Bitran, Jacob D, MD M DBiblio.com
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2000ref. ja-bs44Amer College of Physicians 2000. paperback. Very Good. 5x0x8. Pages are crisp and clean no marking. Cover is verygood. Binding is tight/good. Amer College of Physicians paperback
2014ref. 287839San Francisco: AIDS Emergency Fund & Positive Resource Center 2014. Calendar. 28p 10x10 inches color photos of the 12 shirtless hunks with personal inscriptions signed to the previous owner who has made a few marks on dates in July and August hole for hanging very worn else good wall calendar in stapled color covers. Inscribed & signed by all 12 models. AIDS Emergency Fund & Positive Resource Center unknown books
1968ref. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown
1968ref. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown books
ref. 15725,Paris, Musée de Montmartre 1976, 62 pp., 1 vol. in 12 br. couverture illustrée d'après un dessin de Jean Cocteau, illustrations hors-texte. Liste des oeuvres exposées. Chronologie et bibliographie. Etat de neuf. Rare édition originale.
1982ref. N3446Tel Aviv: Kol Printing Service 1982. Original Plasticlike BoardsDJ. Very Good. 4to. 317pp. Hundreds of illustrations of coins with classifications. Dust jacket with some marginal wear and loss.Otherwise a very good clean and fresh copy. Inscribed by the author to a fellow numismatic Shraga Qedar on title page. Kol Printing Service hardcover
1873ref. 444603 L.A.S. totalisant 4 ff. in-12 rédigés recto-verso,datées des 27 août, 1er septembre et 10 septembre 1873 : détail du texte : Première L.A.S. : " Orléans le 27 août 1873. Monsieur, je vous adresse le spécimen pour le volume de M. d'Aurevilly. Il y a énormément de matières : le spécimen est encore neuf sur une justification assez large comme vous le voyez, interligne à deux points, et nous formerons 10 feuilles pleines à 10 feuilles 1/2. Il faudra évidemment un faux titre pour chaque partie. Le caractère sera très bon, très net. Mais la quantité de matière et le nombre limité de feuilles nous forcent à être compact, trop compact pour faire un volume élégant. Il faudrait pouvoir blanchir davantage et s'étendre jusqu'à 19 feuilles au moins. Je ne vous parle pas du corps 10, nous faisons d'emblée 11 feuilles et plus. Je pourrais me mettre en mesure de vous livrer pour paraître dans la première quinzaine d'octobre". - Seconde L.A.S. : "Orléans, le 1 septembre 1873. Monsieur, Je prends la liberté de venir troubler la tranquillité de votre villégiature pour vous mettre un peu au courant de mes travaux. J'ai envoyé à Monsieur Assollant ses 5 et 6e feuilles. La 7e sera prête sous trois jours au plus. [...] Barbey d'Aurevilly est commencé et d'ici 4 jours j'ajouterai trois compositeurs jusqu'à épuisement de la lettre disponible. Cardenio va partir en ballots chez le brocheur. Veuillez être assez bon pour donner des ordres pour l'expédition du papier pour achever Rachel et commencer le nouveau [... avec les commentaires autographes d'Edouard Dentu à la suite, pour son commis Sauvaitre : ] "La lettre ci-jointe vous mettra au courant des travaux chez Jacob. Envoyez-lui sans tarder le papier qu'il demande. Le volume de Barbey fera onze feuilles. [ ... ] Je vous retourne les deux traites acquittées. Envoyez à Emile Gaboriau, hôtel d'Orléans à Royan (Charente-Inférieure) quinze cents francs [... ] Il est en effet préférable de ne faire paraître l'affiche qu'au moment de la mise en vente des Mémoires de Paul de Kock". - Troisième L.A.S. "Orléans le 10 septembre 1873. Monsieur, J'expédie à M. Barbey d'Aurevilly la dernière feuille de son travail, et la troisième sera finie lundi et expédiée le jour même ou mardi au plus tard. Vous ne m'avez pas fixé de nombre ; prendra-t-on empreintes ? Monsieur Assolant ne renvoie pas plus les épreuves que par le passé. Je lui avais écrit directement le conjurant de hâter sa lecture des épreuves. Ainsi que je vous l'ai dit dans ma dernière lettre j'ai expédié Cardenio chez le brocheur et la facture du volume que M. Sauvaistre doit avoir sous les yeux. Je serai à Paris la semaine prochaine vers le 16. Je serai très heureux de vous y rencontrer [ etc... ]"
1967ref. BL3996Wiesbaden:: Franz Steiner 1967. 1967. Signed. III: Aus dem Sozialmedizinischen erbe Rudolf Virchows Medizin als Wissenschaft vom Menschen. offprint Janus LII 3 1965 pp. 218-240. Leiden: Brill 1965. Inscribed by the author. In 1967 he qualified as a professor of pathology under Wilhelm Doerr with a thesis on Rudolf Virchow assisted by the medical historian Heinrich Schipperges. Jacob initially worked as an internist and tuberculosis doctor in Heidelberg and encountered professional difficulties due to his medical anthropological views. Wikip. Franz Steiner, 1967. unknown books
2007ref. 1-0470109874John Wiley & Sons Inc 2007. Hardcover. New. 1st edition. 207 pages. 9.00x6.25x0.75 inches. John Wiley & Sons Inc hardcover
1993ref. x-0070564248McGraw-Hill 1993. Paperback. New. 1st edition. 704 pages. 11.00x8.25x1.00 inches. McGraw-Hill paperback
ref. ria9780070564244_inpPaperback / softback. New. New Book; Fast Shipping from UK; Not signed; Not First Edition; Lets you practice at your own pace and reminds you of the important problem-solving techniques you need to remember. This guide includes: 3000 solved problems with solutions; an index to help you quickly locate the types of problems you paperback
ref. 6650226The McGraw-Hill Company . Papeback. New. pp. vii 687 The McGraw-Hill Company unknown
1953ref. 194708CA: Camera Craft 1953. Hardcover. Very Good/Very Good. First edition. Very good or better in an about Very good dustwrapper. Dustwrapper rubbed with tears all along all edges. Camera Craft hardcover books
2004ref. BN28156Jovis 2004. 2004. Hardcover. 276 x 238 x 24 cm. Das Märkische Viertel die für die Bundesrepublik einzigartige Großsiedlung für mehr als 40.000 Menschen im Berliner Norden begeht 2004 sein 40-jähriges Bestehen. Es wird bis heute viel beachtet und kontrovers diskutiert: Schon früh schien vielen das planerische Motto "Urbanität durch Dichte" gescheitert und das Märkische Viertel Symbol einer verfehlten inhumanen Stadtplanung zu sein. Entgegen aller Kritik aber hat sich diese Großsiedlung inzwischen zu einem lebendigen und funktionalen Ort entwickelt mit dem sich seine Bewohner identifizieren. Namhafte Autoren äußern sich im vorliegenden Band zum "Phänomen" Märkisches Viertel aus baugeschichtlicher stadtplanerischer und soziologischer Perspektive. Es werden die verschiedenen Positionen der Diskussion in Wort und Bild sowie die unterschiedlichen Entwicklungsschritte vom Problemgebiet zur stabilen Großsiedlung aufgezeigt. Eine Chronik des Märkischen Viertels fasst die entscheidenden Daten und Ereignisse zur 40-jährigen Geschichte zusammen. Autorenporträt: Wolfgang Schäche geboren 1948 ist Professor für Baugeschichte und Architekturtheorie an der TFH Berlin. Seine Schwerpunkte sind Forschungen zur Architektur- und Stadtgeschichte sowie Denkmalpflege des 19. und 20. Jahrhunderts. Zahlreiche Veröffentlichungen zur Architektur der NS-Zeit gelten als Standardwerke der baugeschichtlichen Forschung Eine schöne Geschichtewenn man mit dem MV etwas zu tun hat oder sich einfach für Wohnungsbau und die Entstehung von Wohnsiedlungen interessiert ist dieses Buch sehr empfehlenswert. Die vielen Bilder sind äußerst beeindruckend wenn man sieht wie Schritt für Schritt so ein gigantischer "Hochhauspark" mitten auf ein Feld gesetzt wird wenn man sieht wie ein gigantischer Müllberg zum besten Naherholungsgebiet des MVs wird und wenn man die ein oder andere Stelle wiedererkennt die man vor Jahren einmal live gesehen hatte. Ich finde es super und bin froh es gefunden zu haben!Sprache deutsch Maße 230 x 270 mm Einbandart gebunden Technik Architektur Architekt Kunst Architekten Märkisches Viertel Berlin Stadtplanung ISBN-10 3-936314-07-1 3936314071 ISBN-13 978-3-936314-07-6 9783936314076 40 Jahre Märkisches Viertel. Geschichte und Gegenwart einer Großsiedlung Gebundene Ausgabe Brigitte Jacob Autor Wolfgang Schäche Autor 40 Jahre Märkisches Viertel Geschichte und Gegenwart einer Grosssiedlung Bautechnik Architektur Architekt Kunst Architekten Märkisches Viertel Berlin Stadtplanung ISBN-10 3-936314-07-1 3936314071 ISBN-13 978-3-936314-07-6 9783936314076 40 Jahre Märkisches Viertel. Geschichte und Gegenwart einer Großsiedlung Gebundene Ausgabe Brigitte Jacob Autor Wolfgang Schäche Autor 40 Jahre Märkisches Viertel Geschichte und Gegenwart einer Grosssiedlung Das Märkische Viertel die für die Bundesrepublik einzigartige Großsiedlung für mehr als 40.000 Menschen im Berliner Norden begeht 2004 sein 40-jähriges Bestehen. Es wird bis heute viel beachtet und kontrovers diskutiert: Schon früh schien vielen das planerische Motto "Urbanität durch Dichte" gescheitert und das Märkische Viertel Symbol einer verfehlten inhumanen Stadtplanung zu sein. Entgegen aller Kritik aber hat sich diese Großsiedlung inzwischen zu einem lebendigen und funktionalen Ort entwickelt mit dem sich seine Bewohner identifizieren. Namhafte Autoren äußern sich im vorliegenden Band zum "Phänomen" Märkisches Viertel aus baugeschichtlicher stadtplanerischer und soziologischer Perspektive. Es werden die verschiedenen Positionen der Diskussion in Wort und Bild sowie die unterschiedlichen Entwicklungsschritte vom Problemgebiet zur stabilen Großsiedlung aufgezeigt. Eine Chronik des Märkischen Viertels fasst die entscheidenden Daten und Ereignisse zur 40-jährigen Geschichte zusammen. Autorenporträt: Wolfgang Schäche geboren 1948 ist Professor für Baugeschichte und Architekturtheorie an der TFH Berlin. Seine Schwerpunkte sind Forschungen zur Architektur- und Stadtgeschichte sowie Denkmalpflege des 19. und 20. Jahrhunderts. Zahlreiche Veröffentlichungen zur Architektur der NS-Zeit gelten als Standardwerke der baugeschichtlichen Forschung Eine schöne Geschichtewenn man mit dem MV etwas zu tun hat oder sich einfach für Wohnungsbau und die Entstehung von Wohnsiedlungen interessiert ist dieses Buch sehr empfehlenswert. Die vielen Bilder sind äußerst beeindruckend wenn man sieht wie Schritt für Schritt so ein gigantischer "Hochhauspark" mitten auf ein Feld gesetzt wird wenn man sieht wie ein gigantischer Müllberg zum besten Naherholungsgebiet des MVs wird und wenn man die ein oder andere Stelle wiedererkennt die man vor Jahren einmal live gesehen hatte. Ich finde es super und bin froh es gefunden zu haben!Sprache deutsch Maße 230 x 270 mm Einbandart gebunden Jovis hardcover
1928ref. 126591928 un volume, reliure demi-toile (half cloth-bound) crème grand in-octavo, dos long (spine without raised band) décoré or (gilt decoration) - à fleuron au fer plein (floweret with full blocking stamp) - titre frappé or (gilt title) - pièce de titre sur fond marron foncé, papier peigné aux plats (cover with painting paper), tranches lisses (smooth edges), gouttière rognée (fore-edge smooth), marque-page en tissu (bookmark in tissue), couverture conservée (cover preserved - library edition), envoi autographe manuscrit de l'Auteur sur la 1ère page aprés la page de titre adressé à Théophile Briant (author's autograph on the first page after lhe title page) écrit à l'encre noire dans la partie de la moitié supérieure de la page au dessus de LITHOGRAPHIES : "...A Théophile Briant que j'ai connu au bord de la mer parceque, c'est là que nous nous Etions donné rendez-vous,- à Théo qui a lu mes poêmes sous les pommiers de Saint Suliac et qui les as aimés, à Théo poète et Triton, Son Ami ...signé Georges (Georges HUGNET)" + un Dessin Original de Georges HUGNET à la gouache noire et grise et mine de plomb, sur la deuxième moitié de la page en partie basse représentant : "un homme pleurant devant un autre homme le bras et l'index levé", justification du tirage : tirage limité à 170 exemplaires - 1 des 150 exemplaires sur Vélin d'Arches (N°99), illustré de 2 lithographies et de quatre dessins hors texte en noir par Max JACOB, 80 pages, 1928 Paris Théophile Briant Editeur,
1928ref. 26748Paris, Théophile Briant, éditeur 1928. In-4 broché de 82 pages au format 17 x 26 cm. Couverture rempliée avec titre imprimé en rouge et noir. Dos carré, très légèrement insolé, comme les mors. Plats et intérieur frais. Contient 2 lithographies originale et quatre dessins hors texte en noir par Max Jacob. Tirage unique à 150 exemplaires numérotés sur vélin d’arches ( n° 125 ), après 5 japon et 15 hollande. Rarissime édition originale du premier livre de Georges Hugnet.
1928ref. 153851928 Paris Theophile Briant 1928 in8, broché, couverture imprimée en noir et rouge, rempliée, 80 pp Edition originale. un des 150 exemplaires numérotes sur vélin d'arches,sur un , tirage total à 180 exemplaires. bel exemplaire, en parfait état enrichi d'un bel nvoi de George Hugnet a Jean Jausion, date de Juillet 1943 " D'une enfance a celle qui vient de tout coeur..." belles illustrations de Max jacob
2019ref. BN203806BLURB INC 2019. 2019. Hardcover. 44 Cake Recipes: Cake recipes 44 Cake Recipes: Cake recipes Jacob Riley BLURB INC hardcover
ref. 0968342507-11-1The Conservation Lands of Ontario. 3rd. Very Good. It's a well-cared-for item that has seen limited use. The item may show minor signs of wear. All the text is legible with all pages included. It may have slight markings and/or highlighting. The Conservation Lands of Ontario unknown
ref. 0968342507.Gpaperback. Good. Access codes and supplements are not guaranteed with used items. May be an ex-library book. paperback
1882ref. 902873AGWien:, 1882. Chromolithographie 22,5 x 28,5 cm.
1950ref. 263147New York: National Executive Committee Workmen's Circle 1950. 422 pages hardcover light shelfwear smudges of soil to textblock edge. Text in Yiddish with additional English title "50 years of the Workmen's Circle in Jewish Life. National Executive Committee, Workmen's Circle unknown books
1950ref. 263146New York: National Executive Committee Workmen's Circle 1950. 422 pages hardcover light shelfwear. Text in Yiddish with additional English title "50 years of the Workmen's Circle in Jewish Life. National Executive Committee, Workmen's Circle unknown books
2011ref. 96908Fantagraphics. New. Hardcover. FREE UPGRADE to Courier/Priority Shipping Upon Request - IN STOCK AND IMMEDIATELY AVAILABLE FOR SHIPMENT - Flawless copy brand new pristine never opened -- 200 pp. ; 473 illus. -- with a bonus offer--; The acclaimed cartoonist collects 500 portraits from his 20 year-plus career. 500 Portraits collects for the first time over two decades of portrait work by the beloved and award-winning creator of Drinky Crow’s Maakies Sock Monkey and Billy Hazelnuts. Tony Millionaire’s gorgeous fountain pen illustrations which mingle naturalistic detail with strong doses of the fanciful and grotesque include the famous Bob Dylan the infamous Abu Ghraib soldier/model Lynndie England the fictional Yoda the animal kingdom a cockroach and everything in between. Literary figures Hemingway literary characters Don Quixote and Sancho Panza Hollywood legends Steven Spielberg comics icons Hergé and historical figures Hitler also figure prominently. Millionaire’s impeccable linework resembles that of Johnny Gruelle creator of Raggedy Ann and Andy whom he cites as one of his main sources of inspiration along with Ernest Shepard and “all those freaks from the ’20s and ’30s who did the newspaper strips.” Many of these 500 portraits were created for The Believer the magazine founded by Dave Eggers that Millionaire has helped define visually with his signature portraits of interview subjects in every issue since the magazine started. But it also includes dozens if not hundreds of illustrations from various other publications including The New York Times The New Yorker Ephemera Press Historical Maps The Wall Street Journal and others. 500 black-and-white illustrations . 2011. 1606994735 . Fantagraphics hardcover
2000ref. 500035357L'Etudiant Pratique 2000 1x17x10cm. 2000. Broché.
