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‎Isabelle Monod Fontaine‎

‎Daniel-Henry Kahnweiler: Centre Georges Pompidou Musee national d'art moderne 22 novembre 1984-28 janvier 1985 French Edition‎

‎Le Centre 1984-01-01. Paperback. Used:Good. Le Centre paperback‎

Bookseller reference : DADAX2858502641 ISBN : 2858502641 9782858502646

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‎Isabelle Monod Fontaine‎

‎Daniel-Henry Kahnweiler: Centre Georges Pompidou Musee national d'art moderne 22 novembre 1984-28 janvier 1985 French Edition‎

‎Le Centre 1984. Good. Le Centre unknown‎

Bookseller reference : SONG2858502641 ISBN : 2858502641 9782858502646

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‎Isabelle Monod Fontaine‎

‎Dation Pierre Matisse: Musee national d'art moderne Centre Georges Pompidou French Edition‎

‎1992-05-05. New. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May be re-issue. Buy with confidence excellent customer service! unknown‎

Bookseller reference : 285850671Xn ISBN : 285850671x 9782858506712

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‎Isabelle Monod Fontaine‎

‎Dation Pierre Matisse: Musee national d'art moderne Centre Georges Pompidou French Edition‎

‎1992-05-05. Good. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be re-issue. May be ex-library. Shipping & Handling by region. Buy with confidence excellent customer service! unknown‎

Bookseller reference : 285850671X ISBN : 285850671x 9782858506712

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‎Isabelle Monod Fontaine‎

‎Dation Pierre Matisse: Musee national d'art moderne Centre Georges Pompidou French Edition‎

‎Editions du Centre Pompidou 1992. Paperback. Good. Editions du Centre Pompidou paperback‎

Bookseller reference : SONG285850671X ISBN : 285850671X 9782858506712

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‎Isabelle Monod Fontaine Richard Shiff Dieter Buchhart‎

‎Georges Braque: Pioneer of Modernism‎

‎2011-02-04. New. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May be re-issue. Buy with confidence excellent customer service! unknown‎

Bookseller reference : XH06AXD2SIn ISBN : 0982688601 9780982688601

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‎Isabelle Monod Fontaine Richard Shiff Dieter Buchhart‎

‎Georges Braque: Pioneer of Modernism‎

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Bookseller reference : XH06AXD2SI ISBN : 0982688601 9780982688601

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‎Isabelle Monod Fontaine‎

‎Georges Braque les papiers colle�s: exposition 17 juin-27 septembre 1982 Paris Centre Georges Pompidou Muse�e national d'art moderne : catalogue French Edition‎

‎1982-01-01. Good. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be re-issue. May be ex-library. Shipping & Handling by region. Buy with confidence excellent customer service! unknown‎

Bookseller reference : 2858501505 ISBN : 2858501505 9782858501502

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‎Isabelle Monod Fontaine‎

‎Georges Braque les papiers colles: exposition 17 juin-27 septembre 1982 Paris Centre Georges Pompidou Musee national d'art moderne : catalogue French Edition‎

‎Le Musee 1982. Paperback. Good. Le Musee paperback‎

Bookseller reference : SONG2858501505 ISBN : 2858501505 9782858501502

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‎Isabelle Monod Fontaine‎

‎Henri Matisse: Oeuvres de Henri Matisse 1869-1954‎

‎Paris: Centre Georges Pompidou 1979. Softcover. VG- some mild curling of DJ and covers with foxing spots that seem typical for this book. White wraps tan DJ. 192 pp. 33 color 187 bw plates. Four-page introduction by Isabelle Monod-Fontaine chronological work index catalogue of 61 illustrated annotated works stunning plates biographic chronology and exhibition listing. Text in French. Published to accompany the exhibition held in Paris France: Mus�e National d'Art Moderne 1979. Centre Georges Pompidou paperback‎

Bookseller reference : 12748 ISBN : 2858500223 9782858500222

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‎Isabelle Monod Fontaine‎

‎Matisse: Le reve ou Les belles endormies 1/1 French Edition‎

‎A. Biro 1989. Paperback. Good. A. Biro paperback‎

Bookseller reference : SONG2876600501 ISBN : 2876600501 9782876600508

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‎Isabelle Monod Fontaine‎

‎Matisse: oeuvres de Henri Matisse Collections du Musee national d'art moderne French Edition‎

‎Centre Georges Pompidou 1989-01-01. Hardcover. Used:Good. Centre Georges Pompidou hardcover‎

Bookseller reference : DADAX2858503907 ISBN : 2858503907 9782858503902

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‎Isabelle Monod Fontaine‎

‎Matisse: oeuvres de Henri Matisse Collections du Musee national d'art moderne French Edition‎

‎Centre Georges Pompidou 1989. Hardcover. Good. Centre Georges Pompidou hardcover‎

Bookseller reference : SONG2858503907 ISBN : 2858503907 9782858503902

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‎Isabelle Monod Fontaine‎

‎Sculpture of Henri Matisse‎

‎Thames & Hudson January 1984. Hardcover. Used - Good/Good. Dust jacket discolored along top edge otherwise book in good condition. Wrapped in complimentary Brodart dust jacket protector. Thames & Hudson hardcover‎

Bookseller reference : 255549 ISBN : 0500234000 9780500234006

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‎Isabelle Monod Fontaine‎

‎The Sculpture of Henri Matisse‎

‎Thames & Hudson Ltd 1985. Paperback. Very Good. Cover worn page edges tanned. Shipped from the U.K. All orders received before 3pm sent that weekday. Thames & Hudson Ltd paperback‎

Bookseller reference : pb254-719474 ISBN : 0500273952 9780500273951

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‎Isabelle Monod Fontaine‎

‎The Sculpture of Henri Matisse‎

‎Thames & Hudson. Used - Very Good. Former Library book. Great condition for a used book! Minimal wear. Thames & Hudson unknown‎

Bookseller reference : GRP73074042 ISBN : 0500234000 9780500234006

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‎Isabelle Monod Fontaine‎

‎The Sculpture of Henri Matisse‎

‎Thames & Hudson. Used - Good. Ships from the UK. Former Library book. Shows some signs of wear and may have some markings on the inside. 100% Money Back Guarantee. Your purchase also supports literacy charities. Thames & Hudson unknown‎

Bookseller reference : GRP16602072 ISBN : 0500234000 9780500234006

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‎Isabelle Monod Fontaine‎

‎Henri Matisse: Oeuvres de Henri Matisse 1869-1954‎

‎Paris: Centre Georges Pompidou 1979. Softcover. VG- some mild curling of DJ and covers with foxing spots that seem typical for this book. White wraps tan DJ. 192 pp. 33 color 187 bw plates. Four-page introduction by Isabelle Monod-Fontaine chronological work index catalogue of 61 illustrated annotated works stunning plates biographic chronology and exhibition listing. Text in French. Published to accompany the exhibition held in Paris France: Musée National d'Art Moderne 1979. Centre Georges Pompidou unknown books‎

Bookseller reference : 12748 ISBN : 2858500223 9782858500222

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‎Isabelle. Chicca Castex Celine. Cicali Ilaria. Monod Fontaine‎

‎Matisse la figura‎

‎2014-01-01. Good. Ships with Tracking Number! INTERNATIONAL WORLDWIDE Shipping available. May not contain Access Codes or Supplements. May be re-issue. May be ex-library. Shipping & Handling by region. Buy with confidence excellent customer service! unknown‎

Bookseller reference : 8889793163 ISBN : 8889793163 9788889793169

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‎J.H. MONOD.‎

‎DEUX MOTS SUR ... LES MALADIES PROFESSIONNELLES.‎

‎Deux mots sur.. Non daté. In-12. Broché. Bon état, Couv. convenable, Dos satisfaisant, Intérieur frais. 24 pages. Quelques illustartions en vert et blanc, dans le texte et hors texte.. . . . Classification Dewey : 0-GENERALITES‎

‎Industrielles et agricoles. Classification Dewey : 0-GENERALITES‎

Bookseller reference : RO20073939

Livre Rare Book

Le-livre.fr / Le Village du Livre
Sablons France Francia França France
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‎JACCARD, A.-L. / GUISAN / MONOD / BURNIER / EMERY / DALLER:‎

‎Aux Troupes de surveillance romandes. Honneur Fidelité Solidarité.‎

‎Lausanne, Editions Anré-Louis Jaccard, 1946, gr. in-8vo, 125 p., ill. n./b., brochure originale.‎

‎Ex. sur papier velin, bouffant surfin blanc neige no. 400 sur 700.‎

Bookseller reference : 124929aaf

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‎Jacques Monod‎

‎Le Hasard et La nécessité - Essai Sur La Philosophie Naturelle De La Biologie Moderne‎

‎Editions Du Seuil broché Bristol Paris 1970 197 pages en format grand -8‎

‎Très Bon État‎

Bookseller reference : 027976

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‎Jacques Monod‎

‎Le Hasard et La nécessité - Essai Sur La Philosophie Moderne‎

‎Editions Du Seuil / Points Sciences broché Couverture Illustrée Paris 1973 244 pages en format -12‎

‎Très Bon État‎

Bookseller reference : 053098

Livre Rare Book

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‎Jacob Monod Lwoff and Brenner‎

‎22 offprints mimeographs etc. on molecular biology and bacterial genetics with two others‎

‎1968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. unknown‎

Bookseller reference : 38733

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‎Jacob Monod Lwoff and Brenner‎

‎22 offprints mimeographs etc. on molecular biology and bacterial genetics with two others‎

‎1968. <p>Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints.</p> <p>First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death.</p> <p>The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: </p> <p>1 lysogeny and bacterial conjugation</p> <p> 2 expression of the genetic material via messenger RNA</p> <p> 3 the regulation of the genetic activity of bacterial cells by operons</p> <p>4 the organization of bacterial genetic material.</p> <p> In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology.</p> <p>Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage.</p> <p> "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date.</p> <p>Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. </p> <p>"Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385.</p> <p> In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria.</p> <p>In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103.</p> <p>Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306.</p> <p> Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA.</p> <p>The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. </p> <p>The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below.</p> <p>1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27.</p> <p>2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4.</p> <p>3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles.</p> <p>4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature.</p> <p>5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382.</p> <p>6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7.</p> <p>7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature.</p> <p>8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11.</p> <p>9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400.</p> <p>10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature.</p> <p>11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410.</p> <p>12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature.</p> <p>13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers.</p> <p>14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13.</p> <p>15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning.</p> <p>16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11.</p> <p>17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature.</p> <p>18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature.</p> <p>19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers.</p> <p>20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature.</p> <p>21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers.</p> <p>22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature.</p> <p>23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers.</p> <p>24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp.</p> . unknown books‎

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‎JACQUELINE MUNK COMISARIO DE LA EXPOSICIAN NICHOLAS FOX WEBER ITZHAK GOLDBERG CAMILLE VIEVILLE CAROL JACOBI ISABELLE MONOD‎

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‎Jacques Monod‎

‎Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology Penguin Science‎

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‎Jacques Monod‎

‎Chance and Necessity‎

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‎Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology‎

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‎Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology‎

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‎Jacques Monod Austryn Wainhouse Translator‎

‎Chance and Necessity: An Essay on the Natural Philosophy of Modern Biology‎

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‎El azar y la necesidad‎

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‎El azar y la necesidad‎

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‎Jacques Monod‎

‎El Azar Y La Necesidad Spanish Edition‎

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‎Jacques Monod‎

‎Il caso e la necessit�‎

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‎Il caso e la necessit�‎

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‎Il caso e la necessit�‎

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‎Jacques Monod‎

‎Il caso e la necessit�‎

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‎Il caso e la necessità. Saggio sulla filosofia naturale della biologia contemporanea‎

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‎Il caso e la necessit�. Saggio sulla filosofia naturale della biologia contemporanea‎

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‎Jacques Monod‎

‎Le Hasard et la Necessite - Essai sur la philosophie naturelle de la biologie moderne French Edition‎

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‎Le hasard et la nècessitè‎

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‎Le hasard et la nècessitè‎

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‎Le hasard et la nécessité - Essai sur la philosophie naturelle de la biologie moderne‎

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‎Jacques Monod‎

‎Le Hasard et la Ncessit French Edition‎

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‎Jacques Monod‎

‎Pour une ethique de la connaissance Histoire des sciences French Edition‎

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‎Raslanti ve zorunluluk. = Le hasard et la n�cessit�. Translated by Vehbi Hacikadiroglu.‎

‎Ankara: Dost Kitabevi Yayinlari 1983. Soft cover. Fine. 8vo - over 7� - 9�" tall. Paperback. Pbo. Cr. 8vo. 20 x 14 cm. In Turkish. 207 p. Raslanti ve zorunluluk. = Le hasard et la n�cessit�. Translated by Vehbi Hacikadiroglu. <br/> <br/> Dost Kitabevi Yayinlari paperback‎

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‎Jacques Monod; Editor Andre Lwoff; Editor A. Ullmann‎

‎Selected Papers in Molecular Biology‎

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‎Jacques Monod; FROM THE FRENCH TO GERMAN=GRIESE Translator‎

‎Zufall Und Notwendigkeit Philosophische Fragen Der Moderne Biologie By Jacques Monod‎

‎PIPER & CO VERLAG MUNCHEN 1/1/1971. Hardcover. Very Good. NICE CONDITION HARDCOVER BOOK IN DUST JACKET. SOME WRITING OR MARKINGS IN TEXT. LIGHT WEAR TO COVER. SOME FRAYING CREASING AND FADING TO DUST JACKET. A CLEAN AND SOLID BOOK. PIPER & CO, VERLAG, MUNCHEN hardcover‎

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