modifiers FMRP-associated genes and embryonically expressed genes. Evolution of mosquito preference for humans linked to an odorant receptor Carolyn S. McBride Felix Baier Aman B. Omondi Sarabeth A. Spitzer Joel Lutomiah et al. The mosquito Aedes aegypti includes two subspecies one of which shows a preference for biting humans whereas the other prefers to bite non-human animals genetic analysis reveals that changes in the mosquito odorant receptor Or4 contribute to the behavioural difference in human-preferring mosquitoes Or4 is more highly expressed and more sensitive to sulcatone a compound present at high levels in human odour. Clathrin regenerates synaptic vesicles from endosomes Shigeki Watanabe Thorsten Trimbuch Marcial Camacho-Pérez Benjamin R. Rost Bettina Brokowski et al. Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles however when ultrafast endocytosis does not occur for example in experiments at room temperature rather than physiological temperature clathrin-mediated endocytosis does happen at the plasma membrane. See also News & Views by Lu i Letters Top The expanding fireball of Nova Delphini 2013 G. H. Schaefer T. ten Brummelaar D. R. Gies C. D. Farrington B. Kloppenborg et al. High spatial resolution is needed to study the early development of a nova here measurements of the angular size and radial velocity of Nova Delphini 2013 reveal early structures in the ejected material and a geometric distance to the nova of about 4.5 kiloparsecs from the Sun. Experimental realization of the topological Haldane model with ultracold fermions Gregor Jotzu Michael Messer Rémi Desbuquois Martin Lebrat Thomas Uehlinger et al. The Haldane model which predicts complex topological states of matter has been implemented by placing ultracold atoms in a tunable optical lattice that was deformed and shaken. See also News & Views by Simon See also Letter by Roushan et al. Observation of topological transitions in interacting quantum circuits P. Roushan C. Neill Yu Chen M. Kolodrubetz C. Quintana et al. Superconducting quantum circuits are used to directly observe and characterize topological phase transitions this approach promises to be a powerful and general platform for characterizing topological phenomena in quantum systems. See also News & Views by Simon See also Letter by Jotzu et al. Interfacial mode coupling as the origin of the enhancement of Tc in FeSe films on SrTiO3 J. J. Lee F. T. Schmitt R. G. Moore S. Johnston Y.-T. Cui et al. High-resolution angle-resolved photoemission spectroscopy reveals bosonic modes in a SrTiO3 substrate coupling to electrons in an FeSe overlayer to facilitate high-temperature superconductivity. See also News & Views by Zaanen Formic-acid-induced depolymerization of oxidized lignin to aromatics Alireza Rahimi Arne Ulbrich Joshua J. Coon & Shannon S. Stahl A method for the depolymerization of oxidized lignin under mild conditions in aqueous formic acid is described that results in more than 60 wt% yield of low-molecular-mass aromatics. Subduction-driven recycling of continental margin lithosphere A. Levander M. J. Bezada F. Niu E. D. Humphreys I. Palomeras et al. Seismic images of the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region show that subducting oceanic plates viscously entrain and remove the bottom of the continental thermal boundary layer from adjacent continental margins driving surface tectonics and pre-conditioning the margins for further deformation. Resolving the long-standing enigmas of a giant ornithomimosaur Deinocheirus mirificus Yuong-Nam Lee Rinchen Barsbold Philip J. Currie Yoshitsugu Kobayashi Hang-Jae Lee et al. Two almost complete skeletons are presented for the theropod dinosaur Deinocheirus mirificus revealing a humpbacked form with a duckbill-like skull. See also News & Views by Holtz Comparative population genomics in animals uncovers the determinants of genetic diversity J. Romiguier P. Gayral M. Ballenghien A. Bernard V. Cahais et al. Genome-wide DNA polymorphism analysis across 76 animal species reveals a strong effect of ecological strategies and particularly parental investment on species levels of genetic diversity. Radial glia require PDGFD PDGFR signalling in human but not mouse neocortex Jan H. Lui Tomasz J. Nowakowski Alex A. Pollen Ashkan Javaherian Arnold R. Kriegstein et al. The transcriptional profiles of radial glia are compared between humans and mice during neurogenesis implicating the growth factor PDGFD and its receptor PDGFR in human but not mouse neocortical development. See also News & Views by Gulden & estan The participation of cortical amygdala in innate odour-driven behaviour Cory M. Root Christine A. Denny René Hen & Richard Axel The cortical amygdala is necessary and sufficient for processing odours that evoke aversive and attractive responses without learning. A three-dimensional human neural cell culture model of Alzheimer s disease Se Hoon Choi Young Hye Kim Matthias Hebisch Christopher Sliwinski Seungkyu Lee et al. Early-onset familial Alzheimer s disease mutations induce both amyloid- and tau pathologies in differentiated human neural stem cells in 3D cultures. Piezo1 integration of vascular architecture with physiological force Jing Li Bing Hou Sarka Tumova Katsuhiko Muraki Alexander Bruns et al. The Piezo1 calcium-permeable channel is revealed to have a role in the vascular cellular response to shear stress a mouse knockout reveals that this channel is also important for normal vascular development. The complete structure of the large subunit of the mammalian mitochondrial ribosome Basil J. Greber Daniel Boehringer Marc Leibundgut Philipp Bieri Alexander Leitner et al. The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Ã… resolution revealing the location of 50 ribosomal proteins the peptidyl transferase centre the tRNAs within this active site and the nascent peptide chain within the exit tunnel. Structural basis for the assembly of the Sxl Unr translation regulatory complex Janosch Hennig Cristina Militti Grzegorz M. Popowicz Iren Wang Miriam Sonntag et al. The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein RNA architecture. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042571

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 510 No. 7505 Juni Water Cooled‎

‎NPG Nature publishing group. Hardcover. Gut. comment Stem cells: Taking a stand against pseudoscience Elena Cattaneo and Gilberto Corbellini are among the academics working to protect patients from questionable stem-cell therapies. Here they share their experiences and opinions of the long hard fight for evidence to prevail. Regulation: Sell help not hope Stem cells are being used as a wedge in calls to allow unproven medical interventions onto the market warn Paolo Bianco and Douglas Sipp. Books and Arts Top Evolution: The complexity chronicles Nancy Moran enjoys a treatise on symbiosis the intimate association of species that transformed life and Earth. Review of One Plus One Equals One: Symbiosis and the Evolution of Complex Life John Archibald Articles Top Contextuality supplies the magic for quantum computation Mark Howard Joel Wallman Victor Veitch & Joseph Emerson Quantum computing promises advantages over classical computing for certain problems now quantum contextuality a generalization of the concept of quantum non-locality is shown to be a critical resource that gives the most promising class of quantum computers their power. See also News & Views by Bartlett The genome of Eucalyptus grandisOpen Alexander A. Myburg Dario Grattapaglia Gerald A. Tuskan Uffe Hellsten Richard D. Hayes et al. The Eucalyptus grandis genome has been sequenced revealing the greatest number of tandem duplications of any plant genome sequenced so far and the highest diversity of genes for specialized metabolites that act as chemical defence and provide unique pharmaceutical oils genome sequencing of the sister species E. globulus and a set of inbred E. grandis tree genomes reveals dynamic genome evolution and hotspots of inbreeding depression. Single-cell RNA-seq reveals dynamic paracrine control of cellular variation Alex K. Shalek Rahul Satija Joe Shuga John J. Trombetta Dave Gennert et al. Large-scale single-cell RNA-seq of stimulated primary mouse bone-marrow-derived dendritic cells highlights positive and negative intercellular signalling pathways that promote and restrain cellular variation. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy Baris Bingol Joy S. Tea Lilian Phu Mike Reichelt Corey E. Bakalarski et al. Damaged mitochondria are removed by mitophagy and defects in mitophagy are linked to Parkinson s disease here it is shown that USP30 a deubiquitinase localized to mitochondria antagonizes mitophagy by removing the ubiquitin tags put in place by Parkin USP30 inhibition is therefore potentially beneficial for Parkinson s disease by promoting mitochondrial clearance and quality control. See also News & Views by Ordureau & Harper Letters Top Measurement of the magnetic interaction between two bound electrons of two separate ions Shlomi Kotler Nitzan Akerman Nir Navon Yinnon Glickman & Roee Ozeri The magnetic interaction between two electrons is measured at the micrometre scale exhibiting spin entanglement generation over 15 seconds of coherent evolution varying the inter-electron separation shows a distance dependence consistent with the inverse-cube law. See also News & Views by Schmidt-Kaler Ultrafast X-ray probing of water structure below the homogeneous ice nucleation temperature J. A. Sellberg C. Huang T. A. McQueen N. D. Loh H. Laksmono et al. Femtosecond X-ray laser pulses are used to probe the structure of liquid water in micrometre-sized droplets that have been cooled below the homogeneous ice nucleation temperature revealing the existence of metastable bulk liquid water down to temperatures of 227 kelvin. Metastable liquid liquid transition in a molecular model of water Jeremy C. Palmer Fausto Martelli Yang Liu Roberto Car Athanassios Z. Panagiotopoulos et al. A stable crystal phase and two metastable liquid phases of the ST2 model of water exist at the same deeply supercooled condition and the two liquids undergo a first-order liquid liquid transition that meets stringent thermodynamic criteria. Possible control of subduction zone slow-earthquake periodicity by silica enrichment Pascal Audet & Roland Bürgmann Seismic data from subduction zones that exhibit slow earthquakes reveal that the ratio of compressional-wave to shear-wave velocity of the overriding forearc crust is linearly related to the average recurrence time of slow earthquakes and that this may be associated with quartz enrichment within the forearc crust. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert Joseph T. Rodgers Katherine Y. King Jamie O. Brett Melinda J. Cromie Gregory W. Charville et al. A mouse study reveals that the stem cell quiescent state is composed of two distinct phases G0 and GAlert stem cells reversibly transition between these two phases in response to systemic environmental stimuli acting through the mTORC1 pathway. The metabolite -ketoglutarate extends lifespan by inhibiting ATP synthase and TOR Randall M. Chin Xudong Fu Melody Y. Pai Laurent Vergnes Heejun Hwang et al. Ageing in the worm Caenorhabditis elegans is shown to be delayed by supplementation with -ketoglutarate an effect that is probably mediated by ATP synthase which is identified as a direct target of -ketoglutarate and target of rapamycin TOR. PTEN action in leukaemia dictated by the tissue microenvironment Cornelius Miething Claudio Scuoppo Benedikt Bosbach Iris Appelmann Joy Nakitandwe et al. A mouse model of T-cell leukaemia is used to test whether PTEN loss is required for tumour maintenance as well as initiation although it had little effect on tumour load in haematopoietic organs PTEN reactivation reduced the CCR9-dependent tumour dissemination to the intestine that was amplified on PTEN loss exposing the importance of tumour microenvironment in PTEN-deficient settings. Inactivation of PI3K p110 breaks regulatory T-cell-mediated immune tolerance to cancer Khaled Ali Dalya R. Soond Roberto Piñeiro Thorsten Hagemann Wayne Pearce et al. The kinase PI3K is shown to be required for the immunosuppressive function of regulatory T cells inactivation of PI3K in these cells leads to enhanced cytotoxic T-cell function and restricts tumour growth and metastasis in a variety of mouse tumour models. See also News & Views by Hirsch & Novelli CFIm25 links alternative polyadenylation to glioblastoma tumour suppression Chioniso P. Masamha Zheng Xia Jingxuan Yang Todd R. Albrecht Min Li et al. CFIm25 is identified as a factor that prevents messenger RNAs being shortened due to altered 3 polyadenylation which typically occurs when cells undergo high proliferation and correlates with increased tumorigenic activity in glioblastoma tumours. Persistent gut microbiota immaturity in malnourished Bangladeshi children Sathish Subramanian Sayeeda Huq Tanya Yatsunenko Rashidul Haque Mustafa Mahfuz et al. Bacterial species whose representation defines healthy postnatal assembly of the gut microbiota in Bangladeshi children during their first 2 years are identified and a model is constructed to compare healthy children to those with severe acute malnutrition SAM results show that SAM is associated with microbiota immaturity that is only partially ameliorated by existing nutritional interventions. See also News & Views by Costello & Relman Ribosomal oxygenases are structurally conserved from prokaryotes to humans Rasheduzzaman Chowdhury Rok Sekirnik Nigel C. Brissett Tobias Krojer Chia-hua Ho et al. Crystal structures of human and prokaryotic ribosomal oxygenases reported here with and without their ribosomal protein substrates support their assignments as hydroxylases and provide insights into the evolution of the JmjC-domain-containing hydroxylases and demethylases. Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis Eita Sasaki Xuan Zhang He G. Sun Mei-Yeh Jade Lu Tsung-lin Liu et al. How sulphur is incorporated into sulphur-containing secondary metabolites is poorly understood here the bacterium Amycolatopsis orientalis is shown to co-opt sulphur-carrier proteins from primary metabolic pathways to facilitate the biosynthesis of sulphur-containing natural products. Corrigenda Top Corrigendum: Sea-level and deep-sea-temperature variability over the past 5.3 million years E. J. Rohling G. L. Foster K. M. Grant G. Marino A. P. Roberts et al. Corrigendum: Fuel gain exceeding unity in an inertially confined fusion implosion O. A. Hurricane D. A. Callahan D. T. Casey P. M. Celliers C. Cerjan et al. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042562

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 513 No. 7518 September 2014 Melting Pot‎

‎NPG Nature publishing group. Hardcover. Gut. Medical research: Missing patients Effective clinical studies must consider all ethnicities exclusion can endanger populations says Esteban G. Burchard. Developing world: Discuss inequality Confront economic differences to strengthen global research urge P. Wenzel Geissler and Ferdinand Okwaro. Mental health: Tailor informed-consent processes The first step in studying mental-health interventions across cultures is to adjust procedures to participants needs says Mónica Ruiz-Casares. Collaboration: Strength in diversity Richard B. Freeman and Wei Huang reflect on a link between a team s ethnic mix and highly cited papers. Genetics: Under the skin Nathaniel Comfort wonders at the enduring trend of misrepresenting race. Review of A Troublesome Inheritance: Genes Race and Human History Race Unmasked: Biology and Race in the 20th Century & The Myth of Race: The Troubling Persistence of an Unscientific Idea Nicholas Wade Michael Yudell & Robert Wald Sussman Physics: In thrall to uncertainty A history of how quantum theory has permeated Western culture refreshes Jim Baggott. Review of The Quantum Moment: How Planck Bohr Einstein and Heisenberg Taught Us to Love Uncertainty Robert P. Crease & Alfred Scharff Goldhaber New in paperback Linguistics: The write stuff Steven Pinker s provocative treatise on language use and abuse would benefit from more data finds Paul Raeburn. Review of The Sense of Style: The Thinking Person s Guide to Writing in the 21st Century Steven Pinker Evolution: Tribes like us Tim Lenton is intrigued by E. O. Wilson s sweeping perspective on humanity s past and possible futures. Review of The Meaning of Human Existence Edward O. Wilson Climate policy: A societal sea change Nico Stehr ponders Naomi Klein s call for strategic mass action on climate change. Review of This Changes Everything: Capitalism vs the Climate Naomi Klein Internet: Technology and its discontents Jaron Lanier surveys four studies probing the vexed nexus of mind and digisphere. Review of Mind Change: How Digital Technologies Are Leaving Their Mark on Our Brains The Organized Mind: Thinking Straight in the Age of Information Overload The Impulse Society: What s Wrong With Getting What We Want & The Glass Cage: Automation and Us Susan Greenfield Daniel J. Levitin Paul Roberts & Nicholas Carr When disease strikes from nowhere When healthy parents have a child with a genetic disorder the cause is sometimes a new mutation. Tools are emerging to meet the challenge of finding such changes. Insight: Exoplanets Exoplanets Leslie Sage Doppler spectroscopy as a path to the detection of Earth-like planets Michel Mayor Christophe Lovis & Nuno C. Santos See also Insight by Lissauer et al. See also Insight by Pepe et al. Advances in exoplanet science from Kepler Jack J. Lissauer Rebekah I. Dawson & Scott Tremaine Highlights in the study of exoplanet atmospheres Adam S. Burrows The role of space telescopes in the characterization of transiting exoplanets Artie P. Hatzes See also Insight by Lissauer et al. Instrumentation for the detection and characterization of exoplanets Francesco Pepe David Ehrenreich & Michael R. Meyer See also Insight by Mayor et al. GATM locus does not replicate in rhabdomyolysis study James S. Floyd Joshua C. Bis Jennifer A. Brody Susan R. Heckbert Kenneth Rice et al. Mangravite et al. reply Lara M. Mangravite Barbara E. Engelhardt Matthew Stephens & Ronald M. Krauss News & Views Top Evolutionary biology: Radiating genomes Chris D. Jiggins See also Article by Brawand et al. Condensed-matter physics: Catching relativistic electrons Zhihuai Zhu & Jennifer E. Hoffman Animal behaviour: The evolutionary roots of lethal conflict Joan B. Silk See also Letter by Wilson et al. Astrophysics: Giant black hole in a stripped galaxy Amy E. Reines See also Letter by Seth et al. 50 & 100 Years Ago Neuroscience: Shedding light on a change of mind Tomonori Takeuchi & Richard G. M. Morris See also Letter by Redondo et al. Organic chemistry: Reactivity tamed one bond at a time Matthew T. Villaume & Phil S. Baran See also Article by Meng et al. Articles Top Multifunctional organoboron compounds for scalable natural product synthesis Fanke Meng Kevin P. McGrath & Amir H. Hoveyda A catalytic process is reported that begins with a highly selective copper boron addition to a monosubstituted allene and in which the resulting boron-substituted organocopper intermediate then participates in a chemoselective site-selective and enantioselective allylic substitution this approach is used in the enantioselective synthesis of gram quantities of two natural products. See also News & Views by Villaume & Baran The genomic substrate for adaptive radiation in African cichlid fishOpen David Brawand Catherine E. Wagner Yang I. Li Milan Malinsky Irene Keller et al. Genomes and transcriptomes of five distinct lineages of African cichlids a textbook example of adaptive radiation have been sequenced and analysed to reveal that many types of molecular changes contributed to rapid evolution and that standing variation accumulated during periods of relaxed selection may have primed subsequent diversification. See also News & Views by Jiggins Proteogenomic characterization of human colon and rectal cancer Bing Zhang Jing Wang Xiaojing Wang Jing Zhu Qi Liu et al. Proteome analysis of The Cancer Genome Atlas TCGA colorectal cancer specimens reveals that DNA- or RNA-level measurements cannot reliably predict protein abundance colorectal tumours can be separated into distinct proteotypes and that copy number alterations drive mRNA abundance changes but few extend to protein-level changes. Molecular architecture and mechanism of the anaphase-promoting complex Leifu Chang Ziguo Zhang Jing Yang Stephen H. McLaughlin & David Barford The anaphase-promoting complex/cyclosome APC/C is a large E3 ligase that mediates ubiquitin-dependent proteolysis of cell cycle regulatory proteins here the complete secondary structure architecture of human APC/C complexed with its coactivator CDH1 and substrate HSL1 is determined at 7.4 Ã… resolution revealing allosteric changes induced by the coactivator that enhance affinity for UBCH10 ubiqutin. Letters Top A massive galaxy in its core formation phase three billion years after the Big Bang Erica Nelson Pieter van Dokkum Marijn Franx Gabriel Brammer Ivelina Momcheva et al. Hubble Space Telescope Keck telescope and Spitzer satellite data reveal the formation of the dense stellar core of a massive galaxy occurring three billion years after the Big Bang. A supermassive black hole in an ultra-compact dwarf galaxy Anil C. Seth Remco van den Bosch Steffen Mieske Holger Baumgardt Mark den Brok et al. Dynamical modelling of the ultra-compact dwarf galaxy M60-UCD1 reveals the presence of a supermassive black hole this suggests the object is a stripped galaxy nucleus and implies the existence of supermassive black holes in many other ultra-compact dwarf galaxies. See also News & Views by Reines Aridification of the Sahara desert caused by Tethys Sea shrinkage during the Late Miocene Zhongshi Zhang Gilles Ramstein Mathieu Schuster Camille Li Camille Contoux et al. The drying of the Tethys Sea the progenitor of the modern Mediterranean Black and Caspian seas weakened the northern extension of the African monsoon and led to the creation of the Sahara desert about 7 million years ago. Spreading continents kick-started plate tectonics Patrice F. Rey Nicolas Coltice & Nicolas Flament The slow gravitational collapse of early continents could have kick-started transient episodes of plate tectonics until as the Earth s interior cooled and oceanic lithosphere became heavier plate tectonics became self-sustaining. Ancient human genomes suggest three ancestral populations for present-day Europeans A list of authors and their affiliations appears at the end of the paper A sequencing study comparing ancient and contemporary genomes reveals that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers ancient north Eurasians related to Upper Palaeolithic Siberians and early European farmers of mainly Near Eastern origin. Lethal aggression in Pan is better explained by adaptive strategies than human impacts Michael L. Wilson Christophe Boesch Barbara Fruth Takeshi Furuichi Ian C. Gilby et al. A meta-analysis of studies on chimpanzees and bonobos across Africa shows that their conspecific aggression is the normal and expected product of adaptive strategies to obtain resources or mates and has no connection with the impacts of human activities. See also News & Views by Silk Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations Ofer Fridman Amir Goldberg Irine Ronin Noam Shoresh & Nathalie Q. Balaban Repeated exposure of the bacterium Escherichia coli to clinically relevant concentrations of ampicillin results in the evolution of tolerance the ability to survive until the antibiotic concentration diminishes through an extension of the lag phase a finding that has implications for slowing the evolution of antibiotic resistance. Genome sequencing of normal cells reveals developmental lineages and mutational processes Sam Behjati Meritxell Huch Ruben van Boxtel Wouter Karthaus David C. Wedge et al. On the basis of whole-genome sequences of clonal lines derived from normal mouse tissues variation in mutational patterns and load across different tissues are described and early embryonic cell divisions are reconstructed. Bidirectional switch of the valence associated with a hippocampal contextual memory engram Roger L. Redondo Joshua Kim Autumn L. Arons Steve Ramirez Xu Liu et al. An optogenetic approach in mice was used to investigate the neural mechanisms underlying memory valence association dentate gyrus but not amygdala memory engram cells exhibit plasticity in valence associations suggesting that emotional memory associations can be changed at the circuit level. See also News & Views by Takeuchi & Morris Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malaria Qingfeng Zhang T. Nicolai Siegel Rafael M. Martins Fei Wang Jun Cao et al. A novel type of post-transcriptional regulation controls the expression of virulence genes in blood-stage malaria parasites. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer Jae Myoung Suh Johan W. Jonker Maryam Ahmadian Regina Goetz Denise Lackey et al. Pharmacological fibroblast growth factor 1 FGF1 normalizes blood glucose in diabetic mice by means of an FGF receptor signalling pathway that is independent of its mitogenic activity. Coordinated regulation of protein synthesis and degradation by mTORC1 Yinan Zhang Justin Nicholatos John R. Dreier Stéphane J. H. Ricoult Scott B. Widenmaier et al. mTORC1 is known to stimulate protein synthesis now it is shown to also promote the synthesis of proteasomes which degrade proteins into the amino acids needed to create new proteins. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042585

‎Journal fur Schulentwicklung‎

‎3/2018 Schulautonomie‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Peter Daschner & Krainz-Dürr Schulautonomie - Editorial 5 Herbert Altrichter Stefan Brauckmann &Lorenz Lassnigg Schulautonomie - Konzept und Forschungsergebnisse 8 Matthias Rürup Schulautonomie in Deutschland 15 Jürg Brühlmann Schulautonomie in der Schweiz 19 Herbert Altrichter Lorenz Lassnigg & Stefan Brauckmann Schulautonomie in Österreich 24 Ivan Stuppner & Ursula Pulyer Schulautonomie in Südtirol 29 Ingrid Herzberg Martina Adami Christian Hubatka & Johanna E. Schwarz Schulautonomie aus der Perspektive von Schulleitungen 35 Andrea Widmann & Julia Smolka Kooperation oder Wettbewerb Chancen und Risiken von Schulautonomie und Profilbildung 43 Tobias Stricker & Elvira Eberhardt Schulautonomie und externe Evaluation: Freund oder Feind Erfahrungen aus der Fremdevaluation in Baden-Württemberg 49 Quergedacht Jutta Clarke Autonomie und Freiheit - Ãœberlegungen mit Viktor Frankl 54 Methodenatelier Peter Lackner Get your teacher! Schulleitungen wählen ihr Personal aus Extra David Kemethofer & Christian Wiesner So denken Schulleitungen über Bildungsstandards Service Aktuelle Buchempfehlungen Themen & Termine gutes Exemplar ordentlich StudienVerlag. hardcover‎

Riferimento per il libraio : B00059781

‎Journal fur Schulentwicklung‎

‎1/2015 Horizontale Schulentwicklung‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Jürg Brühlmann & Hans Günther Rolff Horizontale Schulentwicklung Editorial 4 Jürg Brühlmann er Rahel Haymoz Aus der Praxis für die Praxis: Möglichkeiten zur Verbreitung von Ideen und Modellen durch horizontal organisierte Schulentwicklung 8 Hans-Günter Rolff Partner in selbstgesteuerten Projektverbünden. Eine empirische Untersuchung der Regionalen Bildungsnetzwerke in NRW 14 Manfred Künzel Multiplikatorenprojekte in der Schulentwicklung. Wie Ketten- Wellen- und Lawinenprojekte aufgebaut sind und warum sie funktionieren 22 Enikö Zala-Mezö Nina-Cathrin Strauss & Bettina Diethelm Werder Das Prinzip middle up down : jenseits von top down oder bottom up 29 Birgit Korn Hospitieren - reflektieren - adaptieren. Erfahrungen aus dem Netzwerk Hamburger Hospitationsschulen 37 Monika Pfister Netzwerk Luzerner Schulen 44 Methodenatelier Annelies Kreis Carmen Kosorok Labhart & Jeannette Wick Der Kooperationsplaner - ein webbasiertes Instrument zur Klärung von Aufgaben und Verantwortlichkeiten an integrativen Schulen 48 Literatur-Review 52 gutes Exemplar ordentlich StudienVerlag hardcover‎

Riferimento per il libraio : B00051037

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 512 No. 7512 August 2014 Growth Factor‎

‎NPG Nature publishing group. Hardcover. Gut. Polar research: Six priorities for Antarctic science Mahlon C. Kennicutt II Steven L. Chown and colleagues outline the most pressing questions in southern polar research and call for greater collaboration and environmental protection in the region. Books and Arts Top Culture: Artistic alchemy Philip Ball unveils the scientific iconography in Albrecht Dürer s enigmatic engraving Melencolia I. Bias towards large genes in autism Shahar Shohat & Sagiv Shifman Zylka et al. reply Mark J. Zylka Ben D. Philpot & Ian F. King Materials chemistry: Seeds of selective nanotube growth James M. Tour See also Letter by Sanchez-Valencia et al. Cancer: Directions for the drivers Greg Gibson See also Letter by Ongen et al. Neurodegeneration: Alzheimer s disease under strain Adriano Aguzzi Astrophysics: Portrait of a doomed star Stephen Justham See also Letter by McCully et al. HIV: Early treatment may not be early enough Kai Deng & Robert F. Siliciano See also Letter by Whitney et al. Evolution: Tooth structure re-engineered Zhe-Xi Luo See also Article by Harjunmaa et al. Articles Top Convergence of terrestrial plant production across global climate gradients Sean T. Michaletz Dongliang Cheng Andrew J. Kerkhoff & Brian J. Enquist Net primary production is affected by temperature and precipitation but whether this is a direct kinetic effect on plant metabolism or an indirect ecological effect mediated by changes in plant age plant biomass or growing season length is unclear this study develops metabolic scaling theory to be able to answer this question and applies it to a global data set of plant productivity concluding that it is indirect effects that explain the influence of climate on productivity which is characterized by a common scaling relationship across climate gradients. Replaying evolutionary transitions from the dental fossil record Enni Harjunmaa Kerstin Seidel Teemu Häkkinen Elodie Renvoisé Ian J. Corfe et al. Gradual changes that occur to mammalian tooth morphology across evolutionary time were modelled in vitro and in vivo by modulation of signalling pathways in the mouse and computer modelling was used to provide further analysis of the parameters influencing tooth morphology. See also News & Views by Luo Structure of the DDB1 CRBN E3 ubiquitin ligase in complex with thalidomide Eric S. Fischer Kerstin Böhm John R. Lydeard Haidi Yang Michael B. Stadler et al. The crystal structures of thalidomide and its derivatives bound to the E3 ligase subcomplex DDB1 CRBN are shown these drugs are found to have dual functions interfering with the binding of certain cellular substrates to the E3 ligase but promoting the binding of others thereby modulating the degradation of cellular proteins. Letters Top A luminous blue progenitor system for the type Iax supernova 2012Z Curtis McCully Saurabh W. Jha Ryan J. Foley Lars Bildsten Wen-fai Fong et al. The detection of the luminous blue progenitor system of the type Iax supernova 2012Z suggests that this supernova was the explosion of a white dwarf accreting material from a helium-star companion. See also News & Views by Justham Tunable spin spin interactions and entanglement of ions in separate potential wells A. C. Wilson Y. Colombe K. R. Brown E. Knill D. Leibfried et al. The ability of individual ions trapped in separate potential wells to simulate spin spin interactions is demonstrated by tuning the Coulomb interaction between two ions independently controlling their local wells and entangling their internal states with a fidelity of approximately 0.82. Controlled synthesis of single-chirality carbon nanotubes Juan Ramon Sanchez-Valencia Thomas Dienel Oliver Gröning Ivan Shorubalko Andreas Mueller et al. Present preparation methods fail to meet fully the demand for structurally pure single-walled carbon nanotubes surface-catalysed cyclodehydrogenation reactions are now shown to convert precursor molecules deposited on a platinum111 surface into ultrashort nanotube seeds that can then be grown further into defect-free and structurally pure single-walled carbon nanotubes of single chirality. See also News & Views by Tour A global ocean inventory of anthropogenic mercury based on water column measurements Carl H. Lamborg Chad R. Hammerschmidt Katlin L. Bowman Gretchen J. Swarr Kathleen M. Munson et al. GEOTRACES sampling of deep water from the Atlantic Pacific and Southern oceans allows an estimate of the amount tripled in surface waters and distribution two-thirds increase in water less than a thousand metres deep of anthropogenic mercury accumulating in the global ocean. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis Lieselotte Vande Walle Nina Van Opdenbosch Peggy Jacques Amelie Fossoul Eveline Verheugen et al. Pathogenesis of rheumatoid arthritis depends critically on the NLRP3 inflammasome/interleukin-1 signalling axis. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys James B. Whitney Alison L. Hill Srisowmya Sanisetty Pablo Penaloza-MacMaster Jinyan Liu et al. Reservoirs of virus infection represent the most important reason why HIV-1 cannot be cured with current antiretroviral drugs now the refractory viral reservoir is shown to be seeded as early as 3 days after infection in a monkey model even before the virus is detected in the blood. See also News & Views by Deng & Siliciano Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms Lorena Arranz Abel Sánchez-Aguilera Daniel Martín-Pérez Joan Isern Xavier Langa et al. Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell HSC compartment and here the authors show that the HSC niche contributes to the pathogenesis sympathetic innervation of mesenchymal stem cells MSCs is reduced in the bone marrow of patients which leads to reduced MSC numbers and increased mutant HSC expansion and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion. PVT1 dependence in cancer with MYC copy-number increase Yuen-Yi Tseng Branden S. Moriarity Wuming Gong Ryutaro Akiyama Ashutosh Tiwari et al. Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis. Putative cis-regulatory drivers in colorectal cancer Halit Ongen Claus L. Andersen Jesper B. Bramsen Bodil Oster Mads H. Rasmussen et al. Examination of allele-specific expression identifies 71 genes with excess somatic cis-regulatory effects in colorectal cancer CRC and 1693 and 948 expression quantitative trait loci eQTLs in normal samples and tumours respectively with 36% of tumour eQTLs exclusive to CRC tumour-specific eQTLs are more enriched for low CRC genome-wide association study P values and accumulate more somatic mutations than shared eQTLs suggesting a role as germline-derived cancer regulatory drivers. See also News & Views by Gibson Genome-scale functional characterization of Drosophila developmental enhancers in vivo Evgeny Z. Kvon Tomas Kazmar Gerald Stampfel J. Omar Yáñez-Cuna Michaela Pagani et al. Systematically assaying the activity of 7705 candidate enhancers during Drosophila embryogenesis shows that nearly half are active in the embryo and display dynamic spatial patterns during development enhancer activity is matched to expression patterns of putative target genes and predictive cis-regulatory motifs are identified. Enhancer loops appear stable during development and are associated with paused polymerase Yad Ghavi-Helm Felix A. Klein Tibor Pakozdi Lucia Ciglar Daan Noordermeer et al. A high-resolution map of enhancer three-dimensional contacts during Drosophila embryogenesis shows that although local regulatory interactions are frequent long-range interactions are also very common unexpectedly most interactions appear unchanged between tissues and across development and are formed prior to gene expression indicating that transcription initiates from preformed enhancer promoter loops which are associated with paused polymerase. Visualizing the kinetic power stroke that drives proton-coupled zincii transport Sayan Gupta Jin Chai Jie Cheng Rhijuta D Mello Mark R. Chance et al. In the transport cycle of Yiip zincii binding triggers a highly localized all-or-nothing change of water accessibility to the transport site and an adjacent hydrophobic gate. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042565

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎2/1998 Öko Siegel‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Öko-Siegel noch unbesiegelt 4 Bio-Harzer von der Firma Rusack 5 Verbraucherbefragung zum Stellenwert und Bekanntheitsgrad der landwirtschaftlichen Direktvermarktung im Freistaat Sachsen 6 Das Projekt Naturmärkte - eine Bilanz 9 Firmengründung NaturMarkt GmbH: Sächsische Landwirte und Verarbeiter schließen sich zusammen 11 ZMP untersucht Auszahlungen für Öko-Schweine 11 Symposium zum ökologischen Landbau im Stadtgut Görlitz 12 Landwirtschaft und Umwelt Ökologische Ochsenmast - ein Betriebszweig mit ökonomischer Zukunft 13 Verbesserungsmöglichkeiten in der ökologischen Legenhennenhaltung 14 Drunter und Drüber Nachrichten aus den Landesverbänden 18 Buchempfehlung 20 Veranstaltungskalender 21 Anzeigen 22 gutes Exemplar ordentlich hardcover‎

Riferimento per il libraio : B00053189

‎Journal fur Schulentwicklung‎

‎1/2012 Arbeitskulturen in Schulen‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Jürg Brühlmann Monica Gather Thurler Arbeitskulturen in Schulen Editorial Ernst Trachsler Arbeitskultur im Wandel - Außendruck oder Innenzug - oder beides Xavier Dumae Die schulinterne Koordination der Arbeit der Lehrpersonen Fekric Yvon er Emmanuel Poirel Verteilte Leadership und Berufskultur von Lehrpersonen Drei Fallbeispiele Anton Strittmatter Arbeitsplatz Zwickmühle - Ambiguitätstoleranz als Kulturmerkmal gut geführter Schulen Christine Böckeimann Chancen multiprofessioneller Teams für den Arbeitsplatz Schule Jürg Brühlmann Veränderter Schulalltag - Wie sich personalisierte und kooperative Lernformen auf Selbstwahrnehmung und Arbeitsprozesse auswirken Methodenatelier Monica Gather Thurler Lernhemmende versus lernfördernde Merkmale von Arbeitskulturen gutes Exemplar ordentlich StudienVerlag hardcover‎

Riferimento per il libraio : B00051046

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol. 516 No. 7530 Dezember 2014 Life on the Brink‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 143 POLICY Room for growth Europe is taking a step forward in regulation of transgenic crops 143 HUMAN RESEARCH Ethical overkill Cut back on redundant ethics reviews 144 BIODIVERSITY Protect and serve Conservation efforts need to ramp up WORLD VIEW 145 Assess the real cost of research assessment Peter M Atkinson The UK Research Excellence Framework needs tightening up RESEARCH HIGHLIGHTS 146 SELECTIONS FROM THE SCIENTIFIC LITERATURE Early ape could handle alcohol / Ice loss a one-way trip / Cockroaches see the night / New metrics on top / Stunning eels / A Early bat-nav - -- 151 EARTHQUAKES Tsunami warnings for Indian Ocean fall short 153 SPACE Europe hatches plan to join Russian Moon trips 154 PUBLIC HEALTH Experts seek to expand Ebola testing in West Africa 156 MEDICINE Drugfirms encouraged by a cancer immunotherapy s success 157 SYSTEMS BIOLOGY Microsoft billionaire founds US$100-million `cell observatory FEATURES Treatment research should focus on disease not microbes BOOKS & ARTS 16B IN RETROSPECT Elective Affinities Matthew Bell SEVEN DAYS 148 THE NEWS IN BRIEF Orion test flight lifts off / India to join telescope consortium / Einstein documents go open access / EU changes GM-crop stance 277 OCEAN BIOLOGY Marine dreams Marine biologists oller reality check to starry-eyed enthusiasts 279 CAREER BRIEFS Conservationists struggle to keep tabs on extinction rates PAGE 158 162 STEM CELLS The black box of reprogramming Molecular biologists getting a grip on the route to pluripotency 169 GENETICS Genius on the fly Ewen Callaway CORRESPONDENCE 17O Maximize military land use / Europe fails young researchers / Conflict declarations for biodiversity reports / Involve participants in study design / Primates still essential for some research FUTURES 282 Missed message Rache! Reddick NEW ONLINE 171 Papers published this weekat nature.com NEWS & VIEWS 172 STEM CELLS A designer s guide to pluripotency A newly characterized class of pluripotent stem cell Jun Wu & Juan Carlos lzpisua Belmonte SEE ARTICLES P.192 & R198 173 MATERIALS SCIENCE Breakthrough for protons Protons pass through graphene and hexagonal boron nitride Rohit N Karnik SEE LETTER P.227 175 MICROBIOLOGY A beacon for bacterial tubulin The protein MapZ positions the division site in Streptococcus pneumoniae Elizabeth J Harry SEE LETTER P.259 176 STRUCTURAL BIOLOGY Calcium-activated proteins visualized Crystal structures of bestrophin and lipid scramblase proteins Matt Whorton SEE ARTICLES P.207 & P.213 178 APPLIED PHYSICS The virtues of tiling A nanoscale spider-inspired vibration sensor Peter Fratzl SEE LETTER P.222 179 HYDROLOGY When wells run dry Quantifying freshwater supply and use around the world Richard Taylor REVIEW 181 ORGANIC CHEMISTRY Catalytic enantioselective synthesis of quaternary carbon stereocentres K W Quasdorf & L E Overman ARTICLES 192 STEM CELLS Divergent reprogramming routes lead to alternative stem-cell states P D Tonge et al. SEE N&V R172 198 STEM CELLS Genome-wide characterization of the routes to pluripotency S M I Hussein et al. SEE N&V P.172 Cracks are the key to a spider-inspired nanoscale strain detector. PAGE 222 2O7 STRUCTURAL BIOLOGY X-ray structure of a calcium-activated TMEM16 lipid scramblase J D Brunner N K Lim S Schenck A Duerst& R Dutzler SEE N&V P.176 213 STRUCTURAL BIOLOGY Structure and insights into the function of a Ca2- activated Cl2 channel V K Dickson L Pedi & S B Long SEE N&V R176 LETTERS 219 PLANETARY SCIENCE H2D observations give an age of at least one million years for a cloud core forming Sunlike stars S Brünken et al. 222 NANOSCALE DEVICES Ultrasensitive mechanical crack-based sensor inspired by the spider sensory system D Kang et al. SEE N&V R178 227 MATERIALS SCIENCE Proton transport through one-atom-thick crystals S Hu et al. SEE N&V R173 231 CHEMICAL PHYSICS Formation and properties of ice XVI obtained by emptying a type sll clathrate hydrate A Falenty T C Hansen & W F Kuhs 234 CLIMATESCIENCES Isotopic constraints an marine and terrestrial N20 emissions during the last deglaciation A Schilt et al. 23B PALAEONTOLOCY Cell differentiation and germ soma separation in Ediacaran animal embryo-like fossils L Chen S Xiao K Pang C Zhou & X Yuan 242 MOLECULAR EVOLUTION An evolutionary arms race between KRAB zincfinger genes ZNF91/93 and SVA/L1 retrotransposons F M J Jacobs et al. 246 IMMUNOLOGY Dietary modulation of the microbiome affects autoinflammatory disease J R Lukens et al. 250 STRUCTURAL BIOLOGY Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG P Goyal et al. 254 IMMUNOLOGY Loss of signalling via Ga13 in germinal centre B-cellderived lymphoma J R Muppidi et al. 259 CELL BIOLOGY MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae A Fleurie et al. SEE N&V P.175 263 MOLECULAR 610108V Programmable RNA recognition and cleavage by CRISPR/Cas9 M R O Connell et al. 267 MOLECULAR BIOLOGY Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation H Basnet et al. 272 CELL BIOLOGY Regulation of RNA polymerase II activation by histone acetylation in single living cells TJ Stasevich et al. 276 CORRIGENDUM Producing primate embryonic stem cells by somatic cell nuclear transfer JA Byrne et al. 276 CORRIGENDUM Mitochondrial gene replacement in primate offspring and embryonic stem cells M Tachibana et al. 276 CORRIGENDUM Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos E Kang et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042459

‎Journal fur Schulentwicklung‎

‎2/2011 Schulreform aus der Systemperspektive‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Wilfried Schley Ein Beispiel aus der Praxis sieben Sichtweisen Editorial 4 Hans-Günter Rolff Umfeldbezug - Masterplan statt Flickwerk 8 Michael Schratz Schulinterne Curriculumentwicklung lernseits von Unterricht 14 Monica Gather Thurler Leadership im Sinne der Entwicklung des Gesamtsystems - Neue Perspektiven und Herausforderungen 24 Wilfried Schlee Die Kultur von Innovation im Spannungsfeld von Transfer und Transformation 30 Marlies Krainz-Dürr Den Wandel begleiten - Unterstützungssysteme im Paradigma der Aktionsforschung 35 Jürg Brühlmann Steuerung von Innovation - Logik der Politik oder Logik der Schule 41 Uwe Hameeer Scheingewissheiten im Blick - Logik und Psychologik schulischer Transformation 48 Länderberichte Heimut Bachmann & Michael Schratz Die Neue Mittelschule - Strukturreform der Sekundarstufe I in Österreich 57 Ernst Rösner Gemeinschaftsschule in Deutschland 61 gutes Exemplar ordentlich StudienVerlag hardcover‎

Riferimento per il libraio : B00051032

‎Ein urgemutliches sachsisches Journal:‎

‎Der kleine Drache Nummer 3‎

‎Hardcover. Gut. Ein urgemütliches sächsisches Journal: INHALT Kleiner Blick zurück mit Texten von Jan Altenburg Paul Altheer Peter Natron Richard Albert Schneider Alcest Thomas Biskupek: Nächstenliebe / Ralph Grüneberger: Karneval / Gunter Preuß: Sprüche / Jürgen Schebera: Alptraum / Maria Dahms: Theater i Lo- thar Kusche: Erfahrung / Mark Trödel. Auflösungsgeier / Joachim Schöne-. Sächsisch / Eberhard Eichner: Geschichte / Mathias Götz: Aphorismen / Kurt Gerhard Franke: Leipziger Sprachführer Leipziger Allerlei Matthias Biskupek: Wortgut / Gunter Fritzsche: Beutelmann / Hildegard Maria Rauchfuss-. Limericks und Schüttelreime / Gerd E. König: Gaststätte / Fritz-Jochen Kopka: Aufenthalt / Bernd-Lutz Lange: Ansichten / Peter Seidel: Karneval CARTOONS SKIZZEN VIGNETTEN von Matthias Götz Peter Laube Andreas J. Mueller Lothar Otto Werner Rollow Rainer Schade Feierlichkeit / Verkehrsproblem AHA-Black / Jubiläumskonzert Ver- stricktes und Verwickeltes . Stellungswechsel / Literarisches Rätsel / Mitbringsel u.v.a. gepflegtes Exemplar nur kleine Lesespuren Buchblock altersgemäß gebräunt hardcover‎

Riferimento per il libraio : B00008113

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No. 7499 Mai 2014 Beyond Divisions‎

‎NPG Nature publishing group. Hardcover. Gut. Synthetic biology: How best to build a cell Experts weigh in on the biggest obstacles in synthetic biology from names to knowledge gaps and what it will take to overcome them. Society: Realizing China s urban dream Local implementation and public scrutiny will make or break the government s urbanization strategy say Xuemei Bai Peijun Shi and Yansui Liu. Books and Arts Top Developmental biology: Life in flux Renee Reijo Pera enjoys a treatise tracking the rise of embryology from Aristotle to cloning and beyond. Review of Embryos Under the Microscope: The Diverging Meanings of Life Jane Maienschein Q&A: Canopy composer Sound artist Daniel Jones creates self-generating artworks based on human and natural patterns and processes. As he prepares to travel through four UK forests with the installation Living Symphonies a collaboration with artist James Bulley he talks about music that emerges from ecosystem dynamics and works inspired by bacterial genetics and social networks. Review of Living Symphonies Daniel Jones & James Bulley Forum Synthetic biology: Engineering explored Pamela A. Silver Jeffrey C. Way Frances H. Arnold & Joseph T. Meyerowitz Climate science: The origin of regional Arctic warming Jürgen Bader See also Letter by Ding et al. Synthetic biology: Construction of a yeast chromosome Daniel G. Gibson & J. Craig Venter Cosmology: A virtual Universe Michael Boylan-Kolchin See also Article by Vogelsberger et al. Biodiversity: Supply and demand Arne O. Mooers See also Letter by Price et al. Ecology: Diversity in the afterlife Jennie R. McLaren See also Letter by Handa et al. Structural biology: Action at a distance in a light receptor Anna W. Baker & Katrina T. Forest See also Letter by Takala et al. Articles Top Properties of galaxies reproduced by a hydrodynamic simulation M. Vogelsberger S. Genel V. Springel P. Torrey D. Sijacki et al. A simulation that starts 12 million years after the Big Bang and traces 13 billion years of cosmic evolution yields a reasonable population of elliptical and spiral galaxies reproduces the observed distribution of galaxies in clusters and the characteristics of hydrogen on large scales and at the same time matches the metal and hydrogen content of galaxies on small scales. See also News & Views by Boylan-Kolchin FXR is a molecular target for the effects of vertical sleeve gastrectomy Karen K. Ryan Valentina Tremaroli Christoffer Clemmensen Petia Kovatcheva-Datchary Andriy Myronovych et al. Bariatric surgical procedures such as vertical sleeve gastrectomy VSG are the most effective therapy for the treatment of obesity now bile acids and the presence of the nuclear bile acid receptor FXR are shown to underpin the mechanism of VSG action and the ability of VSG to reduce body weight and improve glucose tolerance is substantially reduced if FXR is absent. Astrocyte-encoded positional cues maintain sensorimotor circuit integrity Anna V. Molofsky Kevin W. Kelley Hui-Hsin Tsai Stephanie A. Redmond Sandra M. Chang et al. Populations of astrocytes in the spinal cord are shown to express region-specific genes with ventral astrocyte-encoded Sema3a necessary for proper motor neuron circuit organization and typical sensory afferent projection patterns these findings suggest that astrocytes provide a positional cue for maintaining proper circuit formation and refinement. Synapse elimination and learning rules co-regulated by MHC class I H2-Db Hanmi Lee Barbara K. Brott Lowry A. Kirkby Jaimie D. Adelson Sarah Cheng et al. This study reveals a role for the MHC class I molecule H2-Db in retinogeniculate synapse elimination expression of this immune system molecule in neurons lacking it is sufficient to rescue proper synapse pruning as well as the segregation of eye-specific circuits in mice. Letters Top Circular polarization in the optical afterglow of GRB 121024A K. Wiersema S. Covino K. Toma A. J. van der Horst K. Varela et al. Circularly polarized light is unexpectedly detected in the afterglow of -ray burst GRB 121024A measured 0.15 days after the burst and is shown to be intrinsic to the afterglow and unlikely to be produced by dust scattering or plasma propagation effects. Classical shear cracks drive the onset of dry frictional motion Ilya Svetlizky & Jay Fineberg The transition between static and dynamic friction in a model system is found to be quantitatively captured by the same theoretical framework as is used to describe brittle fracture but deviations from this correspondence are observed as the rupture velocity approaches the speed at which sound waves propagate along the interface. Tropical forcing of the recent rapid Arctic warming in northeastern Canada and Greenland Qinghua Ding John M. Wallace David S. Battisti Eric J. Steig Ailie J. E. Gallant et al. Human-induced climate change is usually assumed to be responsible for the dramatic thawing of glaciers since the mid 1990s in Greenland and northeastern Canada approximately half of the observed warming in this region during this period is now found to be attributable to atmospheric circulation changes that may be of natural origin. See also News & Views by Bader Predicting biodiversity change and averting collapse in agricultural landscapes Chase D. Mendenhall Daniel S. Karp Christoph F. J. Meyer Elizabeth A. Hadly & Gretchen C. Daily A new holistic view of countryside biogeography is emerging for the world s human-modified habitats and the biodiversity they support. Consequences of biodiversity loss for litter decomposition across biomes I. Tanya Handa Rien Aerts Frank Berendse Matty P. Berg Andreas Bruder et al. Field experiments across aquatic and terrestrial ecosystems show that biodiversity positively affects carbon and nitrogen cycling in leaf litter decomposition indicating that reduced decomposition caused by biodiversity loss would modify the global carbon cycle and limit the nitrogen supply to the organisms at the base of the food chain. See also News & Views by McLaren Niche filling slows the diversification of Himalayan songbirds Trevor D. Price Daniel M. Hooper Caitlyn D. Buchanan Ulf S. Johansson D. Thomas Tietze et al. In Himalayan songbirds the speciation rate is ultimately set by ecological competition rather than by the rate of acquisition of reproductive isolation. See also News & Views by Mooers Sensory stimulation shifts visual cortex from synchronous to asynchronous states Andrew Y. Y. Tan Yuzhi Chen Benjamin Scholl Eyal Seidemann & Nicholas J. Priebe Intracellular recordings distinguish between mechanisms that can account for variability in primary visual cortex of alert primates consistent with a scheme in which spiking is driven by infrequent synchronous events during fixation with sensory stimulation shifting the cortex to an asynchronous state. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread Mark A. Czuczman Ramzi Fattouh Jorik M. van Rijn Veronica Canadien Suzanne Osborne et al. The intracellular bacterial pathogen Listeria monocytogenes is shown to exploit efferocytosis the process by which dead or dying cells are removed by phagocytosis to promote cell-to-cell spread during infection. NRROS negatively regulates reactive oxygen species during host defence and autoimmunity Rajkumar Noubade Kit Wong Naruhisa Ota Sascha Rutz Celine Eidenschenk et al. The leucine-rich repeat protein NRROS which resides in the endoplasmic reticulum regulates phagocytic NADPH oxidase minimizing collateral tissue damage caused by reactive oxygen species during inflammatory processes. Endosomes are specialized platforms for bacterial sensing and NOD2 signalling Norihiro Nakamura Jennie R. Lill Qui Phung Zhaoshi Jiang Corey Bakalarski et al. The endo-lysosomal transporters SLC15A3 and SLC15A4 provide a portal of entry for extracellular bacterial products that activate the cytoplasmic sensor NOD2 these results establish the importance of endosomes as signalling platforms specialized for triggering innate immune responses. Signal amplification and transduction in phytochrome photosensors Heikki Takala Alexander Björling Oskar Berntsson Heli Lehtivuori Stephan Niebling et al. The solution and crystal structures of a bacterial phytochrome photosensory core in both its resting and activated states are determined switching between closed resting and open activated forms is found to be mediated by a conserved tongue and the structures indicate that smaller changes in the vicinity of the chromophore are amplified in scale as they are transmitted through the tongue and beyond. See also News & Views by Baker & Forest gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Riferimento per il libraio : B00042568