‎Journal‎

‎Journal fur Schulentwicklung‎

‎3/2011 Lernen in Netzwerken‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Nils Berkemeeer & Hanna Järvinen Lernen in Netzwerken Editorial 4 Stefan Seitz Schulische Netzwerke als Antrieb schulischer Erneuerung 8 Hanna Järvinen & Nils van Holt Mit Netzwerken Schule und Unterricht entwickeln - Erfahrungen aus dem Projekt Schulen im Team 16 Johanna Otto & Norbert Sendzik Schulen im Team: Transferregion Dortmund - Einblicke in ein kommunal gestaltetes Netzwerkmanagement 26 Andrew Townsend Understanding and promoting educational networks - Acknowledging the relational features of education 34 Martin Hartmann Leading Student Achievement - Unterricht erfolgreich im Netzwerk entwickeln: Erfahrungen aus Kanada 41 Hans-Günter Rolff Leitlinien zum Verständnis von Schulentwicklung und Schulentwicklungsbegleitung 46 gutes Exemplar ordentlich StudienVerlag hardcover‎

书商的参考编号 : B00051029

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 506 No. 7488 Februar 2014 Two´s a Crowd‎

‎NPG Nature publishing group. Hardcover. Gut. WORLD VIEW 267 WHO plans for neglected diseases are wrong Mary Moran Pilot projects will oller scant benefits and threaten to derail R&D RESEARCH HIGHLIGHTS 26B SELECTIONS FROM THE SCIENTIFIC LITERATURE Water-powered antifreeze / Windturbine generated lightning / Sugary drink data questioned / Cancer risk byassociation /The Lpower of a soft touch / Whales head count SEVEN DAYS 27O THE NEWS IN BRIEF Stem-cell study under fire / Politicians rally to tackle poaching / China Moon rover down but not out / Long-distance neutrinos detected 397 INTERVIEWS En garde For success in your interview prepare and stay cool 399 CAREER BRIEFS 273 ENVIRONMENT China offers incentives in bid to tackle air pollution 274 ASTRONOMY Mystery of missing galaxy mass resolved by gravitational lensing 276 OCEANOGRAPHY Chinese project looks for weather clues in Pacific 277 POLICY Swiss immigration vote puts strain on EU relationship 27B SPACE Low expectations greet X Prize bid to land on Moon 279 ACADEMIC APPOINTMENTS Hunger strike exposes flaws in Nepal s higher-education system 2B4 SCIENCE IN COURT Smart enough to die Questions are being raised over whether measures of intellectual ability used to assess convicts are appropriate Axel Meyer & Jorge A Huete-Prez The planned Nicaragua Canal could prove to be an environmental disaster PAGE 287 29O HEALTH POLICY How to regulate faecal transplants Mark B Smith Colleen Kelly & Eric J Alm A call to treat stool as a tissue not a drug for changing the gut microbiome BOOKS & ARTS 292 NUCLEAR ENERGY Meltdowns redux Mark Peplow 293 BOOKS IN BRIEF 294 RESEARCH AND DEVELOPMENT No matter try again Anthony King CORRESPONDENCE 295 Carbon currency / Peer review / Drug- resistant TB / A step too far for fiction FUTURES 4O2 Coffee in end times Alvaro ZinosAmaro &Alex Shvartsman NEW ONLINE 297 Papers published this week at nature.com NEWS & VIEWS 298 ASTROPHYSICS Lopsided stellar death A look back at the centre of the Cassiopeia A supernova J Martin Laming SEE LETTER P.339 299 REGENERATIVE BIOLOGY Take the brakes off for liver repair Angiopoietin 2 coordinates hepatic-cell proliferation alter injury Andrew G Cox & Wolfram Goessling 3OO CANCER Persistente of leukaemic ancestors Premalignant clonal populations detected in acute myeloid leukaemia Nicola E Potter & Mel Greaves SEE ARTICLE P.328 3O2 PLASMA PHYSICS A promising advance in nuclear fusion Fusion-energy yield exceeds energy invested in fusion fuel Mark Herrmann SEE LETTER P.343 3O3 MOLECULAR BIOLOGY Protein binding cannot subdue a lively RNA The dynamics of an early step in ribosomal assembly Kathleen 8 Hall SEE ARTICLE P.334 3O4 AGEING Genetic rejuvenation of old muscle Repression of a senescence pathway revives geriatric stem cells Mo Li & Juan Carlos lzpisua Belmonte SEE ARTICLE R316 REVIEW 3O7 PALAEOCLIMATE The rise of oxygen in Earth s early ocean and atmosphere T W Lyons C T Reinhard & N J Planavsky ARTICLES 316 STEM CELLS Geriatric muscle stern cells switch reversible quiescence into senescence P Sousa-Victor et al. SEE N&V P.304 322 STEM CELLS In situ identification of bipotent stem cells in the mammary gland - wir ON THE COVER In it together A bumblebee and honeybee collecting sunflower nectar. Emerging honeybee pathogens are shown to be infectious in an important wild pollinator the bumblebee. This raises the prospect that crop pollination could suffer if the spread of these diseases is unchecked. PAGE 364 A C Rios N Y Fu GJ Lindeman &J E Visvader 328 CANCER Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia L I Shlush et al. SEE N&V R300 334 MOLECULAR BIOLOGY Protein-guided RNA dynamics during early ribosome assembly H Kim et al. SEE N&V P.303 LETTERS 339 ASTROPHYSICS Asymmetries in corecollapse supernovae from maps of radioactive Ti in Cassiopeia A B W Grefenstette et al. SEE N&V P.298 343 PLASMA PHYSICS Fuel gain exceeding unity in an inertially confined fusion implosion 0 A Hurricane et al. SEE N&V R302 349 MATERIALS SCIENCE Exceptional ballistic transport in epitaxial graphene nanoribbons J Baringhaus et al. 355 GEOCHEMISTRY Prodigious degassing of a billion years of accumulated radiogenic helium at Yellowstone J 8 Lowenstern W C Evans D Bergfeld & A G Hunt 359 EVOLUTION Species coexistence and the dynamics of phenotypic evolution in adaptive radiation J A Tobias et al. 364 MOLECULAR ECOLOGY Disease associations between honeybees and bumblebees as a threat to wild pollinators M A Fürst D P McMahon J L Osborne R J Paxton & M J F Brown 367 EVOLUTION Unidirectional pulmonary airflow patterns in the savannah monitor lizard E R Schachner R L CieriJ P Butler &C G Farmer 37I CANCER Landscape of genomic alterations in cervical carcinomas A I Ojesina et al. 376 DRUG DISCOVERY Genetics of rheumatoid arthritis contributes to biology and drug discovery Y Okada et al. 3B2 BIOTECHNOLOGY Selection and evaluation of clinically relevant AAV variants in a xenograft liver model L Lisowski et al. 387 CELL BIOLOGY Convergent evolution of a fused sexual cycle promotes the haploid lifestyle R K Sherwood C M Scaduto S E Torres & R J Bennett 391 STRUCTURAL BIOLOGY Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA H Hashimoto et al. 396 CORRIGENOUM Probabilistic tost estimates for climate change mitigation J Rogelj D L McCollum A Reisinger M Meinshausen & K Riahi 396 CORRIGENDUM Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome S Yoshimoto et al. 396 CORRIGENOUM DWARF 53 acts as a repressor of strigolactone signalling in rice L Jiang et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042466

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No. 7500 Mai 2014 Lost Bearings‎

‎NPG Nature publishing group. Hardcover. Gut. Climate science: Understand Arctic methane variability Expand ground monitoring of polar sources of this greenhouse gas to find out how climate change will influence its release says Torben R. Christensen. Policy: NIH to balance sex in cell and animal studies Janine A. Clayton and Francis S. Collins unveil policies to ensure that preclinical research funded by the US National Institutes of Health considers females and males. Sociobiology: The distributed brain Herbert Gintis salutes the follow-up to a study on sociality and hominin brain size. Review of Thinking Big: How the Evolution of Social Life Shaped the Human Mind Clive Gamble John Gowlett & Robin Dunbar Books in brief Chemistry: Intoxicating science Jamie Goode drinks in two views of that most venerable and destructive drug alcohol. Review of Proof: The Science of Booze & The Drunken Monkey: Why We Drink and Abuse Alcohol Adam Rogers & Robert Dudley Development: Dammed dreams Monya Baker is swept along by a documentary film tracing humanity s complex relationship with water. Review of Watermark Edward Burtynsky & Jennifer Baichwal Climate science: Shifting storms Hamish Ramsay See also Letter by Kossin et al. Synthetic biology: New letters for life s alphabet Ross Thyer & Jared Ellefson See also Letter by Malyshev et al. Organic chemistry: Collaborative synthesis John L. Wood See also Article by Mercado-Marin et al. Neurobiology: To care or not to care Ivan Rodriguez See also Article by Wu et al. 50 & 100 Years Ago Sensory biology: Radio waves zap the biomagnetic compass Joseph L. Kirschvink See also Letter by Engels et al. Evolution: Geology and climate drive diversification Rosemary G. Gillespie & George K. Roderick Articles Top Total synthesis and isolation of citrinalin and cyclopiamine congeners Eduardo V. Mercado-Marin Pablo Garcia-Reynaga Stelamar Romminger Eli. F. Pimenta David K. Romney et al. Natural products citrinalin B and cyclopiamine B which contain basic nitrogen atoms that are susceptible to oxidation during synthesis can be synthesized by the selective introduction and removal of functional groups. See also News & Views by Wood Galanin neurons in the medial preoptic area govern parental behaviour Zheng Wu Anita E. Autry Joseph F. Bergan Mitsuko Watabe-Uchida & Catherine G. Dulac Sexual experience brings radical changes in how male mice behave with pups virgin males attack them whereas mature fathers display parental care here the authors identify a subset of hypothalamic neurons whose ablation leads to parental deficits in both males and females and whose activation in virgin males suppresses aggression and induces pup grooming. See also News & Views by Rodriguez Space time wiring specificity supports direction selectivity in the retina Jinseop S. Kim Matthew J. Greene Aleksandar Zlateski Kisuk Lee Mark Richardson et al. Motion detection by the retina is thought to rely largely on the biophysics of starburst amacrine cell dendrites here machine learning is used with gamified crowdsourcing to draw the wiring diagram involving amacrine and bipolar cells to identify a plausible circuit mechanism for direction selectivity the model suggests similarities between mammalian and insect vision. c-kit cells minimally contribute cardiomyocytes to the heart Jop H. van Berlo Onur Kanisicak Marjorie Maillet Ronald J. Vagnozzi Jason Karch et al. Whether or not endogenous c-kit cells residing within the heart contribute cardiomyocytes during physiological ageing or after injury remains unknown here using an inducible lineage tracing system the c-kit lineage is shown to generate cardiomyocytes at very low levels and by contrast contributes substantially to cardiac endothelial cell generation. Letters Top Cepheid variables in the flared outer disk of our galaxy Michael W. Feast John W. Menzies Noriyuki Matsunaga & Patricia A. Whitelock Five classical Cepheids have been detected in the outer parts of our Galaxy beyond the Galactic bulge they are probably associated with the gas in the flared disk and if so they are the first stars to be identified in the flare. Tracking excited-state charge and spin dynamics in iron coordination complexes Wenkai Zhang Roberto Alonso-Mori Uwe Bergmann Christian Bressler Matthieu Chollet et al. Femtosecond resolution X-ray fluorescence spectroscopy is shown to track the charge and spin dynamics triggered when an iron coordination complex is excited by light and establishes the critical role of intermediate spin states in the de-excitation process. The poleward migration of the location of tropical cyclone maximum intensity James P. Kossin Kerry A. Emanuel & Gabriel A. Vecchi Analysis of global historical data in the Northern and Southern hemispheres reveals a statistically significant poleward migration of 1 per decade in the average latitude at which tropical cyclones have achieved their lifetime-maximum intensity over the past 30 years. See also News & Views by Ramsay Anthropogenic electromagnetic noise disrupts magnetic compass orientation in a migratory bird Svenja Engels Nils-Lasse Schneider Nele Lefeldt Christine Maira Hein Manuela Zapka et al. For the first time under reproducible and fully double-blinded conditions it is shown that anthropogenic electromagnetic noise below the WHO limits affects a biological system: night-migrating birds lose the ability to use the Earth s magnetic field for orientation when exposed to anthropogenic electromagnetic noise at strengths routinely produced by commonly used electronic devices. See also News & Views by Kirschvink Dynamics and associations of microbial community types across the human body Tao Ding & Patrick D. Schloss The microbiome composition of 300 individuals sampled over 12 18 months was partitioned into microbial community types which could be associated with the type found at other body sites as well as with whether individuals were breastfed as an infant their gender and their level of education. T-cell activation by transitory neo-antigens derived from distinct microbial pathways Alexandra J. Corbett Sidonia B. G. Eckle Richard W. Birkinshaw Ligong Liu Onisha Patel et al. Activation of mucosal-associated invariant T MAIT cells is shown to require key genes encoding an early intermediate in bacterial riboflavin synthesis 5-amino-6-d-ribitylaminouracil this reacts non-enzymatically with metabolites to form short-lived antigens that are captured and stabilized by MR1 for presentation to MAIT cells. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases Etienne Meunier Mathias S. Dick Roland F. Dreier Nura Schürmann Daniela Kenzelmann Broz et al. Interferon-inducible GTPases are required for the release of vacuolar Gram-negative bacteria into the cytoplasm and subsequent inflammasome-mediated caspase-11 activation. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq Barbara Treutlein Doug G. Brownfield Angela R. Wu Norma F. Neff Gary L. Mantalas et al. Single-cell transcriptome analysis enables the direct measurement of cell types and lineage hierarchies of the developing distal lung epithelium and identifies a population of bipotential alveolar progenitor cells. Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant Nicholas D. Bonawitz Jeong Im Kim Yuki Tobimatsu Peter N. Ciesielski Nickolas A. Anderson et al. Disruption of lignin biosynthesis has been proposed as a way to improve forage and bioenergy crops but it can result in stunted growth and developmental abnormalities here the undesirable features of one such manipulation are shown to depend on the transcriptional co-regulatory complex Mediator. Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 Abdul Ghafoor Khan Jillian Whidby Matthew T. Miller Hannah Scarborough Alexandra V. Zatorski et al. The crystal structure of the core domain of the hepatitis C virus surface glycoprotein E2 has been solved the structure shows that contrary to expectation E2 is unlikely to be the viral fusion protein. A semi-synthetic organism with an expanded genetic alphabet Denis A. Malyshev Kirandeep Dhami Thomas Lavergne Tingjian Chen Nan Dai et al. Triphosphates of hydrophobic nucleotides d5SICS and dNaM are imported into Escherichia coli by an exogenous algal nucleotide triphosphate transporter and then used by an endogenous polymerase to replicate and faithfully maintain over many generations of growth a plasmid containing the d5SICS dNaM unnatural base pair. See also News & Views by Thyer & Ellefson gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042572

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 514 No. 7522 Oktober 2014 The university Experiment‎

‎NPG Nature publishing group. Hardcover. Gut. 273 Universities challenged The face of higher education is changingat a rapid rate 287 The university experiment Evolution is the name of the game if the campus is to survive 288 Campus as laboratory Universities around the world are finding fresh ways to teach and organize research 292 The research rethink Arizona State University tries to Break down entrenched walls between disciplines COMMENT 295 Chinese university reform in three steps Jie Zhang The way to build a world-class Institution is to value and reward the faculty members 297 Companies on campus Jana J Watson-Capps & Thomas R Cech There are mutual benefits to be gained from having industry labs in an academic setting THIS WEEK EDITORIALS 273 PUBLIC ENGAGEMENT Dust to dust Lessons need to be learned from the media circus around gravitational waves 274 PUBLISHING Review rewards Welcome recognition for science publishing s unsung heroes 115 How terror-proof is your economy Erwann Michel-Kerjan Make use of scientific skills to analyse the threats posed to finance RESEARCH HIGHLIGHTS 276 SELECTIONS FROM THE = SCIENTIFIC LITERATURE Colour-coordinated nests / Plant-derived anticlotting agent / Alzheimer s mode / SCID gene therapy / Nobel guesswork/ Bionic limb control .SEVEN DAYS THE NEWS IN BRIEF Ebola s economic Impact/ Ancient Greek treasures / Climate change as security risk / Research vessel sinks / Record high for sea ice NEWS IN FOCUS 281 STEM CELLS Reprogrammed cells oller diabetes hope and immunity challenge 282 GENOMICS Mass merger of genome data creates analytical powerhouse 283 MARINE LIFE Researchers struggle to arrest decline in African penguins 284 INFECTIOUS DISEASE Ebola outbreak quantified 285 NOBEL PRIZE Optics pioneers scoop chemistry prize for revealing inner lives of cells 395 MOLECULAR BIOLOGY Genetic touch-ups The development of CRISPR Cas and similar techniques means that anybody with basic molecular-biology skills can be a gene editor 299 INFECTIOUS DISEASE Ebola: learn from the past David L Heymann Previous outbreaks hold the key to quelling the current crisis in West Africa BOOKS & ARTS 302 ORIGIN OF LIFE The first spark David Deamer 303 BOOKS IN BRIEF 304 POLITICS When Hodgkin met Thatcher Jessa Gamble CORRESPONDENCE 305 Pakistan s response to disaster / The Internets energy consumption / Threats to wales and dolphins / Waugh on badgers / Sanctions hit wildlife NEW ONLINE 307 Papers published this weekat nature.com NEWS & VIEWS 308 EVOLUTIONARY BIOLOGY Survival of the fittest group Group-level selection drives adaptation in social spiders Timothy Linksvayer SEE LETTER R359 309 CANCER Staying together an the road to metastasis Circulatingtumour-cell Clusters have high metastatic potential Alessia Bottos & Nancy E Hynes 310 ASTROPHYSICS How tiny galaxies form stars Inefficient star formation in two small faint galaxies Bruce Elmegreen SEE LETTER R335 312 CANCER The origin of human retinoblastoma A childhood eye cancer arises in differentiating cone-cell precursors Rod Bremner & Julien Sage SEE LETTER P.385 313 SOLID-STATE PHYSICS A historic experiment redesigned Detection of Rydberg excitons in a natura crystal of copper oxide Sven Höfling & Alexey Kavokin SEE LETTER P.343 314 GENOMICS Of monarchs and migration The DNA sequences of 101 monarch butterflies Richard H ffrench-Constant SEE ARTICLE R317 ARTICLES 317 POPULATION GENETICS The genetics of monarch butterfly migration and warning colouration S Zhan et al. SEE N&V R314 322 STEM CELLS Clonal dynamics of native haematopoiesis J Sun et al. 328 NEUROSCIENCE Structural mechanism of glutamate receptor activation and desensitization J R Meyerson et al. LETTERS 335 ASTROPHYSICS Inefficient star formation in extremely metal poor galaxies Y Shi et al. SEE N&V R310 339 ASTROPHYSICS Binary orbits as the driver of y-ray emission and mass ejection in classical novae L Chomiuk et al. 343 SOLID-STATE PHYSICS Giant Rydberg excitons in the copper oxide Cu20 T Kazimierczuk D Fröhlich S Scheel H Stolz & M Bayer SEE N&V R313 348 ELECTROCHEMISTRY Lithium-antimonylead liquid metal battery for grid-level energy storage K Wang et al. 351 ATMOSPHERIC CHEMISTRY High winter ozone pollution from carbonyl photolysis in an oil and gas basin P M Edwards et al. 355 GEOCHEMISTRY Helium and Iead isotopes reveal the geochemical geometry of the Samoan plume M G Jackson et al. 359 EVOLUTION Site-specific group selection drives locally adapted group compositions J N Pruitt & CJ Goodnight SEE N&V R308 363 EVOLUTION Hallucigenia s onychophoran-like claws and the case for Tactopoda M R Smith &J Ortega-Hernandez 367 PLANT SCIENCE OSCA1 mediates osmotic-stress-evoked Ca increases vital for osmosensing in Arabidopsis F Yuan et al. 372 IMMUNOLOGY Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5 -diphosphates D Goubau et al. 376 CELL BIOLOGY Stochasticity of metabolism and growth at the single-cell level DJ Kiviet et al. 390 CANCER CRISPR-mediated direct mutation of cancer genes in the mouse liver WXue et al. 385 CANCER Rb suppresses human cone-precursor-derived retinoblastoma tumours X L Xu et al. SEE N&V P.312 389 IMMUNOLOGY Noncoding RNA transcription targets AID to divergently transcribed loci in B cells E Pefanis et al. 394 CORRIGENDUM Three keys to the radiation of angiosperms into freezing environments A EZanne et al. 394 CORRIGENDUM A microbial ecosystem beneath the West Antarctic ice sheet B C Christner et al. 394 CORRIGENDUM Connectomic reconstruction of the inner plexiform layer in the mouse retina M Helmstaedter et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042456

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎3/1998‎

‎Hardcover. Gut. Vorwort 3 Landwirtschaft und Umwelt Mist lagert sicher auf Bentonit 4 Mistkompost - die edelste Form des Wirtschaftsdüngers 8 Bodenbewirtschaftung ohne Pflug 10 Pfälzer und Württemberger Ökogemüse erfolgreich im Großhandel 12 Bericht zum 2. Feldtag Ökologischer Gemüsebau in Sachsen 14 Beiträge zum bäuerlichen Obstbau 16 Sonderteil - Zehn Jahre Gäa - Entwicklung eines Öko-Landbauverbandes in Ostdeutschland Teil 1 19 Vorreiter im ostdeutschen Ökolandbau - Ökozentrum Werratal in Vachdorf Thüringen 20 Drunter und Drüber Aktuelle Informationen aus der Biobranche 23 Nachrichten aus den Landesverbänden 26 Buchempfehlung 27 Veranstaltungskalender 28 Anzeigen 30 gutes Exemplar ordentlich hardcover‎

书商的参考编号 : B00053197

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎2/1996‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Aktionswoche Ökologische Mensa 4 Studenten befürworten Ökoprodukte in der Mensa - Auswertung einer Mensaumfrage an der TU Dresden 5 Was ist eigentlich mit dem HANSA KEKS 6 Absatzchancen für Sachsens Ökofleisch 7 Kosten und Preise der Fleischerzeugung 12 Landwirtschaft und Umwelt Bericht über eine Exkursion zum ökologischen Landbau nach Brandenburg 14 Warum machen wir unser Gemüsesaatgut nicht selbst 15 Humusersatzwirtschaft im ökologischen Landbau 16 Extraktionsschrote in der Tierfütterung :weiterhin tabu im kontrolliert ökologischen Landbau 18 Bericht vom Feldtag Ökologischer Landbau in Bernburg 21 Gentechnische Freilandversuche in der Oberlausitz 21 Die Stellung des Ökologischen Landbaus zum Umgang mit Genresourcen 22 Drunter und Drüber AGÖL beschließ einheitliches Ökoprüfsiegel 23 Buchbesprechung zu den Themen Verpackung / Preise - Arbeitsbericht ZMP 96 23 Buchbesprechung zu den Themen Obstbau / Gründüngung / 24 FÖJ - eine Riesenchance für junge Leute 25 Ökologischer Landbau neuer Ausbildungsschwerpunkt an der Fachschule in Stadtroda /Thüringen 27 Kleinanzeigen 27 Veranstaltungskalender 28 Gäa -Werbemittel und Verpackungen Hintere Umschlagseite gutes Exemplar ordentlich hardcover‎

书商的参考编号 : B00053196

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎4/1996‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Verbraucherkenntnisse zu Produktionsverfahren in der Landwirtschaft 4 Eine - Ökokarawane zieht durch Sachsen oder was Ökoprodukte und Kamele gemeinsam haben 5 Das N in und am Naturkostladen - Imageverbesserung für Bioläden durch Profilierung 7 Ãœberreichung der Zertifikate zum Sächs. Ökoprüfsiegel auf der Sachsenback 96 8 Ein Weg zur Direktvermarktung von Fleisch 9 Landwirtschaft und Umwelt Schweinehaltung auf Ökobetrieben - eine lohnende Alternative 10 Gelbe Süßlupine als Eiweißkomponente in der Schweinefütterung 12 Ökologische Pflanzkartoffeln - in Zukunft auch aus Sachsen 14 Möhrenanbau in Dammkultur - Bericht vom Gäa Seminar Feldgemüse in Meißen / Sachsen 16 Fa. REUDINK ein Hersteller biologischer Futtermittel stellt sich vor 18 Drunter und Drüber Ausbildungs-und Arbeitsplätze im Verkauf ökol. Lebensmittel bei den Hermannsdorfer Landwerkstätten 19 Urlaub auf Biohöfen - Reiseführer 1997 wird neu zusammengestellt ! Neuaufnahmen möglich ! 19 Veranstaltungskalender 20 Buchempfehlung / Nutzhanf - vom konventionellen zum ökologischen Anbau 21 Kleinanzeigen 22 gutes Exemplar ordentlich hardcover‎

书商的参考编号 : B00053191

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No. 7498 Mai 2014 Checks and Balances‎

‎NPG Nature publishing group. Hardcover. Gut. Agriculture: Engage farmers in research A new wave of small-scale agricultural innovation will boost yields and protect the planet contend Tom MacMillan and Tim G. Benton. Policy: Regulate embryos made for research As technical barriers fall the United States should adapt existing measures to govern the generation of human embryos for research says Insoo Hyun. Science biography: A voyage round Newton Mordechai Feingold savours a study on how the fitful release of the scientist s papers shaped his reputation. Review of The Newton Papers: The Strange and True Odyssey of Isaac Newton s Manuscripts Sarah Dry Space policy: A clearer final frontier David Southwood finds that a study on safeguarding space is shorter on cooperation than conflict. Review of Crowded Orbits: Conflict and Cooperation in Space James Clay Moltz Ecology: Drought in the Congo Basin Jeffrey Q. Chambers & Dar A. Roberts See also Letter by Zhou et al. Applied physics: Bright electron twisters Jun Yuan Neuroscience: Feedback throttled down for smooth moves Stephen H. Scott & Frédéric Crevecoeur See also Article by Fink et al. Geophysics: Making the Earth move Rob L. Evans See also Letter by Sifré et al. 50 & 100 Years Ago Astronomy: A new spin on exoplanets Travis Barman See also Letter by Snellen et al. Articles Top Presynaptic inhibition of spinal sensory feedback ensures smooth movement Andrew J. P. Fink Katherine R. Croce Z. Josh Huang L. F. Abbott Thomas M. Jessell et al. A population of spinal interneurons that form axo axonic connections with the terminals of proprioceptive afferents are shown to mediate presynaptic inhibition their ablation elicits harmonic oscillations during goal-directed forelimb movements which can be modelled as the consequence of an increase in sensory feedback gain. See also News & Views by Scott & Crevecoeur Haematopoietic stem cells require a highly regulated protein synthesis rate Robert A. J. Signer Jeffrey A. Magee Adrian Salic & Sean J. Morrison Haematopoietic stem cells HSCs have a lower rate of protein synthesis in vivo than most other haematopoietic cells and both increases and decreases in the rate of protein synthesis impair HSC function demonstrating that HSC maintenance and hence cellular homeostasis requires the rate of protein synthesis to be highly regulated. Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Nicole A. Doria-Rose Chaim A. Schramm Jason Gorman Penny L. Moore Jinal N. Bhiman et al. A longitudinal study of an individual patient developing neutralizing antibodies against HIV-1 targeting the V1V2 region of gp120 reveals how such neutralizing antibodies develop and evolve over time providing important insights relevant to vaccine development. Letters Top Fast spin of the young extrasolar planet Pictoris b Ignas A. G. Snellen Bernhard R. Brandl Remco J. de Kok Matteo Brogi Jayne Birkby et al. Near-infrared spectroscopic observations of the young extrasolar planet Pictoris b indicate that it spins significantly faster than any planet in the Solar System in line with the extrapolation of the known trend in spin velocity with planet mass. See also News & Views by Barman Molecular photons interfaced with alkali atoms Petr Siyushev Guilherme Stein Jörg Wrachtrup & Ilja Gerhardt Single organic dye molecules have high-flux narrow-bandwidth single-photon emission and can be spectrally matched to the transitions of atoms acting as a quantum memory making them promising for use in quantum information and communication schemes. Spontaneous transfer of chirality in an atropisomerically enriched two-axis system Kimberly T. Barrett Anthony J. Metrano Paul R. Rablen & Scott J. Miller An enantioselective reaction involving a molecule with two axes of stereochemical consequence produces four stereoisomers and rather than racemizing as the system approaches equilibrium one of the diastereomeric pairs drifts spontaneously to a higher enantiomeric ratio. North Atlantic forcing of tropical Indian Ocean climate Mahyar Mohtadi Matthias Prange Delia W. Oppo Ricardo De Pol-Holz Ute Merkel et al. New sea surface temperature and oxygen isotope records combined with climate modelling experiments show that slowdowns of the Atlantic meridional overturning circulation during Heinrich stadials and the Younger Dryas stadial affected the tropical Indian Ocean hydroclimate through changes to the Hadley circulation. Electrical conductivity during incipient melting in the oceanic low-velocity zone David Sifré Emmanuel Gardés Malcolm Massuyeau Leila Hashim Saswata Hier-Majumder et al. Determination of the electrical conductivity of carbon-dioxide- and water-rich melts which are typically produced at the onset of mantle melting shows that incipient melts can trigger the high electrical conductivities found in oceanic regions of the asthenosphere. See also News & Views by Evans Widespread decline of Congo rainforest greenness in the past decade Liming Zhou Yuhong Tian Ranga B. Myneni Philippe Ciais Sassan Saatchi et al. The long-term drying trend in central African rainforests might help to explain satellite-detected large-scale vegetation browning in the Congolese forests. See also News & Views by Chambers & Roberts Identification of genomic alterations in oesophageal squamous cell cancer Yongmei Song Lin Li Yunwei Ou Zhibo Gao Enmin Li et al. Using whole-genome and whole-exome sequencing this study identifies eight significantly mutated genes in oesophageal squamous cell cancer including two genes ADAM29 and FAM135B not previously associated with this cancer type. Cystathionine -lyase deficiency mediates neurodegeneration in Huntington s disease Bindu D. Paul Juan I. Sbodio Risheng Xu M. Scott Vandiver Jiyoung Y. Cha et al. Cystathionine -lyase which is responsible for the production of cysteine is decreased in the striatum and cortex of mouse models of Huntington s disease and in patients with Huntington s disease and cysteine supplementation in diet and drinking water partly rescues the phenotype and the diminished longevity of the mouse model. Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos Eunju Kang Guangming Wu Hong Ma Ying Li Rebecca Tippner-Hedges et al. Reprogramming after somatic cell nuclear transfer had been thought to be dependent on the recipient cytoplasm being arrested at the metaphase stage but here interphase two-cell mouse embryos are shown to support successful reprogramming and generation of embryonic stem cells or cloned mice. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy Joseph D. Mancias Xiaoxu Wang Steven P. Gygi J. Wade Harper & Alec C. Kimmelman Through a quantitative proteomics analysis a cohort of proteins is identified that associate with autophagosomes among them a new cargo receptor called NCOA4 that in response to iron deprivation targets ferritin to autophagosomes and thereby releases iron. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I Alys Peisley Bin Wu Hui Xu Zhijian J. Chen & Sun Hur RIG-I protein recognizes viral duplex RNA with a 5 -triphosphate group activating innate immune responses a crystal structure of its tetrameric CARD signalling domain reveals that non-covalently linked ubiquitin chains stabilize the tetramer in a lock-washer structure that serves as a signalling platform for the recruitment and activation of MAVS. Structure of the human P2Y12 receptor in complex with an antithrombotic drug Kaihua Zhang Jin Zhang Zhan-Guo Gao Dandan Zhang Lan Zhu et al. The X-ray crystal structure of the human P2Y12 receptor which regulates platelet activation and thrombus formation is solved in complex with an antithrombotic drug providing insights for the development of new drugs. Agonist-bound structure of the human P2Y12 receptor Jin Zhang Kaihua Zhang Zhan-Guo Gao Silvia Paoletta Dandan Zhang et al. An X-ray structure of human P2Y12 receptor a clinical drug target for platelet aggregation inhibitors is presented in complex with an agonist providing insight into the -group of class A G-protein-coupled receptors. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042567

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 505 No. 7483 Januar 2014 Flight Plan‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 261 PRIVACY Power to the people UK plans for a centralized health database will be beneficial but they require clarity in communication 261 CLIMATE CHARGE Cool heads needed Freakish cold weather does not undermine the case for global warming 262 ANIMAL BEHAVIOUR V is for von Birds in flight Show the power of the obvious answer WORLD VIEW 263 Physiological data must remain confidential Stephen Fairclough Electronic monitors can now follow our every move and thought so we must fight for our privacy RESEARCH HIGHLIGHTS 264 SELECTIONS FROM THE SCIENTIFIC LITERATURE Hot lubricant research / Light arms for star fish / A handle on active RNA / The trilobite has landed / Penguins catch a wave / Sea level see-saws SEVEN DAYS 266 THE NEWS IN BRIEF Space station gets mission extension / Explosion atJapanese chemical plant/ Novartis under attack over blood-pressure drug / Hubble snaps deepest galaxy cluster 269 SPACE Tension rides high as comet craft prepares to switch on 270 ANTARCTIC EXPLORATION Questions raised over scientific value of private expeditions 272 RESEARCH COMMUNITY Biorepositories make their mark 273 METRDLOGY Physicists rally to redefine the ampere 274 ASTROPHYSICS Kepler data rewrite origins of supernovae FEATURES 2BO ASTROPHYSICS The heart of darkness Unravelling the mysteries of cl InarnInccilfiz Hark hnIcc 2B3 SUSTAINABLE ECONOMICS Time to leave GDP behind Robert Costanza et al. The current measure of national success neglects ecology psychology and much eise 2B6 PUBLIC HEALTH The FDA is overcautious on consumer genomics Robert C Green & Nita A Farahany Evidence that gene testing doesn t cause distress or risky acts 2BB DEVELOPMENT Liquid assets Margaret Catley-Carlson 289 BOOKS IN BRIEF CORRESPONDENCE 291 Science secondary to tourism in polar cruise / Fault lines in China s university system / Outmoded graut applications need upgrade / Unavoidable sex bias 443 DISEASE RESEARCH Rare insights Working on neglected diseases can be a rewarding experience 445 CAREER BRIEFS 437 HIGH-SECURITY LABS Life in the danger zone Designing equipment for use in a biological containment facility calls for new ways of thinking NEW ONLINE 293 Papers published this week at natu re.com NEWS & VIEWS 294 EARTH SCIENCE River incision revisited The observation timescale affects measurements of bedrock river incision Roman A DiBiase SEE LETTER R391 295 BIR D FLICHT Fly with a little flap from your frienc Ibises spatially synchronize their wing movements during formation flight Florian T Muijres & Michael H Dickinsor SEE LETTER P.399 296 ASTROPHYSICS Black hole found orbiting a fast rotator Discovery of a quiescent stellar-mass black hole around a Be star M Virginia McSwain SEE LETTER P.378 299 PLANT SCIENCE Fairy chemicals Plants produce the growth stimulant associated with fairy rings Andrew Mitchinson 29B MOLECULAR BIOLOGY The tug of DNA repair RNA polymerase can be pulled backwards from DNA lesions Irina Artsimovitch SEE ARTICLE P.372 ARTICLES 361 NEUROSCIENCE CNVs conferring risk of autism or schizophrenia affect cognition in controls H Stefansson et al. 367 CELL BIOLOGY Biochemical reconstitution of topological DNA binding by the cohesin ring Y Murayama & F Uhlmann 372 MOLECULAR BIOLOGY UvrD facilitates DNA repair by pulling RNA polymerase backwards V Epshtein et al. SEE N&V R298 LETTERS 378 ASTROPHYSICS A Be-type star with a black-hole companion J Casares et al. SEE N&V R296 Northern bald ibises in V formation during a human-led migratory flight. Birds in the `V phase their wing-beats to path-match allowing a trailing bird to exploit aerodynamic upwash from the bird in frönt. A bi rd flying directly behind flaps with opposite phasing in order to minimize the detrimentaL downwash from the leader s wings. - PAGES 295 & 399 reMP 382 MATERIALS SCIENCE Nanoparticle solutions as adhesives for gels and biological tissues S Rose et al. 386 CHEMISTRY Asymmetric Synthesis from terminal alkenes by cascades of diboration and cross-coupling S N Mlynarski C H Schuster &J P Morken 391 EARTH SCIENCE A signature of transience in bedrock river incision rates over timescales of 104-10 years NJ Finnegan R Schumer &S Finnegan SEE N&V R294 395 ECOLOGY Amazon River carbon dioxide outgassing fuelled by wetlands G Abril et al. 399 BIRD FLICHT Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight S J Portugal et al. SEE N&V R295 403 HUMAN EVOLUTION A mitochondrial genome sequence of a hominin from Sima de los Huesos M Meyer et al. 407 NEUROSCIENCE Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period C Whiteus C Freitas &J Grutzendler 4I2 IMMUNOLOGY Muc5b is required for 2 airway defence M G Roy et al. 417 PLANT SCIENCES Cytokinin signalling inhibitory fields provide robustness to phyllotaxis F Besnard et al. 422 BIOCHEMISTRY Chasing acyl carrier protein through a catalytic cycle of lipid A production A Masoudi C R H Raetz P Zhou & C W Pemble IV 427 BIOCHEMISTRY Trapping the dynamic acyl carrier protein in fatty acid biosynthesis C Nguyen et al. 432 STRUCTURAL BIOLOGY Icosahedral bacteriophage DX174 forms a tail for DNA transport during infection L Sun et al. 436 CORRIGENDUM A Jurassic mammaliaform and the earliest mammalian evolutionary adaptations C-F Zhou S Wu T Martin & Z-X Luo 436 ERRATUM Reducing the contact time of a bouncing drop J C Bird R Dhiman H-M Kwon & K K Varanasi A nanoparticle solution that can achieve the tricky task of gluing swollen gels together. PAGE 382 NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042470

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 505 No. 7482 Januar 2014 Life in the slow Lane‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 131 DRUG DEVELOPMENT Data sharing will pay dividends The pharmaceutical industry needs to stay on track over transparency 131 VIOLENCE Risk management Threat assessments can help protect employees at their place of work 132 WAR Conflict of interest Science can have a mutually beneficial relationship with war WORLD VIEW 133 This was no Antarctic pleasure cruise Chris Turney There was a clear scientific Basis for polar expedition RESEARCH HIGHLIGHTS 134 SELECTIONS FROM THE SCIENTIFIC LITERATURE In vivo glia-to-neuron switch / Handy graphene / Dietary fibre link to asthma / Chemotherapy-provoked resistance / Sinkhole prediction SEVEN DAYS 136 THE NEWS IN BRIEF Cannabis goes on sale in Colorado / China joins ivory-crushing campaign / Alan Turing gets royal pardon /Asteroid followed from space to landfall 249 EQUALITY Standing out There s plenty of advice for LGBT scientists contemplating a career in research if you know where to look 251 TURNING POINT Huffington Post blogger Eleni Antoniadou sees artificial skin as an immediate goal in tissue engineeririg 139 REGENERATIVE MEDICINE Leaked documents reinforce doubts over Italian foundation s stem-cell treatments 141 PUBLISHING Open-access library for physics starts up with reduced capacity 142 PHARMACEUTICALS World Health Organization s bid to tackte orphan diseases draws fire 143 EARTH SCIENCE Mini-satellites provide near real-time images of Earth 144 RESEARCH FUNDING China overtakes Europe in percentage spend on R&D FEATURES 146 COMPUTER SCIENCE The learning machines By sifting through massive amounts of data computers are edging towards artificial intelligence BOOKS & ARTS 156 MILITARY SCIENCE The evolving science of war Sharon Weinberger 157 PSYCHOLOGY Feeling the fear David Adam 15B ORNITHOLOGY Under their wing Ben Sheldon Tinnitus tunesmith Non-sufferers can learn from Daniel Fishkin s series of installations Composing the Tinnitus Suites CORRESPONDENCE 16O Towards effective general ecosystem models / Self-referential citation should not count / Himalayan network needs support / Pollinator decline estimated NEW ONLINE 161 Papers published this week at nature.con NEWS & VIEWS I62 FORUM: DEVELOPMENTAL BIOLOGY Tethered wings Drosophila wings develop even when Wingless protein cannot spread Gines Morata Gary Struhl SEE ARTICLE P.180 163 ELECTROCHEMISTRY Metal-free energy storage A non-metallic electroactive material for flow batteries Grigorii L Soloveichik SEE LETTER R195 I65 THERAPEUTlCS Detective work on drug dosage A device that tracks drug levels in blood in real time Richard M Crooks I66 QUANTUM PHYSICS An atomic SQUID An analogue of a superconducting device based on ultracold atoms Charles A Sackett 167 HIV Ringside views Binding of Vif or Vpx mediates ubiquitination of restriction factors Michael H Malim SEE LETTERS P.229 & R234 ARTICLES 169 AGEING Diversity of ageing across the tree of life n Face-to-face transfeelSr4 device-ready graphite sheets PAGE 190 174 GENOMICS Elephant shark genome provides unique insights into gnathostome evolution B Venkatesh et al. 18O DEVELOPMENTAL BIOLOGY Patterning and growth control by membranetethered Wingless C Alexandre A Baena-Lopez &J-P Vincent SEE N&V R162 LETTERS I86 ASTROPHYSICS The rarity of dust in metal-poor galaxies D B Fisher et al. I9O MATERIALS Face-to-face transfer of wafer-scale graphene films L Gao et al. 195 ELECTROCHEMISTRY A metal-free organic-inorganic aqueous flow battery B Huskinson et al. SEE N&V P. 163 199 CHEMISTRY Merging allylic carbonhydrogen and selective carboncarbon Bond activation A Masarwa et al. 2O4 OCEANOGRAPHY Primitive layered gabbros from fast-spreading lower oceanic crust K M Gillis et al. 2OB GENETICS The effects of genetic variation on gene expression dynamics during development M Francesconi & B Lehner 2 212 CANCER HMGA2 functions as a competing endogenous RNA to promote lung cancer progression MS Kumar et al. . 0 21B IMMUNOLOGY Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids CJ Cambier et al. 223 NEUROSCIENCE Transcranial amelioration of inflammation and cell death alter brain injury T L Roth et al. 229 STRUCTURAL BIOLOGY Structural basis for hijacking CBF-13 and CUL5 E3 ligase complex by HIV-1 Vif YGuo et al. SEE N&V P.167 234 STUCTURAL BIOLOGY Structural basis of lentiviral subversion of a cellular protein degradation pathway D Schwefel et al. SEE N&V R167 239 BIOTECHNOLOGY Efficient ethanol production from brown macroalgae sugars by a synthetic yeast platform M Enquist-Newman et al. 244 STRUCTURAL BIOLOGY De novo protein crystal structure determination from X-ray free-electron laser data T R M Barends et al. 248 CORRIGENDUM The zebrafish reference genome sequence and its relationship to the human genome K Howe et al. Dust buster Local observations suggest distant galaxies are not so dusty. PAGE186 Analysis of the genome of the elephant shark a native of temperate waters off southern Australia and New Zealand Shows it to be the slowest evolving vertebrate known coelacanth included. lt has an unusual adaptive immune system and lacks genes for calcium-binding phosphoproteins in line with the absence of bone - in catlaginous 40 fish. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042469

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎3/1997‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Sächsisches Ökogemüse im Supermarkt 4 ZMP erfaßt Ökopreise für Milch Fleisch u. Eier 5 Landwirtschaft und Umwelt Gemüseerbsen und -bohnen seit 3 Jahren sehr gefragt 5 Stickstoffdüngung im ökologischen Gemüsebau 8 Berichte zur Gemüseexkursion nach NRW u. Holland Teil 2 11 Erfahrungen im Möhrenanbau Hinweise zum ökologischen Zwiebelanbau 14 Bericht zum Feldtag ökologischer Gemüseanbau in Sachsen 16 Beratung zum Nützlingseinasatz im Gartenbau 18 Wie kann der erhöhten Nachfrage nach Öko-emüse im Mai/Juni besser nachgekommen werden 18 Der Kräuter und Blumengarten in der landwirtschaftlichen Individualität Teil 1 20 Gärtnerbriefe aus Brandenburg 22 Ökokartoffeltag in Podemus/Sachsen 23 Erfahrungen beim Aufbau des Ökogeflügelhofes in Eskildsen in Deersheim / Sachsen Anhalt 23 Auszeichnung für artgerechte Legehennenhaltung geht an Stadtgut Görlitz 24 Drunter und Drüber Neuer Projektleiter für Sächsisches Ökoprüfsiegel 25 Förderung für Ökobetriebe in Brandenburg ab 1998 gestrichen 26 Buchempfehlung 27 Veranstaltungskalender 28 Kleinanzeigen 29 gutes Exemplar ordentlich hardcover‎

书商的参考编号 : B00053195

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 506 No. 7498 Februar 2014 Dropletons‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 4O7 ANIMAL RESEARCH Fish have Feelings too Scientists have an obligation to limit suffering for all lab animals 4O7 COLLABORATIVE RESEARCH Parallel lines Crowd-sourcing adds up to a success for maths that offers lessons for other disciplines 4O8 SPACE FLICHT Virgin territory Richard Branson s space-plane shows the power of optimism WORLD VIEW 4O9 Scientist-versus-activist debates mislead the public Simon L Lewis Science and policy are separate parts of the global-warmig debate RESEARCH HIGHLIGHTS 41O SELECTIONS FROM THE SCIENTIFIC LITERATURE Healing proteins / Why did the bear cross the road / Muscle materials / Early plate tectonics / Brain cell - renewal SEVEN DAYS 4I2 THE NEWS IN BRIEF Leak at US nuclear waste plant / Actavis buys Forest Laboratories / Europe backs planet-hunting mission / Deforestation atlas launches 517 COMPUTER SCIENCE Hacking into the underworld The arms-race nature of cybersecurity means there should be opportunities in the field for years to come 519 CAREER BRIEFS 415 VIROLOGY Bird influenza strain threatens to spread from China to Vietnam 416 NEUROSCIENCE Macaques oller glimpse of neurons that drive cooperative behaviour . 417 ASTRONOMY Säo Paulo prepares to join giant telescope project 418 COSMOLOGY Manuscript reveals Einstein s dalliance with a steady-state Universe 419 ANIMAL RESEARCH Questions raised over method of dispatch for zebrafish 420 ASTRONOMY Airborne telescope edges towards full capability Online collaborations oller mathematics a significant boost PAGE 422 424 SCIENCE IN COURT Disease detectives Microbial family trees are finding their wav into the courtroom as evidence 427 EARTH SCIENCE Crystallography s journey to the deep Earth Thomas Duffy lmproved mineral analysis is opening fresh vistas an the heart of the planet BOOKS & ARTS 43O VIROLOGY Vanquishing HIV Sharon Lewin 431 PHYSICS Inside utter strangeness David Seery 432 ABTS Eclipse of power Jay M Pasachoff & Naomi Pasachoff 433 Il&A Melodic psychologist Variations and improvization can hit the emotional Spot says music psychologist John Sloboda CORRESPONDENCE 434 Raising funds in Brazil / Stem-cell therapy that should stop / Education for developing countries NEW ONLINE 435 Papers published this week at nature.com NEWS & VIEWS 436 TUBERCULOSIS Drug discovery goes au nature! Semisynthetic spectinomycin derivatives with antitubercular activity Clifton E Bany 437 APPLIED PHYSICS Optical trapping for space mirrors An optically bound structure of microscopic particles David McGloin 438 CANCER Tumours outside the mutation box Two ependymoma subtypes show no recurrent gene mutations Rogier Versteeg SEE ARTICLES P.445 & P.451 44O CONSERVATION Wind blown Effects of habitat corridors an seed dispersal Andrew Mitchinson 44O FUNDAMENTAL CONSTANTS The teamwork of precision A new measurement of the atomic mass of the electron Edmund G Myers SEE LETTER R467 44I CELL BIOLOGY Stressful genetics in Crohn s disease Caspase 3 cleaves a risk variant of the autophagy protein ATG16L1 Arthur Kaser & Richard S Blumberg SEE ARTICLE R456 442 ATMOSPHERIC SCIENCE Involatile particles from rapid oxidation Direct production of highly oxygenated compounds from biogenic emissions Gordon McFiggans SEE LETTER R476 ARTICLES 445 CANCER Epigenomic alterations define lethal CIMP-positive ependymomas of infancy S C Mack et al. SEE N&V R438 451 CANCER Cllorf95-RELA fusions drive oncogenic NF-KB signalling in ependymoma M Parker et al. SEE N&V P.438 Dropletons New quasiparticles are rare but here s one. The cover illustrates the paircorrelation function gr of quantum droplets or dropletons. The central peak of the function Shows that the electrons and holes that form dropleton are likely to be co-located and ripples show that otherwise they form regularly spaced shells. 456 CELL BIOLOGY A Crohn s disease variant in Atg1611 enhances its degradation by caspase 3 A Murthy et al. SEE N&V P.441 LETTERS 463 COSMOLOGY A single low-energy iron-poor supernova as the source of metals in the star SMSS J031300.36670839.3 S C Keller et al. 467 PARTICLE PHYSICS High-precision measurement of the atomic mass of the electron S Sturm et al. SEE N&V R440 471 QUANTUM OPTICS Quantum droplets of electrons and holes A E Almand-Hunter et al. 476 ATMOSPHERIC SCIENCE A large source of low-volatility secondary organic aerosol M Ehn et al. SEE N&V R442 48O GEOCHEMISTRY Rapid remobilization of magmatic crystals kept in cold storage K M Cooper & AJ R Kent 4B4 PALAEONTOLOGY Skin pigmentation provides evidence of convergent melanism in extinct marine reptiles J Lindgren et al. 4B9 MICROBIOLOGY Sequential evolution of bacterial morphology by co-option of a developmental regulator CJiang P J 8 Brown A Ducret & Y V Brun 13:1 494 GENE EXPRESSION Genetics of single- 0 cell protein abundance variation in large yeast populations F W Albert S Treusch A H Shockley J S Bloom & L Kruglyak 498 NUTRITION A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes J Larsbrink et al. 5O3 IMMUNDLOGY Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity K Westphalen et al. 5O7 MICROBIOLOGY A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis G W Liechti et al. 511 STEM CELLS Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity T-H Kim et al. 516 RETRACTION The NAD-dependent deacetylase SIRT2 is required for programmed necrosis N Narayan et al. 516 ERRATUM Asymmetric Synthesis from terminal alkenes by cascades of diboration and cross-coupling S N Mlynarski C H Schuster &J P Morken 5I6 AODENDUM Enterotypes of the human gut microbiome M Arumugam et al. Melanin traces in fossilized skin are adding convincing colours to our picture of extinct animals. PAGE 484 NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042468

‎Journal fur Schulentwicklung‎

‎4/2015 Transfer von Innovationen‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Heftherausgeber: Hans-Günter Rolf er Michael Schratz Transfer von Innovationen Editorial 4 Hans-Günter Rolff Transfer - Skizze eines theoretischen Bezugsrahmens 7 Nils van Holt er Veronika Manitius Unterstützung von Transfer durch Change Agents 17 Mario Roland Johannes Schnurr er Nicole Kummer Lernumgebungen gestalten. Arbeitsfelder und Angebote der Transferagentur Kommunales Bildungsmanagement Nordrhein-Westfalen 22 Annemarie Kummer Wyss & Hans Roth Transferprozesse bei schulinternen Weiterbildungen anregen 31 Angelika Fiedler Cornelia von Ilsemann er Nils Kleemann Transfer von Innovation in einem Netzwerk: der Schulverbund Blick über den Zaun 37 Louise Stoll Enhancing teaching and learning through enquiry-based collaborative R&D 45 Armin Lohmann Erkenntnisse aus Bildungsregionen - Transfer in Regionale Netzwerke 53 Methodenatelier Christoph Hofbauer & Tanja Westfall-Greiter Der School Walkthrough als Transferinstrument 61 gutes Exemplar ordentlich StudienVerlag hardcover‎

书商的参考编号 : B00051034

‎Journal fur Schulentwicklung‎

‎3/2012 Schulentwicklung was wirkt‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Uwe Hameeer er Peter Daschner Schulentwicklung - Was wirkt Editorial 4 Martin Hartmann Die Hattie-Studie auf dem Prüfstand - Resonanzen Ergebnisse kritische Perspektiven 7 Jürgen Wiechmann Unterrichtsqualität - Was wissen wir heute über wirksamen Unterricht 15 Stephan Gerhard Huber Schulische Führung und ihre Wirksamkeit für Schulentwicklung 22 Peter Daschner Hrsg. Was hat meine Schule vorangebracht Was davon wirkt nachhaltig Resümees von sieben Schulleiterinnen und Schulleitern aus Deutschland Österreich und der Schweiz 29 Hans-Ake Scherp Eine lernorientierte Perspektive auf Schulentwicklung - Erfahrungen aus Schweden 37 Stephan Gerhard Huber Durch wirksame Kooperation Schulqualität sichern und Schulentwicklung fördern 44 Mats Ekholm Learning Democracy in Swedish Schools - Insights from longitudinal studies 50 Guido Stolle Was wirkt beim Aufbau von Bildungsregionen - der bildungsbiographische Ansatz! 56 gutes Exemplar ordentlich StudienVerlag hardcover‎

书商的参考编号 : B00051045

‎Journal fur Schulentwicklung‎

‎2/2009 Schulentwicklung und Symbolpolitik‎

‎StudienVerlag. Hardcover. Gut. Inhalt Thema Wilfried Schley Schulentwicklung und Symbolpolitik - Editorial 4 Ernst Rösner Ãœber Alltagsmythen das Schulwesen betreffend 9 Peter Wendt Schulentwicklung: mediale Scheinwelt oder realer Prozess vor Ort 17 Karl-Volker Sauer Fusionen Konfusionen Lebenslügen und andere Phänomene der rollenden Schulreform in Deutschland 26 Olivier Maulini Das öffentliche Bildungswesen und seine Legitimation: zwischen instrumenteller Vernunft und symbolischer Botschaft 33 Dennis Shirley Die Musik der Demokratie. Die Entstehung von Strategien für eine neue Ära der Post-Standardisierung 44 gutes Exemplar ordentlich StudienVerlag hardcover‎

书商的参考编号 : B00051022

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 511 No. 7509 Juli 2014 Inside Jupiter‎

‎NPG Nature publishing group. Hardcover. Gut. Struggle for independence The faculty of the Scripps Research Institute is bucking a national trend with its refusal to merge with the University of Southern California. Within reach A redoubling of efforts should swiftly eradicate polio from its last strongholds. Food for thought Researchers investigating different farming practices should not have to pick sides. World View Top Misjudgements will drive social trials underground A Facebook study that manipulated news feeds was not definitively unethical and offered valuable insight into social behaviour says Michelle Meyer. Research Highlights Top Agriculture: Global warming could hurt crops Planetary science: Titan s sea is super salty Cancer: Roving tumour cells tracked down Ecology: Ocean reserves miss key target Neurodegeneration: Antibodies fight Parkinson s Applied physics: Phone powers electronic label Vision: Prism of the eye guides light Virology: What makes HIV fit to spread Cognition: Chimp intelligence partly inherited The week in science: Smallpox found in fridge HIV-rebound dashes hope of cure and scandal over faked peer review. News in Focus Quantum-hub finalists picked No Alt text available for this image UK government considers eight proposals for up to six research centres. Katia Moskvitch Landslide risks rise up agenda No Alt text available for this image Forum on deadly natural phenomena discusses use of simulation and hazard-mapping technologies. Jane Qiu Scripps merger fiasco highlights US funding woes No Alt text available for this image Other independent biomedical research institutions have turned to private benefactors. Erika Check Hayden Charity begins at CERN No Alt text available for this image Particle-physics lab sets up fund for extras as other big institutes mull similar move. Elizabeth Gibney Correction Features Top Physics: Wave of the future No Alt text available for this image After two decades and more than half a billion dollars LIGO the world s largest gravitational-wave observatory is on the verge of a detection. Maybe. Alexandra Witze Weight-loss surgery: A gut-wrenching question No Alt text available for this image Gastric-bypass surgery can curb obesity as well as diabetes and a slew of other problems. Researchers are now trying to find out how it works. Virginia Hughes comment Infectious disease: Polio eradication hinges on child health in Pakistan Boosting basic medical services and routine immunizations not travel vaccinations is the key to ending polio worldwide says Zulfiqar Ahmed Bhutta. Psychological treatments: A call for mental-health science Clinicians and neuroscientists must work together to understand and improve psychological treatments urge Emily A. Holmes Michelle G. Craske and Ann M. Graybiel. Books and Arts Top History of medicine: Typhus and tyranny Tilli Tansey ponders a turbulent history of vaccine research in Nazi-occupied Europe. Review of The Fantastic Laboratory of Dr. Weigl: How Two Brave Scientists Battled Typhus and Sabotaged the Nazis Arthur Allen research News & Views Top High-pressure physics: Piling on the pressure Chris J. Pickard & Richard J. Needs Ecology: Pesticides linked to bird declines Dave Goulson Astrophysics: Survival of the largest Haley Gomez Neurobiology: Keeping a lid on it Gina Turrigiano Cancer: Sugar-coated cell signalling Andrew J. Ewald & Mikala Egeblad Materials science: A superelastic organic crystal Tomiki Ikeda & Toru Ube 50 & 100 Years Ago Stem cells: Reprogramming finds its niche Daniel Lucas & Paul S. Frenette Analysis Top A deep crust mantle boundary in the asteroid 4 Vesta Harold Clenet Martin Jutzi Jean-Alix Barrat Erik I. Asphaug Willy Benz et al. Data on Vesta s surface material provided by the Dawn probe and impacts modelling reveals that Vesta s crust mantle boundary must be deeper than 80 kilometres below the surface. Articles Top Genetics of ecological divergence during speciation Matthew E. Arnegard Matthew D. McGee Blake Matthews Kerry B. Marchinko Gina L. Conte et al. Traits responsible for recent niche divergence between sympatric threespine stickleback species are subjected to forward genetic analysis additive variation at several loci across the genome accounts for most of the genetic basis of ecological divergence with a further role for epistatic interactions that disadvantage hybrids. Reprogramming human endothelial cells to haematopoietic cells requires vascular induction Vladislav M. Sandler Raphael Lis Ying Liu Alon Kedem Daylon James et al. This study describes the conversion of human fetal and adult vascular endothelial cells into engraftable haematopoietic progenitors by transduction with some transcription factors and then culture on a vascular niche feeder layer the haematopoietic progenitors may be useful for the generation of engraftable healthy and long-lasting haematopoietic cells for treatment of inherited and acquired blood disorders. The cancer glycocalyx mechanically primes integrin-mediated growth and survival Matthew J. Paszek Christopher C. DuFort Olivier Rossier Russell Bainer Janna K. Mouw et al. Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins by funnelling integrins into adhesions integrin clustering and signalling is promoted which leads to enhanced cell survival and proliferation. Rapid formation of large dust grains in the luminous supernova 2010jl Christa Gall Jens Hjorth Darach Watson Eli Dwek Justyn R. Maund et al. The formation of dust in the dense circumstellar medium of the bright supernova 2010jl is at first rapid and produces very large grains which resist destruction whereas later the dust production rate increases meaning its source is ejecta this links early and late dust mass evolution in supernovae with dense circumstellar media. See also News & Views by Gomez Ramp compression of diamond to five terapascals R. F. Smith J. H. Eggert R. Jeanloz T. S. Duffy D. G. Braun et al. New laboratory techniques for applying enormous pressures allow diamond to be compressed to 50 million atmospheres providing insight into the interiors of planets and theoretical implications. See also News & Views by Pickard & Needs A low-cost non-toxic post-growth activation step for CdTe solar cells J. D. Major R. E. Treharne L. J. Phillips & K. Durose MgCl2 is shown to be a cheap and non-toxic replacement for the costly and environmentally unfriendly salt CdCl2 that has long been used as the activation step in the production of cadmium telluride solar cells. Pathway from subducting slab to surface for melt and fluids beneath Mount Rainier R. Shane McGary Rob L. Evans Philip E. Wannamaker Jimmy Elsenbeck & Stéphane Rondenay Magnetotelluric data from the state of Washington USA are used to image the fluid melt phase of volcanic subduction in Mt Rainier revealing fluid release at or near the top of the slab and its migration into the overlying mantle. Declines in insectivorous birds are associated with high neonicotinoid concentrations Caspar A. Hallmann Ruud P. B. Foppen Chris A. M. van Turnhout Hans de Kroon & Eelke Jongejans The water concentrations of imidacloprid a neonicotinoid pesticide correlate with declines in farmland bird populations in the Netherlands. See also News & Views by Goulson Genome sequencing identifies major causes of severe intellectual disability Christian Gilissen Jayne Y. Hehir-Kwa Djie Tjwan Thung Maartje van de Vorst Bregje W. M. van Bon et al. Whole-genome sequencing is used to identify genetic alterations in patients with severe intellectual disability for whom all other tests including array and exome sequencing returned negative results de novo single-nucleotide and copy number variations affecting the coding region seem to be a major cause of this disorder. Engineering a memory with LTD and LTP Sadegh Nabavi Rocky Fox Christophe D. Proulx John Y. Lin Roger Y. Tsien et al. A rodent study using optogenetics to induce long-term potentiation and long-term depression provides a causal link between synaptic plasticity and memory. ABCB5 is a limbal stem cell gene required for corneal development and repair Bruce R. Ksander Paraskevi E. Kolovou Brian J. Wilson Karim R. Saab Qin Guo et al. The loss of limbal stem cells LSCs due to injury or disease is one of the leading causes of blindness here the ABCB5 protein is identified as a marker of LSCs in mouse and human eye and shown to be functionally required for LSC maintenance corneal development and repair. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis Hong Ouyang Yuanchao Xue Ying Lin Xiaohui Zhang Lei Xi et al. p63 and PAX6 act to specify limbal stem or progenitor cells LSCs and WNT7A controls corneal epithelium differentiation through PAX6 loss of WNT7A or PAX6 induces LSCs into epithelium and transduction of PAX6 in skin epithelial stem cells converts them to LSC-like cells and transplantation in a rabbit corneal injury model can replenish corneal epithelial cells and repair damaged corneal surface. BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2 Vaibhav Bhatia Sonia I. Barroso María L. García-Rubio Emanuela Tumini Emilia Herrera-Moyano et al. BRCA2 the breast cancer susceptibility gene factor interacts with TREX-2 a protein complex involved in the biogenesis and export of messenger ribonucleoprotein to process DNA RNA hybrid structures called R-loops that can trigger genome instability these may be a central cause of the stress occurring in early cancer cells that drives oncogenesis. The structural basis of transfer RNA mimicry and conformational plasticity by a viral RNA Timothy M. Colussi David A. Costantino John A. Hammond Grant M. Ruehle Jay C. Nix et al. RNA molecules can perform multiple functions which can be driven by different conformational states here the crystal structure of the transfer-RNA-like structure of the turnip yellow mosaic virus is solved providing insight into the structural basis of RNA multifunctionality. Corrigendum Top Corrigendum: Sustained translational repression by eIF2 -P mediates prion neurodegeneration Julie A. Moreno Helois Radford Diego Peretti Joern R. Steinert Nicholas Verity et al. Erratum Top Erratum: CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation Emmanuel Martin Noé Palmic Sylvia Sanquer Christelle Lenoir Fabian Hauck et al. Retraction Top Retraction: Generation of cell polarity in plants links endocytosis auxin distribution and cell fate decisions Pankaj Dhonukshe Hirokazu Tanaka Tatsuaki Goh Kazuo Ebine Ari Pekka Mähönen et al. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042560

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 512 No. 7514 August Early Adapters‎

‎NPG Nature publishing group. Hardcover. Gut. Biogeochemistry: Microbes eat rock under ice Martyn Tranter See also Letter by Christner et al. Developmental biology: It takes muscle to make blood cells Suphansa Sawamiphak & Didier Y. R. Stainier See also Letter by Nguyen et al. See also Letter by Kobayashi et al. Earth science: Warning signs of the Iquique earthquake Roland Bürgmann See also Letter by Hayes et al. See also Letter by Schurr et al. Palaeoanthropology: The time of the last Neanderthals William Davies See also Letter by Higham et al. Molecular physics: Complexity trapped by simplicity Francesca Ferlaino See also Letter by Barry et al. Population history: Human melting pots in southeast Asia Jared Diamond Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway Ashton Trey Belew Arturas Meskauskas Sharmishtha Musalgaonkar Vivek M. Advani Sergey O. Sulima et al. Programmed 1 ribosomal frameshifting 1 PRF is a process by which a signal in a messenger RNA causes a translating ribosome to shift by one nucleotide thus changing the reading frame here 1 PRF in the mRNA for the co-receptor for HIV-1 CCR5 is stimulated by two microRNAs and leads to degradation of the transcript by nonsense-mediated decay and at least one other decay pathway. Crystal structure of a human GABAA receptor Paul S. Miller & A. Radu Aricescu GABAA receptors are the principal mediators of rapid inhibitor synaptic transmission in the brain and a decline in GABAA signalling leads to diseases including epilepsy insomnia anxiety and autism here the first X-ray crystal structure of a human GABAA receptor the human 3 homopentamer reveals structural features unique for this receptor class and uncovers the locations of key disease-causing mutations. X-ray structure of the mouse serotonin 5-HT3 receptor Ghérici Hassaine Cédric Deluz Luigino Grasso Romain Wyss Menno B. Tol et al. The first X-ray crystal structure of the mouse serotonin 5-HT3 receptor a pentameric ligand-gated ion channel is similar to those of other Cys-loop receptors though here electron density for part of the cytoplasmic domain which is important for trafficking synaptic localization and modulation by cytoplasmic proteins but not visible in previous structures is also described. Letters Top Interacting supernovae from photoionization-confined shells around red supergiant stars Jonathan Mackey Shazrene Mohamed Vasilii V. Gvaramadze Rubina Kotak Norbert Langer et al. A model in which the stellar wind of the fast-moving red supergiant Betelgeuse is photoionized by radiation from external sources can explain the dense almost static shell recently discovered around the star and predicts both that debris from Betelgeuse s eventual supernova explosion will violently collide with the shell and that other red supergiants should have similar but much more massive shells. Magneto-optical trapping of a diatomic molecule J. F. Barry D. J. McCarron E. B. Norrgard M. H. Steinecker & D. DeMille Magneto-optical trapping is the standard method for laser cooling and confinement of atomic gases but now this technique has been demonstrated for the diatomic molecule strontium monofluoride leading to the lowest temperature yet achieved by cooling a molecular gas. See also News & Views by Ferlaino Abrupt glacial climate shifts controlled by ice sheet changes Xu Zhang Gerrit Lohmann Gregor Knorr & Conor Purcell The volume of the Northern Hemisphere ice sheet controlled abrupt millennial-scale climate changes during the last glacial. Continuing megathrust earthquake potential in Chile after the 2014 Iquique earthquake Gavin P. Hayes Matthew W. Herman William D. Barnhart Kevin P. Furlong Sebástian Riquelme et al. The 2014 Iquique event was not the earthquake that had been expected to fill the regional seismic gap given that significant sections of the northern Chile subduction zone have not ruptured in almost 150 years it is likely that future megathrust earthquakes will occur south and potentially north of the 2014 Iquique sequence. See also News & Views by Bürgmann See also Letter by Schurr et al. Gradual unlocking of plate boundary controlled initiation of the 2014 Iquique earthquake Bernd Schurr Günter Asch Sebastian Hainzl Jonathan Bedford Andreas Hoechner et al. A long foreshock series unlocked the South American plate boundary until eventually initiating the M 8.1 Iquique Chile earthquake. See also News & Views by Bürgmann See also Letter by Hayes et al. Dietary specializations and diversity in feeding ecology of the earliest stem mammals Pamela G. Gill Mark A. Purnell Nick Crumpton Kate Robson Brown Neil J. Gostling et al. Differences in function and dietary ecology between Morganucodon and Kuehneotherium show that lineage splitting during the earliest stages of mammalian evolution was associated with ecomorphological specialization and niche partitioning. The timing and spatiotemporal patterning of Neanderthal disappearance Tom Higham Katerina Douka Rachel Wood Christopher Bronk Ramsey Fiona Brock et al. Accelerator mass spectrometry radiocarbon dating is used to construct a chronology of Neanderthal disappearance showing that Neanderthals overlapped with anatomically modern humans for between about 2000 and 5000 years. See also News & Views by Davies A microbial ecosystem beneath the West Antarctic ice sheet Brent C. Christner John C. Priscu Amanda M. Achberger Carlo Barbante Sasha P. Carter et al. There has been active debate over microbial life in Antarctic subglacial lakes owing to a paucity of direct observations from beneath the ice sheet and concerns about contamination in the samples that do exist here the authors present the first geomicrobiological description of pristine water and surficial sediments from Subglacial Lake Whillans and show that the lake water contains a diverse microbial community many members of which are closely related to chemolithoautotrophic bacteria and archaea. See also News & Views by Tranter Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1 Phong Dang Nguyen Georgina Elizabeth Hollway Carmen Sonntag Lee Barry Miles Thomas Edward Hall et al. A new somite compartment called the endotome that contributes to the formation of the embryonic dorsal aorta by providing endothelial progenitors is identified here endotome-derived endothelial progenitors whose formation is regulated by the activity of the meox1 gene induce haematopoietic stem cell formation upon colonization of the nascent dorsal aorta. See also News & Views by Sawamiphak & Stainier See also Letter by Kobayashi et al. Jam1a Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling Isao Kobayashi Jingjing Kobayashi-Sun Albert D. Kim Claire Pouget Naonobu Fujita et al. Notch signalling has a key role in the generation of haematopoietic stem cells HSCs during vertebrate development here two adhesion molecules Jam1a and Jam2a are shown to be essential for the contact between precursors of HSCs and the somite during embryonic migration and the Jam1a Jam2a interaction is shown to be needed to transmit the Notch signal and produce HSCs. See also News & Views by Sawamiphak & Stainier See also Letter by Nguyen et al. A vaccine targeting mutant IDH1 induces antitumour immunity Theresa Schumacher Lukas Bunse Stefan Pusch Felix Sahm Benedikt Wiestler et al. The mutant IDH1 protein which is expressed in a large fraction of human gliomas is shown to be immunogenic mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner. Dynamic pathways of 1 translational frameshifting Jin Chen Alexey Petrov Magnus Johansson Albert Tsai Seán E. O Leary et al. To investigate the mechanism of frameshifting during messenger RNA translation a technique was developed to monitor translation of single molecules in real time using Förster resonance energy transfer FRET ribosomes were revealed to pause tenfold longer than usual during elongation at the frameshifting sites. X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors Thorsten Althoff Ryan E. Hibbs Surajit Banerjee & Eric Gouaux This study solved structures of the glutamate-gated chloride channel GluCl a Cys-loop receptor from C. elegans in an apo closed state and in a lipid-bound state comparison of these structures with a previously published structure of GluCl in an ivermectin-bound state reveals what conformational changes probably occur as this membrane protein transitions from the closed/resting state towards an open/activated state. Corrigendum Top Corrigendum: Palladium-catalysed C H activation of aliphatic amines to give strained nitrogen heterocycles Andrew McNally Benjamin Haffemayer Beatrice S. L. Collins & Matthew J. Gaunt Retraction Top Retraction: Generation of pluripotent stem cells from adult human testis Sabine Conrad Markus Renninger Jörg Hennenlotter Tina Wiesner Lothar Just et al. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042563

‎Ein urgemutliches sachsisches Journal‎

‎Der kleine Drache Nummer 7‎

‎Hardcover. Gut. INHALT Jürgen Hart: Tauchstation / Klaus Werner Hennig: Der Schwimmer / Eberhard Heinze: Qualität / Reinhold Schleusinger: s Scheundwännscher und De Impfenduhr / Heinz Hamann: Schöner Leben & Co / Günter Krause: Dr Aawergloowe / Bruno Zwickauer: Keine Ahnung LEIPZIGER ALLERLEI Demokratie jetzt auch bei der LVB / Der Fluch des Politbüros /Angeldeutsch Altmagnifizenz / Italo-Fan / Höhere Gewalt / Aphorismen /Von den Tücken des Sächsischen / Das Sandwich u.a.m. Bernd-Lutz Lange: Im Park / Cornelia Molle: 0 Kinderlein kommet / Roman Vinkowski: De Nähmwärkungk / FDJ-Stadtleitung: Losungen zum 1. Mai / Hans-Walter Molle: Bruderlied / Hanskarl Hoerning: Tem- pora mutantur / Uwe A. Fink: Aktuelle Morphologie / Reni Tent: Walter Ulbricht der letzte sächsische Herrscher CARTOONS COLLAGEN und ILLUSTRATIONEN von Werner David und Lothar Otto gepflegtes Exemplar kaum Lesespuren Buchblock altersgemäß gebräunt SEHR SCHÖN!!! hardcover‎

书商的参考编号 : B00008125

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 507 No 7493 März 2014 How to keep a secret‎

‎NPG Nature publishing group. Hardcover. Gut. Physics: QBism puts the scientist back into science A participatory view of science resolves quantum paradoxes and finds room in classical physics for the Now says N. David Mermin. Preclinical research: Make mouse studies work More investment to characterize animal models can boost the ability of preclinical work to predict drug effects in humans says Steve Perrin. In Retrospect: The Social Function of Science Roger Pielke Jr assesses the legacy of J. D. Bernal s science-policy classic on its 75th anniversary. Review of The Social Function of Science J. D. Bernal Microbiology: Majority rule Mark O. Martin relishes a stimulating tour of little lives from fungi to bacteria. Review of The Amoeba in the Room: Lives of the Microbes Nicholas P. Money Books in brief Mathematics: Numbers game George Szpiro enjoys a history of the slow but irresistible rise of mathematical symbols. Review of Enlightening Symbols: A Short History of Mathematical Notation and Its Hidden Powers Joseph Mazur Neuroscience: Updating views of visual updating John A. Assad See also Letter by Zirnsak et al. Solar System: Stranded in no-man s-land Megan E. Schwamb See also Letter by Trujillo & Sheppard Biogeochemistry: Methane minimalism Tori M. Hoehler & Marc J. Alperin See also Letter by Yvon-Durocher et al. Climate science: A high bar for decadal forecasts of El Niño Pedro DiNezio Alzheimer s disease: A protective factor for the ageing brain Li-Huei Tsai & Ram Madabhushi See also Article by Lu et al. Low-temperature physics: Chaos in the cold Paul S. Julienne See also Letter by Frisch et al. Osteoarthritis: The zinc link Virginia Byers Kraus Perspectives Top The ultimate physical limits of privacy Artur Ekert & Renato Renner Developments in quantum cryptography show that it is possible to protect secrets from those with superior technology those who profess to provide our security and even those who manipulate us without our knowledge under surprisingly weak assumptions. Articles Top REST and stress resistance in ageing and Alzheimer s disease Tao Lu Liviu Aron Joseph Zullo Ying Pan Haeyoung Kim et al. REST a developmental regulator is markedly induced in human neurons during ageing but is lost in Alzheimer s disease REST represses genes that promote neurodegeneration is neuroprotective in animal models and is associated with cognitive preservation and longevity in humans. See also News & Views by Tsai & Madabhushi An atlas of active enhancers across human cell types and tissues Robin Andersson Claudia Gebhard Irene Miguel-Escalada Ilka Hoof Jette Bornholdt et al. Using the FANTOM5 CAGE expression atlas the authors show that bidirectional capped RNAs are a signature feature of active enhancers and identify over 40000 enhancer candidates from over 800 human cell and tissue samples across the whole human body. A promoter-level mammalian expression atlas The FANTOM Consortium and the RIKEN PMI and CLST DGT A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types. Letters Top A Sedna-like body with a perihelion of 80 astronomical units Chadwick A. Trujillo & Scott S. Sheppard The discovery of the distant dwarf planet 2012 VP113 with its large perihelion like that of the dwarf planet Sedna shows that Sedna is not isolated and may be part of the putative massive inner Oort cloud which extends far beyond the observable Solar System. See also News & Views by Schwamb Quantum chaos in ultracold collisions of gas-phase erbium atoms Albert Frisch Michael Mark Kiyotaka Aikawa Francesca Ferlaino John L. Bohn et al. An ultracold gas of erbium atoms is shown to have many scattering resonances whose quantum fluctuations exhibit chaotic behaviour resulting from the anisotropy of the atoms interactions. See also News & Views by Julienne Reconciliation of the carbon budget in the ocean s twilight zone Sarah L. C. Giering Richard Sanders Richard S. Lampitt Thomas R. Anderson Christian Tamburini et al. The discrepancy between the components of the oceanic carbon budget export of carbon from the surface and its conversion into carbon dioxide by water-column biota at depth is reconciled using field data and a steady-state model which indicates that synergy between microbes and zooplankton is an important factor. Geomagnetic fluctuations reveal stable stratification at the top of the Earth s core Bruce Buffett MAC waves arising from magnetic Archimedes and Coriolis forces in the liquid core indicate a 140-kilometre-thick stratified layer on top of the Earth s core and account for the 60-year geomagnetic fluctuations observed in the Earth s geomagnetic field. Methane fluxes show consistent temperature dependence across microbial to ecosystem scales Gabriel Yvon-Durocher Andrew P. Allen David Bastviken Ralf Conrad Cristian Gudasz et al. Meta-analyses show that the temperature dependence of methane fluxes scales consistently across populations of methanogens microbial communities and whole ecosystems and that this temperature dependence is higher than for respiration and photosynthesis this indicates that global warming may impact the relative contributions of CO2 and CH4 to total greenhouse gas emissions. See also News & Views by Hoehler & Alperin Geographical limits to species-range shifts are suggested by climate velocity Michael T. Burrows David S. Schoeman Anthony J. Richardson Jorge García Molinos Ary Hoffmann et al. Global maps constructed using climate-change velocities to derive spatial trajectories for climatic niches between 1960 and 2100 show past and future shifts in ecological climate niches properties of these trajectories are used to infer changes in species distributions and thus identify areas that will act as climate sources and sinks and geographical barriers to species migrations. A suspension-feeding anomalocarid from the Early Cambrian Jakob Vinther Martin Stein Nicholas R. Longrich & David A. T. Harper Tamisiocaris borealis an Early Cambrian member of the anomalocarids giant predatory marine stem arthropods probably used its frontal appendage to trap microscopic planktonic animals. A primitive placoderm sheds light on the origin of the jawed vertebrate face Vincent Dupret Sophie Sanchez Daniel Goujet Paul Tafforeau & Per E. Ahlberg Studies of the head of the very primitive jawed vertebrate Romundina show that it combines jawed vertebrate architecture with cranial and cerebral proportions resembling those of extant jawless vertebrates such as lampreys. Visual space is compressed in prefrontal cortex before eye movements Marc Zirnsak Nicholas A. Steinmetz Behrad Noudoost Kitty Z. Xu & Tirin Moore Saccadic eye movements cause substantial shifts in the retinal image as we take in visual scenes but our perception is stable and continuous here visual receptive fields are shown to shift dramatically towards the saccadic goal running counter to the long-standing hypothesis of receptive field remapping as the basis of perceived stability. See also News & Views by Assad The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells Magdalena Paolino Axel Choidas Stephanie Wallner Blanka Pranjic Iris Uribesalgo et al. The E3 ligase Cbl-b acts on TAM tyrosine kinase receptors and has a critical role in the regulation of natural killer NK cell rejection of metastatic tumours a small molecule TAM kinase inhibitor is shown to enhance the anti-metastatic NK cell activity. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development Xindong Liu Xin Chen Bo Zhong Aibo Wang Xiaohu Wang et al. Here the helix loop helix transcription factor Ascl2 is shown to be critically important for the initiation of follicular T-helper-cell development and the germinal centre response. Structure-based programming of lymph-node targeting in molecular vaccines Haipeng Liu Kelly D. Moynihan Yiran Zheng Gregory L. Szeto Adrienne V. Li et al. An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042575

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 509 No 7501 Mai 2014 Type Cast‎

‎NPG Nature publishing group. Hardcover. Gut. Mental health: A road map for suicide research and prevention It is time for policy-makers funders researchers and clinicians to tackle high suicide rates say André Aleman and Damiaan Denys. Evolutionary biology: Darwin and the women Sarah S. Richardson relishes a study of how nineteenth-century US feminists used the biologist s ideas. Review of From Eve to Evolution: Darwin Science and Women s Rights in Gilded Age America Kimberly A. Hamlin Information technology: Forgotten prophet of the Internet Philip Ball ponders the tale of a librarian who dreamed of networking information. Review of Cataloging the World: Paul Otlet and the Birth of the Information Age Alex Wright European pollution: Investigate smog to inform policy Paul S. Monks Databases: Soil observatory lets researchers dig deep Russell Lawley Bridget A. Emmett & David A. Robinson Health care: Strict vaccine quality control in China Zhenglun Liang Qunying Mao & Junzhi Wang Political ecology: Rethink Campania s toxic-waste scandal Giacomo D Alisa Marco Armiero & Salvatore Paolo De Rosa Technology: Internal factors drive Chinese patent surge Ching-Yan Wu Mei-Chih Hu & John A. Mathews Epigenetics: Keeping one s sex Douglas L. Chalker See also Article by Singh et al. Astrophysics: Windy stars that go with a bang John J. Eldridge See also Letter by Gal-Yam et al. Physiology: Double function at the blood brain barrier Christer Betsholtz See also Letter by Nguyen et al. See also Letter by Ben-Zvi et al. Materials chemistry: Selectivity from flexibility Ryotaro Matsuda Cancer: Darwinian tumour suppression Eduardo Moreno See also Article by Martins et al. Earth science: Fertile fields for seismicity Paul Lundgren See also Letter by Amos et al. Articles Top Genome-defence small RNAs exapted for epigenetic mating-type inheritance Deepankar Pratap Singh Baptiste Saudemont Gérard Guglielmi Olivier Arnaiz Jean-François Goût et al. The molecular basis for mating-type determination in the ciliate Paramecium has been elucidated revealing a novel function for a class of small RNAs these scnRNAs are typically involved in reprogramming the Paramecium genome during sexual reproduction by recognizing and excising transposable elements but they are now found to be co-opted to switch off expression of the newly identified mating-type gene mtA by excising its promoter and to mediate epigenetic inheritance of mating types across sexual generations. See also News & Views by Chalker Amygdala interneuron subtypes control fear learning through disinhibition Steffen B. E. Wolff Jan Gründemann Philip Tovote Sabine Krabbe Gilad A. Jacobson et al. Plasticity within neuronal microcircuits is believed to be the substrate of learning and this study identifies two distinct disinhibitory mechanisms involving interactions between PV and SOM interneurons that dynamically regulate principal neuron activity in the amygdala and thereby control auditory fear learning. Contrasting forms of cocaine-evoked plasticity control components of relapse Vincent Pascoli Jean Terrier Julie Espallergues Emmanuel Valjent Eoin Cornelius O Connor et al. Information integration in the nucleus accumbens is commandeered by cocaine at discrete synapses to allow relapse. Cell competition is a tumour suppressor mechanism in the thymus Vera C. Martins Katrin Busch Dilafruz Juraeva Carmen Blum Carolin Ludwig et al. T cells develop from thymic precursor cells that are constantly replaced with newly arriving bone marrow progenitor cells and the old and new cells are shown here to compete in the absence of cell competition when the influx of new bone marrow progenitor cells is blocked the old cells acquire the ability to self-renew and eventually become transformed leading to the development of a form of leukaemia. See also News & Views by Moreno Letters Top A Wolf Rayet-like progenitor of SN 2013cu from spectral observations of a stellar wind Avishay Gal-Yam I. Arcavi E. O. Ofek S. Ben-Ami S. B. Cenko et al. The detection of strong emission lines in an early-time spectrum of type IIb supernova SN 2013cu reveals Wolf Rayet-like wind signatures suggesting that the supernova s progenitor may have been a Wolf Rayet star with a wind dominated by helium and nitrogen with traces of hydrogen. See also News & Views by Eldridge Practical quantum key distribution protocol without monitoring signal disturbance Toshihiko Sasaki Yoshihisa Yamamoto & Masato Koashi Conventional quantum cryptography relies on monitoring signal disturbance to make sure that information leakage is negligible here a new quantum method of achieving security is described in which little information is leaked to the eavesdropper regardless of the signal disturbance. Future increases in Arctic precipitation linked to local evaporation and sea-ice retreat R. Bintanja & F. M. Selten Precipitation is expected to increase far more over the twenty-first century in the Arctic than the global average climate models show that this is driven mainly by increased local evaporation and sea-ice retreat rather than by increased moisture transport from lower latitudes. Uplift and seismicity driven by groundwater depletion in central California Colin B. Amos Pascal Audet William C. Hammond Roland Bürgmann Ingrid A. Johanson et al. Human-caused groundwater depletion in California s San Joaquin Valley contributes to uplift of the surrounding mountains and may affect the stability of the San Andreas Fault. See also News & Views by Lundgren High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells Yuexin Zhou Shiyou Zhu Changzu Cai Pengfei Yuan Chunmei Li et al. This study describes the construction of a focused CRISPR/Cas-based lentiviral library in human cells and a method of gene identification based on functional screening and high-throughput sequencing analysis. Copper is required for oncogenic BRAF signalling and tumorigenesis Donita C. Brady Matthew S. Crowe Michelle L. Turski G. Aaron Hobbs Xiaojie Yao et al. Tumorigenesis driven by the oncogene BRAFV600E is shown both to depend on the BRAF substrates MEK1/2 associating with copper and to be sensitive to copper-chelating drugs suggesting merit in testing such drugs for the treatment of BRAF mutation-positive cancers. Protective mucosal immunity mediated by epithelial CD1d and IL-10 Torsten Olszak Joana F. Neves C. Marie Dowds Kristi Baker Jonathan Glickman et al. Here the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells resulting in the production of IL-10. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid Long N. Nguyen Dongliang Ma Guanghou Shui Peiyan Wong Amaury Cazenave-Gassiot et al. Mfsd2a is the major transporter of the omega-3 fatty acid docosahexaenoic acid DHA into brain with Mfsd2a-knockout mice showing reduced DHA in brain neuronal cell loss in hippocampus and cerebellum behavioural disorders and reduced brain size DHA is transported in a sodium-dependent manner in the form of lysophosphatidylcholines LPCs carrying long-chain fatty acids. See also News & Views by Betsholtz Mfsd2a is critical for the formation and function of the blood brain barrier Ayal Ben-Zvi Baptiste Lacoste Esther Kur Benjamin J. Andreone Yoav Mayshar et al. Mfsd2a is a key regulator of blood brain barrier BBB formation and function in mice: Mfsd2a is selectively expressed in BBB-containing blood vessels in the CNS Mfsd2a / mice have a leaky BBB and increased vesicular transcytosis in CNS endothelial cells and Mfsd2a endothelial expression is regulated by pericytes to facilitate BBB integrity. See also News & Views by Betsholtz Structure of the AcrAB TolC multidrug efflux pump Dijun Du Zhao Wang Nathan R. James Jarrod E. Voss Ewa Klimont et al. Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules here the structure of one such pump AcrAB TolC is determined using X-ray crystallography and cryo-electron microscopy. Structural basis of Sec-independent membrane protein insertion by YidC Kaoru Kumazaki Shinobu Chiba Mizuki Takemoto Arata Furukawa Ken-ichi Nishiyama et al. The crystal structure of the bacterial protein YidC is reported together with a structure-based functional analysis providing insight into the role of YidC in inserting single-spanning membrane proteins into the membrane. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042576

‎Gaa, okologischer Landbau, Journal, Fachmagazin fur Landwirtschaft Handel und Verbraucher der Oko Branche‎

‎4-1/1998‎

‎Hardcover. Gut. Vorwort 3 Markt und Meinung Globalisierung contra Regionalität - Herausforderung an Biohöfe in Ostdeutschland 4 Rückblick - Grüne Woche Berlin - Biofach in Frankfurt 6 Firmenportrait: Rolle Mühle-Handwerkstradition aus dem Erzgebirge 7 Rückblick - Ost-West Dialog auf der AGÖL Beratertagung 1997 8 Landwirtschaft und Umwelt Zuckerrübenanbau im Öko-Landbau wieder aktuell ! 11 Bördebauer meistert den ökologischen Landbau 14 Heil- und Gewürzkräuter im Bauerngarten 16 Bericht zur Lehrfahrt artgerechte und kostengünstige Mastschweineställe 18 Drunter und Drüber Kurzinformationen für die Verarbeitung 22 Nachrichten aus den Landesverbänden 23 Sächsische Bio-Verarbeitungsbetriebe erhalten Umweltpreise 24 Nachruf Eberhard Bizer 25 Europäisches Kochfestival am 28.Mai 1998 26 Buchempfehlung 27 Veranstaltungskalender 28 Kleinanzeigen 29 Anzeigen 30 gutes Exemplar ordentlich hardcover‎

书商的参考编号 : B00053200

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 505 No. 7484 Januar 2014 Decrypting the Mitoribosome‎

‎NPG Nature publishing group. Hardcover. Gut. EDITORIALS 453 STEM CELLS Don t rush to rehabilitate Hwang Woo Suk Hwang s return to the scientific stage merits a degree of caution 453 US POLICY A return to order With a budget deal finally done US lawmakers need to avoid another funding hiatus 454 METROLOGY A question of time A time reminder of the power of science WORLD VIEW 455 Don t stop the quest to measure Big G Terry Quinn Pinning down the coupling constant in Newton s law of gravity will be hard but not impossible RESEARCH HIGHLIGHTS 456 SELECTIONS FROM THE SCIENTIFIC LITERATURE Dopamine and eye disease / Counterproductive antibiotics / Laser-guided particles / Waves powered by climate change / Sweet-seeking mosquitoes SEVEN DAYS 458 THE NEWS IN BRIEF Rosetta comet probe phones home / H7N9 fly makes a comeback/ Illumina prepares for $1000 genome / Sharks face extinction 461 POLICY US budget finally gets signed into law 463 ANTARCTIC RESEARCH Report picks through bones of failed polar-drilling project 464 CARBON CHEMISTRY Researchers seek ways to boost olivine s carbon-sequestering power 465 ECOLOGY Protected status of Yellowstone s grizzly bears comes under threat 466 EARTH SCIENCE Drilling mission aims to date South China Sea We need an international effort backed by governments and l exiA commercial interests to save the seabed ecosystem say Edward B seit Barbier et al. 477 EDUCATION Embed social awareness in science curricula Erin A Cech Cultural and political context should be integral to science and technology teaching BOOKS & ARTS 4BO CONSERVATION Rewilding Oz Tim Flannery 4B1 BOOKS IN BRIEF 4B2 DIGITAL DEVELOPMENT Wired cultures John Gilbey CORRESPONDENCE 4B3 Peer review / Irreproducible results / Soil pollution in China / Soviet croplands / Natural killer cells take an cancer 575 CHARITIES Profiting from non-profits The vital link between goal-oriented charities and hands-on researchers 577 TURNING POINT Marine ecologist Kristin Laidre sees art as well as data in the Arctic 577 CAREER BRIEFS Can Woo Suk Hwang redeem himself and rebuild his scientific reputation 472 QUANTUM PHYSICS Flawed to perfection Synthetic diamonds are paving the way to better quantum computers and biomedical sensors NEW ONLINE 485 Papers published this week at nature.com NEWS & VIEWS 4B6 ECOLOGY Good dirt with good friends Mycorrhizal fungus type regulates amounts of soil organic matter Mark A Bradford SEE LETTER R543 487 SOLAR SYSTEM Evaporating asteroid Discovery of water molecules escaping from the asteroid Ceres Humberto Campins & Christine M Comfort SEE LETTER P.525 488 STEM CELLS Sex specificity in the blood Oestrogen regulates division frequency of haematopoietic stem cells Dena S Leeman & Anne Brunet SEE LETTER R555 49O ELECTRONICS Protecting the weak from the strong A metasurface microwave absorber George V Eleftheriades 491 CLIMATE SCIENCE A resolution of the Antarctic paradox The Atlantic Ocean may drive changes in Antarctic winds and sea ice John King SEE LETTER R538 492 HIV Not-so-innocent bystanders Abortive HIV-1 infection triggers pyroptosis in CD4 T cells Andrea L Cox & Robert F Siliciano SEE ARTICLE P.509 J_J 11.J The intestinal bile acid transporter now a possible drug target. PAGE 569 ON THE COVER Power base Abstract representation of RNA and protein folds in the !arge 39S mammalian mitoribosomal subunit The 3D structure of this subunit provides insights into the changes that have occurred in this ribosome now specialized for the translation of the very hydrophobic proteins encoded by the mitochondrial genome. PAGE 515 ARTICLES 495 CANCER GENOMICS Discovery and saturation analysis of cancer genes across 21 tumour types M S Lawrence et al. 502 IMMUNOLOGY Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV M Roederer et al. 509 IMMUNOLOGY Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection G Doitsh et al. SEE N&V P.492 515 STRUCTURAL BIOLOGY Architecture of the large subunit of the mammalian mitochondrial ribosome BJ Greber et al. LETTERS 52O ASTROPHYSICS A millisecond pulsar in a stellar triple system SM Ransom et al. 525 ASTRONOMY Localized sources of water vapour on the dwarf planet 1 Ceres M Küppers et al. SEE N&V P.487 528 QUANTUM ELECTRONICS Tunable symmetry breaking and helical edge transport in a graphene quantum spin Hall state A F Young et al. 533 MATERIALS SCIENCE Dislocations in bilayer graphene B Butz et al. 538 CLIMATE SCIENCE Impacts of the north and tropical Atlantic Ocean on the Antarctic Peninsula and sea ice X Li D M Holland E P Gerber & C Yoo SEE N&V P.491 543 ECOLOGY Mycorrhiza-mediated competition between plants and decomposers drives soil carbon storage C Averill B L Turner & A C Finzi SEE N&V P.486 546 CROP SCIENCE The genome of the recently domesticated crop plant sugar beet Beta vulgaris J C Dohm et al. 550 NEUROSCIENCE Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer s disease C Cruchaga et al. 555 STEM CELLS Oestrogen increases haematopoietic stem-cell selfrenewal in females and during pregnancy D Nakada et al. SEE N&V P.488 . 559 MICROBIOLOGY Diet rapidly and reproducibly alters the human gut microbiome LA David et al. 564 MOLECULAR BIOLOGY Glutamine methylation in histone H2A is an kNA-polymerase-l-dedicated modification P Tessarz et al. 569 STRUCTURAL BIOLOGY Structural basis of the alternating-access mechanism in a bile acid transporter X Zhou et al. 574 RETRACTIDN GIcNAcylation of a histone methyltransferase in retinoic-acidinduced granulopoiesis R Fujiki et al. 574 CORRIGENDUM Deglacial pulses of deep-ocean Silicate into the subtropical North Atlantic Ocean A N Meckler et al. NEUWERTIGkeine LesespurenSEHR SCHÖN NPG Nature publishing group hardcover‎

书商的参考编号 : B00042471

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 508 No. 7496 April 2014 Out of the shadows‎

‎NPG Nature publishing group. Hardcover. Gut. Policy: Bring sustainable energy to the developing world Investment and policies must support cheap clean energy technologies to cut both poverty and climate change say Reid Detchon and Richenda Van Leeuwen. Publishing: Credit where credit is due Liz Allen Amy Brand Jo Scott Micah Altman and Marjorie Hlava are trialling digital taxonomies to help researchers to identify their contributions to collaborative projects. Astronomy: Art of the eclipse As the next solar eclipse approaches Jay M. Pasachoff and Roberta J. M. Olson ponder how artists from the early Renaissance onwards have interpreted the phenomenon. Geology: Parsing eruptions Ted Nield weighs up histories of two momentous volcanic events in Iceland and Indonesia. Review of Island on Fire: The Extraordinary Story of Laki: The Volcano That Turned Eighteenth-Century Europe Dark Tambora: The Eruption That Changed the World Alexandra Witze Jeff Kanipe & Gillen D Arcy Wood Animal behaviour: Nomads of necessity Joel Greenberg casts an ornithologist s eye on a wide-ranging reading of animal migration. Review of The Homing Instinct: Meaning and Mystery in Animal Migration Bernd Heinrich Obesity Tony Scully Society at large Tony Scully Cell physiology: The changing colour of fat Brian Owens Treatment: Marginal gains Emily Anthes Perspective: Obesity is not a disease D. L. Katz Heritability: The family roots of obesity Cassandra Willyard Microbiome: A complicated relationship status Sarah Deweerdt Neuroscience: Dissecting appetite Bijal P. Trivedi Perspective: Tricks of the trade Stephen J. Simpson & David Raubenheimer Evolutionary biology: Dating chimpanzees Michael Haslam Genetics: Up and down in Down s syndrome Benjamin D. Pope & David M. Gilbert See also Article by Letourneau et al. Organic chemistry: Catalysis marches on James P. Morken See also Article by Mei et al. Synthetic biology: Biocircuits in synchrony Ricard Solé & Javier Macía See also Letter by Prindle et al. Thermoelectricity: The ugly duckling Joseph P. Heremans See also Letter by Zhao et al. Review Top The ensemble nature of allostery Hesam N. Motlagh James O. Wrabl Jing Li & Vincent J. Hilser Allostery is the process by which biological macromolecules transmit the effect of binding at one site to another often distal functional site allowing for the regulation of activity here facilitation of allostery through dynamic and intrinsically disordered proteins is discussed and a framework to unify the description of allosteric mechanisms for different systems is proposed. Articles Top Enantioselective construction of remote quaternary stereocentres Tian-Sheng Mei Harshkumar H. Patel & Matthew S. Sigman A catalytic and enantioselective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids provides direct access to quaternary stereocentres remote from a carbonyl group. See also News & Views by Morken Domains of genome-wide gene expression dysregulation in Down s syndrome Audrey Letourneau Federico A. Santoni Ximena Bonilla M. Reza Sailani David Gonzalez et al. By studying the transcriptome of fetal cells of monozygotic twins discordant for trisomy 21 this paper finds that differential expression between the twins is organized in domains along all chromosomes these gene expression dysregulation domains are conserved in the mouse model of Down s syndrome and correlate with the lamina-associated domains and replication domains. See also News & Views by Pope & Gilbert Brainstem nucleus MdV mediates skilled forelimb motor tasks Maria Soledad Esposito Paolo Capelli & Silvia Arber The authors use a combination of viral tracing and genetics to characterize the diversity of neurons projecting from mouse brainstem to motor neurons that control limb movements in particular they discover that the medullary reticular formation ventral part MdV is functionally specialized for skilled forelimb motor control. Skilled reaching relies on a V2a propriospinal internal copy circuit Eiman Azim Juan Jiang Bror Alstermark & Thomas M. Jessell Cervical propriospinal neurons PNs form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals their ablation in mice impairs reaching movements selectively and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement. Letters Top Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars Heather B. Franz Sang-Tae Kim James Farquhar James M. D. Day Rita C. Economos et al. Isotopic analyses of 40 Martian meteorites indicate that assimilation of sulphur into Martian magmas was a common occurrence throughout much of the planet s history and that the atmospheric imprint of photochemical processing preserved in Martian meteoritic sulphide and sulphate is distinct from that observed in terrestrial analogues. Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles Ioan M. Pop Kurtis Geerlings Gianluigi Catelani Robert J. Schoelkopf Leonid I. Glazman et al. The long-predicted suppression of quasiparticle dissipation in a Josephson junction when the phase difference across the junction is is inferred from a sharp maximum in the energy relaxation time of a superconducting artificial atom. Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals Li-Dong Zhao Shih-Han Lo Yongsheng Zhang Hui Sun Gangjian Tan et al. The main obstacle to improving the thermoelectric efficiency of a material arises from the common interdependence of electrical and thermal conductivity whereas one ideally wants to raise the former while lowering the latter: a simple layered crystalline material SnSe is now reported that seems to have these qualities built in. See also News & Views by Heremans Mid-latitude interhemispheric hydrologic seesaw over the past 550000 years Kyoung-nam Jo Kyung Sik Woo Sangheon Yi Dong Yoon Yang Hyoun Soo Lim et al. Tropical and subtropical speleothems show that the latitudinal migration of the Intertropical Convergence Zone tends to produce increased precipitation in one hemisphere and drying in the other now it is shown using speleothems from the Korean peninsula that this phenomenon extended to the mid-latitudes during the past 550000 years. A new fossil species supports an early origin for toothed whale echolocation Jonathan H. Geisler Matthew W. Colbert & James L. Carew Phylogenetic analysis of a new species of fossil toothed whale Cotylocara macei from the Oligocene epoch places it in a basal clade of odontocetes and its features suggest that rudimentary echolocation evolved in the early Oligocene and was followed by convergent evolution in their skulls. Rapid and tunable post-translational coupling of genetic circuits Arthur Prindle Jangir Selimkhanov Howard Li Ivan Razinkov Lev S. Tsimring et al. Protease competition is used to produce rapid and tunable coupling of genetic circuits enabling a coupled clock network that can encode independent environmental cues into a single time series output a form of frequency multiplexing in a genetic circuit context. See also News & Views by Solé & Macía Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation Bing He Konstantin Doubrovinski Oleg Polyakov & Eric Wieschaus The lengthening phase of ventral furrow formation in Drosophila gastrulation is driven by cytoplasmic flows triggered by apical constriction of mesoderm cells independent of the mechanical inputs from the basolateral membranes. A committed precursor to innate lymphoid cells Michael G. Constantinides Benjamin D. McDonald Philip A. Verhoef & Albert Bendelac A committed precursor to innate lymphoid cell lineages but not classical natural killer and lymphoid tissue inducer cells is derived from common lymphoid precursors and distinguished by high levels of expression of the transcription factor PLZF. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 Travis K. Warren Jay Wells Rekha G. Panchal Kelly S. Stuthman Nicole L. Garza et al. A broad-spectrum antiviral small molecule is reported to act as an inhibitor of viral polymerase activity and is shown to be effective in protecting non-human primates from lethal filovirus infection when administered after exposure. Caenorhabditis elegans pathways that surveil and defend mitochondria Ying Liu Buck S. Samuel Peter C. Breen & Gary Ruvkun A genome-wide RNA interference screen in Caenorhabditis elegans identifies 45 genes with roles in protective pathways following drug- and genetic-disruption-induced mitochondrial inhibition. See also News & Views by Wolff & Dillin miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis Kate M. Creasey Jixian Zhai Filipe Borges Frederic Van Ex Michael Regulski et al. The generation of widespread epigenetically activated short interfering RNAs by the targeting of microRNAs to transposon transcripts in Arabidopsis thaliana is shown to be a latent mechanism that only becomes active when the transcripts are epigenetically reactivated for example during reprogramming of the germ line. Structural basis for translocation by AddAB helicase nuclease and its arrest at sites Wojciech W. Krajewski Xin Fu Martin Wilkinson Nora B. Cronin Mark S. Dillingham et al. A dual-function helicase nuclease typified by RecBCD in Escherichia coli acts on free DNA ends during bacterial double-stranded break repair until it reaches a sequence at which it pauses before continuing with modified enzymatic properties here several crystal structures of the related AddAB enzyme from Bacillus subtilis bound to -containing DNA are presented offering insight into recognition and its effect on DNA translocation. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042580

‎Ein urgemutliches sachsisches Journal‎

‎Der kleine Drache Nummer 5‎

‎Hardcover. Gut. INHALT Kleiner Blick zurück mit Texten von Walter Gilbricht Bruno Apitz Heinz Petzold Alexander Dittrich Rudolf Ganz und Emmann Roman Vinkowski: Buchschdadd-Fandasie / Bernd-Lutz Lange: Alltags- dreierlei / Franz Hohler: Spurensicherung / Hans Lanz: Leipzig / Jürgen Hart: Hofnarren / Helmut Richter: Freundschaftsgeschenke / Rose Thal: Die perplexe Jury / Gunter Böhnke: Liebeserklärung LEIPZIGER ALLERLEI Künstler bei Arbeitern / Fragen / Das aktuelle Interview / Die Haupt- aufgabe / Der Größte / Unter Amtskollegen / Wir lernen immer / Rück- sicht / Seenstadt Leipzig u.a.m. Hanskarl Hoerning Wie ich Theaterblut leckte / Steffen Mohr: Lied für Gabriele Gabriela Der grüne Elefant / Mark Trödel: Flohmargddibbs / Ich Träumer: Kulturelle Alpträume / Bruno Zwickauer: Sächsische Minia- turen / Briefkasten mei Leipzsch / Wolfgang U. Schütte: Darf ein Schlückchen mehr sein / ARTDONS und ILLUSTRATIONEN von Werner David Egbert und Renate Herfurth Lothar Otto und eine COLLAGE von Andreas Prüstel gepflegtes Exemplar nur kleine Lesespuren Buchblock altersgemäß gebräunt hardcover‎

书商的参考编号 : B00008114

‎nature, THE INTERNATIONAL WEEKLY JOURNAL OF SCIENCE‎

‎Vol 517 No 7532 Januar 2015 Sands of Titan‎

‎NPG Nature publishing group. Hardcover. Gut. Editorials Time for the social sciences Governments that want the natural sciences to deliver more for society need to show greater commitment towards the social sciences and humanities. World View The rising pressure of global water shortages Water is becoming more scarce as populations increase potentially leading to conflict. The age of hydro-diplomacy is upon us says Jan Eliasson. Nicaragua defies canal protests No Alt text available for this image Scientists call for independent environmental assessment. Lucas Laursen Planet hunters plot course for habitable worlds No Alt text available for this image Researchers aim to set aside differences in search for life on distant spheres. Alexandra Witze Ebola raises profile of blood-based therapy No Alt text available for this image Convalescent plasma therapy is trialled to fight Ebola but could also be used for new and emerging pathogens. Declan Butler What to expect in 2015 No Alt text available for this image Nature looks at what the New Year holds for science. Elizabeth Gibney Science in 2015 No Alt text available for this image From Gradzilla to coffee consumption: the research enterprise quantified for the year to come. Mark Zastrow comment Leadership: New year s resolutions Nine scientific leaders share their goals for 2015 professional and personal. Books and Arts Top Listings: Science in culture 2015 Explore the gory glories of forensic science grapple with Tom Stoppard s take on consciousness learn what it takes to live on Mars re-enter Jurassic Park dive into a coral reef and dally with Robert Oppenheimer. Daniel Cressey reports. Review of Oppenheimer Countdown to Zero: Defeating Disease Imagine Science Films Forensics: The Anatomy of Crime Emerge Arsenic and New Medicine: Paul Ehrlich s Pioneering Research EXPO 2015 Jurassic World Coral Reefs: Secret Cities of the Sea A Brief History of the Future The Martian The Hard Problem Designers in Residence 2015: Migration It s Alive! Frankenstein on Film Marvellous Creatures Frida Kahlo s Garden Lava & The Francis Crick Institute Correspondence Top European Union: New law risks release of invasive species Philip E. Hulme Air pollution: Harmful soot spurs climate-policy action David G. Victor V. Ramanathan & Durwood Zaelke Emissions limits: Green heating plan threatens air quality Gordon McFiggans Publishing: Criteria for Nature Index questioned Robin Haunschild & Lutz Bornmann Obituary Top Paul von Ragué Schleyer 1930 2014 Chemist who launched the study of caged hydrocarbons. Henry F. Schaefer Careers Feature Top Hopes for the year ahead To kick off 2015 Nature s Careers section asked several young scientists all 40 or under about their plans for the year ahead and their wishes for the future of science. Monya Baker research News & Views Top Molecular biology: Entry signals control development Jonathan D. Dinman See also Article by Xue et al. Materials science: Like cartilage but simpler Anne Ladegaard Skov See also Letter by Liu et al. Structural biology: Photosynthetic complex in close-up Ilme Schlichting See also Letter by Suga et al. 50 & 100 Years Ago Microbiology: Diverted on the way to memory Gordon Y. C. Cheung & Michael Otto Cell cycle: It takes three to find the exit Mathieu Bollen See also Letter by Grallert et al. Earth science: Ocean circulation and rapid climate change Ellen E. Martin See also Letter by Böhm et al. Articles Top RNA regulons in Hox 5 UTRs confer ribosome specificity to gene regulation Shifeng Xue Siqi Tian Kotaro Fujii Wipapat Kladwang Rhiju Das et al. Specialized ribosomes with a particular protein composition carry out translation of specific transcripts analysis of Hox mRNA translation in mice reveals that unique RNA structural elements within their 5 UTRs including internal ribosome entry sites and translation inhibitory elements are responsible for this specialized mode of translation. See also News & Views by Dinman Architecture and conformational switch mechanism of the ryanodine receptor Rouslan G. Efremov Alexander Leitner Ruedi Aebersold & Stefan Raunser Using electron cryomicroscopy the structure of the rabbit RyR1 calcium channel is determined at 6.1 Ã… resolution in the closed state and 8.5 Ã… in the open state revealing how calcium binding to the EF-hand of RyR1 regulates channel opening and facilitates calcium-induced calcium release. Structure of a mammalian ryanodine receptor Ran Zalk Oliver B. Clarke Amédée des Georges Robert A. Grassucci Steven Reiken et al. Using electron cryomicroscopy the closed-state structure of rabbit RyR1 is determined at 4.8 Ã… resolution analysis confirms that the RyR1 architecture consists of a six-transmembrane ion channel with a cytosolic -solenoid scaffold and suggests a mechanism for Ca2-induced channel opening. Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution Zhen Yan Xiao-chen Bai Chuangye Yan Jianping Wu Zhangqiang Li et al. Using electron cryomicroscopy the structure of the closed-state rabbit ryanodine receptor RyR1 in complex with its modulator FKBP12 is solved at 3.8 Ã… in addition to determining structural details of the ion-conducting channel domain three previously uncharacterized domains help to reveal a molecular scaffold that allows long-range allosteric regulation of channel activities. Letters Top A higher-than-predicted measurement of iron opacity at solar interior temperatures J. E. Bailey T. Nagayama G. P. Loisel G. A. Rochau C. Blancard et al. Laboratory measurements of iron opacity made under conditions similar to those inside the Sun reveal much higher opacity than predicted helping to resolve inconsistencies within stellar models of the internal temperatures of stars. Higher-than-predicted saltation threshold wind speeds on Titan Devon M. Burr Nathan T. Bridges John R. Marshall James K. Smith Bruce R. White et al. Wind tunnel experiments designed to simulate the conditions on Saturn s moon Titan yield threshold wind speeds for particle saltation higher than those predicted by models derived from simulations of terrestrial-planet conditions the results can be reconciled by modifying the models to take into account the low ratio of particle density to fluid density on Titan. Observation of quantized conductance in neutral matter Sebastian Krinner David Stadler Dominik Husmann Jean-Philippe Brantut & Tilman Esslinger Quantized conductance in the transport of neutral atoms is observed in an optically produced channel either a quantum point contact or a quantum wire between two atom reservoirs the lowest non-zero conductance value is the universal conductance quantum the reciprocal of Planck s constant. An anisotropic hydrogel with electrostatic repulsion between cofacially aligned nanosheets Mingjie Liu Yasuhiro Ishida Yasuo Ebina Takayoshi Sasaki Takaaki Hikima et al. Usually materials design focuses on attractive interactions but here a hydrogel is described whose properties are dominated by electrostatic repulsion between negatively charged titanate nanosheets embedded within it the material inspired by articular cartilage deforms easily when sheared parallel to the sheets but resists compressive forces applied orthogonally. See also News & Views by Ladegaard Skov Strong and deep Atlantic meridional overturning circulation during the last glacial cycle E. Böhm J. Lippold M. Gutjahr M. Frank P. Blaser et al. Reconstruction of the Atlantic meridional overturning circulation from a highly resolved marine sedimentary record shows that a deep vigorous overturning circulation mode has persisted for most of the last glacial cycle dominating ocean circulation in the Atlantic but that a shallower glacial mode prevailed during glacial maxima. See also News & Views by Martin Origins of major archaeal clades correspond to gene acquisitions from bacteria Shijulal Nelson-Sathi Filipa L. Sousa Mayo Roettger Nabor Lozada-Chávez Thorsten Thiergart et al. A comparison of protein-coding genes from 134 archaeal genomes with their homologues in 1847 bacterial genomes reveals that during evolution genes are transferred more often from bacteria to archaea than vice versa and that gene influxes from bacteria can bring about the origin of major archaeal groups. Identification of multipotent mammary stem cells by protein C receptor expression Daisong Wang Cheguo Cai Xiaobing Dong Qing Cissy Yu Xiao-Ou Zhang et al. Using transplantation and lineage-tracing strategies protein C receptor is identified as a marker of mammary stem cells in mice with potential implications for understanding the initiation of breast cancer. Hepatitis A virus and the origins of picornaviruses Xiangxi Wang Jingshan Ren Qiang Gao Zhongyu Hu Yao Sun et al. Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood this paper now provides high-resolution crystal structures of both the mature and the empty hepatitis A virus particle which show that the three-dimensional structure resembles insect picorna-like viruses. Human intracellular ISG15 prevents interferon- / over-amplification and auto-inflammation Xianqin Zhang Dusan Bogunovic Béatrice Payelle-Brogard Véronique Francois-Newton Scott D. Speer et al. ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18 triggering an increase in type I interferon production and signalling and promoting auto-inflammatory disease. A PP1 PP2A phosphatase relay controls mitotic progression Agnes Grallert Elvan Boke Anja Hagting Ben Hodgson Yvonne Connolly et al. The activation and coordination of phosphatase activity is important during mitotic exit here a mitotic phosphatase relay is described in fission yeast between the two major phosphatases PP1 and PP2A a mode of regulation that may be a feature of signalling networks across eukaryotes. See also News & Views by Bollen Native structure of photosystem II at 1.95 Ã… resolution viewed by femtosecond X-ray pulses Michihiro Suga Fusamichi Akita Kunio Hirata Go Ueno Hironori Murakami et al. The radiation-damage-free structure of the photosystem II membrane protein complex which oxidizes water into dioxygen in an oxygen evolving complex has been determined by an X-ray free electron laser at a resolution of 1.95 Ã… one of the substrate oxygen atoms in this reaction is now identified. See also News & Views by Schlichting Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum Xiaochun Li Rita Roberti & Günter Blobel Solving the X-ray crystal structure of a 14-sterol reductase and homologue of human C14SR and DHCR7 two enzymes that reduce specific carbon carbon double bonds in the cholesterol biosynthetic pathway may provide insight into how specific mutations in DHCR7 and lamin B receptor lead to human diseases. gepflegtes Exemplar nur kleine Lesespuren NPG Nature publishing group hardcover‎

书商的参考编号 : B00042557