Incêndio

Incêndio — marelibri

Fire, A, S Xu, M K Montgomery, S A Kostas, S E Driver, & C C MelloBiblio.com

Potent and Specific Genetic Interference by Double-Stranded RNA in Caenorhabditis elegans in Nature 391 February 19 1998 pp. 806-811 LANDMARK DISCOVERY OF RNA INTERFERENCE RNAi

1998ref. 1696London: Macmillan & Sons 1998. 1st Edition. FIRST EDITION IN ORIGINAL WRAPS OF THE LANDMARK DISCOVERY OF RNA INTERFERENCE RNAi A FUNDAMENTAL MECHANISM OF GENE REGULATION. RNAi became both a major research tool and a new class of therapeutics. In terms of impact on biology medicine and biotechnology this paper is considered a foundational discovery not just an incremental advance. Fire and Mello won the Nobel Prize in Physiology or Medicine IN 2006 just eight years after publication unusually fast recognition for how transformative it was. Prior to Fire and Mello's paper researchers knew that injecting antisense RNA into C. elegans could sometimes silence genes but the effect was often weak inconsistent and poorly understood. Fire and Mello showed that the actual trigger was double-stranded RNA dsRNA not single-stranded antisense RNA as had been assumed. They found that dsRNA was far more potent than either sense or antisense strands alone effective at just a few molecules per cell that it could silence genes with striking specificity that the effect could spread between cells and even to offspring and that it worked catalytically rather than stoichiometrically - implying an amplification mechanism. The discovery that RNAi is a natural evolutionarily conserved gene-regulation and antiviral defense mechanism found across plants animals and fungi. The rapid development of RNAi as a laboratory tool for knocking down specific genes to study their function - now a standard technique in virtually every molecular biology lab. CONDITION & DETAILS: London: Macmillan & Co. Nature Volume 391 No. 6669. Original Wraps. 10 x 7 inches; 250 x 175mm. Original paper wraps. Bearing the mail sticker of Robert R. Rofen the American ichthyologist. Bright and clean inside and out. Fine condition in every way. Macmillan & Sons paperback

Atticus Rare Books · Estados UnidosUS$ 625,00≈ € 557,29

Fire Department ModernizationBiblio.com

Modernizing Fire Departments in Massachusetts and the Northeast Archive of 33 Photos Documenting the Transition from Horse-Drawn Steam Engines to Modern Automotive Fire Trucks 1910-1940s

1910ref. 233921910. TechnologyRescue Operations American fire engine modernization archive documenting the transition from horse drawn steam engines to motorized trucks and rescue wagons in Massachusetts and across the Northeast between the 1910s and 1940s. Fire departments across the U.S. began to transition from horses and steam pumpers to gasoline powered apparatus to account for urban growth taller buildings electrical wiring and automobile traffic changing the speed and scale of emergency response. The archive records identified departments and apparatus makers including Mack GMC Ford Seagrave Studebaker American LaFrance and Maxim mostly showing departments across Massachusetts departments and with additional images from New York Pennsylvania New Jersey Rhode Island and Vermont. Photo archive of 33 silver gelatin photographs many with captions ranging from 2 x 3 to 4 x 6 inches chiefly Massachusetts with additional material from Vermont Pennsylvania New York New Jersey and Rhode Island 1910s to 1940s. Fire engines and firefighters appear in station fronts street parades apparatus portraits airport grounds and active fire scenes. Captions identify New York City Rescue 1 Mack; Syracuse Rescue 1 GMC; Highland Park Pennsylvania Rescue 2 Mack; Plainfield New Jersey Rescue GMC; Chelmsford Massachusetts Emergency No. 7 Studebaker; Camp Edwards Massachusetts Mack Engine 4; Needham Massachusetts Mack Engine 3; Lawrence Massachusetts Engine 3 American LaFrance; Boston Ladder 8 Ladder 9 and Ladder 21; Cambridge Engine 3; Canton Massachusetts Mack engine; Shrewsbury Massachusetts Engine 3 and Ladder 3; Barrington Vermont; Stoneham Massachusetts Bell Block; River Street Boston; First Scientist Church Somerville; and Fort House Somerville. Horse drawn apparatus appears outside Hope No. 1 in Pittsburgh and in a parade scene while motorized ladder trucks carry long wooden extension ladders hose reels searchlights bells sirens polished pumps and side mounted tools. The images provide a side by side record of old and new fire protection: horse teams exposed steam machinery open cab ladder trucks and later motorized emergency vehicles. Chas. E. Beckwith's Fire Dept. Photographer stamp connects at least part of the group to a specialist working for Massachusetts fire departments. Photographs stapled to eight disbound black album pages; scattered fading handling wear with legible captions. Some with additional handwritten captions on versos. Overall in good condition. unknown

Max Rambod Inc. · Estados UnidosUS$ 650,00≈ € 579,58

Fire Department ModernizationABAA

Modernizing Fire Departments in Massachusetts and the Northeast Archive of 33 Photos Documenting the Transition from Horse-Drawn Steam Engines to Modern Automotive Fire Trucks 1910-1940s

Max Rambod Inc. · Estados UnidosUS$ 650,00≈ € 579,58

Trinity United Methodist Church FireBiblio.com

Sequential Photographs of the Fire Destruction of Trinity United Methodist Church Clearfield Pennsylvania: Large Scale Urban Fire and Volunteer Firefighting Operations December 1968

1968ref. 233001968. Fire destruction of Trinity United Methodist Church on South 2nd Street in Clearfield Pennsylvania photographed during the active overnight blaze of December 21 1968 in a dramatic sequential record of one of the borough's largest twentieth century urban fires. The archive captures the church while fully engulfed preserving flames erupting through the roofline smoke pouring from the arcaded façade hose streams striking the structure from darkened streets and the silhouette of the church tower rising above the fire. The photographs record not only the destruction of a major downtown religious landmark led at the time by Rev. Oliver H. R. Krapf but also the operational reality of late 1960s volunteer firefighting systems in small town Pennsylvania where borough police volunteer companies ladder apparatus hydrant pressure and regional mutual aid networks were rapidly assembled in an effort to contain a spreading structural fire. The blaze was first spotted around 2:10 a.m. by taxi driver Billy Knepp after which Fire Chief William Swisher summoned neighboring companies to prevent the fire from spreading beyond the church into the surrounding civic center. Photo archive of 16 silver gelatin photographs mounted to a large cardstock sheet measuring approximately 20" x 14" each image roughly 3.5" x 5" Clearfield Pennsylvania December 1968. Each photograph is numbered by hand from 1 to 16 and together they function almost cinematically moving through different stages and vantage points of the firefight. The images center the church's cut stone arcades and bell tower as bright interior firelight blows outward through the large arched openings and flames tear across the roof structure above. Several photographs show powerful hose streams cutting diagonally across the frame toward the burning façade while others pull back into wider nighttime street scenes where bare winter trees utility poles parked cars wet pavement and gathered onlookers remain visible beneath smoke and reflected firelight. One frame includes a firefighter seen from behind at street level facing the inferno while another captures a bicyclist or passerby entering the foreground as the church burns behind him. Multiple views emphasize the repetition of the long arcade row transforming the church exterior into a glowing sequence of arches illuminated by active fire inside the structure. The resulting series preserves not only the destruction itself but the visual atmosphere of the emergency response: steam smoke glare darkness reflective pavement and shifting vantage points from the surrounding streets as firefighters attempted to control the blaze. The archive is especially significant as documentation of pre modernized municipal fire response during a period when Pennsylvania boroughs depended heavily on intercompany volunteer assistance for major structural fires. The identified responding companies from Lawrence Township Hyde Curwensville Philipsburg and Chester Hill gives the group great specificity within the history of regional mutual aid firefighting networks. At the same time the photographs preserve the loss of an architecturally prominent early twentieth century Methodist church before widespread sprinkler retrofitting and later fire protection standards transformed many American religious and civic structures in the decades that followed. Mount toning with expected contrast loss and glare in several high intensity night exposures. Overall good condition. unknown