55.923 risultati
1854rif. 51129Brussels: Comptoir des éditeurs 1854. Bourgery Jean-Baptiste Marc 1797-1849 and Nicolas Henri Jacob 1782-1871. Anatomie élémentaire en vingt planches representant chacune un sujet dans son entier à la proportion de demi-nature . . . Atlas only. Elephant folio. Title-leaf and 20 lithographed plates most hand-colored. Brussels: Meline Cans et Cie; Comptoir des Éditeurs 1854. 888 x 600 mm. 20th-century quarter morocco boards slight wear. A few marginal tears repaired minor dampstaining but very good. Later edition first published in both Paris and Brussels in 1836 of this set of very large anatomical plates that were intended to be mounted on the walls of dissection rooms. All editions are extremely rare-OCLC does not cite any copies of the 1854 edition. This is the only copy of any edition of this work that we have handled in over 50 years of trading. The work was originally accompanied by a small 20-page pamphlet of text that is not present here. The impressive plates in this atlas reproduce the illustrations in Bourgery and Jacob's Traité complet d'anatomie at a much larger scale than their counterparts in the Traité-roughly half life-size. Some plates were lithographed in Paris; others in Brussels. Plates I and II are devoted to osteology and syndesmology; plates III - VIII to myology and aponeurology; plates IX-XIV to angiology; plates XV-XVII to neurology; plates XVIII-XIX to the digestive system; and plate XX to the reproductive organs. The plates were originally sold separately; uncolored versions were priced at 6 francs and colored versions at 12 francs. Currently two uncolored plates from this series are on the market for about $1300. . Comptoir des éditeurs unknown books
1901rif. 1228141901. First Edition. Signed. RIIS Jacob. The Making of an American. New York: Macmillan 1901. Octavo modern full blue morocco gilt raised bands marbled endpapers top edge gilt with original gilt stamped cloth front cover bound in at rear. $4500.First edition of the pioneering photographer and reformer's autobiography published the decade after his influential work How the Other Half Lives with frontispiece portrait and 83 photographic illustrations many full-page in original bright gilt cloth inscribed to a prominent social reformer and close friend of Jane Addams mentioned in the text: ""Mrs Emmons Blaine with the admiration and respect of the author Jacob A. Riis. New York Dec 9 1901.""In this profusely illustrated autobiography Riis charts his life from his youth in Denmark to his immigration to America and his dedication to documenting the social injustice of New York's slums first as a police photographer and then as a newspaper photographerÑ""the first photographer to use the power of the image as a tool for reform"" McDarrah 381. His 1890 photobook How the Other Half Lives marks the landmark beginning of ""a photographic attitude an ethos-humanist documentary photographyÑin which the photographic social document is employed to bear critical witness to what is going on in the world"" Parr & Badger I:53. ""A pioneer in the development of the documentary"" to Theodore Roosevelt Jacob Riis was ""the staunchest most efficient friend the children of New York City have ever had"" and ""the ideal American citizen"" ANB. With rear leaf of publisher's advertisements. This copy is inscribed to Anita McCormick Blaine a famous Chicago philanthropist and the widow of Emmons Blaine. The son of a powerful political operative his father was a former Republican Secretary of State who lost the presidential race to Grover Cleveland Emmons Blaine was vice president of the B&O Railroad. However he died at just 33 years old leaving his 26-year-old wife a widow. Fortunately her family's intervention into the financial aspects of her marriage ensured that she was a wealthy widow while her late husband guaranteed that she was welcomed into the highest social and political circles. As a newly single mother Blaine became deeply interested in her son's education. She became acquainted with Col. Francis Parker and began to absorb and enact progressive ideas on education. She helped to found the Chicago Institute for teacher training. She also founded two additional schools including a free school for poor children. The success of Blaine's educational initiatives earned her a spot on the Chicago School Board. Blaine soon came to be recognized as a leading philanthropist and social reformer. Much of her work focused on Jane Addams' Hull-House and similar ventures aimed at improving the lives of the poor. Blaine's empirical mindset set her apart and the information and data she doggedly collected supported further social and legislative reform. As a result Blaine was welcome onto the Chicago Board of Charities and the United Charities. She also worked together with Jane Addams to create the City Homes Association dedicated to providing housing for the poor. Collaborating with Addams Blaine fought for labor reform particularly the eight-hour work day and peace. Peace soon became her primary interest after her son died from the 1918 flu spread by World War I. A supporter of the League of Nations and later the United Nations Blaine hoped that she could spare other mothers her fate. At her death Blaine was one of the greatest philanthropists of her time the acknowledged doyenne of the social reform world. She donated over 10 million dollars to social causes and left a huge fortune to the New World Financial Trust. Blaine is mentioned in the last chapter of The Making of an American which is essentially an acknowledgments chapter. Riis writes: ""Jane Addams and Mrs. Emmons Blaine leaven that shall yet leaven the whole unsightly lump out yonder by the western lake and let in the light"" page 436. Blaine's archived correspondence at the University of Wisconsin reveals a request from John Bogue to sell tickets for Riis' lecture ""How the other half lives"" and an invitation from Maud Warner McCormick to a lecture by Jacob Riis. Interestingly Warner McCormick was married to Alexander Agnew McCormick a Chicago alderman and Daily News editor who was a residential member of the University of Illinois' Chicago Literary Club and a member of Chicago Historical Society with possible relative Cyrus Hall McCormick Jr. Blaine's brother.Interior generally fine with a few leaves reinforced at gutter's edge. Attractive in blue morocco most desirable inscribed. hardcover books
1963rif. vas5336Gainesville: University of Florida Press 1963. Octavo green cloth hardcover xxxv 326 pp. Fine in a Near Fine dust jacket with mylar wrapper. From dust jacket: In June 1836 24-year-old Jacob Rhett Motte a Harvard-educated Southern gentleman trained as a surgeon departed his hometown of Charleston to serve as an Army surgeon in wars against the Creek and Seminole Indians. Motte who had a genuine literary flair began keeping a journal -- “While witnessing the dreadful scenes of Indian warfare I was also impressed with the conviction that descriptions of horrible massacres imminent and hairbreadth escapes bloody battles and dreadful murders have always been subjects of interest to the human mind” he later wrote. University of Florida Press, 1963. hardcover books
1987rif. 79187Whitethorn: Holmgangers Press 1987. First edition. 20 pp. Fine in stapled wrappers. Kestrel 11. Whitethorn: Holmgangers Press unknown books
1973rif. 79151Oak Park: Cat's Pajamas Press 1973. First edition. 8 pp. Very good plus in stapled wrappers. INSCRIBED by Jacob on the verso of the title page “This one’s / for Gary - / John.” Oak Park: Cat's Pajamas Press unknown books
1853rif. 50480London: Taylor and Francis 1853. Whole issue in original printed wrappers mostly uncut & unopened. iv 311-561 1 15pp.; 7 plates Plates XIX. - XXVI. Jacob Augustus Lockhart Clarke 1817-1880 was an English physician physiologist histologist and neurologist. Clarke received his material edication at Guy's Hispital and St. Thomas's Hospital in London. He was liscenced by the Apothecaries Society and subsequently went to love with his mother at Pimlico where he established a private practice. From 1851 to 1868 while Clarke was engaged in general practice and continuing his studies at St. George's Hospital he conducted his now famous research on the central nervous system. "Most of his numerous works were published in in the Philosophical Transactions 1851 53 58 59 60 65 68 in the Proceedings of the Royal Society 1857 61 the Microscopical Journal British and Foreign Medical Review 1864 and others. His earlier works concern the anatomy and the physiology of the medulla oblongata and the spinal marrow as well as the brain. His discovery of the Clark's column also designated nucleus dorsalis was done in this period. His later research is more concerned with pathological studies in his special field. he also published on tetanus diabetes paraplegias of muscular atrophy. Clarke was described as a man of the highest character "with s singleness of purpose of noble independence honest and just conscientious and intellectually keen but with a singularly retiring and reserved disposition. He never acquired a large practice and is reputed not to have been well off financially." Whonamedit Jacob Augustus Lockhart Clarke. Accessed 11/4/2022. . Taylor and Francis unknown books
1856rif. 9751gcsNew York: Harper & Brothers Publishers 1856. Signed by Elias Loomis to his son Henry Elias Loomis famous scientist. Duodecimo red blind-stamped cloth hardcover gilt letters 160 pp. Very Good with edgewear. Harper & Brothers, Publishers, (1856). hardcover books
1858rif. 1354648Boston: Phillips Sampson and Company 1858. First Edition. Hardcover. Octavo v 7-75 pages. In Good plus condition. Bound in embossed brown cloth with gilt lettering. Boards show some discoloration to covers; spine with light wear to edges and corners. Text block foxed. Inscribed by author on front free endpaper: "Prof. Geo. B. Wood with the author's regards." An ex-library embossed stamp on title page. MF Consignment. NOTE: Shelved in Rockville Annex Aisle A Top Shelf. George Bacon Wood received his B.A. and M.D. from the University of Pennsylvania. Wood first taught at the Philadelphia College of Pharmacy beginning in 1822 as professor of chemistry and then in 1831 becoming professor of materia medica. He concluded his teaching at the College of Pharmacy in 1835 when he was named professor of materia medica at the University of Pennsylvania; in 1850 he became professor of the theory and practice of medicine a position he held until he retired in 1860. In 1863 he was elected to the University of Pennsylvania's board of trustees where he remained until his death. In 1865 Wood endowed an Auxiliary Faculty of Medicine at Penn with five chairs in zoology and comparative anatomy; botany; mineralogy and geology; hygiene; and medical jurisprudence and toxicology. Up until 1855 he continued to instruct medical students privately as well. Wood was connected with many other institutions during his career. He was an attendant physician at the Pennsylvania Institute for the Deaf and Dumb from 1822 to 1844 and at Philadelphia Hospital later Philadelphia General Hospital from 1835 to 1859. He was president of the American Philosophical Society from 1859 until his death of the American Medical Association from 1855 to 1856 and also for many years of Philadelphia's College of Physicians. Wood was also the author of many books most notably the Dispensatory of the United States with Dr. Franklin Bache in 1833 and Treatise on the Practice of Medicine in 1847. - University of Pennsylvania website. 1354648. Special Collections - Upstairs. Phillips, Sampson and Company hardcover books
1987rif. 67546Whitethorn: Holmgangers Press 1987. First edition. 20 pp. Fine in stapled wrappers. Dated 9/23/87 and warmly INSCRIBED by Jacob on the title page. Laid into this copy is a full page holograph letter from Jacob to the book’s publisher. Kestrel 11. Whitethorn: Holmgangers Press unknown books
1993rif. 67175Washington DC: Rappahannock Press/Phillips Collection 1993. First edition. 4to. 172 pp w/selected bibliography & index. Fine in fine dust jacket. Introductory essay by Henry Louis Gates Jr. 116 illustrations of which 60 are in full color. Washington DC: Rappahannock Press/Phillips Collection, unknown books
1775rif. 1087571775. London: T. Payne 1775/1776. 3 vols 4to xx 516; 2 vi 535; viii 602 pp with 31 engravings on the 30 listed plates. A very good and attractive set in clean condition bound in original calf with gilt decorated rules to covers and gilt decoration to spine panels with six compartments and red and black labels. § Second edition of Vol. 1 and 2 1775 and only edition of Vol. 3 1796. The three maps are lacking. All other illustrations are present in good condition but including usual offsetting and a few showing minor mottling and browning. Plate XI stated in the List of Plates to be a Bartolozzi engraved plate designed by Cypriani from an original onyx Camaio by the Greek artist Tryphon is the correct plate although in fact it bears no plate No. and the imprint "G. B. Cipriani Del I.K. Sherwin Sculp." Although Bartolozzi normally signs his studio's plates J. K. Sherwin was an apprentice of Bartolozzi's and presumably was allowed to sign his engraving in this instance. The plate's design matches "The Marriage of Eros and Psyche" from Tryphon's Camaio in the Duke of Marlborough's Collection see e.g Wikipaedia: "The Marlborough Gem". Bentley BB 439. Essick CBI p. 117 entry C. unknown books
rif. 64347np: nd. nd. First edition. 8 pp including covers. Very near fine in side-stapled wrappers. SIGNED by Jake. A collection of five poems dedicated to “JMC & Cate.” (np): (nd). unknown books
1848rif. 433851848. Berzelius Jöns Jacob 1779-1848. Jacobus Berzelius. Medal in bronze showing a right-facing bust of Berzelius on the obverse with his birth and death dates in roman numerals; the reverse with a standing winged figure and the seated figure of Hygeia along with text in Latin. Signed "P. H. Lundgren fec. - C. G. Quarnstroem inv." N.p. n.d. 1848. 57 mm. diameter. A few minor scratches and dings but very good. The Berzelius Medal was commissioned by the Royal Swedish Academy of Sciences in memory of the famous Swedish chemist who is regarded as one of the founders of modern chemistry. Berzelius invented the current system of chemical symbols originated the duality theory of chemical affinity classing chemical elements as either electronegative or electropositive an ancestor of 20th century electron theories of bonding developed new and important methods of chemical synthesis and analysis and discovered the elements cerium selenium and thorium. T he Latin motto above the figures on the reverse reads "Naturam jussit vires proferre latentes" He commanded forth the secrets of nature. The text below the figures reads "Fundatorum supremo lugens in deepest mourning/ Medic. Suec. Societas." The medal was issued in silver bronze and Berlin iron; this is an example of the bronze. Storer Medicina in Nummis no. 337. . unknown books
2008rif. 57395Brooklyn: Cuneiform Press 2008. First edition. Single sheet folded twice to make a booklet 7 1/2 x 4 1/2 inches closed. Fine. Jacob’s poem in French Fagin’s version in English. SIGNED by Fagin on the rear cover. [Brooklyn]: Cuneiform Press unknown books
1839rif. 430451839. Einige Blicke auf die Entwicklungsgeschichte des vegetabilischen Organismus bei den Phanerogamen. Offprint from Archiv für Naturgeschichte 3 1837: 289-320. Plate. 206 x 126 mm. Original plain wrappers front wrapper detached; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. Botanische Notizen. Offprint from Archiv für Naturgeschichte 4 1838: 49-66. Plate. 205 x 129 mm. Original plain wrappers sun-darkened detached; modern bookplate. Inscribed by Schleiden to William Francis inscription partially lost due to sunning Botanische Notizen. Offprint from Archiv für Naturgeschichte 5 1839: 253-292. Plate. 214 x 128 mm. Original plain wrappers small tear in lower margin; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. Botanische Notizen. Offprint from Archiv für Naturgeschichte 5 1839: 211-234. Lacking plate. Original plain wrappers back wrapper lacking; modern bookplate. Inscribed by Schleiden to William Francis on the front wrapper. A collection of four extremely rare offprints on botanical science by Schleiden whose landmark 1838 paper "Beiträge zur Phytogenesis" marks the beginning of cell theory and plant cytology. The first offprint is on the development of organs in phanerogams plants with seeds; "his theory of the flower and fruit is an admirable performance for the time even though we abandon his view of the stalk nature of placentas and some other notions as we obviously must. As Robert Brown founded the history of the development of the ovule so Schleiden founded that of the flower and his example influenced other botanists" Von Sachs History of Botany 1530-1860. Schleiden presented these offprints to British chemist Dr. William Francis who in 1852 joined with publisher Richard Taylor to found the firm of Taylor and Francis. unknown books
1800rif. 41277London: William Richardson 1800. Plate: 196x144 mm. Margin: 275x200 mm. Little faint soiling right and bottom margins are trimmed faint crease in top right margin. William Richardson unknown books
rif. 41853Margin: 76x45 mm. Chip in left margin faint soiling edges trimmed. unknown books
rif. 41558Plate: 152x101 mm. Print: 188x137 mm. Mount: 201x137 mm. Mounted on paper. Print has three frayed edges. some minor tearing Light soiling faint foxing trimmed edges. unknown books
2009rif. 50201Oak Park: Black Cat Bone Press 2009. First edition. 18 pp. Fine in printed wrappers. Poems. One of 75 copies printed letterpress and handbound at the Adastra Press. Oak Park: Black Cat Bone Press unknown books
1769rif. 410381769. Trew Christoph Jacob 1695-1769. Mezzotint portrait by Johann Jacob Haid 1704-67. N.p. Nuremberg 1769 or after. 531 x 356 mm. image measures 406 x 268 mm. Margins a little frayed not affecting image a few small marginal tears repaired but very good. Excellent mezzotint portrait of German physician and botanist Christoph Jacob Trew after whom the East Indian plant genus Trewia is named. Trew was the author of the lavishly illustrated Hortus nitidissimis omnem per annum superbiens floribus 1750-86 and Plantae selectae quarum imagines ad exemplaria naturalia Londini in hortis curiosorum nutrita 1750-73 both with plates engraved after drawings by the noted 18th century botanical artist Georg Dionysius Ehret; the latter work has been described as "one of the great botanical iconographies" Lazarus and Pardoe p. 43. The present portrait appeared as a frontispiece to the Plantae selectae. Trew founded the periodical Commercium litterarium ad rei et medicinae scientiae naturalis one of the first general medical journals and from 1743 served as director of the Kaiserlich-Leopoldinisch-Carolingischen Akademie der Naturforscher. Trew's scientific correspondence numbering over 19000 letters is the largest such collection known; his natural history library of 34000 volumes is now at the University of Erlangen. Lazarus and Pardoe Catalogue of botanical prints and drawings at the National Museums & Galleries of Wales 2003. . unknown books
1882rif. 40720London 1882. Very Good. Brett Jacob. A.L.s. to Latimer Clark. London September 18 1882. 2- pp. 181 x 114 mm. Remains of mounting present. Provenance: Latimer Clark. Regarding Clark's request for a portrait photograph. Jacob Brett was the younger brother of John Brett the head of the Magnetic Telegraph Company in England and one of the co-founders of Cyrus Field's Atlantic Telegraph Company. In 1850 John and Jacob Brett laid the first undersea cable between England and France. This failed after one garbled message a French fisherman cut the cable thinking it was a new variety of seaweed but in 1851 the Bretts laid a much stronger cable that remained in use for many years. . unknown books
1870rif. 31578Paris 1870. Preparation by Ludovic. Engraved by Roussin after a drawing by Jacob. Very good to fine condition. 60 x 40 cm. This is one of the largest and most dramatic images in the spectacular Bourgery & Jacob set of anatomical atlases. unknown books
1909rif. 131161909. First edition offprint issue. 231-264pp. Original printed wrappers. Very good. "This work led to the universal clinical use of phenolsulphonephthalein in renal function tests and of phenoltetrachlorphthalein in hepatic function tests" Garrison-Morton.com 1896. unknown books
1968rif. 387331968. Jacob Francois 1920- ; Monod Jacques 1910-75; Lwoff Andre 1902-94; & Brenner Sydney 1927- . Group of 22 offprints mimeographs etc. on molecular biology and bacterial genetics together with 2 related papers by other authors. Various sizes. 1947-1968. Together in one volume cloth "Institut Pasteur" in gilt on the spine. Overall good to very good; see detailed condition descriptions below. From the library of G. G. and Elinor Meynell authors of Theory and Practice in Experimental Biology 1970 with their address label on the front endpaper and ownership signatures on several of the offprints. First / First Separate Editions. Jacob Monod and Lwoff all colleagues at the Institut Pasteur received the 1965 Nobel Prize in physiology / medicine for their discoveries concerning genetic control of enzyme and virus synthesis-discoveries that "opened up a new field of research that deserved to be called 'molecular biology'" Magill The Nobel Prize Winners: Physiology or Medicine II p. 921. Their work answered the fundamental question of how the hereditary information contained in DNA can be translated into the chemical processes that synthesize cellular proteins this question had been posed most succinctly and explicitly in Francis Crick's theoretical paper "On protein synthesis" 1957 which laid the groundwork for over a decade's worth of research in this area. Brenner another key figure in this field worked with Jacob and Matthew Meselson on providing experimental evidence for messenger RNA; he was awarded a share of the 2002 Nobel Prize for his discoveries concerning genetic regulation of organ development and programmed cell death. The collection we are offering here focuses largely on the Nobel Prize-winning work done by the Institut Pasteur group-Lwoff Jacob and Monod-in the 1950s and 1960s. The work can be divided into four sections: 1 lysogeny and bacterial conjugation 2 expression of the genetic material via messenger RNA 3 the regulation of the genetic activity of bacterial cells by operons 4 the organization of bacterial genetic material. In the following paragraphs we will attempt to highlight the more important papers in this remarkable collection; however all the papers here touch upon these central questions of molecular biology. Lysogeny defined as the hereditary ability to produce the bacteriophage virus is a peculiar type of infection in which the phage becomes part of the genetic material of a bacterial cell; in this non-infective form prophage it can then be inherited by succeeding generations of cells becoming virulent only when some environmental stimulus causes the bacterium to produce and release phage. "Lysogeny brought a model for the interrelation between a virus and a cell. And also a model for the possible mode of action of carcinogenic agents which could disturb something in this balance" Judson p. 368. Lwoff studied this phenomenon intensively in the late 1940s and early 1950s successfully demonstrating the genetic nature of lysogeny which was disputed by several scientists including Delbruck and discovering how it is induced. In 1953 he published an important review of the subject "Lysogeny" Bacteriological Review 17; see no. 2 below. Lysogeny was also studied by Jacob and Elie Wollman whose paper "Induction of phage development in lysogenic bacteria" CSH Symposia on Quant. Biol. 18 1953; see no. 5 below summarizes what had been learned about lysogeny as of that date. Lwoff's work on lysogeny inspired Jacob and Wollman to investigate the phenomenon of bacterial conjugation the transfer of genetic information from a male donor bacterium to a female recipient resulting in genetic recombination to see if they could discover where in the bacterium's genetic material the prophage was located. In 1955 working with a highly recombinant strain of E. coli K12 discovered by William Hayes Jacob and Wollman performed what came to be known as their "coitus interruptus" experiment in which they used a Waring blender to interrupt the mating bacteria at various stages of their conjugation. They found that the donor cell's genetic characteristics were not transferred all at once but rather sequentially over time-a discovery of great importance. "Wollman and Jacob had stumbled upon a way to measure off the genes on the bacterial chromosome as directly and physically as a child squeezes toothpaste onto a brush or a carpenter unrolls a coiled steel tape measure. As they saw instantly and reported in a note in mid-June 1955 in the weekly Comptes rendus of the Academie des Sciences "Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12"; see no. 6 below they had the means to make a genetic map of biochemical characteristics expressed in units of time" Judson p. 385. In 1956 Wollman and Jacob published the first albeit rudimentary timed map of the K12 strain of E. coli in a paper published in France. This map was printed again in their English-language paper "Conjugation and genetic recombination in E. coli K-12" CSH Symposia on Quant. Biol. 21 1956; see no. 8 below which also contained the first publication of Thomas Anderson's famous electron micrograph of two conjugated bacteria. In 1958 Jacob delivered his paper "Transfer and expression of genetic information in E. coli K12" see no. 9 below at a symposium in Brussels; this paper together with one given by Jacob's sometime colleague Arthur Pardee "ranged over the whole matter of transfer of genes between bacteria and the regulation of their expression" Judson p. 400. Jacob and Wollman had originally represented the hereditary material in linear form while stating that the genetic map could be formally represented as a circle. In 1963 at a Cold Spring Harbor conference the researcher J. Cairns provided physical evidence that the E. coli chromosome was circular; at this same conference Jacob Brenner and co-author Francois Cuzin presented their paper "On the regulation of DNA replication in bacteria" CSH Symposia on Quant. Biol. 28; see no. 16 below containing their "replicon model of chromosome replication in bacteria a model that almost required circularity of chromosomal and F factor DNA" Brock p. 103. Experimental proof of the existence of messenger RNA the substance responsible for coding protein synthesis was announced in Brenner Jacob and Meselson's landmark paper "An unstable intermediate carrying information from genes to ribosomes for protein synthesis" Nature 190 1961; see no. 1 below. The theoretical groundwork for messenger RNA had been laid in Crick's "On protein synthesis" 1957; demonstration of the substance's existence had been foreshadowed by Volkin and Astrachan's discovery of a high-turnover unstable RNA distinct from the ribosomal and transfer varieties 1956 and by the famous "PaJaMo" experiment demonstrating the negative control mechanism of enzyme induction 1958. However it was not until the spring of 1960 that these previous findings were combined by Brenner Jacob and Francis Crick into a biological model setting forth the exact means of communication between gene and cytoplasm while eliminating the various problems associated with earlier ribosome-based theories of gene expression. As Brock puts it the ribosome was now seen as "simply a nonspecific translation machine something like a computer whose behavior depended on what software it contained" Brock p. 306. Working with Matthew Meselson who had developed experimental techniques for tagging and separating ribosomes Brenner and Jacob performed the critical experiment described in their paper which provided direct evidence for the existence of an unstable rapidly turning over messenger RNA. The concept of the operon-a group of adjacent genes functioning as a unit under the control of another gene the operator gene-developed between 1958 and 1960 on the basis of work done by Monod and Jacob who were investigating the repressor model of gene regulation. Jacob developed the idea that gene regulation was based on a repression system that operated like an on-off switch and that "genetic units of a higher order existed . . . that contained several genes subject to unitary expression. . . . On the basis of these ideas and observations Jacob and Monod developed the concept of two kinds of genes structural which coded for the synthesis of proteins and regulatory which did not" Brock p. 300. In October 1959 Jacob and Monod published the theoretical basis for the operon in "Genes de structure et genes de regulation dans la biosynthese des proteines" C. r. Acad. Sci. 249; see no. 11 below. Their paper "established the sharp distinction between the familiar genes that determined protein structures and the new class of genes that regulated. It even looked to them then as though the product of the regulatory gene were not a protein by RNA. But the fact to be underlined they said was that in every known case when several structural genes had their expression controlled by the same regulatory gene-'that is to say in all probability by a unique repressor'-the structural genes were grouped tightly together. . . . The best fit to the evidence was that the group of genes had among them a single element: the operator target of the repressor" Judson p. 410. The Jacob/Monod operon model of gene expression was further explored in their 1961 paper "On the regulation of gene activity CSH Symposia on Quant. Biol. 26; see no. 14 below which presented a more detailed examination of the mechanics of protein synthesis. For further information see Judson The Eighth Day of Creation 2nd ed. and Brock The Emergence of Bacterial Genetics; specific references are given below. 1. Brenner Sydney; Jacob Francois; & Meselson Matthew. An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Offprint from Nature 190 May 13 1961. 576-581pp. Diagrams. Without wrappers as issued. Light toning. Ownership signature of E. W. Meynell on the first page. Garrson-Morton 256.10. Brock ch. 10.12. Judson pp. 414-27. 2. Lwoff Andre. Lysogeny. Offprint from Bacteriological Review 17 1953. 269-337pp. Without wrappers. Small stamp on first page. Brock ch. 7.4. 3. Monod Jacques. Inhibition de l'adaptation enzymatique chez une bacterie E. coli infectee par un bacteriophage. Offprint from C. r. Acad. Sci. 224 1947. 2 2 blankpp. Without wrappers. Light browning creased horizontally with small tear along crease. Ownership stamp and ms. annotations of A. A. Miles. 4. Lwoff & Siminovitch Louis. Induction de la lyse d'une bacterie lysogene sans production de bactÈrophage. Offprint from C. r. Acad. Sci. 233 1951. 3pp. Fore-edge frayed marginal tear affecting a few words. A. A. Miles's signature. 5. Jacob Francois & Wollman Elie. Induction of phage development in lysogenic bacteria. Offprint from CSH Symposia on Quant. Biol. 18 1953. 101-121pp. Without wrappers. Light soiling a few annotations. Owner's name on first page. Judson p. 382. 6. Wollman & Jacob. Sur le mecanisme du transfert de materiel genetique au cours de la recombinaison chez E. coli K12. Offprint from C. r. Acad. Sci. 240 1955. 3pp. Without wrappers. Creased horizontally light toning. Ownership signature of Elinor Meynell. Brock ch. 5.7. 7. Jacob; Alfoldi Lajos; & Wollman Elie. Zygose letale dans des croisements entre souches colicinogenes et non colicinogËnes d'E. coli. Offprint from C. r. Acad. Sci. 244 1957. 3pp. Without wrappers. Small marginal tears. Elinor Meynell signature. 8. Wollman; Jacob & Hayes W. Conjugation and genetic recombination in E. coli K-12. Offprint from CSH Symposia on Quant. Biol. 21 1956. 141-162pp. Without wrappers. Brock ch. 5.11. 9. Jacob. Transfer and expression of genetic information in E. coli K12. Manuscript for the Symposium of the Society for Cell Biology Brussels 1958. 29 3pp. Dittoed table. Mimeographed. Without wrappers. Edges a bit frayed. E. Meynell signature. Judson p. 400. 10. Jacob & Fuerst Clarence R. The mechanism of lysis by phage studied with defective lysogenic bacteria. Offprint from J. Gen. Microbiol. 18 1958. 518-526pp. Without wrappers. E. Meynell signature. 11. Jacob & Monod. Genes de structure et genes de regulation dans la biosynthese des proteines. Offprint from C. r. Acad. Sci. 249 1959. 3pp. Without wrappers. Creased horizontally. E. Meynell signature. Brock ch. 10.10. Judson p. 410. 12. Changeux Jean-Pierre. Sur l'expression biochimique de determinants genetiques d'E. coli introduits chez Salmonella typhimurium. Offprint from C. r. Acad. Sci. 250 1960. 3pp. Creased horizontally. Meynell signature. 13. Jacob. Comments. Offprint from Cancer Research 20 1960. 695-697pp. Without wrappers. 14. Jacob & Monod. On the regulation of gene activity. Offprint from CSH Symposia on Quant. Biol. 26 1961. 193-211pp. Without wrappers. Meynell signature. Brock ch. 10.13. 15. Jacob & Monod. Elements of regulatory circuits in bacteria. Unesco Symposium on Biological Organization. Paris 1962. Mimeographed. 27pp. plus tables and figures. Without wrappers. Light browning. 16. Jacob; Brenner Sydney; & Cuzin Francois. On the regulation of DNA replication in bacteria. Offprint from CSH Symposia on Quant. Biol. 28 1963. 329-348pp. Without wrappers. Meynell signature. Brock ch. 5.11. 17. Jacob & Ryter Antoinette. Etude au microscope Èlectronique des relations entre mÈsosomes et noyaux chez Bacillus subtilis. Offprint from C. r. Acad. Sci. 257 1963. 4pp. Plate. Without wrappers. Meynell signature. 18. Lennox Edwin S. ; Novick Aaron; & Jacob. Relation between repression level and rate of enzyme synthesis. Offprint from Colloques Internationaux du Centre Nat. de la Recherche Scientifique. No. 124. Mecanismes de regulation des activites cellulaires chez les microorganisms 1965. 209-219pp. Orig. wrappers. Meynell signature. 19. Sebald Madeleine & Schaeffer Pierre. Toxinogenese et sporulation chez Clostridium histolyticum. Offprint from C. r. Acad. Sci. 260 1965. 3pp. Without wrappers. 20. Jacob & Ryter. Segregation des noyaux chez Bacillus subtilis au cours de la germination des spores. Offprint from C. r. Acad. Sci. 263 1966. 4pp. Plate. Without wrappers. Meynell signature. 21. Jacob & Ryter. Segregation des noyaux pendant la croissance et la germination de B. subtilis. Offprint from C. r. Acad. Sci. 264 1967. 3pp. Plate. Without wrappers. 22. Jacob. Genetics of the bacterial cell. Offprint from Science 152 1966. 9pp. Orig. printed self-wrappers. Nobel address. Meynell signature. 23. Jacob; Pereira da Silva Luiz; & Eisen Harvey. Sur la rÈplication du bacteriophage l. Offprint from C. r. Acad. Sci. 266 1968. 3pp. Without wrappers. 24. Ryter A.; Hirota Y.; & Jacob. DNA-Membrane complex and nuclear segregation in bacteria. Offprint from CSH Symposia on Quant. Biol. 33 1968. 669-676pp. . unknown books
1981rif. 36990Markesan: Pentagram Press 1981. First edition. 32 pp. Fine in printed wrappers. Prose. One of 550 copies. Markesan: Pentagram Press, unknown books
