[Monod, G H]ABAA
1218 risultati
1930rif. 43483Saigon: Édition Photo Nadal 1930. First edition oblong 4to pp. 113 1; profusely illustrated throughout with sepia toned and black & white photographic illustrations of various people places and way of life in Saigon & Cholon; parallel text in French and English; marbled endpapers front hinge cracked corners bumped and chipped else very good in quarter brown calf over marbled boards with gilt lettering and decoration on spine with raised bands. Édition Photo Nadal unknown books
rif. 77661, vers 19508, in-4, 43 p, fig. dans le texte, Broché, Document tapuscrit original dans lequel Jacques Monod fait état de l'ensemble de ses titres et travaux scientifiques jusqu'à la date de 1958 : curriculum vitae, rapports et conférences, résumé de ses travaux de recherche et publications. Jacques Monod remporta le Prix Nobel en 1965 grâce à son travail de recherche à L'Institut Pasteur. Envoi manuscrit à l'encre brune de Jacques Monod à Louis De Broglie sur la première de couverture. Couverture rigide
1991rif. 008423Paris Futuropolis Gallimard 1991 Cartonnage de L'éditeur
1899rif. 74833Imprimerie Champenois pour CH. Masson H. Piazza | Paris (Mars 1899) | 30.50 x 25 cm | une feuille et une serpente
1899rif. 74833Paris: Imprimerie Champenoispour CH. MassonH. Piazza 1899. Fine. Imprimerie Champenois pour CH. Masson H. Piazza Paris Mars 1899 30.50 x 25 cm une feuille et une serpente Rare original color lithograph executed by Lucien Hector Monod for L'Estampe Moderne series number 23 published in March 1899. One of 50 deluxe proofs printed on Japan paper with wide margins artist's signature in the plate publisher's dry stamp depicting a child's profile in the lower margin numbered luxury edition stamp on the verso; engraving preceded by a tissue guard captioned with the artist's name the title and text. Lithograph inspired by an extract from a work by Henri de Régnier reproduced on the print's tissue guard. Magnificent French monthly publication edited between May 1897 and April 1899 L'Estampe moderne consists of original chromolithographs which unlike other magazines such as Les Maîtres de l'Affiche and as stipulated on the tissue guards were created specially by each artist for the magazine. Thus 100 prints appeared in total covering the major artistic movements of the late 19th century: Symbolism Art Nouveau Pre-Raphaelites Orientalists and Belle Époque. Each delivery of four prints was issued in 2000 copies sold for 3.50F and 100 on Japan paper offered at 10F. Henri Piazza also planned a confidential very deluxe printing: 50 copies on Japan paper with wide margins and 50 in black on China paper at the considerable price of 30F. This print of beautiful format is superbly printed on the most prestigious of papers: Japan paper. Thick silky satiny and pearlescent it contributes to making each page a work in its own right. Its quality of ink absorption and its affinity with colors also make it the ideal support for these very beautiful lithographs. The interest of French collectors in artistic posters intensified at the beginning of the 1890s. Octave Uzanne to qualify this fever invented the term ""affichomanie."" The poster originally popular and plastered in the streets of the capital then became an art object and its ephemeral support became precious and destined for preservation. Piazza decided to remove the poster from its advertising vocation and elevate it to the rank of a work of art in its own right on the same level as the illustrated deluxe book. He thus composed a prestigious collection of entirely original works by the most prominent European artists of the moment: Georges de Feure Eugène Grasset Henri Detouche Emile Berchmans Louis Rhead Gaston de Latenay Lucien Lévy-Dhurmer Gustave-Max Stevens Charles Doudelet Hans Christiansen Henri Fantin-Latour Steinlen Ibels Engels Willette Henri Meunier Evenepoël Bellery-Desfontaines Charles Léandre etc. Handsome copy. Imprimerie Champenoispour CH. MassonH. Piazza unknown
1890rif. R300140104E.DENTU. 1890. In-4. Cartonnage d'éditeurs. Bon état, Couv. convenable, Dos satisfaisant, Intérieur frais. 666 pages + 618 pages + 670 pages + album contenant environ 70 planches en noir et blanc - nombreuses illustrations en noir et blanc dans et hors texte - 7 photos disponibles.. . . . Classification Dewey : 708-Galeries, musées, collections d'art
1940rif. 32687Saïgon Edition photo Nadal s.d. [vers 1940] in-4 oblong broché
1920rif. 007893Paris: Librairie Lutetia 1920. Limited First Edition. Wraps. Fine. No. 150 of 250 copies and now truly scarce with no copies located on OCLC First Search nor in commerce on the date of this listing. Exquisite Art Deco pochoir leporello with 12 humorous caricature panels one for each month. The leporello is housed in a larger light card stock wrapper which is basically a folded sheet and the leporello is loosely held in by a string. The cover of the wrapper has a lovely stylized pochoir illustration of a woman in a panniered dress. The rear has a simple woodcut of a potted tree and the date of publication. The inside of the wrappers is a repeat motive of a potted plant against a blue background. The characters of "caricature" are mostly a French everyman. Each illustration has two lines of captioning at the base. The artist whose real name was Samuel Monod was accomplished in many aspects of letters. He was not just a cartoonist and illustrator but also a writer publisher journalist art critic and theorist and finally a historian of typography. Librairie Lutetia unknown
1920rif. 007893Paris: Librairie Lutetia 1920. Limited First Edition. Wraps. Fine. No. 150 of 250 copies and now truly scarce with no copies located on OCLC First Search nor in commerce on the date of this listing. Exquisite Art Deco pochoir leporello with 12 humorous caricature panels one for each month. The leporello is housed in a larger light card stock wrapper which is basically a folded sheet and the leporello is loosely held in by a string. The cover of the wrapper has a lovely stylized pochoir illustration of a woman in a panniered dress. The rear has a simple woodcut of a potted tree and the date of publication. The inside of the wrappers is a repeat motive of a potted plant against a blue background. The characters of "caricature" are mostly a French everyman. Each illustration has two lines of captioning at the base. The artist whose real name was Samuel Monod was accomplished in many aspects of letters. He was not just a cartoonist and illustrator but also a writer publisher journalist art critic and theorist and finally a historian of typography. Librairie Lutetia unknown books
1890rif. 61004Paris: E. Dentu Editeur Libraire de la Societe des Gens de Letteres 1890. Four Vols. Folio. 9.75 x 13 in. xxxi 1 666 2; 4 618 2; 4 670 2; 8 pp unpaginated. with 82 engravings on 70 plates many double-page. Extra-illustrated title page frontispiece in vol. I 100’s of text woodcut-engravings tables diagrams charts decorated head- and tail-pieces decorated initials. Uniformly bound in elaborately decorated gray-lilac-coloured cloth embossed decorative borders in burgundy-colour gilt lettering front covers & spines t.e.g. minor edgewear inner hinges starting in a few places due to weight of the textblock minor wear and slight bumping to corners darkening and more wear to Atlas volume still a VG set. First edition of this nicely printed and weighty set chronicling the fourth great Paris World’s Fair an extraordinary Exposition which refashioned Paris and celebrated the Centennial of the French Revolution and the storming of the Bastille. The Exposition was intended to pull France out of a ruinous recession and attracted over 61000 exhibitors as well as 32 million visitors many of whom came to view the iconic Eiffel Tower and even a profit of 8000000 francs. This lavish production details the development and history of the Exposition the construction of the Eiffel Tower as well as the development of the sites along the Seine. The companion album includes 82 woodcut-engraved images executed by such artists as Baude Baulenaz and Hauger many of them from original photographs shot by Messiers J. Levy et Cie. Levy had also shot photographs for the 1867 Paris L’Exposition Universelle and his photos captured many views of the exhibition grounds and buildings and focused on many in the Javanese Tonkin and Streets of Cairo attractions. E. Dentu, Editeur, Libraire de la Societe des Gens de Letteres, hardcover
2012rif. 106472Kehrer Verlag Heidelberg. New. Hardcover. FREE UPGRADE to Courier/Priority Shipping Upon Request - IN STOCK AND IMMEDIATELY AVAILABLE FOR SHIPMENT - Flawless copy brand new pristine never opened - Text in English and German. 72 pages; illustrated. -- with a bonus offer-- . 2012. 3868283145 . Kehrer Verlag Heidelberg hardcover
1958rif. DISPLAY5RM002Comptes rendus hebdomadaires des seances de l 1958. very good clean pages. 4x1x6. Prompt shipment with tracking. we ship in CLEAN SECURE NEW boxes Offprint. Faded at edges. First separate edition. Very good in wrappers. Garrison and Morton 6894 . The PaJaMo experiment of PArdee JAcob and MOnod broke the impasse in Crick and Brenner's comprehension of how information in the sequence of bases in DNAcame to be expressed as a sequence of the amino acids in protein and thus led to the theory of the messenger and the solution of the coding problem. Judson 390. Provenance: William B. Provine Comptes rendus hebdomadaires des seances de l unknown
1958rif. display5rm00Comptes rendus hebdomadaires des seances de l 1958. Very Good. Prompt shipment with tracking. we ship in CLEAN SECURE NEW boxes Offprint. Faded at edges. First separate edition. Very good in wrappers. Garrison and Morton 6894 . The PaJaMo experiment of PArdee JAcob and MOnod broke the impasse in Crick and Brenner's comprehension of how information in the sequence of bases in DNAcame to be expressed as a sequence of the amino acids in protein and thus led to the theory of the messenger and the solution of the coding problem. Judson 390. Provenance: William B. Provine Comptes rendus hebdomadaires des seances de l unknown
1961rif. 18040Various places and publications 1961-1965 Includes the following offprints: 1. JACOB François and Jacques Monod. "On the Regulation of Gene Activity." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVI 1961 pp. 193-211; 2. MONOD Jacques and François Jacob. "General Conclusions: Teleonomic Mechanisms in Cellular Metabolism Growth and Differentiation." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVI 1961 pp. 389-401; 3. JACOB François and Jacques Monod. "Determinisme et regulation specifique de la synthèse des proteines." Reprinted from "Proceedings of the Fifth International Congress of Biochemistry" Volume I Pergamon Press 1963. pp. 132-154l; 4. JACOB François and Jacques Monod. "Genetic Repression Allosteric Inhibition and Cellular Differentiation. Reprinted from Cytodifferential & Macromolecular Scynthesis New York: Academic Press Inc. 1963. pp. 30-64; 5. MONOD Jacques Jean-Pierre Changeux and François Jacob. "Allosteric Proteins and Cellular Control Systems." Reprinted from the Journal of Molecular Biology Volume 6 1963 pp. 306-329. All ten papers are in excellent condition. Also includes: 6. JACOB François Sydney Brenner and François Cuzin. "On the Regulation of DNA Replication in Bacteria." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVIII 1963 pp. 329-348;7. JACOB François and Jacques Monod. "Mécanismes biochimiques et génétiques de la régulation dans la cellule bactérienne." Reprinted from Bulletin de la Société de Chimie biologique Extrait du Tome XLVI No. 12 1964 pp. 1499-1532; 8. MONOD Jacques Jeffries Wyman and Jean-Pierre Changeux. "On the Nature of Allosteric Transitions: A Plausible Model." From the Journal of Moleculary Biology Volume 12 1965 pp. 88-118; and 9. JACOB François A. Ullmann and J. Monod. "Délétions fusionnant l'Opéron Lactose et un Opéron Purine chez Escherichia coli." Reprinted from the Journal of Molecular Biology Volume 13 1965 pp. 704-719. Also with an extra paper by Jean-Pierre CHANGEUX collaborator of François Jacob and Jacques Monod: Effet des Analogues de la L-Thréonine et de la L-Isoleucine sur la L-Thréonine Désaminase." Reprinted from the Journal of Molecular Biology pp 220-255. December 1961.
1961rif. 18040Various places and publications 1961-1965 Includes the following offprints: 1. JACOB François and Jacques Monod. "On the Regulation of Gene Activity." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVI 1961 pp. 193-211; 2. MONOD Jacques and François Jacob. "General Conclusions: Teleonomic Mechanisms in Cellular Metabolism Growth and Differentiation." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVI 1961 pp. 389-401; 3. JACOB François and Jacques Monod. "Determinisme et regulation specifique de la synthèse des proteines." Reprinted from "Proceedings of the Fifth International Congress of Biochemistry" Volume I Pergamon Press 1963. pp. 132-154l; 4. JACOB François and Jacques Monod. "Genetic Repression Allosteric Inhibition and Cellular Differentiation. Reprinted from Cytodifferential & Macromolecular Scynthesis New York: Academic Press Inc. 1963. pp. 30-64; 5. MONOD Jacques Jean-Pierre Changeux and François Jacob. "Allosteric Proteins and Cellular Control Systems." Reprinted from the Journal of Molecular Biology Volume 6 1963 pp. 306-329. All ten papers are in excellent condition. Also includes: 6. JACOB François Sydney Brenner and François Cuzin. "On the Regulation of DNA Replication in Bacteria." Reprinted from Cold Spring Harbor Symposia on Quantitative Biology Volume XXVIII 1963 pp. 329-348;7. JACOB François and Jacques Monod. "Mécanismes biochimiques et génétiques de la régulation dans la cellule bactérienne." Reprinted from Bulletin de la Société de Chimie biologique Extrait du Tome XLVI No. 12 1964 pp. 1499-1532; 8. MONOD Jacques Jeffries Wyman and Jean-Pierre Changeux. "On the Nature of Allosteric Transitions: A Plausible Model." From the Journal of Moleculary Biology Volume 12 1965 pp. 88-118; and 9. JACOB François A. Ullmann and J. Monod. "Délétions fusionnant l'Opéron Lactose et un Opéron Purine chez Escherichia coli." Reprinted from the Journal of Molecular Biology Volume 13 1965 pp. 704-719. Also with an extra paper by Jean-Pierre CHANGEUX collaborator of François Jacob and Jacques Monod: Effet des Analogues de la L-Thréonine et de la L-Isoleucine sur la L-Thréonine Désaminase." Reprinted from the Journal of Molecular Biology pp 220-255. December 1961. books
1960rif. DISPLAY5RM004Journal of Molecular Biology v2 n4 1960: 216-225 1960. Pamphlet. Very Good. Prompt shipment with tracking. we ship in CLEAN SECURE NEW boxes Offprint. Very good. Journal of Molecular Biology, v2 n4 (1960): 216-225 unknown
1968rif. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown
1968rif. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown books
