‎Journal‎

‎Journal fur Schulentwicklung‎

‎3/2012 Schulentwicklung was wirkt‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Uwe Hameeer er Peter Daschner Schulentwicklung - Was wirkt Editorial 4 Martin Hartmann Die Hattie-Studie auf dem Prüfstand - Resonanzen Ergebnisse kritische Perspektiven 7 Jürgen Wiechmann Unterrichtsqualität - Was wissen wir heute über wirksamen Unterricht 15 Stephan Gerhard Huber Schulische Führung und ihre Wirksamkeit für Schulentwicklung 22 Peter Daschner Hrsg. Was hat meine Schule vorangebracht Was davon wirkt nachhaltig Resümees von sieben Schulleiterinnen und Schulleitern aus Deutschland Österreich und der Schweiz 29 Hans-Ake Scherp Eine lernorientierte Perspektive auf Schulentwicklung - Erfahrungen aus Schweden 37 Stephan Gerhard Huber Durch wirksame Kooperation Schulqualität sichern und Schulentwicklung fördern 44 Mats Ekholm Learning Democracy in Swedish Schools - Insights from longitudinal studies 50 Guido Stolle Was wirkt beim Aufbau von Bildungsregionen - der bildungsbiographische Ansatz! 56 gutes Exemplar ordentlich StudienVerlag hardcover‎

Referentie van de boekhandelaar : B00051045

‎Journal fur Schulentwicklung‎

‎2/2009 Schulentwicklung und Symbolpolitik‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Wilfried Schley Schulentwicklung und Symbolpolitik - Editorial 4 Ernst Rösner Ãœber Alltagsmythen das Schulwesen betreffend 9 Peter Wendt Schulentwicklung: mediale Scheinwelt oder realer Prozess vor Ort 17 Karl-Volker Sauer Fusionen Konfusionen Lebenslügen und andere Phänomene der rollenden Schulreform in Deutschland 26 Olivier Maulini Das öffentliche Bildungswesen und seine Legitimation: zwischen instrumenteller Vernunft und symbolischer Botschaft 33 Dennis Shirley Die Musik der Demokratie. Die Entstehung von Strategien für eine neue Ära der Post-Standardisierung 44 gutes Exemplar ordentlich StudienVerlag hardcover‎

Referentie van de boekhandelaar : B00051022

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 511 No. 7509 Juli 2014 Inside Jupiter‎

‎NPG Nature publishing group. Hardcover. Gut. Struggle for independence The faculty of the Scripps Research Institute is bucking a national trend with its refusal to merge with the University of Southern California. Within reach A redoubling of efforts should swiftly eradicate polio from its last strongholds. Food for thought Researchers investigating different farming practices should not have to pick sides. World View Top Misjudgements will drive social trials underground A Facebook study that manipulated news feeds was not definitively unethical and offered valuable insight into social behaviour says Michelle Meyer. Research Highlights Top Agriculture: Global warming could hurt crops Planetary science: Titan s sea is super salty Cancer: Roving tumour cells tracked down Ecology: Ocean reserves miss key target Neurodegeneration: Antibodies fight Parkinson s Applied physics: Phone powers electronic label Vision: Prism of the eye guides light Virology: What makes HIV fit to spread Cognition: Chimp intelligence partly inherited The week in science: Smallpox found in fridge HIV-rebound dashes hope of cure and scandal over faked peer review. News in Focus Quantum-hub finalists picked No Alt text available for this image UK government considers eight proposals for up to six research centres. Katia Moskvitch Landslide risks rise up agenda No Alt text available for this image Forum on deadly natural phenomena discusses use of simulation and hazard-mapping technologies. Jane Qiu Scripps merger fiasco highlights US funding woes No Alt text available for this image Other independent biomedical research institutions have turned to private benefactors. Erika Check Hayden Charity begins at CERN No Alt text available for this image Particle-physics lab sets up fund for extras as other big institutes mull similar move. Elizabeth Gibney Correction Features Top Physics: Wave of the future No Alt text available for this image After two decades and more than half a billion dollars LIGO the world s largest gravitational-wave observatory is on the verge of a detection. Maybe. Alexandra Witze Weight-loss surgery: A gut-wrenching question No Alt text available for this image Gastric-bypass surgery can curb obesity as well as diabetes and a slew of other problems. Researchers are now trying to find out how it works. Virginia Hughes comment Infectious disease: Polio eradication hinges on child health in Pakistan Boosting basic medical services and routine immunizations not travel vaccinations is the key to ending polio worldwide says Zulfiqar Ahmed Bhutta. Psychological treatments: A call for mental-health science Clinicians and neuroscientists must work together to understand and improve psychological treatments urge Emily A. Holmes Michelle G. Craske and Ann M. Graybiel. Books and Arts Top History of medicine: Typhus and tyranny Tilli Tansey ponders a turbulent history of vaccine research in Nazi-occupied Europe. Review of The Fantastic Laboratory of Dr. Weigl: How Two Brave Scientists Battled Typhus and Sabotaged the Nazis Arthur Allen research News & Views Top High-pressure physics: Piling on the pressure Chris J. Pickard & Richard J. Needs Ecology: Pesticides linked to bird declines Dave Goulson Astrophysics: Survival of the largest Haley Gomez Neurobiology: Keeping a lid on it Gina Turrigiano Cancer: Sugar-coated cell signalling Andrew J. Ewald & Mikala Egeblad Materials science: A superelastic organic crystal Tomiki Ikeda & Toru Ube 50 & 100 Years Ago Stem cells: Reprogramming finds its niche Daniel Lucas & Paul S. Frenette Analysis Top A deep crust mantle boundary in the asteroid 4 Vesta Harold Clenet Martin Jutzi Jean-Alix Barrat Erik I. Asphaug Willy Benz et al. Data on Vesta s surface material provided by the Dawn probe and impacts modelling reveals that Vesta s crust mantle boundary must be deeper than 80 kilometres below the surface. Articles Top Genetics of ecological divergence during speciation Matthew E. Arnegard Matthew D. McGee Blake Matthews Kerry B. Marchinko Gina L. Conte et al. Traits responsible for recent niche divergence between sympatric threespine stickleback species are subjected to forward genetic analysis additive variation at several loci across the genome accounts for most of the genetic basis of ecological divergence with a further role for epistatic interactions that disadvantage hybrids. Reprogramming human endothelial cells to haematopoietic cells requires vascular induction Vladislav M. Sandler Raphael Lis Ying Liu Alon Kedem Daylon James et al. This study describes the conversion of human fetal and adult vascular endothelial cells into engraftable haematopoietic progenitors by transduction with some transcription factors and then culture on a vascular niche feeder layer the haematopoietic progenitors may be useful for the generation of engraftable healthy and long-lasting haematopoietic cells for treatment of inherited and acquired blood disorders. The cancer glycocalyx mechanically primes integrin-mediated growth and survival Matthew J. Paszek Christopher C. DuFort Olivier Rossier Russell Bainer Janna K. Mouw et al. Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins by funnelling integrins into adhesions integrin clustering and signalling is promoted which leads to enhanced cell survival and proliferation. Rapid formation of large dust grains in the luminous supernova 2010jl Christa Gall Jens Hjorth Darach Watson Eli Dwek Justyn R. Maund et al. The formation of dust in the dense circumstellar medium of the bright supernova 2010jl is at first rapid and produces very large grains which resist destruction whereas later the dust production rate increases meaning its source is ejecta this links early and late dust mass evolution in supernovae with dense circumstellar media. See also News & Views by Gomez Ramp compression of diamond to five terapascals R. F. Smith J. H. Eggert R. Jeanloz T. S. Duffy D. G. Braun et al. New laboratory techniques for applying enormous pressures allow diamond to be compressed to 50 million atmospheres providing insight into the interiors of planets and theoretical implications. See also News & Views by Pickard & Needs A low-cost non-toxic post-growth activation step for CdTe solar cells J. D. Major R. E. Treharne L. J. Phillips & K. Durose MgCl2 is shown to be a cheap and non-toxic replacement for the costly and environmentally unfriendly salt CdCl2 that has long been used as the activation step in the production of cadmium telluride solar cells. Pathway from subducting slab to surface for melt and fluids beneath Mount Rainier R. Shane McGary Rob L. Evans Philip E. Wannamaker Jimmy Elsenbeck & Stéphane Rondenay Magnetotelluric data from the state of Washington USA are used to image the fluid melt phase of volcanic subduction in Mt Rainier revealing fluid release at or near the top of the slab and its migration into the overlying mantle. Declines in insectivorous birds are associated with high neonicotinoid concentrations Caspar A. Hallmann Ruud P. B. Foppen Chris A. M. van Turnhout Hans de Kroon & Eelke Jongejans The water concentrations of imidacloprid a neonicotinoid pesticide correlate with declines in farmland bird populations in the Netherlands. See also News & Views by Goulson Genome sequencing identifies major causes of severe intellectual disability Christian Gilissen Jayne Y. Hehir-Kwa Djie Tjwan Thung Maartje van de Vorst Bregje W. M. van Bon et al. Whole-genome sequencing is used to identify genetic alterations in patients with severe intellectual disability for whom all other tests including array and exome sequencing returned negative results de novo single-nucleotide and copy number variations affecting the coding region seem to be a major cause of this disorder. Engineering a memory with LTD and LTP Sadegh Nabavi Rocky Fox Christophe D. Proulx John Y. Lin Roger Y. Tsien et al. A rodent study using optogenetics to induce long-term potentiation and long-term depression provides a causal link between synaptic plasticity and memory. ABCB5 is a limbal stem cell gene required for corneal development and repair Bruce R. Ksander Paraskevi E. Kolovou Brian J. Wilson Karim R. Saab Qin Guo et al. The loss of limbal stem cells LSCs due to injury or disease is one of the leading causes of blindness here the ABCB5 protein is identified as a marker of LSCs in mouse and human eye and shown to be functionally required for LSC maintenance corneal development and repair. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis Hong Ouyang Yuanchao Xue Ying Lin Xiaohui Zhang Lei Xi et al. p63 and PAX6 act to specify limbal stem or progenitor cells LSCs and WNT7A controls corneal epithelium differentiation through PAX6 loss of WNT7A or PAX6 induces LSCs into epithelium and transduction of PAX6 in skin epithelial stem cells converts them to LSC-like cells and transplantation in a rabbit corneal injury model can replenish corneal epithelial cells and repair damaged corneal surface. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2 Vaibhav Bhatia Sonia I. Barroso María L. García-Rubio Emanuela Tumini Emilia Herrera-Moyano et al. BRCA2 the breast cancer susceptibility gene factor interacts with TREX-2 a protein complex involved in the biogenesis and export of messenger ribonucleoprotein to process DNA RNA hybrid structures called R-loops that can trigger genome instability these may be a central cause of the stress occurring in early cancer cells that drives oncogenesis. The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA Timothy M. Colussi David A. Costantino John A. Hammond Grant M. Ruehle Jay C. Nix et al. RNA molecules can perform multiple functions which can be driven by different conformational states here the crystal structure of the transfer-RNA-like structure of the turnip yellow mosaic virus is solved providing insight into the structural basis of RNA multifunctionality. Corrigendum Top Corrigendum: Sustained translational repression by eIF2 -P mediates prion neurodegeneration Julie A. Moreno Helois Radford Diego Peretti Joern R. Steinert Nicholas Verity et al. Erratum Top Erratum: CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation Emmanuel Martin Noé Palmic Sylvia Sanquer Christelle Lenoir Fabian Hauck et al. Retraction Top Retraction: Generation of cell polarity in plants links endocytosis auxin distribution and cell fate decisions Pankaj Dhonukshe Hirokazu Tanaka Tatsuaki Goh Kazuo Ebine Ari Pekka Mähönen et al. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Referentie van de boekhandelaar : B00042560

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 512 No. 7514 August Early Adapters‎

‎NPG Nature publishing group. Hardcover. Gut. Biogeochemistry: Microbes eat rock under ice Martyn Tranter See also Letter by Christner et al. Developmental biology: It takes muscle to make blood cells Suphansa Sawamiphak & Didier Y. R. Stainier See also Letter by Nguyen et al. See also Letter by Kobayashi et al. Earth science: Warning signs of the Iquique earthquake Roland Bürgmann See also Letter by Hayes et al. See also Letter by Schurr et al. Palaeoanthropology: The time of the last Neanderthals William Davies See also Letter by Higham et al. Molecular physics: Complexity trapped by simplicity Francesca Ferlaino See also Letter by Barry et al. Population history: Human melting pots in southeast Asia Jared Diamond Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway Ashton Trey Belew Arturas Meskauskas Sharmishtha Musalgaonkar Vivek M. Advani Sergey O. Sulima et al. Programmed 1 ribosomal frameshifting 1 PRF is a process by which a signal in a messenger RNA causes a translating ribosome to shift by one nucleotide thus changing the reading frame here 1 PRF in the mRNA for the co-receptor for HIV-1 CCR5 is stimulated by two microRNAs and leads to degradation of the transcript by nonsense-mediated decay and at least one other decay pathway. Crystal structure of a human GABAA receptor Paul S. Miller & A. Radu Aricescu GABAA receptors are the principal mediators of rapid inhibitor synaptic transmission in the brain and a decline in GABAA signalling leads to diseases including epilepsy insomnia anxiety and autism here the first X-ray crystal structure of a human GABAA receptor the human 3 homopentamer reveals structural features unique for this receptor class and uncovers the locations of key disease-causing mutations. X-ray structure of the mouse serotonin 5-HT3 receptor Ghérici Hassaine Cédric Deluz Luigino Grasso Romain Wyss Menno B. Tol et al. The first X-ray crystal structure of the mouse serotonin 5-HT3 receptor a pentameric ligand-gated ion channel is similar to those of other Cys-loop receptors though here electron density for part of the cytoplasmic domain which is important for trafficking synaptic localization and modulation by cytoplasmic proteins but not visible in previous structures is also described. Letters Top Interacting supernovae from photoionization-confined shells around red supergiant stars Jonathan Mackey Shazrene Mohamed Vasilii V. Gvaramadze Rubina Kotak Norbert Langer et al. A model in which the stellar wind of the fast-moving red supergiant Betelgeuse is photoionized by radiation from external sources can explain the dense almost static shell recently discovered around the star and predicts both that debris from Betelgeuse s eventual supernova explosion will violently collide with the shell and that other red supergiants should have similar but much more massive shells. Magneto-optical trapping of a diatomic molecule J. F. Barry D. J. McCarron E. B. Norrgard M. H. Steinecker & D. DeMille Magneto-optical trapping is the standard method for laser cooling and confinement of atomic gases but now this technique has been demonstrated for the diatomic molecule strontium monofluoride leading to the lowest temperature yet achieved by cooling a molecular gas. See also News & Views by Ferlaino Abrupt glacial climate shifts controlled by ice sheet changes Xu Zhang Gerrit Lohmann Gregor Knorr & Conor Purcell The volume of the Northern Hemisphere ice sheet controlled abrupt millennial-scale climate changes during the last glacial. Continuing megathrust earthquake potential in Chile after the 2014 Iquique earthquake Gavin P. Hayes Matthew W. Herman William D. Barnhart Kevin P. Furlong Sebástian Riquelme et al. The 2014 Iquique event was not the earthquake that had been expected to fill the regional seismic gap given that significant sections of the northern Chile subduction zone have not ruptured in almost 150 years it is likely that future megathrust earthquakes will occur south and potentially north of the 2014 Iquique sequence. See also News & Views by Bürgmann See also Letter by Schurr et al. Gradual unlocking of plate boundary controlled initiation of the 2014 Iquique earthquake Bernd Schurr Günter Asch Sebastian Hainzl Jonathan Bedford Andreas Hoechner et al. A long foreshock series unlocked the South American plate boundary until eventually initiating the M 8.1 Iquique Chile earthquake. See also News & Views by Bürgmann See also Letter by Hayes et al. Dietary specializations and diversity in feeding ecology of the earliest stem mammals Pamela G. Gill Mark A. Purnell Nick Crumpton Kate Robson Brown Neil J. Gostling et al. Differences in function and dietary ecology between Morganucodon and Kuehneotherium show that lineage splitting during the earliest stages of mammalian evolution was associated with ecomorphological specialization and niche partitioning. The timing and spatiotemporal patterning of Neanderthal disappearance Tom Higham Katerina Douka Rachel Wood Christopher Bronk Ramsey Fiona Brock et al. Accelerator mass spectrometry radiocarbon dating is used to construct a chronology of Neanderthal disappearance showing that Neanderthals overlapped with anatomically modern humans for between about 2000 and 5000 years. See also News & Views by Davies A microbial ecosystem beneath the West Antarctic ice sheet Brent C. Christner John C. Priscu Amanda M. Achberger Carlo Barbante Sasha P. Carter et al. There has been active debate over microbial life in Antarctic subglacial lakes owing to a paucity of direct observations from beneath the ice sheet and concerns about contamination in the samples that do exist here the authors present the first geomicrobiological description of pristine water and surficial sediments from Subglacial Lake Whillans and show that the lake water contains a diverse microbial community many members of which are closely related to chemolithoautotrophic bacteria and archaea. See also News & Views by Tranter Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1 Phong Dang Nguyen Georgina Elizabeth Hollway Carmen Sonntag Lee Barry Miles Thomas Edward Hall et al. A new somite compartment called the endotome that contributes to the formation of the embryonic dorsal aorta by providing endothelial progenitors is identified here endotome-derived endothelial progenitors whose formation is regulated by the activity of the meox1 gene induce haematopoietic stem cell formation upon colonization of the nascent dorsal aorta. See also News & Views by Sawamiphak & Stainier See also Letter by Kobayashi et al. Jam1a Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling Isao Kobayashi Jingjing Kobayashi-Sun Albert D. Kim Claire Pouget Naonobu Fujita et al. Notch signalling has a key role in the generation of haematopoietic stem cells HSCs during vertebrate development here two adhesion molecules Jam1a and Jam2a are shown to be essential for the contact between precursors of HSCs and the somite during embryonic migration and the Jam1a Jam2a interaction is shown to be needed to transmit the Notch signal and produce HSCs. See also News & Views by Sawamiphak & Stainier See also Letter by Nguyen et al. A vaccine targeting mutant IDH1 induces antitumour immunity Theresa Schumacher Lukas Bunse Stefan Pusch Felix Sahm Benedikt Wiestler et al. The mutant IDH1 protein which is expressed in a large fraction of human gliomas is shown to be immunogenic mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner. Dynamic pathways of 1 translational frameshifting Jin Chen Alexey Petrov Magnus Johansson Albert Tsai Seán E. O Leary et al. To investigate the mechanism of frameshifting during messenger RNA translation a technique was developed to monitor translation of single molecules in real time using Förster resonance energy transfer FRET ribosomes were revealed to pause tenfold longer than usual during elongation at the frameshifting sites. X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors Thorsten Althoff Ryan E. Hibbs Surajit Banerjee & Eric Gouaux This study solved structures of the glutamate-gated chloride channel GluCl a Cys-loop receptor from C. elegans in an apo closed state and in a lipid-bound state comparison of these structures with a previously published structure of GluCl in an ivermectin-bound state reveals what conformational changes probably occur as this membrane protein transitions from the closed/resting state towards an open/activated state. Corrigendum Top Corrigendum: Palladium-catalysed C H activation of aliphatic amines to give strained nitrogen heterocycles Andrew McNally Benjamin Haffemayer Beatrice S. L. Collins & Matthew J. Gaunt Retraction Top Retraction: Generation of pluripotent stem cells from adult human testis Sabine Conrad Markus Renninger Jörg Hennenlotter Tina Wiesner Lothar Just et al. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Referentie van de boekhandelaar : B00042563

‎Ein urgemutliches sachsisches Journal‎

‎Der kleine Drache Nummer 7‎

‎Hardcover. Gut. INHALT Jürgen Hart: Tauchstation / Klaus Werner Hennig: Der Schwimmer / Eberhard Heinze: Qualität / Reinhold Schleusinger: s Scheundwännscher und De Impfenduhr / Heinz Hamann: Schöner Leben & Co / Günter Krause: Dr Aawergloowe / Bruno Zwickauer: Keine Ahnung LEIPZIGER ALLERLEI Demokratie jetzt auch bei der LVB / Der Fluch des Politbüros /Angeldeutsch Altmagnifizenz / Italo-Fan / Höhere Gewalt / Aphorismen /Von den Tücken des Sächsischen / Das Sandwich u.a.m. Bernd-Lutz Lange: Im Park / Cornelia Molle: 0 Kinderlein kommet / Roman Vinkowski: De Nähmwärkungk / FDJ-Stadtleitung: Losungen zum 1. Mai / Hans-Walter Molle: Bruderlied / Hanskarl Hoerning: Tem- pora mutantur / Uwe A. Fink: Aktuelle Morphologie / Reni Tent: Walter Ulbricht der letzte sächsische Herrscher CARTOONS COLLAGEN und ILLUSTRATIONEN von Werner David und Lothar Otto gepflegtes Exemplar kaum Lesespuren Buchblock altersgemäß gebräunt SEHR SCHÖN!!! hardcover‎

Referentie van de boekhandelaar : B00008125

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 507 No 7493 März 2014 How to keep a secret‎

‎NPG Nature publishing group. Hardcover. Gut. Physics: QBism puts the scientist back into science A participatory view of science resolves quantum paradoxes and finds room in classical physics for the Now says N. David Mermin. Preclinical research: Make mouse studies work More investment to characterize animal models can boost the ability of preclinical work to predict drug effects in humans says Steve Perrin. In Retrospect: The Social Function of Science Roger Pielke Jr assesses the legacy of J. D. Bernal s science-policy classic on its 75th anniversary. Review of The Social Function of Science J. D. Bernal Microbiology: Majority rule Mark O. Martin relishes a stimulating tour of little lives from fungi to bacteria. Review of The Amoeba in the Room: Lives of the Microbes Nicholas P. Money Books in brief Mathematics: Numbers game George Szpiro enjoys a history of the slow but irresistible rise of mathematical symbols. Review of Enlightening Symbols: A Short History of Mathematical Notation and Its Hidden Powers Joseph Mazur Neuroscience: Updating views of visual updating John A. Assad See also Letter by Zirnsak et al. Solar System: Stranded in no-man s-land Megan E. Schwamb See also Letter by Trujillo & Sheppard Biogeochemistry: Methane minimalism Tori M. Hoehler & Marc J. Alperin See also Letter by Yvon-Durocher et al. Climate science: A high bar for decadal forecasts of El Niño Pedro DiNezio Alzheimer s disease: A protective factor for the ageing brain Li-Huei Tsai & Ram Madabhushi See also Article by Lu et al. Low-temperature physics: Chaos in the cold Paul S. Julienne See also Letter by Frisch et al. Osteoarthritis: The zinc link Virginia Byers Kraus Perspectives Top The ultimate physical limits of privacy Artur Ekert & Renato Renner Developments in quantum cryptography show that it is possible to protect secrets from those with superior technology those who profess to provide our security and even those who manipulate us without our knowledge under surprisingly weak assumptions. Articles Top REST and stress resistance in ageing and Alzheimer s disease Tao Lu Liviu Aron Joseph Zullo Ying Pan Haeyoung Kim et al. REST a developmental regulator is markedly induced in human neurons during ageing but is lost in Alzheimer s disease REST represses genes that promote neurodegeneration is neuroprotective in animal models and is associated with cognitive preservation and longevity in humans. See also News & Views by Tsai & Madabhushi An atlas of active enhancers across human cell types and tissues Robin Andersson Claudia Gebhard Irene Miguel-Escalada Ilka Hoof Jette Bornholdt et al. Using the FANTOM5 CAGE expression atlas the authors show that bidirectional capped RNAs are a signature feature of active enhancers and identify over 40000 enhancer candidates from over 800 human cell and tissue samples across the whole human body. A promoter-level mammalian expression atlas The FANTOM Consortium and the RIKEN PMI and CLST DGT A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types. Letters Top A Sedna-like body with a perihelion of 80 astronomical units Chadwick A. Trujillo & Scott S. Sheppard The discovery of the distant dwarf planet 2012 VP113 with its large perihelion like that of the dwarf planet Sedna shows that Sedna is not isolated and may be part of the putative massive inner Oort cloud which extends far beyond the observable Solar System. See also News & Views by Schwamb Quantum chaos in ultracold collisions of gas-phase erbium atoms Albert Frisch Michael Mark Kiyotaka Aikawa Francesca Ferlaino John L. Bohn et al. An ultracold gas of erbium atoms is shown to have many scattering resonances whose quantum fluctuations exhibit chaotic behaviour resulting from the anisotropy of the atoms interactions. See also News & Views by Julienne Reconciliation of the carbon budget in the ocean s twilight zone Sarah L. C. Giering Richard Sanders Richard S. Lampitt Thomas R. Anderson Christian Tamburini et al. The discrepancy between the components of the oceanic carbon budget export of carbon from the surface and its conversion into carbon dioxide by water-column biota at depth is reconciled using field data and a steady-state model which indicates that synergy between microbes and zooplankton is an important factor. Geomagnetic fluctuations reveal stable stratification at the top of the Earth s core Bruce Buffett MAC waves arising from magnetic Archimedes and Coriolis forces in the liquid core indicate a 140-kilometre-thick stratified layer on top of the Earth s core and account for the 60-year geomagnetic fluctuations observed in the Earth s geomagnetic field. Methane fluxes show consistent temperature dependence across microbial to ecosystem scales Gabriel Yvon-Durocher Andrew P. Allen David Bastviken Ralf Conrad Cristian Gudasz et al. Meta-analyses show that the temperature dependence of methane fluxes scales consistently across populations of methanogens microbial communities and whole ecosystems and that this temperature dependence is higher than for respiration and photosynthesis this indicates that global warming may impact the relative contributions of CO2 and CH4 to total greenhouse gas emissions. See also News & Views by Hoehler & Alperin Geographical limits to species-range shifts are suggested by climate velocity Michael T. Burrows David S. Schoeman Anthony J. Richardson Jorge García Molinos Ary Hoffmann et al. Global maps constructed using climate-change velocities to derive spatial trajectories for climatic niches between 1960 and 2100 show past and future shifts in ecological climate niches properties of these trajectories are used to infer changes in species distributions and thus identify areas that will act as climate sources and sinks and geographical barriers to species migrations. A suspension-feeding anomalocarid from the Early Cambrian Jakob Vinther Martin Stein Nicholas R. Longrich & David A. T. Harper Tamisiocaris borealis an Early Cambrian member of the anomalocarids giant predatory marine stem arthropods probably used its frontal appendage to trap microscopic planktonic animals. A primitive placoderm sheds light on the origin of the jawed vertebrate face Vincent Dupret Sophie Sanchez Daniel Goujet Paul Tafforeau & Per E. Ahlberg Studies of the head of the very primitive jawed vertebrate Romundina show that it combines jawed vertebrate architecture with cranial and cerebral proportions resembling those of extant jawless vertebrates such as lampreys. Visual space is compressed in prefrontal cortex before eye movements Marc Zirnsak Nicholas A. Steinmetz Behrad Noudoost Kitty Z. Xu & Tirin Moore Saccadic eye movements cause substantial shifts in the retinal image as we take in visual scenes but our perception is stable and continuous here visual receptive fields are shown to shift dramatically towards the saccadic goal running counter to the long-standing hypothesis of receptive field remapping as the basis of perceived stability. See also News & Views by Assad The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells Magdalena Paolino Axel Choidas Stephanie Wallner Blanka Pranjic Iris Uribesalgo et al. The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer NK cell rejection of metastatic tumours a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development Xindong Liu Xin Chen Bo Zhong Aibo Wang Xiaohu Wang et al. Here the helix loop helix transcription factor Ascl2 is shown to be critically important for the initiation of follicular T-helper-cell development and the germinal centre response. Structure-based programming of lymph-node targeting in molecular vaccines Haipeng Liu Kelly D. Moynihan Yiran Zheng Gregory L. Szeto Adrienne V. Li et al. An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No 7501 Mai 2014 Type Cast‎

‎NPG Nature publishing group. Hardcover. Gut. Mental health: A road map for suicide research and prevention It is time for policy-makers funders researchers and clinicians to tackle high suicide rates say André Aleman and Damiaan Denys. Evolutionary biology: Darwin and the women Sarah S. Richardson relishes a study of how nineteenth-century US feminists used the biologist s ideas. Review of From Eve to Evolution: Darwin Science and Women s Rights in Gilded Age America Kimberly A. Hamlin Information technology: Forgotten prophet of the Internet Philip Ball ponders the tale of a librarian who dreamed of networking information. Review of Cataloging the World: Paul Otlet and the Birth of the Information Age Alex Wright European pollution: Investigate smog to inform policy Paul S. Monks Databases: Soil observatory lets researchers dig deep Russell Lawley Bridget A. Emmett & David A. Robinson Health care: Strict vaccine quality control in China Zhenglun Liang Qunying Mao & Junzhi Wang Political ecology: Rethink Campania s toxic-waste scandal Giacomo D Alisa Marco Armiero & Salvatore Paolo De Rosa Technology: Internal factors drive Chinese patent surge Ching-Yan Wu Mei-Chih Hu & John A. Mathews Epigenetics: Keeping one s sex Douglas L. Chalker See also Article by Singh et al. Astrophysics: Windy stars that go with a bang John J. Eldridge See also Letter by Gal-Yam et al. Physiology: Double function at the blood brain barrier Christer Betsholtz See also Letter by Nguyen et al. See also Letter by Ben-Zvi et al. Materials chemistry: Selectivity from flexibility Ryotaro Matsuda Cancer: Darwinian tumour suppression Eduardo Moreno See also Article by Martins et al. Earth science: Fertile fields for seismicity Paul Lundgren See also Letter by Amos et al. Articles Top Genome-defence small RNAs exapted for epigenetic mating-type inheritance Deepankar Pratap Singh Baptiste Saudemont Gérard Guglielmi Olivier Arnaiz Jean-François Goût et al. The molecular basis for mating-type determination in the ciliate Paramecium has been elucidated revealing a novel function for a class of small RNAs these scnRNAs are typically involved in reprogramming the Paramecium genome during sexual reproduction by recognizing and excising transposable elements but they are now found to be co-opted to switch off expression of the newly identified mating-type gene mtA by excising its promoter and to mediate epigenetic inheritance of mating types across sexual generations. See also News & Views by Chalker Amygdala interneuron subtypes control fear learning through disinhibition Steffen B. E. Wolff Jan Gründemann Philip Tovote Sabine Krabbe Gilad A. Jacobson et al. Plasticity within neuronal microcircuits is believed to be the substrate of learning and this study identifies two distinct disinhibitory mechanisms involving interactions between PV and SOM interneurons that dynamically regulate principal neuron activity in the amygdala and thereby control auditory fear learning. Contrasting forms of cocaine-evoked plasticity control components of relapse Vincent Pascoli Jean Terrier Julie Espallergues Emmanuel Valjent Eoin Cornelius O Connor et al. Information integration in the nucleus accumbens is commandeered by cocaine at discrete synapses to allow relapse. Cell competition is a tumour suppressor mechanism in the thymus Vera C. Martins Katrin Busch Dilafruz Juraeva Carmen Blum Carolin Ludwig et al. T cells develop from thymic precursor cells that are constantly replaced with newly arriving bone marrow progenitor cells and the old and new cells are shown here to compete in the absence of cell competition when the influx of new bone marrow progenitor cells is blocked the old cells acquire the ability to self-renew and eventually become transformed leading to the development of a form of leukaemia. See also News & Views by Moreno Letters Top A Wolf Rayet-like progenitor of SN 2013cu from spectral observations of a stellar wind Avishay Gal-Yam I. Arcavi E. O. Ofek S. Ben-Ami S. B. Cenko et al. The detection of strong emission lines in an early-time spectrum of type IIb supernova SN 2013cu reveals Wolf Rayet-like wind signatures suggesting that the supernova s progenitor may have been a Wolf Rayet star with a wind dominated by helium and nitrogen with traces of hydrogen. See also News & Views by Eldridge Practical quantum key distribution protocol without monitoring signal disturbance Toshihiko Sasaki Yoshihisa Yamamoto & Masato Koashi Conventional quantum cryptography relies on monitoring signal disturbance to make sure that information leakage is negligible here a new quantum method of achieving security is described in which little information is leaked to the eavesdropper regardless of the signal disturbance. Future increases in Arctic precipitation linked to local evaporation and sea-ice retreat R. Bintanja & F. M. Selten Precipitation is expected to increase far more over the twenty-first century in the Arctic than the global average climate models show that this is driven mainly by increased local evaporation and sea-ice retreat rather than by increased moisture transport from lower latitudes. Uplift and seismicity driven by groundwater depletion in central California Colin B. Amos Pascal Audet William C. Hammond Roland Bürgmann Ingrid A. Johanson et al. Human-caused groundwater depletion in California s San Joaquin Valley contributes to uplift of the surrounding mountains and may affect the stability of the San Andreas Fault. See also News & Views by Lundgren High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells Yuexin Zhou Shiyou Zhu Changzu Cai Pengfei Yuan Chunmei Li et al. This study describes the construction of a focused CRISPR/Cas-based lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis. Copper is required for oncogenic BRAF signalling and tumorigenesis Donita C. Brady Matthew S. Crowe Michelle L. Turski G. Aaron Hobbs Xiaojie Yao et al. Tumorigenesis driven by the oncogene BRAFV600E is shown both to depend on the BRAF substrates MEK1/2 associating with copper and to be sensitive to copper-chelating drugs suggesting merit in testing such drugs for the treatment of BRAF mutation-positive cancers. Protective mucosal immunity mediated by epithelial CD1d and IL-10 Torsten Olszak Joana F. Neves C. Marie Dowds Kristi Baker Jonathan Glickman et al. Here the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells resulting in the production of IL-10. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Long N. Nguyen Dongliang Ma Guanghou Shui Peiyan Wong Amaury Cazenave-Gassiot et al. Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid DHA into brain with Mfsd2a-knockout mice showing reduced DHA in brain neuronal cell loss in hippocampus and cerebellum behavioural disorders and reduced brain size DHA is transported in a sodium-dependent manner in the form of lysophosphatidylcholines LPCs carrying long-chain fatty acids. See also News & Views by Betsholtz Mfsd2a is critical for the formation and function of the blood brain barrier Ayal Ben-Zvi Baptiste Lacoste Esther Kur Benjamin J. Andreone Yoav Mayshar et al. Mfsd2a is a key regulator of blood brain barrier BBB formation and function in mice: Mfsd2a is selectively expressed in BBB-containing blood vessels in the CNS Mfsd2a / mice have a leaky BBB and increased vesicular transcytosis in CNS endothelial cells and Mfsd2a endothelial expression is regulated by pericytes to facilitate BBB integrity. See also News & Views by Betsholtz Structure of the AcrAB TolC multidrug efflux pump Dijun Du Zhao Wang Nathan R. James Jarrod E. Voss Ewa Klimont et al. Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules here the structure of one such pump AcrAB TolC is determined using X-ray crystallography and cryo-electron microscopy. Structural basis of Sec-independent membrane protein insertion by YidC Kaoru Kumazaki Shinobu Chiba Mizuki Takemoto Arata Furukawa Ken-ichi Nishiyama et al. The crystal structure of the bacterial protein YidC is reported together with a structure-based functional analysis providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Referentie van de boekhandelaar : B00042576

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎4-1/1998‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Globalisierung contra Regionalität - Herausforderung an Biohöfe in Ostdeutschland 4 Rückblick - Grüne Woche Berlin - Biofach in Frankfurt 6 Firmenportrait: Rolle Mühle-Handwerkstradition aus dem Erzgebirge 7 Rückblick - Ost-West Dialog auf der AGÖL Beratertagung 1997 8 Landwirtschaft und Umwelt Zuckerrübenanbau im Öko-Landbau wieder aktuell ! 11 Bördebauer meistert den ökologischen Landbau 14 Heil- und Gewürzkräuter im Bauerngarten 16 Bericht zur Lehrfahrt artgerechte und kostengünstige Mastschweineställe 18 Drunter und Drüber Kurzinformationen für die Verarbeitung 22 Nachrichten aus den Landesverbänden 23 Sächsische Bio-Verarbeitungsbetriebe erhalten Umweltpreise 24 Nachruf Eberhard Bizer 25 Europäisches Kochfestival am 28.Mai 1998 26 Buchempfehlung 27 Veranstaltungskalender 28 Kleinanzeigen 29 Anzeigen 30 gutes Exemplar ordentlich hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 505 No. 7484 Januar 2014 Decrypting the Mitoribosome‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 453 STEM CELLS Don t rush to rehabilitate Hwang Woo Suk Hwang s return to the scientific stage merits a degree of caution 453 US POLICY A return to order With a budget deal finally done US lawmakers need to avoid another funding hiatus 454 METROLOGY A question of time A time reminder of the power of science WORLD VIEW 455 Don t stop the quest to measure Big G Terry Quinn Pinning down the coupling constant in Newton s law of gravity will be hard but not impossible RESEARCH HIGHLIGHTS 456 SELECTIONS FROM THE SCIENTIFIC LITERATURE Dopamine and eye disease / Counterproductive antibiotics / Laser-guided particles / Waves powered by climate change / Sweet-seeking mosquitoes SEVEN DAYS 458 THE NEWS IN BRIEF Rosetta comet probe phones home / H7N9 fly makes a comeback/ Illumina prepares for $1000 genome / Sharks face extinction 461 POLICY US budget finally gets signed into law 463 ANTARCTIC RESEARCH Report picks through bones of failed polar-drilling project 464 CARBON CHEMISTRY Researchers seek ways to boost olivine s carbon-sequestering power 465 ECOLOGY Protected status of Yellowstone s grizzly bears comes under threat 466 EARTH SCIENCE Drilling mission aims to date South China Sea We need an international effort backed by governments and l exiA commercial interests to save the seabed ecosystem say Edward B seit Barbier et al. 477 EDUCATION Embed social awareness in science curricula Erin A Cech Cultural and political context should be integral to science and technology teaching BOOKS & ARTS 4BO CONSERVATION Rewilding Oz Tim Flannery 4B1 BOOKS IN BRIEF 4B2 DIGITAL DEVELOPMENT Wired cultures John Gilbey CORRESPONDENCE 4B3 Peer review / Irreproducible results / Soil pollution in China / Soviet croplands / Natural killer cells take an cancer 575 CHARITIES Profiting from non-profits The vital link between goal-oriented charities and hands-on researchers 577 TURNING POINT Marine ecologist Kristin Laidre sees art as well as data in the Arctic 577 CAREER BRIEFS Can Woo Suk Hwang redeem himself and rebuild his scientific reputation 472 QUANTUM PHYSICS Flawed to perfection Synthetic diamonds are paving the way to better quantum computers and biomedical sensors NEW ONLINE 485 Papers published this week at nature.com NEWS & VIEWS 4B6 ECOLOGY Good dirt with good friends Mycorrhizal fungus type regulates amounts of soil organic matter Mark A Bradford SEE LETTER R543 487 SOLAR SYSTEM Evaporating asteroid Discovery of water molecules escaping from the asteroid Ceres Humberto Campins & Christine M Comfort SEE LETTER P.525 488 STEM CELLS Sex specificity in the blood Oestrogen regulates division frequency of haematopoietic stem cells Dena S Leeman & Anne Brunet SEE LETTER R555 49O ELECTRONICS Protecting the weak from the strong A metasurface microwave absorber George V Eleftheriades 491 CLIMATE SCIENCE A resolution of the Antarctic paradox The Atlantic Ocean may drive changes in Antarctic winds and sea ice John King SEE LETTER R538 492 HIV Not-so-innocent bystanders Abortive HIV-1 infection triggers pyroptosis in CD4 T cells Andrea L Cox & Robert F Siliciano SEE ARTICLE P.509 J_J 11.J The intestinal bile acid transporter now a possible drug target. PAGE 569 ON THE COVER Power base Abstract representation of RNA and protein folds in the !arge 39S mammalian mitoribosomal subunit The 3D structure of this subunit provides insights into the changes that have occurred in this ribosome now specialized for the translation of the very hydrophobic proteins encoded by the mitochondrial genome. PAGE 515 ARTICLES 495 CANCER GENOMICS Discovery and saturation analysis of cancer genes across 21 tumour types M S Lawrence et al. 502 IMMUNOLOGY Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV M Roederer et al. 509 IMMUNOLOGY Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection G Doitsh et al. SEE N&V P.492 515 STRUCTURAL BIOLOGY Architecture of the large subunit of the mammalian mitochondrial ribosome BJ Greber et al. LETTERS 52O ASTROPHYSICS A millisecond pulsar in a stellar triple system SM Ransom et al. 525 ASTRONOMY Localized sources of water vapour on the dwarf planet 1 Ceres M Küppers et al. SEE N&V P.487 528 QUANTUM ELECTRONICS Tunable symmetry breaking and helical edge transport in a graphene quantum spin Hall state A F Young et al. 533 MATERIALS SCIENCE Dislocations in bilayer graphene B Butz et al. 538 CLIMATE SCIENCE Impacts of the north and tropical Atlantic Ocean on the Antarctic Peninsula and sea ice X Li D M Holland E P Gerber & C Yoo SEE N&V P.491 543 ECOLOGY Mycorrhiza-mediated competition between plants and decomposers drives soil carbon storage C Averill B L Turner & A C Finzi SEE N&V P.486 546 CROP SCIENCE The genome of the recently domesticated crop plant sugar beet Beta vulgaris J C Dohm et al. 550 NEUROSCIENCE Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer s disease C Cruchaga et al. 555 STEM CELLS Oestrogen increases haematopoietic stem-cell selfrenewal in females and during pregnancy D Nakada et al. SEE N&V P.488 . 559 MICROBIOLOGY Diet rapidly and reproducibly alters the human gut microbiome LA David et al. 564 MOLECULAR BIOLOGY Glutamine methylation in histone H2A is an kNA-polymerase-l-dedicated modification P Tessarz et al. 569 STRUCTURAL BIOLOGY Structural basis of the alternating-access mechanism in a bile acid transporter X Zhou et al. 574 RETRACTIDN GIcNAcylation of a histone methyltransferase in retinoic-acidinduced granulopoiesis R Fujiki et al. 574 CORRIGENDUM Deglacial pulses of deep-ocean Silicate into the subtropical North Atlantic Ocean A N Meckler et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 508 No. 7496 April 2014 Out of the shadows‎

‎NPG Nature publishing group. Hardcover. Gut. Policy: Bring sustainable energy to the developing world Investment and policies must support cheap clean energy technologies to cut both poverty and climate change say Reid Detchon and Richenda Van Leeuwen. Publishing: Credit where credit is due Liz Allen Amy Brand Jo Scott Micah Altman and Marjorie Hlava are trialling digital taxonomies to help researchers to identify their contributions to collaborative projects. Astronomy: Art of the eclipse As the next solar eclipse approaches Jay M. Pasachoff and Roberta J. M. Olson ponder how artists from the early Renaissance onwards have interpreted the phenomenon. Geology: Parsing eruptions Ted Nield weighs up histories of two momentous volcanic events in Iceland and Indonesia. Review of Island on Fire: The Extraordinary Story of Laki: The Volcano That Turned Eighteenth-Century Europe Dark Tambora: The Eruption That Changed the World Alexandra Witze Jeff Kanipe & Gillen D Arcy Wood Animal behaviour: Nomads of necessity Joel Greenberg casts an ornithologist s eye on a wide-ranging reading of animal migration. Review of The Homing Instinct: Meaning and Mystery in Animal Migration Bernd Heinrich Obesity Tony Scully Society at large Tony Scully Cell physiology: The changing colour of fat Brian Owens Treatment: Marginal gains Emily Anthes Perspective: Obesity is not a disease D. L. Katz Heritability: The family roots of obesity Cassandra Willyard Microbiome: A complicated relationship status Sarah Deweerdt Neuroscience: Dissecting appetite Bijal P. Trivedi Perspective: Tricks of the trade Stephen J. Simpson & David Raubenheimer Evolutionary biology: Dating chimpanzees Michael Haslam Genetics: Up and down in Down s syndrome Benjamin D. Pope & David M. Gilbert See also Article by Letourneau et al. Organic chemistry: Catalysis marches on James P. Morken See also Article by Mei et al. Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía See also Letter by Prindle et al. Thermoelectricity: The ugly duckling Joseph P. Heremans See also Letter by Zhao et al. Review Top The ensemble nature of allostery Hesam N. Motlagh James O. Wrabl Jing Li & Vincent J. Hilser Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another often distal functional site allowing for the regulation of activity here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed and a framework to unify the description of allosteric mechanisms for different systems is proposed. Articles Top Enantioselective construction of remote quaternary stereocentres Tian-Sheng Mei Harshkumar H. Patel & Matthew S. Sigman A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group. See also News & Views by Morken Domains of genome-wide gene expression dysregulation in Down s syndrome Audrey Letourneau Federico A. Santoni Ximena Bonilla M. Reza Sailani David Gonzalez et al. By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21 this paper finds that differential expression between the twins is organized in domains along all chromosomes these gene expression dysregulation domains are conserved in the mouse model of Down s syndrome and correlate with the lamina-associated domains and replication domains. See also News & Views by Pope & Gilbert Brainstem nucleus MdV mediates skilled forelimb motor tasks Maria Soledad Esposito Paolo Capelli & Silvia Arber The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements in particular they discover that the medullary reticular formation ventral part MdV is functionally specialized for skilled forelimb motor control. Skilled reaching relies on a V2a propriospinal internal copy circuit Eiman Azim Juan Jiang Bror Alstermark & Thomas M. Jessell Cervical propriospinal neurons PNs form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals their ablation in mice impairs reaching movements selectively and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement. Letters Top Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars Heather B. Franz Sang-Tae Kim James Farquhar James M. D. Day Rita C. Economos et al. Isotopic analyses of 40 Martian meteorites indicate that assimilation of sulphur into Martian magmas was a common occurrence throughout much of the planet s history and that the atmospheric imprint of photochemical processing preserved in Martian meteoritic sulphide and sulphate is distinct from that observed in terrestrial analogues. Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles Ioan M. Pop Kurtis Geerlings Gianluigi Catelani Robert J. Schoelkopf Leonid I. Glazman et al. The long-predicted suppression of quasiparticle dissipation in a Josephson junction when the phase difference across the junction is is inferred from a sharp maximum in the energy relaxation time of a superconducting artificial atom. Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals Li-Dong Zhao Shih-Han Lo Yongsheng Zhang Hui Sun Gangjian Tan et al. The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity whereas one ideally wants to raise the former while lowering the latter: a simple layered crystalline material SnSe is now reported that seems to have these qualities built in. See also News & Views by Heremans Mid-latitude interhemispheric hydrologic seesaw over the past 550000 years Kyoung-nam Jo Kyung Sik Woo Sangheon Yi Dong Yoon Yang Hyoun Soo Lim et al. Tropical and subtropical speleothems show that the latitudinal migration of the Intertropical Convergence Zone tends to produce increased precipitation in one hemisphere and drying in the other now it is shown using speleothems from the Korean peninsula that this phenomenon extended to the mid-latitudes during the past 550000 years. A new fossil species supports an early origin for toothed whale echolocation Jonathan H. Geisler Matthew W. Colbert & James L. Carew Phylogenetic analysis of a new species of fossil toothed whale Cotylocara macei from the Oligocene epoch places it in a basal clade of odontocetes and its features suggest that rudimentary echolocation evolved in the early Oligocene and was followed by convergent evolution in their skulls. Rapid and tunable post-translational coupling of genetic circuits Arthur Prindle Jangir Selimkhanov Howard Li Ivan Razinkov Lev S. Tsimring et al. Protease competition is used to produce rapid and tunable coupling of genetic circuits enabling a coupled clock network that can encode independent environmental cues into a single time series output a form of frequency multiplexing in a genetic circuit context. See also News & Views by Solé & Macía Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation Bing He Konstantin Doubrovinski Oleg Polyakov & Eric Wieschaus The lengthening phase of ventral furrow formation in Drosophila gastrulation is driven by cytoplasmic flows triggered by apical constriction of mesoderm cells independent of the mechanical inputs from the basolateral membranes. A committed precursor to innate lymphoid cells Michael G. Constantinides Benjamin D. McDonald Philip A. Verhoef & Albert Bendelac A committed precursor to innate lymphoid cell lineages but not classical natural killer and lymphoid tissue inducer cells is derived from common lymphoid precursors and distinguished by high levels of expression of the transcription factor PLZF. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Travis K. Warren Jay Wells Rekha G. Panchal Kelly S. Stuthman Nicole L. Garza et al. A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure. Caenorhabditis elegans pathways that surveil and defend mitochondria Ying Liu Buck S. Samuel Peter C. Breen & Gary Ruvkun A genome-wide RNA interference screen in Caenorhabditis elegans identifies 45 genes with roles in protective pathways following drug- and genetic-disruption-induced mitochondrial inhibition. See also News & Views by Wolff & Dillin miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis Kate M. Creasey Jixian Zhai Filipe Borges Frederic Van Ex Michael Regulski et al. The generation of widespread epigenetically activated short interfering RNAs by the targeting of microRNAs to transposon transcripts in Arabidopsis thaliana is shown to be a latent mechanism that only becomes active when the transcripts are epigenetically reactivated for example during reprogramming of the germ line. Structural basis for translocation by AddAB helicase nuclease and its arrest at sites Wojciech W. Krajewski Xin Fu Martin Wilkinson Nora B. Cronin Mark S. Dillingham et al. A dual-function helicase nuclease typified by RecBCD in Escherichia coli acts on free DNA ends during bacterial double-stranded break repair until it reaches a sequence at which it pauses before continuing with modified enzymatic properties here several crystal structures of the related AddAB enzyme from Bacillus subtilis bound to -containing DNA are presented offering insight into recognition and its effect on DNA translocation. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

Referentie van de boekhandelaar : B00042580

‎Ein urgemutliches sachsisches Journal‎

‎Der kleine Drache Nummer 5‎

‎Hardcover. Gut. INHALT Kleiner Blick zurück mit Texten von Walter Gilbricht Bruno Apitz Heinz Petzold Alexander Dittrich Rudolf Ganz und Emmann Roman Vinkowski: Buchschdadd-Fandasie / Bernd-Lutz Lange: Alltags- dreierlei / Franz Hohler: Spurensicherung / Hans Lanz: Leipzig / Jürgen Hart: Hofnarren / Helmut Richter: Freundschaftsgeschenke / Rose Thal: Die perplexe Jury / Gunter Böhnke: Liebeserklärung LEIPZIGER ALLERLEI Künstler bei Arbeitern / Fragen / Das aktuelle Interview / Die Haupt- aufgabe / Der Größte / Unter Amtskollegen / Wir lernen immer / Rück- sicht / Seenstadt Leipzig u.a.m. Hanskarl Hoerning Wie ich Theaterblut leckte / Steffen Mohr: Lied für Gabriele Gabriela Der grüne Elefant / Mark Trödel: Flohmargddibbs / Ich Träumer: Kulturelle Alpträume / Bruno Zwickauer: Sächsische Minia- turen / Briefkasten mei Leipzsch / Wolfgang U. Schütte: Darf ein Schlückchen mehr sein / ARTDONS und ILLUSTRATIONEN von Werner David Egbert und Renate Herfurth Lothar Otto und eine COLLAGE von Andreas Prüstel gepflegtes Exemplar nur kleine Lesespuren Buchblock altersgemäß gebräunt hardcover‎

Referentie van de boekhandelaar : B00008114

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 517 No 7532 Januar 2015 Sands of Titan‎

‎NPG Nature publishing group. Hardcover. Gut. Editorials Time for the social sciences Governments that want the natural sciences to deliver more for society need to show greater commitment towards the social sciences and humanities. World View The rising pressure of global water shortages Water is becoming more scarce as populations increase potentially leading to conflict. The age of hydro-diplomacy is upon us says Jan Eliasson. Nicaragua defies canal protests No Alt text available for this image Scientists call for independent environmental assessment. Lucas Laursen Planet hunters plot course for habitable worlds No Alt text available for this image Researchers aim to set aside differences in search for life on distant spheres. Alexandra Witze Ebola raises profile of blood-based therapy No Alt text available for this image Convalescent plasma therapy is trialled to fight Ebola but could also be used for new and emerging pathogens. Declan Butler What to expect in 2015 No Alt text available for this image Nature looks at what the New Year holds for science. Elizabeth Gibney Science in 2015 No Alt text available for this image From Gradzilla to coffee consumption: the research enterprise quantified for the year to come. Mark Zastrow comment Leadership: New year s resolutions Nine scientific leaders share their goals for 2015 professional and personal. Books and Arts Top Listings: Science in culture 2015 Explore the gory glories of forensic science grapple with Tom Stoppard s take on consciousness learn what it takes to live on Mars re-enter Jurassic Park dive into a coral reef and dally with Robert Oppenheimer. Daniel Cressey reports. Review of Oppenheimer Countdown to Zero: Defeating Disease Imagine Science Films Forensics: The Anatomy of Crime Emerge Arsenic and New Medicine: Paul Ehrlich s Pioneering Research EXPO 2015 Jurassic World Coral Reefs: Secret Cities of the Sea A Brief History of the Future The Martian The Hard Problem Designers in Residence 2015: Migration It s Alive! Frankenstein on Film Marvellous Creatures Frida Kahlo s Garden Lava & The Francis Crick Institute Correspondence Top European Union: New law risks release of invasive species Philip E. Hulme Air pollution: Harmful soot spurs climate-policy action David G. Victor V. Ramanathan & Durwood Zaelke Emissions limits: Green heating plan threatens air quality Gordon McFiggans Publishing: Criteria for Nature Index questioned Robin Haunschild & Lutz Bornmann Obituary Top Paul von Ragué Schleyer 1930 2014 Chemist who launched the study of caged hydrocarbons. Henry F. Schaefer Careers Feature Top Hopes for the year ahead To kick off 2015 Nature s Careers section asked several young scientists all 40 or under about their plans for the year ahead and their wishes for the future of science. Monya Baker research News & Views Top Molecular biology: Entry signals control development Jonathan D. Dinman See also Article by Xue et al. Materials science: Like cartilage but simpler Anne Ladegaard Skov See also Letter by Liu et al. Structural biology: Photosynthetic complex in close-up Ilme Schlichting See also Letter by Suga et al. 50 & 100 Years Ago Microbiology: Diverted on the way to memory Gordon Y. C. Cheung & Michael Otto Cell cycle: It takes three to find the exit Mathieu Bollen See also Letter by Grallert et al. Earth science: Ocean circulation and rapid climate change Ellen E. Martin See also Letter by Böhm et al. Articles Top RNA regulons in Hox 5 UTRs confer ribosome specificity to gene regulation Shifeng Xue Siqi Tian Kotaro Fujii Wipapat Kladwang Rhiju Das et al. Specialized ribosomes with a particular protein composition carry out translation of specific transcripts analysis of Hox mRNA translation in mice reveals that unique RNA structural elements within their 5 UTRs including internal ribosome entry sites and translation inhibitory elements are responsible for this specialized mode of translation. See also News & Views by Dinman Architecture and conformational switch mechanism of the ryanodine receptor Rouslan G. Efremov Alexander Leitner Ruedi Aebersold & Stefan Raunser Using electron cryomicroscopy the structure of the rabbit RyR1 calcium channel is determined at 6.1 Ã… resolution in the closed state and 8.5 Ã… in the open state revealing how calcium binding to the EF-hand of RyR1 regulates channel opening and facilitates calcium-induced calcium release. Structure of a mammalian ryanodine receptor Ran Zalk Oliver B. Clarke Amédée des Georges Robert A. Grassucci Steven Reiken et al. Using electron cryomicroscopy the closed-state structure of rabbit RyR1 is determined at 4.8 Ã… resolution analysis confirms that the RyR1 architecture consists of a six-transmembrane ion channel with a cytosolic -solenoid scaffold and suggests a mechanism for Ca2-induced channel opening. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution Zhen Yan Xiao-chen Bai Chuangye Yan Jianping Wu Zhangqiang Li et al. Using electron cryomicroscopy the structure of the closed-state rabbit ryanodine receptor RyR1 in complex with its modulator FKBP12 is solved at 3.8 Ã… in addition to determining structural details of the ion-conducting channel domain three previously uncharacterized domains help to reveal a molecular scaffold that allows long-range allosteric regulation of channel activities. Letters Top A higher-than-predicted measurement of iron opacity at solar interior temperatures J. E. Bailey T. Nagayama G. P. Loisel G. A. Rochau C. Blancard et al. Laboratory measurements of iron opacity made under conditions similar to those inside the Sun reveal much higher opacity than predicted helping to resolve inconsistencies within stellar models of the internal temperatures of stars. Higher-than-predicted saltation threshold wind speeds on Titan Devon M. Burr Nathan T. Bridges John R. Marshall James K. Smith Bruce R. White et al. Wind tunnel experiments designed to simulate the conditions on Saturn s moon Titan yield threshold wind speeds for particle saltation higher than those predicted by models derived from simulations of terrestrial-planet conditions the results can be reconciled by modifying the models to take into account the low ratio of particle density to fluid density on Titan. Observation of quantized conductance in neutral matter Sebastian Krinner David Stadler Dominik Husmann Jean-Philippe Brantut & Tilman Esslinger Quantized conductance in the transport of neutral atoms is observed in an optically produced channel either a quantum point contact or a quantum wire between two atom reservoirs the lowest non-zero conductance value is the universal conductance quantum the reciprocal of Planck s constant. An anisotropic hydrogel with electrostatic repulsion between cofacially aligned nanosheets Mingjie Liu Yasuhiro Ishida Yasuo Ebina Takayoshi Sasaki Takaaki Hikima et al. Usually materials design focuses on attractive interactions but here a hydrogel is described whose properties are dominated by electrostatic repulsion between negatively charged titanate nanosheets embedded within it the material inspired by articular cartilage deforms easily when sheared parallel to the sheets but resists compressive forces applied orthogonally. See also News & Views by Ladegaard Skov Strong and deep Atlantic meridional overturning circulation during the last glacial cycle E. Böhm J. Lippold M. Gutjahr M. Frank P. Blaser et al. Reconstruction of the Atlantic meridional overturning circulation from a highly resolved marine sedimentary record shows that a deep vigorous overturning circulation mode has persisted for most of the last glacial cycle dominating ocean circulation in the Atlantic but that a shallower glacial mode prevailed during glacial maxima. See also News & Views by Martin Origins of major archaeal clades correspond to gene acquisitions from bacteria Shijulal Nelson-Sathi Filipa L. Sousa Mayo Roettger Nabor Lozada-Chávez Thorsten Thiergart et al. A comparison of protein-coding genes from 134 archaeal genomes with their homologues in 1847 bacterial genomes reveals that during evolution genes are transferred more often from bacteria to archaea than vice versa and that gene influxes from bacteria can bring about the origin of major archaeal groups. Identification of multipotent mammary stem cells by protein C receptor expression Daisong Wang Cheguo Cai Xiaobing Dong Qing Cissy Yu Xiao-Ou Zhang et al. Using transplantation and lineage-tracing strategies protein C receptor is identified as a marker of mammary stem cells in mice with potential implications for understanding the initiation of breast cancer. Hepatitis A virus and the origins of picornaviruses Xiangxi Wang Jingshan Ren Qiang Gao Zhongyu Hu Yao Sun et al. Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood this paper now provides high-resolution crystal structures of both the mature and the empty hepatitis A virus particle which show that the three-dimensional structure resembles insect picorna-like viruses. Human intracellular ISG15 prevents interferon- / over-amplification and auto-inflammation Xianqin Zhang Dusan Bogunovic Béatrice Payelle-Brogard Véronique Francois-Newton Scott D. Speer et al. ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18 triggering an increase in type I interferon production and signalling and promoting auto-inflammatory disease. A PP1 PP2A phosphatase relay controls mitotic progression Agnes Grallert Elvan Boke Anja Hagting Ben Hodgson Yvonne Connolly et al. The activation and coordination of phosphatase activity is important during mitotic exit here a mitotic phosphatase relay is described in fission yeast between the two major phosphatases PP1 and PP2A a mode of regulation that may be a feature of signalling networks across eukaryotes. See also News & Views by Bollen Native structure of photosystem II at 1.95 Ã… resolution viewed by femtosecond X-ray pulses Michihiro Suga Fusamichi Akita Kunio Hirata Go Ueno Hironori Murakami et al. The radiation-damage-free structure of the photosystem II membrane protein complex which oxidizes water into dioxygen in an oxygen evolving complex has been determined by an X-ray free electron laser at a resolution of 1.95 Ã… one of the substrate oxygen atoms in this reaction is now identified. See also News & Views by Schlichting Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum Xiaochun Li Rita Roberti & Günter Blobel Solving the X-ray crystal structure of a 14-sterol reductase and homologue of human C14SR and DHCR7 two enzymes that reduce specific carbon carbon double bonds in the cholesterol biosynthetic pathway may provide insight into how specific mutations in DHCR7 and lamin B receptor lead to human diseases. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No 7502 Mai 2014 The Human Proteome‎

‎NPG Nature publishing group. Hardcover. Gut. Policy: An intergovernmental panel on antimicrobial resistance Drug-resistant microbes are spreading. A coordinated global effort is needed to keep drugs working and develop alternatives say Mark Woolhouse and Jeremy Farrar. Health care: Bring microbial sequencing to hospitals Analysing bacterial and viral DNA can help doctors to pick effective drugs quickly says Sharon Peacock. Cosmology: Matter and mixology Francis Halzen is exhilarated by an account of the hunt for the particles of dark matter. Review of The Cosmic Cocktail: Three Parts Dark Matter Katherine Freese Books in brief Q&A: The space crusader US astronomer Neil deGrasse Tyson director of New York s Hayden Planetarium currently hosts the television series Cosmos an update of Carl Sagan s 1980 show broadcast in 181 countries and 45 languages. As it winds down Tyson talks about the rich mix of science and pop culture the neurosynaptic snapshot of public responses to his tweets and his momentous meeting with Sagan. Cancer Herb Brody Statistics: Attacking an epidemic Mike May Therapy: This time it s personal Lauren Gravitz Clinical trials: More trials fewer tribulations Michael Eisenstein Nanotechnology: Deliver on a promise Jessica Wright Comparative biology: Naked ambition Sarah Deweerdt Prevention: Air of danger Rebecca Kessler Developing world: Global warning Eric Bender Bioinformatics: Big data versus the big C Neil Savage Perspective: Learning to share John Quackenbush Biology: Three known unknowns Katherine Bourzac Climate science: A sink down under Daniel B. Metcalfe See also Letter by Poulter et al. Microbiology: Barriers to the spread of resistance Morten O. A. Sommer See also Letter by Forsberg et al. Materials science: Energy storage wrapped up Yury Gogotsi 50 & 100 Years Ago Developmental genetics: Female silkworms have the sex factor Franti ek Marec See also Letter by Kiuchi et al. Precision measurement: The magnetic proton V. Alan Kostelecký See also Letter by Mooser et al. Cardiovascular biology: Switched at birth Katherine E. Yutzey Immunology: To affinity and beyond David M. Tarlinton See also Letter by Gitlin et al. Articles Top A draft map of the human proteome Min-Sik Kim Sneha M. Pinto Derese Getnet Raja Sekhar Nirujogi Srikanth S. Manda et al. A draft map of the human proteome is presented here accounting for over 80% of the annotated protein-coding genes in humans some novel protein-coding regions including translated pseudogenes non-coding RNAs and upstream open reading frames are identified. Mass-spectrometry-based draft of the human proteome Mathias Wilhelm Judith Schlegl Hannes Hahne Amin Moghaddas Gholami Marcus Lieberenz et al. A mass-spectrometry-based draft of the human proteome and a public database for analysis of proteome data are presented assembled information is used to estimate the size of the protein-coding genome to identify organ-specific proteins proteins predicting drug resistance or sensitivity and many translated long intergenic non-coding RNAs and to reveal conserved control of protein abundance. Structural basis of the non-coding RNA RsmZ acting as a protein sponge Olivier Duss Erich Michel Maxim Yulikov Mario Schubert Gunnar Jeschke et al. A novel combined NMR and EPR spectroscopy approach reveals the structure and assembly mechanism of a 70-kDa bacterial ribonucleoprotein complex acting as a protein sponge in translational regulation. Letters Top Three regimes of extrasolar planet radius inferred from host star metallicities Lars A. Buchhave Martin Bizzarro David W. Latham Dimitar Sasselov William D. Cochran et al. Analysis of the metallicities of more than 400 stars hosting 600 candidate extrasolar planets shows that the planets can be categorized by size into three populations terrestrial-like planets gas dwarf planets with rocky cores and hydrogen helium envelopes and ice or gas giant planets on the basis of host star metallicity. Direct high-precision measurement of the magnetic moment of the proton A. Mooser S. Ulmer K. Blaum K. Franke H. Kracke et al. The magnetic moment of the proton is directly measured with unprecedented precision using a double Penning trap. See also News & Views by Kostelecký Contribution of semi-arid ecosystems to interannual variability of the global carbon cycle Benjamin Poulter David Frank Philippe Ciais Ranga B. Myneni Niels Andela et al. The unusually large land carbon sink reported in 2011 can mostly be attributed to semi-arid vegetation growth in the Southern Hemisphere following increased rainfall and long-term greening trends. See also News & Views by Metcalfe Storm-induced sea-ice breakup and the implications for ice extent A. L. Kohout M. J. M. Williams S. M. Dean & M. H. Meylan Concurrent observations at multiple locations indicate that storm-generated ocean waves propagating through Antarctic sea ice can transport enough energy to break first-year sea ice hundreds of kilometres from the ice edge which is much farther than would be predicted by the commonly assumed exponential wave decay. A Palaeozoic shark with osteichthyan-like branchial arches Alan Pradel John G. Maisey Paul Tafforeau Royal H. Mapes & Jon Mallatt A description of the gill skeleton of a very early fossil shark-like fish shows that it bears more resemblance to gill skeletons from bony fishes rather than to those from modern cartilaginous fishes suggesting that modern sharks are not anatomically primitive as previously thought. Bacterial phylogeny structures soil resistomes across habitats Kevin J. Forsberg Sanket Patel Molly K. Gibson Christian L. Lauber Rob Knight et al. Functional metagenomic selections for resistance to 18 antibiotics in 18 different soils reveal that bacterial community composition is the primary determinant of soil antibiotic resistance gene content. See also News & Views by Sommer Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors Srdjan Maksimovic Masashi Nakatani Yoshichika Baba Aislyn M. Nelson Kara L. Marshall et al. The cellular basis of touch has long been debated in particular the relationship between sensory neurons and non-neuronal cells a mouse study uses optogenetics to identify their distinct and collaborative roles with skin-derived Merkel cells both transducing touch and actively tuning responses of touch-sensitive neurons. Piezo2 is required for Merkel-cell mechanotransduction Seung-Hyun Woo Sanjeev Ranade Andy D. Weyer Adrienne E. Dubin Yoshichika Baba et al. A mouse study shows that non-neuronal epidermal Merkel cells aid fine-touch perception in the skin through their expression of the Piezo2 mechanosensitive cation channel which then actively tunes the response to touch in adjacent somatosensory neurons. Scalable control of mounting and attack by Esr1 neurons in the ventromedial hypothalamus Hyosang Lee Dong-Wook Kim Ryan Remedios Todd E. Anthony Angela Chang et al. Activation of Esr1 neurons of the mouse ventromedial hypothalamus initiates graded social behavioural responses weak activation triggers close investigation sniffing during a social encounter that often leads with continued stimulation to mounting behaviours by males towards either gender mounting behaviour transitions to aggressive attacks with greater stimulation intensity. A single female-specific piRNA is the primary determiner of sex in the silkworm Takashi Kiuchi Hikaru Koga Munetaka Kawamoto Keisuke Shoji Hiroki Sakai et al. It is known that in the silkworm Bombyx mori males have two Z sex chromosomes whereas females have Z and W and the W chromosome has a dominant role in female determination here a single female-specific W-chromosome-derived PIWI-interacting RNA is shown to be the feminizing factor in B. mori. See also News & Views by Marec Clonal selection in the germinal centre by regulated proliferation and hypermutation Alexander D. Gitlin Ziv Shulman & Michel C. Nussenzweig Clonal expansion and hypermutation of B cells in the germinal centre are regulated by the amount of antigen that the B cells present to follicular helper T cells. See also News & Views by Tarlinton Dichloroacetate prevents restenosis in preclinical animal models of vessel injury Tobias Deuse Xiaoqin Hua Dong Wang Lars Maegdefessel Joerg Heeren et al. During development of myointimal hyperplasia in human arteries smooth muscle cells have hyperpolarized mitochondrial membrane potential m high proliferation and apoptosis resistance PDK2 is a key regulatory protein whose activation is necessary for myointima formation and its blockade with dichloroacetate prevents m hyperpolarization facilitates apoptosis and reduces myointima formation in injured arteries without preventing vessel re-endothelialization possibly representing a novel strategy to prevent proliferative vascular diseases. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

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‎Journal fur Schulentwicklung‎

‎3/2014 Kulturelle Bildung‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Uwe Hameyer er Marlie Krainz-Dürr Kulturelle Bildung Editorial 4 Michael Wimmer Kulturelle Bildung zwischen traditioneller Randständigkeit und möglicher zentraler Bedeutung für die Schulentwicklung - ein Standortversuch 8 Interview mit Dr. Claudia Schmied geführt von Marlies Krainz-Dürr Kulturelle Bildung aus der Sicht der Schulpolitik 17 Tanja Nagel Was I wir I lernen - ohne es zu merken - Das Potenzial von forschendem Lernen in Kunst und Kultur für Schulentwicklung am Beispiel von Kultur.Forscher! 21 Maren Wichmann & Cornelia Feige Lernen als kulturelle Entdeckungsreise 26 Helene J. Feichter Schülerinnen und Schüler erforschen den Kulturraum Schule 32 Ruth Kunz Die Bedeutung aktiver Rezeption im Kontext fotografischer Bildfindungsprozesse - Ein Projekt der Pädagogischen Hochschule Zürich in Zusammenarbeit mit der Sekundarschule Im Birch 39 Wulf Wersig e7 Karl-Volker Sauer Schulterschluss Schule und Theater 47 Birgit Schüller Was bleibt. Erinnerungen einer Lehrerin 54 gutes Exemplar ordentlich StudienVerlag hardcover‎

Referentie van de boekhandelaar : B00051039

‎Journal fur Schulentwicklung‎

‎1/2010 Re-Vision Schulentwicklung Lernen im Fokus‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Marlies Krainz-Dürr er Monica Gather Thurler Re-Vision Schulentwicklung - Lernen im Fokus / Editorial 4 Hans-Günter Rolff Vom Lehren zum Lernen - Von der Notwendigkeit einer pädagogischen Theorie des Lernens 11 Michael Schratz & Tanja Westfall-Greiter Das Dilemma der Individualisierungsdidaktik. Plädoyer für personalisiertes Lernen in der Schule 18 Petra Balke & Peter Daschner Wie LehrerInnen lernen. Aktuelle Herausforderungen in der Lehrerinnenbildung 32 Marlies Krainz-Dürr & Gabriele Khan-Svik Wie Schulen lernen - zur Balance von innerer und äußerer Schulreform am Beispiel des Schulversuchsmodells Neue Mittelschule 40 Monica Gather Thurler & Silvio Herzog Warum widersteht Schulform so hartnäckig allen Entwicklungsabsichten 49 gutes Exemplar ordentlich StudienVerlag hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 516 No. 7529 Dezember 1914 A Quick Look‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 7 NATURAL RESOURCES The uncertain dash for gas Predictions of fracking s bounty may be on shaky ground 7 SCIENCE AND SOCIETY Harsh reality The postdoc s lot is not a happy one and that needs to change 8 CLIMATE CHANCE Look ahead lt is prudent to research geoengineering strategies even if they won t be used WORLD VIEW n Science should keep out of partisan politics Daniel Sarewitz lt is too simplistic to demonize the right and laud the left SEVEN DAYS 12 THE NEWS IN BRIEF HIV on the rise in Eastern Europe and Central Asia / Polio vaccinators killed in Pakistan /James Watson sells Nobel medal / UK chooses quantum hubs 15 INFECTIOUS DISEASE Race to bring Ebola vaccine to the field gets under way 16 BIOENGINEERING Investigations launched into artificial trachea work 18 PALAEONTOLOGY Meet the fossils challenging Archaeopteryx s status as the first bird 2O CLIMATE CHANCE Researchers thrash out guidelines for geoengineering 21 MEDICAL RESEARCH Initiative aims to träck off-label use of drugs to treat cancer FEATURES 24 PHYSICS Quantum computer quest Thirty years of struggle are finally bearing fruit for quantum computers Sea-level rise and river engineering spell disaster say Liviu Giosan James Syvitski Stefan Constantinescu &John Day BOOKS & ARTS 34 MATHEMATICS Set theory for six-year-olds Alex Bellos 35 BOOKS IN BRIET 36 ROBOTICS Bottom-up innovation Noel Sharkey CORRESPONDENCE 37 Conservation policy debated / New pasture plants or invasive weeds OBITUARY 3B Herman Eisen 1918-2014 Lisa Steiner & Hidde Ploegh 133 INDUSTRY SKILLS Boosting business A number of programmes exist to ease the transition from biomedical trainee to management I35 CAREER BRIEFS TOOLBOX 131 ROBOTICS The automated lab The nature of research is changingas new software and advanced robotics begin to take care of the manual work NEW ONLINE 39 Papers published this week at nature.com NEWS & VIEWS 40 CELL EIETOOL/9A Autophagy transcribed Nuclear receptors control expression of lysosomal and autophagy genes Carmine Settembre & Andrea Ballabio SEE LETTERS R108 & P.112 41 EARTH SCIENCE Controls on isotopic gradients in rain Modelling depletion of heavy isotopes in rain as storms cross land Katherine H Freeman 42 MICROBIOLOGY A backup for bacteria Norovirus infection restores immune development in germ-free mice Yao Wang & Julie K Pfeiffer SEE LETTER R94 44 ASTROPHYSICS Stars fight back A massive galactic outflow of molecular gas in a compact galaxy Philip F Hopkins SEE LETTER R68 45 NEUROBIOLOGY A molecular knife to dice depression A pathway involving 13-catenin and Dicer Proteins may mediate resilience Gerhard Schraff SEE ARTICLE P.51 46 TECHNOLOGY Ultrafast imaging takes on a new design Capturing non-repetitive events at 100 billion frames per second Brian W Pogue SEE LETTER R74 48 BEHAVIOURAL ENADAMS Professional identity can increase dishonesty Banking business culture may weaken employees honesty norms Marie Claire Villeval SEE LETTER P.86 49 DIABETES The good in Tat Fatty acids that enhance glucose uptake from blond in mice Deborah M Muoio & Christopher B Newgard ARTICLES 51 NEUROSCIENCE ß-catenin mediates stress resilience through Dicer1/ A representation of single-shot ultrafast photography at 100 billion frames a second. Gao et al. use compressed imaging with a streak camera to video record non-repetitive transient events in two dimensions with resolution down to tens of picoseconds. PAGES 46 & 74 microRNA regulation C Dias et al. SEE N&V P.45 56 STEM CELLS Deconstructing transcriptional heterogeneity in pluripotent stem cells R M Kumar et al. 62 CELL BIOLOGY Structure of the V. cholerae Na-pumping NADH:quinone oxidoreductase J Steuber et al. LETTERS 68 ASTROPHYSICS Stellar feedback as the origin of an extended molecular outflow in a starburst galaxy J E Geach et al. SEE N&V R44 7I SUPERCONDUCMITY Nonlinear lattice dynamics as a basis for enhanced superconductivity in YBa2Cu306.5 R Mankowsky et al. 74 TECHNOLOGY Single-shot compressed ultrafast photography at one hundred billion frames per second L GaoJ Liang C Li & L V Wang SEE N&V P.46 79 MATERIALS SCIENCE Conductive two-dimensional titanium carbide `clay with high volumetric capacitance M Ghidiu M R Lukatskaya M-Q Zhao Y Gogotsi & M W Barsoum 82 CUMATE Eastern Pacific tropical cyclones intensified by EI Nino delivery of subsurface ocean hegt F-F JinJ. Boucharel & 1-1 Lin 86 BEHAVIOURAL ECONOMICS Business culture and dishonesty in the banking industry A Cohn E Fehr & M A Marechal SEE N&V P.48 90 PLANT SCIENCES Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules X Chen et al. 94 MICROBIOLOGY An enteric virus can replace the beneficial function of commensal bacteria E Kernbauer Y Ding & K Cadwell SEE N&V P.42 99 CELL BIOLOGY The ESCRT machinery regulates the secretion and longrange activity of Hedgehog T Matusek et al. 104 CELL BIOLOGY Centriole amplification by mother and daughter centrioles differs in multiciliated cells A A Jord et al. I08 CELL BIOLOGY Transcriptional regulation of autophagy by an FXR CREB axis S Seok et al. SEE N&V P.40 112 CELL. 810100V Nutrient-sensing nuclear receptors coordinate autophagy M Lee et al. SEE N&V R40 116 CANCER TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein S Bhatnagar et al. 12I NEUROSCIENCE Piezo2 is the major transducer of mechanical Torces for touch sensation in mice SS Ranade et al. 126 NEUROSCIENCE Physical mechanism for gating and mechanosensitivity of the human TRAAK K channel S G Brohawn E B Campbell & R MacKinnon NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol. 514 No. 7523 Solar Storm brewing‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 403 BIOSAFETY A ripe time for gaining ground The frosty debate over gain-of-function work Shows signs of a thaw 403 ANIMAL RESEARCH The ice bucket Success of social-media challenge sidestepped emotive issue 404 ENVIRONMENT Toxic influence Europe raust respond to threat to vultures nosed by livestock drugs. WORLD VIEW 405 Stormy outlook for long-term ecology studies Tim Birkhead Axed guillemot survey raises fears over funders priorities RESEARCH HIGHLIGHTS 406 SELECTIONS FROM THE SCIENTIFIC LITERATURE Sleep loss and obesity / Saving rhinos / Solar corona heating / PhD supply tops demand / Tomadoes clustered SEVEN DAYS 408 THE NEWS IN BRIEF Contentious snails / L Aquila appeal gets under way / Australia boosts ties between science and industry 523 CAREER CHANGES Open for business An MBA can open new career paths for the business-minded scientist 525 TURNING POINT Andrew Dove sees the latest biodegradable polymers as a potential boon to regenerative medicine 411 BIOSECURITY - White House enforces moratorium an gain-of-function research 412 POLITICS US elections hold promise of bleak outlook for science funding 413 ANTHROPOLOGY Oldest genome from modern human gives fresh twist to African exodus 414 ASTRONOMY Solar force offers Kepler telescope new lease of life 416 STRUCTURAL BIOLOGY Protein database wrestles with challenge posed by molecular machines FEATURES 418 RESEARCH The ethics squad Scientists with moral dilemmas dial up ethics consultancies 430 EMERGENCY PLANNING Be prepared Jennifer K Pullium Gordon S Roble & Mark A Raymond Standard emergency preparations tend to fall when the worst happens but there is another way BOOKS & ARTS 432 IN RETROSPECT On the Connexion of the Physical Sciences Richard Holmes CORRESPONDENCE 434 Keep the 2 C climate target / GlobeLand30 mapping for all / Realistic sustainability goals / Research evaluations FUTURES 528 Google car takes the test Norman Spinrad NEW ONLINE 435 Papers published this week at nature.com NEWS & VIEWS 436 CLIMATE CHANCE A crack in the natural-gas bridge Abundant natural gas may have little effect on CO emissions Steven J Davis & Christine Shearer SEE LETTER P.482 437 HIV A stamp on the envelope A high-resolution crystal structure of the pre-fusion Env trimer Rogier W Sanders & John P Moore SEE ARTICLE P.455 438 LUNG DISEASE Treatment by cell transpiant Gene-corrected macrophages treat pulmonary alveolar proteinosis in mice Mary Jane Thomassen & Mani S Kavuru SEE ARTICLE R450 49 ASTRONOM Hurling comets around a planetary nursery Star-grazing comets in the ß Pictoris planetary system form two families Aki Roberge SEE LETTER R462 PHYSIOLOGY Relax and come in Dendritic-cell Signals promote relaxation of lymph-node stromal cells Kari Vaahtomeri & Michael Sixt SEE LETTER R498 42 HIV Potency needs constancy FcyR-mediated effector functions needed for antibody-based viral control Alexandra Trkola ARTICLES 445 GENETICS Genome sequence of a 45000-year-old modern human from western Siberia Q Fu et al. 450 CELL BIOLOGY Pulmonary macrophage transplantation therapy T Suzuki et al. SEE N&V R438 455 IMMUNOLOGY Structure and immune recognition of trimeric pre-fusion HIV-1 Env M Pancera et al. SEE N&V R437 ON THE COVER Solar storm A magnetic model of the Sun before a solar eruption produced by an ejected magnetic rope based on data from the Helioseismic and Magnetic Imager of the NASA Solar Dynamics Observatory mission. Tahar Amari et al. show that the probable driving force for such ejections is the appearance and then the ejection of a `twisted rope of magnetic flux. LETTERS I62 PLANETARY SCIENCE Two families of exocomets in the ß Pictoris system F Kiefer et al. SEE N&V R440 Characterizing and predicting the magnetic environment leading to solar eruptions T Amari A Canou & J-J Aly 170 NANOTECHNOLOLGY Piezoelectricity of single-atomic-layer MoS2 for energy conversion and piezotronics W Wu et al. 175 INORGANIC CHEMISTE Identification of an iridium-containing compound with a formal oxidation state of IX G Wang et al. 178 CLIMATESCIENCF Methane dynamics regulated by microbial community response to permafrost thaw C K McCalley et al. Limited Impact on decadal-scale climate change from increased use of natural gas H McJeon et al. SEE N&V P.436 486 ECOLOGY Producing more grain with lower environmental costs X Chen et al. A Hox regulatory network of hindbrain segmentation is conserved to the base of vertebrates HJ Parker M E Bronner & R Krumlauf 494 EVOLUTIONARY GENETICS Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis KlBosetal. Dendritic cells control fibroblastic reticular network tension and lymph node expansion S EActon et al. SEE N&V R441 5-Ca Diabetes recovery by age-dependent conversion of pancreatic 8-cells into Insulin producers S Chera et al. High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity MD Schulz et al. 513 CANCER Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia P Ntziachnstos et al. STRUCTURAL BIOLOGY Structure and mechanism of Zn2-transporting P-type ATPases K Wang et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

Referentie van de boekhandelaar : B00042457

‎Journal fur Schulentwicklung‎

‎2/2012 Schulentwicklung im ganztätigen Lernen‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Heinz Günter Holtappels er Marlies Krainz-Dürr Schulentwicklung im ganztägigen Lernen Editorial 4 Wolfram Rollett Lea Spillebeen & Heinz Günter Holtappels Schulentwicklungsprozess an Ganztagsschulen Bedeutung systematischer Qualitätsentwicklung und der Nutzung externer Unterstützung 8 Gabriele Hörl er Elgrid Messner Ansatzpunkte für Schulentwicklung aus der Praxis verschränkter Ganztagsschulen 19 Hans Haenisch Schlüsselfaktoren der Entwicklung offener Ganztagsgrundschulen 25 Ulrike Popp Welche Lehrerinnen braucht die verschränkte Ganztagsschule 33 Wolf Schwarz Qualitätskriterien für Ganztagsschulen - Ein Qualitätsrahmen am Beispiel Hessens 40 Zdenko Medves Länderbericht: Ganztägig Lernen in Slowenien 47 Methodenatelier Anneliese Nageler-Schluga Ratingkonferenz: Zwischen Datenerhebung und Reflexion 51 gutes Exemplar ordentlich StudienVerlag hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 512 No 7513 August The Cop9 Signalosome‎

‎NPG Nature publishing group. Hardcover. Gut. Society: Don t blame the mothers Careless discussion of epigenetic research on how early life affects health across generations could harm women warn Sarah S. Richardson and colleagues. Books and Arts Top History of engineering: Wonder maker Andrew Robinson delves into a study inspired by James Watt s fascinating workshop. Review of James Watt: Making the World Anew Ben Russell Books in brief Barbara Kiser reviews five of the week s best science picks. Neuroscience: What females really want Leslie C. Griffith Solar system: Sandcastles in space Daniel J. Scheeres See also Letter by Rozitis et al. Ageing: Old blood stem cells feel the stress Jiri Bartek & Zdenek Hodny See also Letter by Flach et al. Condensed-matter physics: Glasses made from pure metals Jan Schroers See also Letter by Zhong et al. Cancer: One cell at a time Edward J. Fox & Lawrence A. Loeb See also Article by Wang et al. Astronomical instrumentation: Atmospheric blurring has a new enemy Brent Ellerbroek Structural biology: Corralling a protein-degradation regulator Raymond J. Deshaies See also Article by Lingaraju et al. Limits on fundamental limits to computation Igor L. Markov To evaluate the promise of potential computing technologies this review examines a wide range of fundamental limits such as to performance power consumption size and cost from the device level to the system level. Articles Top Clonal evolution in breast cancer revealed by single nucleus genome sequencing Yong Wang Jill Waters Marco L. Leung Anna Unruh Whijae Roh et al. To investigate genomic diversity within tumours a new type of whole-genome and exome single cell sequencing has been developed using G2/M nuclei the technique was used to sequence single nuclei from an oestrogen-positive breast cancer and a triple-negative ductal carcinoma aneuploidy rearrangements emerged as early events in tumour formation and then point mutations evolved gradually over time. See also News & Views by Fox & Loeb Crystal structure of the human COP9 signalosome Gondichatnahalli M. Lingaraju Richard D. Bunker Simone Cavadini Daniel Hess Ulrich Hassiepen et al. The COP9 signalosome CSN complex regulates cullin RING E3 ubiquitin ligases the largest class of ubiquitin ligase enzymes which are involved in a multitude of regulatory processes here the crystal structure of the entire human CSN holoenzyme is presented. See also News & Views by Deshaies Three-dimensional structure of human -secretase Peilong Lu Xiao-chen Bai Dan Ma Tian Xie Chuangye Yan et al. The three-dimensional structure of intact human -secretase complex at 4.5 Ã… resolution is revealed by cryo-electron-microscopy single-particle analysis the complex comprises a horseshoe-shaped transmembrane domain containing 19 transmembrane segments and a large extracellular domain from nicastrin which sits immediately above the hollow space formed by the horseshoe. Letters Top The origin of the local 1/4-keV X-ray flux in both charge exchange and a hot bubble M. Galeazzi M. Chiao M. R. Collier T. Cravens D. Koutroumpa et al. The contribution of solar-wind ions exchanging electrons with helium and hydrogen near the Sun is shown to be only about 40 per cent of the 1/4-keV X-ray flux observed in the Galactic plane this supports the existence of a local hot bubble filled with X-ray-emitting gas accounting for the rest of the flux. Cohesive forces prevent the rotational breakup of rubble-pile asteroid 29075 1950 DA Ben Rozitis Eric MacLennan & Joshua P. Emery Modelling and observations of the kilometre-sized asteroid 29075 1950 DA reveal it to be a rubble pile that is rotating faster than is allowed by gravity and friction cohesive forces such as those in lunar regolith are required to prevent it breaking up. See also News & Views by Scheeres Formation of monatomic metallic glasses through ultrafast liquid quenching Li Zhong Jiangwei Wang Hongwei Sheng Ze Zhang & Scott X. Mao Metallic liquids of single elements have been successfully vitrified to their glassy states by achieving an ultrafast quenching rate in a new experimental design of which the process has been monitored and studied by a combination of in situ transmission electron microscopy and atoms-to-continuum computer modelling. See also News & Views by Schroers The tidal rotational shape of the Moon and evidence for polar wander Ian Garrick-Bethell Viranga Perera Francis Nimmo & Maria T. Zuber Analysis of the Moon s topography reveals that when its largest basins are removed the lunar shape is consistent with processes controlled by early Earth tides and implies a reorientation of the Moon s principal shape axes. Neuropsychosocial profiles of current and future adolescent alcohol misusers Robert Whelan Richard Watts Catherine A. Orr Robert R. Althoff Eric Artiges et al. Many factors have been proposed as contributors to risk of alcohol abuse but quantifying their influence has been difficult here a longitudinal study of a large sample of adolescents and machine learning are used to generate models of predictors of current and future alcohol abuse assessing the relative contribution of many factors including life history individual personality differences brain structure and genotype. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes Ida Moltke Niels Grarup Marit E. Jørgensen Peter Bjerregaard Jonas T. Treebak et al. An association mapping study of type-2-diabetes-related quantitative traits in the Greenlandic population identified a common variant in TBC1D4 that increases plasma glucose levels and serum insulin levels after an oral glucose load and type 2 diabetes risk with effect sizes several times larger than any previous findings of large-scale genome-wide association studies for these traits. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA Emilia Huerta-Sánchez Xin Jin Asan Zhuoma Bianba Benjamin M. Peter et al. Admixture with other hominin species helped humans to adapt to high-altitude environments the EPAS1 gene in Tibetan individuals has an unusual haplotype structure that probably resulted from introgression of DNA from Denisovan or Denisovan-related individuals into humans and this haplotype is only found in Denisovans and Tibetans and at low frequency among Han Chinese. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Johanna Flach Sietske T. Bakker Mary Mohrin Pauline C. Conroy Eric M. Pietras et al. Haematopoietic stem cell HSC function is known to degrade with age here replication stress is shown to be a potent driver of the functional decline of HSCs during physiological ageing in mice due to decreased expression of mini-chromosome maintenance helicase components and reduced activity of the DNA replication machinery. See also News & Views by Bartek & Hodny Historical contingency and its biophysical basis in glucocorticoid receptor evolution Michael J. Harms & Joseph W. Thornton By characterizing a very large number of might-have-been evolutionary trajectories starting from a resurrected ancestral protein the authors show that the evolution of an essential modern protein was contingent on extremely unlikely historical mutations. DENR MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth Sibylle Schleich Katrin Strassburger Philipp Christoph Janiesch Tatyana Koledachkina Katharine K. Miller et al. This study identifies the DENR MCT-1 complex as the first factors in animals specific for translation re-initiation downstream of upstream Open Reading Frames uORFs. Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA William L. Hwang Sebastian Deindl Bryan T. Harada & Xiaowei Zhuang A nucleosome-spacing mechanism for human ATP-dependent chromatin assembly and remodelling factor ACF. Visualization of arrestin recruitment by a G-protein-coupled receptor Arun K. Shukla Gerwin H. Westfield Kunhong Xiao Rosana I. Reis Li-Yin Huang et al. Single-particle electron microscopy and hydrogen deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor arrestin complex. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

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‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 512 No. 7515 August 2014 In The Loop‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 347 SCIENTIFIC ADVICE Diplomatic service Governmental advisers can be crucial in the heat of a crisis 347 CLIMATE CHANCE People power Wanted: models to assess human adaptation to global warming WORLD VIEW 349 AIIow use of electronic cigarettes to assess risk Daniel Sarewitz Research into the health effects of e-cigarettes would waste time and money. Just keep an eye on the users RESEARCH HIGHLIGHTS 35O SELECTIONS FROM THE SCIENTIFIC LITERATURE Opioids from yeast / Meteorites with a history / Coral-averse reefs / Plants novel water supply / Misconduct costed / Lakes by the million / Vaccineresistant polio SEVEN DAYS 352 THE NEWS IN BRIEF Ominous rumblings from lcelandic volcano / Galileo satellites go into wrong orbit / Iran s science minister dismissed / Ice-sheet shrinkage 365 CLIMATE SCINCE Model human adaptation to climate change Paul 1 Palmer & MatthewJ Smith We are adapting to as well as causing environmental change and need to understand the implications 36R ASTROBIOLOGY Cosmic prestige Mario Livio 369 budtire. An Co RIEF 37O FICTION Transgressive treats Paul L McEuen CORRESPONDENCE 371 Supplying China s drinkable water / The eco-friendly dairy farm / Public access to privately owned fossils / Leaming from misconduct cases Mulm nv Peter Marler 1928-2014 Fernando Nottebohm 355 INFECTIOUS DISEASES Agencies call for stronger intemational intervention in Ebola outbreak 357 BIOTECHNOLOGY GM eucalyptus poised for commercial debut in Brazil 35B CONSERVATION Ecotourism not so `eco for whales alter all 359 CLIMATE CHANGE Race is on to record rapidly changing Himalayan vegetation 457 COLUMN zr -- Bold moves Peter Fiske Self-promotion is frowned upon in the academic world but on the butside it can get you noticed and employed 45B CAREER BRIEFS The angle of the light on the bloodstained kitchen floor Matt Mikalatos NEW ONLINE 373 Papers published this week at nature.com NEWS & VIEWS 374 GENOMICS Hiding in plain sight A doubling of data sets from the ENCODE and modENCODE projects Felix Muerdter & Alexander Stark SEE PAGES 393 400 445 449 & 453 375 ASTROPHYSICS Supernova seen through y-ray eyes Evidence that type la supernovae are thermonuclear events Robert P Kirshner SEE LETTER R406 377 IMMUNOLOGY Mammalian watchdog targets bacteria Recognition of virulence factors by the aryl hydrocarbon receptor Parag Kundu & Sven Pettersson SEE ARTICLE P.387 37B NEUTRINO PHYSICS What makes the Sun shine Neutrinos from the nuclear reaction that triggers solar-energy generation Wick Haxton SEE ARTICLE P.383 3BO APPLIED PHYSICS Hybrid sensors ring the changes A highly sensitive optomechanical magnetometer Jörg Wrachtrup & Amit Finkler 3B1 BEHAVIOURAL ECOLOGY Love thy neighbour Enhanced male cooperation may underlie extra-pair mating by females Ben C Sheldon & Marc Mangel ARTICLES 383 PABTICLE PHYSICS Neutrinos from the primary proton proton fusion process in the Sun Borexino Collaboration SEE N&V P.378 387 IMMUNOLOGY AhR sensing of bacterialpigments regulates antibacterial defence P Moura-Alves et al. SEE N&V R377 393 GENOMICS Diversity and dynamics of the Drosophila transcriptome J B Brown et al. SEE N&V R374 4OO GENOMICS Regulatory analysis of the Some new neural activity patterns in learning Rhesus macaques are easier to generate than others corresponding to more easily learned tasks and these can be predicted from network topology at the start of the experiment. This finding could form a basis for a neural explanation for the balance between adaptability and persistence in action and thought. PAGE 423 elegans genome with spatiotemporal resolution C L Araya et al. SEE N&V R374 LETTERS 4O6 ASTROPHYSICS Cobalt-56 y -ray emission lines from the type la supernova 2014J E Churazov et al. SEE N&V P.375 4O9 QUANTUM PHYSICS Quantum imaging with undetected photons G Barreto Lemos et al. 413 ORGANIC CHEMISTRY Carbon carbon bond cleavage and rearrangement of benzene by a trinuclear titanium hydride S Hu T Shima & Z Hou 416 CLIMATE SCIENCE Contrasting responses of mean and extreme snowfall to climate change P A O Gorman 419 EVOLUTION A primitive fish from the Cambrian of North America S Conway Morris & J-8 Caron 423 NEUROSCIENCE Neural constraints an learning P T Sadtler et al. 427 NEUROSCIENCE Processing properties of ON and OFF pathways for Drosophila motion detection R Behnia D A Clark A G Carter T R Clandinin & C Desplan 431 CANCER miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 J Y Krzeszinski et al. 436 PLANT SCIENCE The long-term maintenance of a resistance polymorphism through diffuse interactions T L Karasov et al. 441 CELL BIOLOGY The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase F Wang C Chan N R Weir & V Denic 445 GENOMICS Comparative analysis of the transcriptome across distant species M B Gerstein et al. SEE N&V P.374 449 GENOMICS Comparative analysis of metazoan chromatin organization J W K Ho et al. SEE N&V P.374 453 GENOMICS Comparative analysis of regulatory information and circuits across distant species A P Boyle et al. SEE N&V R374 QUANTUM PHYSICS Seeing red How to generate quantum images using undetected photons PAGE 409 NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

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‎Journal fur Schulentwicklung‎

‎4/2009 Empowerment‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Monica Gather Thurler & Peter Daschner Empowerment - Editorial 4 Anne Barrere Vom Klassenzimmer zum Schulhaus Bewährungsproben der Lehrerinnenarbeit in Reformzeiten 9 Karl Mäder Empowerment durch Beratung - Professionalisierung von Lehrpersonen und Schulen 18 Georges Pasquier Lehrerinnen brauchen Hoffnung und Freiräume 24 Jean Wagner Eine Schule die die Personalentwicklung ihrer Lehrpersonen ernst nimmt. Ein Praxisbericht 30 Monica Gather Thurler er Laetitia Progin Verteiltes Leadership und Empowerment von Lehrpersonen 37 Reiner Lehberger er Uwe Schaarschmidt Eignungsberatung für Lehramtsstudierende - Rückmeldungen und Angebote zum Kompetenzausbau 46 gutes Exemplar ordentlich StudienVerlag hardcover‎

Referentie van de boekhandelaar : B00051024

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 508 No. 7497 April 2014 Reasons for Y‎

‎NPG Nature publishing group. Hardcover. Gut. Medical genomics: Gather and use genetic data in health care Research into how genetic variants can guide successful treatments must become part of routine medical practice and records says Geoffrey Ginsburg. Books and Arts Top Natural history: A scientist s eye Beatrix Potter s meticulous artistry served mycology and entomology as well as children s fiction reveals Linda Lear. Medicine: The commodified body Scott Carney assesses a study of banked human blood sperm and milk. Review of Banking on the Body: The Market in Blood Milk and Sperm in Modern America Kara W. Swanson Climate science: Stratospheric folly Tim Kruger examines an argument against injecting aerosols into the atmosphere to counter climate change. Review of Can Science Fix Climate Change A Case Against Climate Engineering Mike Hulme Electrochemistry: Catalysis at the boundaries Aaron M. Appel See also Letter by Li et al. Sensory systems: Do you hear what I see Ione Fine Infection biology: Nibbled to death Nancy Guillén See also Letter by Ralston et al. Genetics: The vital Y chromosome Andrew G. Clark See also Article by Cortez et al. See also Article by Bellott et al. 50 & 100 Years Ago Climate science: Sea levels from ancient seashells Ralph Schneider See also Article by Rohling et al. Reproductive biology: Sperm protein finds its mate Paul M. Wassarman See also Article by Bianchi et al. Letters Top Superconducting quantum circuits at the surface code threshold for fault tolerance R. Barends J. Kelly A. Megrant A. Veitia D. Sank et al. A universal set of logic gates in a superconducting quantum circuit is shown to have gate fidelities at the threshold for fault-tolerant quantum computing by the surface code approach in which the quantum bits are distributed in an array of planar topology and have only nearest-neighbour couplings. Electroreduction of carbon monoxide to liquid fuel on oxide-derived nanocrystalline copper Christina W. Li Jim Ciston & Matthew W. Kanan The electrochemical conversion of CO and H2O into liquid fuel is made feasible at modest potentials with the use of oxide-derived nanocystalline Cu as the catalyst. See also News & Views by Appel Hybrid shallow on-axis and deep off-axis hydrothermal circulation at fast-spreading ridges Jörg Hasenclever Sonja Theissen-Krah Lars H. Rüpke Jason P. Morgan Karthik Iyer et al. High-resolution three-dimensional simulations of hydrothermal flow beneath fast-spreading ridges predict two interacting flow components shallow on-axis flow and deeper off-axis flow that merge to feed axial vent sites reconciling previously incompatible models favouring only one flow component. Plate tectonics damage and inheritance David Bercovici & Yanick Ricard Lithospheric damage combined with transient mantle flow and migrating proto-subduction is proposed to explain the apparent emergence of plate tectonics three billion years ago modelling confirms that tectonic plate boundaries and fully formed tectonic plates can arise under conditions characteristic of Earth but not of Venus. Herbivores and nutrients control grassland plant diversity via light limitation Elizabeth T. Borer Eric W. Seabloom Daniel S. Gruner W. Stanley Harpole Helmut Hillebrand et al. Experimental data collected from 40 grasslands on 6 continents show that nutrients and herbivores can serve as counteracting forces to control local plant diversity nutrient addition reduces local diversity through light limitation and herbivory rescues diversity at sites where it alleviates light limitation. Eutrophication weakens stabilizing effects of diversity in natural grasslands Yann Hautier Eric W. Seabloom Elizabeth T. Borer Peter B. Adler W. Stanley Harpole et al. Experimental eutrophication weakens the stabilizing effects of plant diversity on the productivity of natural grasslands. Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion Katherine S. Ralston Michael D. Solga Nicole M. Mackey-Lawrence Somlata Alok Bhattacharya et al. Entamoeba histolytica the causative agent of fatal diarrhoeal disease in children in the developing world is shown here to kill human cells by biting off and ingesting pieces of cells in a process reminiscent of the trogocytosis seen between immune cells ingestion of bites is required for killing and this mechanism is used both in tissue culture and during invasion of intestinal explants. See also News & Views by Guillén Inhibition of miR-25 improves cardiac contractility in the failing heart Christine Wahlquist Dongtak Jeong Agustin Rojas-Muñoz Changwon Kho Ahyoung Lee et al. Reduced activity of the calcium-transporting ATPase SERCA2a is a hallmark of heart failure here microRNAs that downregulate SERCA2a function are identified and antagonism of one miR-25 is shown to halt heart failure in mice. Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation Yoshiki Omatsu Masanari Seike Tatsuki Sugiyama Tsutomu Kume & Takashi Nagasawa Transcription factor Foxc1 is a key regulator of haematopoietic stem/progenitor cell niche formation. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus Pengda Liu Michael Begley Wojciech Michowski Hiroyuki Inuzuka Miriam Ginzberg et al. Phosphorylation of Akt at its carboxy-terminal tail is an essential layer of Akt activation to regulate its physiological functions. Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9 I Winnie Lin Davide Sosso Li-Qing Chen Klaus Gase Sang-Gyu Kim et al. Although nectar is known to be important for example in plant insect interactions little has been known about the mechanism of its secretion sucrose phosphate synthases are now reported to be essential for the synthesis of the sucrose component of nectar and the transporter protein SWEET9 is shown to mediate sucrose export into the extracellular space of the nectary. Structure of a type IV secretion system Harry H. Low Francesca Gubellini Angel Rivera-Calzada Nathalie Braun Sarah Connery et al. The three-dimensional structure of the type IV secretion system encoded by the Escherichia coli R388 conjugative plasmid. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

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‎Ein urgemutliches sachsisches Journal‎

‎Der kleine Drache Nummer 8‎

‎Hardcover. Gut. INHALT Lutz Lange: Mein buntes deutsches Leipzig / Andreas Reimann: taus der gegenwart / Jochen Meier: Leipzigs Straßen / Reinhard Lochnerz Politische Sprüche / Jürgen Hart: Die letzte Fahrt / Ramona Kraetke: Vorstadtabend / Sepp Sachs: Es braucht alles seine Zeit LEIPZIGER ALLERLEI Hoffnung / Unsere klerikale Frage / Gut gesagt / Im Kaufhaus / ficht zu helfen / Frühkindlicher Fernseh-Schaden / Musik- enner u.a. obias Jurack: Heemebaadn /Gunter Böhnke: Der touristische Sach- Eirtikel / Hans-Walter Molle: In der Kneipe / Hanskarl Hoerning: Kurt besucht die Litfaßsäule / Thomas Reuter: Ich Früchtchen Cartoons und Illustrationen von Matthias Götz und Lothar Otto / Alfred Glaser: Ne schdille Schdunde / Matthias Götz: Herren- gepflegtes Exemplar nur kleine Lesespuren Buchblock altersgemäß gebräunt hardcover‎

Referentie van de boekhandelaar : B00008116

‎T. Thaphada Journal‎

‎Paris Mon Amour A Cook's Journal: 160 Blank Recipe Book 8x10" Blank Recipe Journal/Blank Cookbook/CookbookNote/Recipe Journal / Recipe Notebook / Blank Cook Book - Full Color Cover‎

‎CreateSpace Independent Publishing Platform 2016. Paperback. New. jou edition. 160 pages. 10.00x8.00x0.37 inches. CreateSpace Independent Publishing Platform paperback‎

Referentie van de boekhandelaar : __1541269942 ISBN : 1541269942 9781541269941

‎DIARIO DE NAVARRA‎

‎EL ARTE EN NAVARRA. TOMO 1‎

‎1994. DURA GRAN FORMATO. Bien/Sin cubierta. EL ARTE DE NAVARRA QUE AHORA VE LA LUZ CONSTITUYE EL PRIMER INTENTO DE OFRECER A UN PÚBLICO AMPLIO LOS GRANDES TEMAS DEL ARTE NAVARRO VISTOS DESDE EL ESTADO ACTUAL DE NUESTROS CONOCIMIENTOS E ILUMINADOS POR LOS ÚLTIMOSENFOQUES METODOLÓGICOD DE LA HISTORIOGRAFÃA ARTÃSTICA. hardcover‎

Referentie van de boekhandelaar : 119357alzo ISBN : 8489103011 9788489103016