1848ref. 433851848. Berzelius Jöns Jacob 1779-1848. Jacobus Berzelius. Medal in bronze showing a right-facing bust of Berzelius on the obverse with his birth and death dates in roman numerals; the reverse with a standing winged figure and the seated figure of Hygeia along with text in Latin. Signed "P. H. Lundgren fec. - C. G. Quarnstroem inv." N.p. n.d. 1848. 57 mm. diameter. A few minor scratches and dings but very good. The Berzelius Medal was commissioned by the Royal Swedish Academy of Sciences in memory of the famous Swedish chemist who is regarded as one of the founders of modern chemistry. Berzelius invented the current system of chemical symbols originated the duality theory of chemical affinity classing chemical elements as either electronegative or electropositive an ancestor of 20th century electron theories of bonding developed new and important methods of chemical synthesis and analysis and discovered the elements cerium selenium and thorium. T he Latin motto above the figures on the reverse reads "Naturam jussit vires proferre latentes" He commanded forth the secrets of nature. The text below the figures reads "Fundatorum supremo lugens in deepest mourning/ Medic. Suec. Societas." The medal was issued in silver bronze and Berlin iron; this is an example of the bronze. Storer Medicina in Nummis no. 337. . unknown books
1865ref. 64770New York: E. S. Dodge & Co 1865. Historical Outline of Lower California. New York: E. S. Dodge & Co. 1865. First edition. Octavo 8 3/4 x 5 3/4 inches; 223 x 146 mm.1-46 2 blank pp. Original grey printed wrappers. Wrappers chipped along lower portion of the spine and slightly chipped along edges. Some light foxing throughout. Overall a very good copy. "Jacob Primer Leese was a Santa Fe trader who settled in San Francisco in 1836 and engaged in the hide and tallow trade with Yankee ships. He married a sister of General Vallejo and became very wealthy. In 1863 Leese and other promoters founded the Mexican Mining and Colonization Company and obtained a land grant from the Mexican government of some 46800 square miles between the 24th and 31st parallels of latitude in Baja California. They failed to meet their obligations however and the grant was transferred to another party in 1866. The outline was written "in the interest of the Mexican Mining and Colonization Company." In addition to details on the grant it provides material on the discovery early settlements missions mineral resources and pearl fisheries of Baja California." Hill 998. Hill 998. Sabin 39834. HBS 64770. $2500. E. S. Dodge & Co unknown books
1839ref. 430451839. Einige Blicke auf die Entwicklungsgeschichte des vegetabilischen Organismus bei den Phanerogamen. Offprint from Archiv für Naturgeschichte 3 1837: 289-320. Plate. 206 x 126 mm. Original plain wrappers front wrapper detached; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. Botanische Notizen. Offprint from Archiv für Naturgeschichte 4 1838: 49-66. Plate. 205 x 129 mm. Original plain wrappers sun-darkened detached; modern bookplate. Inscribed by Schleiden to William Francis inscription partially lost due to sunning Botanische Notizen. Offprint from Archiv für Naturgeschichte 5 1839: 253-292. Plate. 214 x 128 mm. Original plain wrappers small tear in lower margin; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. Botanische Notizen. Offprint from Archiv für Naturgeschichte 5 1839: 211-234. Lacking plate. Original plain wrappers back wrapper lacking; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. A collection of four extremely rare offprints on botanical science by Schleiden whose landmark 1838 paper "Beiträge zur Phytogenesis" marks the beginning of cell theory and plant cytology. The first offprint is on the development of organs in phanerogams plants with seeds; "his theory of the flower and fruit is an admirable performance for the time even though we abandon his view of the stalk nature of placentas and some other notions as we obviously must. As Robert Brown founded the history of the development of the ovule so Schleiden founded that of the flower and his example influenced other botanists" Von Sachs History of Botany 1530-1860. Schleiden presented these offprints to British chemist Dr. William Francis who in 1852 joined with publisher Richard Taylor to found the firm of Taylor and Francis. unknown books
1879ref. 2558331879. With watercolours photos etc. 4to. Quarter contemporary morocco gilt spine and marbled boards a.e.g. Minor rubbing some pages have been excised. With watercolours photos etc. 4to. Front free endpaper has charming small watercolour of house tipped in with legend in pencil "I believe this is the first dwelling after marriage Rainham Kent. G.T.N. ordained 1806 preached at Romsey. 2. Lumley Lodge Richmond pen and ink drawing. Laid in. 3. Watercolour : "House & chapel built by him of Dr César Malam Prè du Champs- Geneva 4. Pencil drawing "Birthplace of Phillip George de Grand Jacob: Roath Court was left for Somerton in 1808." Signed in picture "Roath Court Frant. July9-39." 5. 2. Lumley Lodge Richmond pencil drawing 6. Crawley Rectory 1832 by A.S.J. Pencil drawing 7. Crawley Rectory and grounds by ASJ 8. Wash drawing of "Abbey Close Winchester" identified lower left From hence mostly photographs. unknown books
1720ref. 607721720. London 1720. third & final edition. London 1720. third & final edition. Best Edition of Jacob's JP Manual Jacob Giles 1686-1744. The Modern Justice: Containing the Business of a Justice of Peace In All its Parts. As an Abridgment of the Common Law And of All the Acts of Parliament Relating to Justices of Peace Constables and Other Parish Officers Under Them Compleat Down to this Time; And Some Special Law-Cases to Illustrate the Same. With Great Variety of the Most Authentick Precedents of Precepts Summons Warrants Examinations Commitments Indictments &c. Regularly Interspersed Fitting all Occasions for Putting of the Laws in Force. Also the Chairman's Charge in the Quarter-Sessions; Proceedings in Trying of Criminals Motions and Trials of Causes Relating to Settlements &c. And the Particular Power of Mayors Given by Statute with Precedents of Warrants &c. in all Cases. To Which are Added A Concise Account of the Constitution and Government of a Considerable Workhouse for Employing of the Poor Within the City of Bristol. An Alphabetical Table Shewing what Acts of Parliament do Concern the Business of a Justice. And a Compleat Table to the Whole. Corrected Improv'd and Continued to this Present Year 1720. London: Printed by Eliz. Nutt and R. Gosling 1720. viii 502 42 pp. Octavo 7-1/2" x 4-1/2". Contemporary paneled calf rebacked in period style raised bands and lettering piece to spine hinges mended. Some rubbing to extremities with some wear to corners light toning to text. Later owner signature to front free endpaper brief annotation to rear pastedown internally clean. $500. Third edition. This is the final and most complete edition. The first edition appeared in 1717. It was reissued in 1718 with new preliminaries. In the third edition Jacob has "continued the statutes to the present year; added many new entire heads and precedents never before printed; a very great number of references and variety of cases and resolutions in the superior courts" preface. He also added about 100 pages of new material. One of the most interesting features is the detailed six-page description of the workhouse at Bristol. It forms part of a full chapter devoted to the Poor Law pp.324-348. OCLC locates 11 copies of this edition in North American law libraries. English Short-Title Catalogue T136996. unknown books
1768ref. 598411768. The Dawn of the "Self-Help" Legal Genre in the New World Jacob Giles 1686-1744. Every Man His Own Lawyer: Or A Summary of the Laws of England In a New and Instructive Method Under the Following Heads Viz. I. Of Actions and Remedies Writs Process Arrests and Bail. II. Of Courts Attornies and Solicitors Therein Juries Witnesses Trials Executions &c. III. Of Estates and Property in Lands and Goods And How Acquired Ancestors Heirs Executors and Administrators. IV. Of the Laws Relating to Marriage Bastardy Infants Ideots Lunaticks. V. Of the Liberty of the Subject Magna Charta the Habeas Corpus Act and other Statutes. VI. Of the King and his Prerogative the Queen and Prince Peers Judges Sheriffs Coroners Justices of Peace Constables &c. VII. Of Publick Offences Treason Murder Felony Burglary Robbery Rape Sodomy Forgery Perjury &c. and Their Punishment. All of Them so Plainly Treated of That All Manner of Persons May be Particularly Acquainted With Our Laws and Statutes Concerning Civil and Criminal Affairs And Know How to Defend Themselves and Their Estates and Fortunes An All Cases Whatsoever. Corrected and Improved With Many Additions from Lord Raymond Comyn Strange Foster And with the Statute Law Down to 4 Geo. 3. Inclusive. New-York: Printed by Hugh Gaine 1768. iv 289 13 pp. Octavo 7-1/4" x 4-1/2". Contemporary sheep blind fillets and decorative blind tooling to boards. Moderate rubbing to extremities some chipping to spine ends corners bumped and lightly worn a few minor scuffs to boards hinges cracked light browning to text. Early owner signature to rear pastedown interior otherwise clean. $2000. First American edition designated the seventh on the title page in reference to the prior six editions published in London. Before the Revolution access to legal knowledge was often guarded by the elite. Giles Jacob one of the 18th century's most prolific legal minds sought to change that. While his peers wrote for the bench and bar Jacob wrote for "All Manner of Persons." He was a legal idealist who believed that a society is only as just as its citizens are informed-a philosophy clearly reflected in this landmark publication. While the work saw ten successful editions in London between 1736 and 1788 this 1768 New York printing marks a pivotal. unknown books
2011ref. 119729Raleigh NC & New York: The Gregg Museum of Art & Design distributed by D.A.P. 2011. First edition. Hardcover. Monograph for a show that ran September 15 through December 17 2011. A very fine copy in cloth binding without dust jacket as issued. Still in the original shrinkwrap. The Gregg Museum of Art & Design distributed by D.A.P. unknown books
1998ref. 120458New York: DCA Gallery 1998. First edition. Softcover. Exhibition catalog for a show that ran May 16 through June 20 1998. Essays by Ann Lumbye Sorensen and Jacob Greve. Includes numerous black and white illustrations. A very near fine copy in white printed wrappers. Seemingly fairly uncommon. DCA Gallery unknown books
1953ref. 601731953. Jacob Ernest Fraser. Essays in the Conciliar Epoch. 2nd ed. Manchester: Manchester University Press 1953. viii 264 pp. With index. Cloth Good. $5. Second edition with two further chapters and critical comments first published in 1943. Contents: Conciliar thought. Dietrich of Niem. Englishmen and the general councils of the fifteenth century. English conciliar activity 1395-1418. Ockham as a political thinker. Sir John Fortescue and the law of nature. The Brethren of the Common Life. The De imitatione Christi. Cusanus the Theologian. "Middle Ages" and "Renaissance." Verborum florida venustas. English university clerks in the later Middle Ages. unknown books
1973ref. 117154np 1973. Probable first edition of this broadside. Measures 8.5" x 11." A fine copy. Uncommon. No copies listed in OCLC. Please note that broadsides can not ship with media mail and will require additonal shipping charges. unknown books
1972ref. 113780Essen: Museum Folkwang 1972. First edition. Softcover. Exhibition catalog for a show that ran November 28 1971 through January 5 1972. Text in German by Hassner. Includes 24 black and white images. A fine copy in wrappers. Museum Folkwang unknown books
1800ref. 41277London: William Richardson 1800. Plate: 196x144 mm. Margin: 275x200 mm. Little faint soiling right and bottom margins are trimmed faint crease in top right margin. William Richardson unknown books
ref. 41853Margin: 76x45 mm. Chip in left margin faint soiling edges trimmed. unknown books
ref. 41558Plate: 152x101 mm. Print: 188x137 mm. Mount: 201x137 mm. Mounted on paper. Print has three frayed edges. some minor tearing Light soiling faint foxing trimmed edges. unknown books
1973ref. 113439Chicago IL: The Wine Press 1973. First edition. Broadside. Measures 11" x 17." One of only 90 numbered copies with this being number 28. A near fine copy. Signed by Jacob. Uncommon with only 4 copies listed in OCLC. Please note that broadsides can not ship with media mail and will require additonal shipping charges. The Wine Press unknown books
1789ref. 247021Paris: Chez Barrois 1789. First edition in French. Avec trente-quatre planches. 34 finely etched plates by Copia EXQUISITELY COLORED by a contemporary hand. 4 324; 4 295 pp. 2 vols. 8vo. Contemporary tan polished calf triple gilt-filet borders smooth spines richly gilt with 2 black leather spine label by Bozerien jeune. First edition in French. Avec trente-quatre planches. 34 finely etched plates by Copia EXQUISITELY COLORED by a contemporary hand. 4 324; 4 295 pp. 2 vols. 8vo. An extremely rare if not unique copy of Engel's classic treatise on acting with the plates colored by hand. This is the very scarce first French edition of Engel's famous Ideen Zu Einer Mimik first printed in German in 1785-86 and one of the most important works on the theory and psycho-physiology of acting. Engel 1741-1802 was a German philosopher who was professor of moral philosophy in the Joachimstal Gymnasium in Berlin and following that tutor to the crown prince of Prussia the future Frederik William III. In 1787 he became director of the Royal Theater in Berlin where he wrote many plays which enjoyed considerable success as well as many essays on aesthetic subjects ONE OF A VERY FEW COPIES WITH HAND-COLORED PLATES. Cohen-De Ricci 346-347; Brunet III 982; Magriel p. 179 Chez Barrois unknown books
1769ref. 410381769. Trew Christoph Jacob 1695-1769. Mezzotint portrait by Johann Jacob Haid 1704-67. N.p. Nuremberg 1769 or after. 531 x 356 mm. image measures 406 x 268 mm. Margins a little frayed not affecting image a few small marginal tears repaired but very good. Excellent mezzotint portrait of German physician and botanist Christoph Jacob Trew after whom the East Indian plant genus Trewia is named. Trew was the author of the lavishly illustrated Hortus nitidissimis omnem per annum superbiens floribus 1750-86 and Plantae selectae quarum imagines ad exemplaria naturalia Londini in hortis curiosorum nutrita 1750-73 both with plates engraved after drawings by the noted 18th century botanical artist Georg Dionysius Ehret; the latter work has been described as "one of the great botanical iconographies" Lazarus and Pardoe p. 43. The present portrait appeared as a frontispiece to the Plantae selectae. Trew founded the periodical Commercium litterarium ad rei et medicinae scientiae naturalis one of the first general medical journals and from 1743 served as director of the Kaiserlich-Leopoldinisch-Carolingischen Akademie der Naturforscher. Trew's scientific correspondence numbering over 19000 letters is the largest such collection known; his natural history library of 34000 volumes is now at the University of Erlangen. Lazarus and Pardoe Catalogue of botanical prints and drawings at the National Museums & Galleries of Wales 2003. . unknown books
2010ref. 547402010. ISBN-13: 9781584779704; ISBN-10: 1584779705. A Tribute to Calamandrei Stein Jacob A. Eulogy of Lawyers: Written by a Lawyer. Clark: The Lawbook Exchange Ltd. 2010. xix xi-xiii new introduction 317 pp. Preface by Bryan A. Garner President Law Prose Inc.; Distinguished Research Professor of Law Southern Methodist University Dallas Texas; Editor current editions of Black's Law Dictionary. ISBN-13: 9781584779704; ISBN-10: 1584779705. Paperback. New. $24.95 In 1936 Piero Calamandrei an Italian lawyer and law professor published Elogio dei Giudici Scritto da un Avvocato a wry collection of maxims anecdotes and observations on the nature of the legal process. Translated in 1946 as Eulogy of Judges Written by a Lawyer it gradually acquired a reputation among sophisticated legal circles as the best lawyer's book ever written. Written by a self-described member of the "Piero Calamandrei Freemasonry Society" Eulogy of Lawyers revives the spirit of its great predecessor while shifting the focus to the other side of the bench. "Stein is a rare breed: a superb noted advocate - one of the finest of his day - who is also a literary essayist. I can think of only two comparable predecessors: Lord Brougham and Clarence Darrow." Bryan A. Garner Preface xii-xiii. Jacob A. Stein has for over 60 years conducted a trial practice. He has been an adjunct professor at American University Law School George Washington University Law School and Georgetown University Law School where he has taught for the last 21 years. He has been president of the District of Columbia Bar. He has served on various judicial committees connected with the Federal Judiciary. He was appointed in 1985 to serve as the United States Independent Counsel to inquire as to the suitability of the President's choice as Attorney General of the United States. His articles have appeared in The American Scholar Times Literary Supplement The Washington Post The Wilson Quarterly the Washington Lawyer the Green Bag Litigation and other publications. His books include Legal Spectator & More 2003 The Law of Law Firms 1994 Closing Argument: The Art and the Law 1969 and other titles. unknown books
2010ref. 547392010. ISBN-13: 9781584779698; ISBN-10: 1584779691. A Tribute to Calamandrei Stein Jacob A. Eulogy of Lawyers: Written by a Lawyer. Clark: The Lawbook Exchange Ltd. 2010. xix xi-xiii new introduction 317 pp. Preface by Bryan A. Garner President LawProse Inc.; Distinguished Research Professor of Law Southern Methodist University Dallas Texas; Editor current editions of Black's Law Dictionary. ISBN-13: 9781584779698; ISBN-10: 1584779691. Hardcover with dust jacket. New. $39.95 In 1936 Piero Calamandrei an Italian lawyer and law professor published Elogio dei Giudici Scritto da un Avvocato a wry collection of maxims anecdotes and observations on the nature of the legal process. Translated in 1946 as Eulogy of Judges Written by a Lawyer it gradually acquired a reputation among sophisticated legal circles as the best lawyer's book ever written. Written by a self-described member of the "Piero Calamandrei Freemasonry Society" Eulogy of Lawyers revives the spirit of its great predecessor while shifting the focus to the other side of the bench. "Stein is a rare breed: a superb noted advocate - one of the finest of his day - who is also a literary essayist. I can think of only two comparable predecessors: Lord Brougham and Clarence Darrow." Bryan A. Garner Preface xii-xiii. Jacob A. Stein conducted a trial practice for over 60 years and was an adjunct professor at American University Law School George Washington University Law School and Georgetown University Law School where he has taught for over 20 years. He has been president of the District of Columbia Bar. He has served on various judicial committees connected with the Federal Judiciary. He was appointed in 1985 to serve as the United States Independent Counsel to inquire as to the suitability of the President's choice as Attorney General of the United States. His articles have appeared in The American Scholar the Times Literary Supplement The Washington Post The Wilson Quarterly the Washington Lawyer The Green Bag Litigation and other publications. His books include Legal Spectator & More 2003 The Law of Law Firms 1994 Closing Argument: The Art and the Law 1969 and other titles. unknown books
1934ref. 219112London 1934. Variant of the portrait from the same session published in PORTRAITS: the Photographs of Carl Van Vechten 1978 edited by Saul Mauriber. Bust portrait of the sculptor in profile. 1 vols. 35 x 27.7 cm. approximately 14 x 11 inches. Docketed in pencil on verso giving the name of the sitter the date of the session and a reference to negative and print "XXIII - F - 30". Variant of the portrait from the same session published in PORTRAITS: the Photographs of Carl Van Vechten 1978 edited by Saul Mauriber. Bust portrait of the sculptor in profile. 1 vols. 35 x 27.7 cm. approximately 14 x 11 inches. unknown books
1934ref. 219114London 1934. Variant of the portrait from the same session published in PORTRAITS: the Photographs of Carl Van Vechten 1978 edited by Saul Mauriber. Bust portrait of the sculptor. 1 vols. 23.2 x 31.5 cm. approximately 12-1/2 x9 inches. Docketed in pencil on verso giving the name of the sitter "Jason Epstein - Hyde Park Gate London" the date of the session and a reference to negative and print "XXIII - F - 28". Variant of the portrait from the same session published in PORTRAITS: the Photographs of Carl Van Vechten 1978 edited by Saul Mauriber. Bust portrait of the sculptor. 1 vols. 23.2 x 31.5 cm. approximately 12-1/2 x9 inches. unknown books
1882ref. 40720London 1882. Very Good. Brett Jacob. A.L.s. to Latimer Clark. London September 18 1882. 2- pp. 181 x 114 mm. Remains of mounting present. Provenance: Latimer Clark. Regarding Clark's request for a portrait photograph. Jacob Brett was the younger brother of John Brett the head of the Magnetic Telegraph Company in England and one of the co-founders of Cyrus Field's Atlantic Telegraph Company. In 1850 John and Jacob Brett laid the first undersea cable between England and France. This failed after one garbled message a French fisherman cut the cable thinking it was a new variety of seaweed but in 1851 the Bretts laid a much stronger cable that remained in use for many years. . unknown books
1870ref. 31578Paris 1870. Preparation by Ludovic. Engraved by Roussin after a drawing by Jacob. Very good to fine condition. 60 x 40 cm. This is one of the largest and most dramatic images in the spectacular Bourgery & Jacob set of anatomical atlases. unknown books
1909ref. 131161909. First edition offprint issue. 231-264pp. Original printed wrappers. Very good. "This work led to the universal clinical use of phenolsulphonephthalein in renal function tests and of phenoltetrachlorphthalein in hepatic function tests" Garrison-Morton.com 1896. unknown books
1968ref. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown books
